Spp1

Summary

Gene Symbol: Spp1
Description: secreted phosphoprotein 1
Alias: 2AR, Apl-1, BNSP, BSPI, Bsp, ETA-1, Eta, Opn, Opnl, Ric, Spp-1, osteopontin, 44 kDa bone phosphoprotein, bone sialoprotein 1, calcium oxalate crystal growth inhibitor protein, early T-lymphocyte activation 1 protein, minopontin, osteopontin-like protein
Species: mouse
Products:     Spp1

Top Publications

  1. Da Silva A, Pollett A, Rittling S, Denhardt D, Sodek J, Zohar R. Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death. J Cell Physiol. 2006;208:629-39 pubmed
    b>Osteopontin (OPN), a pro-inflammatory mediator, is constitutively expressed in normal gut and is upregulated in inflammatory colitis...
  2. Leali D, Moroni E, Bussolino F, Presta M. Osteopontin overexpression inhibits in vitro re-endothelialization via integrin engagement. J Biol Chem. 2007;282:19676-84 pubmed
    The extracellular matrix protein osteopontin (OPN) plays a nonredundant role in atherosclerosis and restenosis...
  3. Kiefer F, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, et al. Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes. 2010;59:935-46 pubmed publisher
    ..b>Osteopontin (OPN) is an inflammatory cytokine, the expression of which is strongly upregulated in adipose tissue and liver ..
  4. Syn W, Choi S, Liaskou E, Karaca G, Agboola K, Oo Y, et al. Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology. 2011;53:106-15 pubmed publisher
    ..The gene encoding osteopontin (OPN), a profibrogenic extracellular matrix protein and cytokine, is a direct transcriptional target of the Hh ..
  5. Sumitomo A, Ishino R, Urahama N, Inoue K, Yonezawa K, Hasegawa N, et al. The transcriptional mediator subunit MED1/TRAP220 in stromal cells is involved in hematopoietic stem/progenitor cell support through osteopontin expression. Mol Cell Biol. 2010;30:4818-27 pubmed publisher
    ..that MED1 in stromal cells is involved in supporting hematopoietic stem and/or progenitor cells (HSPCs) through osteopontin (OPN) expression...
  6. Saika S, Shirai K, Yamanaka O, Miyazaki K, Okada Y, Kitano A, et al. Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium. Lab Invest. 2007;87:130-8 pubmed
    We previously reported that osteopontin (OPN), a matrix structural glycophosphoprotein, is upregulated in the injured mouse lens prior to the epithelial-mesenchymal transition (EMT)...
  7. Vetrone S, Montecino Rodriguez E, Kudryashova E, Kramerova I, Hoffman E, Liu S, et al. Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta. J Clin Invest. 2009;119:1583-94 pubmed publisher
    ..1/8.2 TCR that is predominant among TCR-beta+ T cells. These cells expressed high levels of osteopontin (OPN), a cytokine that promotes immune cell migration and survival...
  8. Sahai A, Malladi P, Melin Aldana H, Green R, Whitington P. Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol. 2004;287:G264-73 pubmed
    ..Feeding mice a diet deficient in methionine and choline (MCD diet) induces experimental NASH. Osteopontin (OPN) is a Th1 cytokine that plays an important role in several fibroinflammatory diseases...
  9. Kiefer F, Zeyda M, Todoric J, Huber J, Geyeregger R, Weichhart T, et al. Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Endocrinology. 2008;149:1350-7 pubmed
    ..b>Osteopontin (OPN) is a multifunctional protein involved in various inflammatory processes, cell migration, and tissue ..

More Information

Publications79

  1. van der Windt G, Hoogerwerf J, de Vos A, Florquin S, van der Poll T. Osteopontin promotes host defense during Klebsiella pneumoniae-induced pneumonia. Eur Respir J. 2010;36:1337-45 pubmed publisher
    Klebsiella pneumoniae is a common cause of nosocomial pneumonia. Osteopontin (OPN) is a phosphorylated glycoprotein involved in inflammatory processes, some of which is mediated by CD44...
  2. Yoon B, Pogue R, Ovchinnikov D, Yoshii I, Mishina Y, Behringer R, et al. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006;133:4667-78 pubmed
    ..These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways. ..
  3. Mori N, Majima T, Iwasaki N, Kon S, Miyakawa K, Kimura C, et al. The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation. Matrix Biol. 2007;26:42-53 pubmed
    ..Importantly, the transient up-regulation of osteopontin (OPN) expression was characteristic during the early phase of tendon tissue remodeling...
  4. Kopp J, Dubois C, Schaffer A, Hao E, Shih H, Seymour P, et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011;138:653-65 pubmed publisher
  5. Hayashi C, Rittling S, Hayata T, Amagasa T, Denhardt D, Ezura Y, et al. Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration. J Cell Biochem. 2007;101:979-86 pubmed
    ..b>Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, extracellular matrix ..
  6. Duvall C, Weiss D, Robinson S, Alameddine F, Guldberg R, Taylor W. The role of osteopontin in recovery from hind limb ischemia. Arterioscler Thromb Vasc Biol. 2008;28:290-5 pubmed
    b>Osteopontin (OPN) is a highly phosphorylated extracellular matrix glycoprotein that is involved in a diversity of biological processes...
  7. Ishijima M, Ezura Y, Tsuji K, Rittling S, Kurosawa H, Denhardt D, et al. Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res. 2006;312:3075-83 pubmed
    ..Although the mechanisms underlying this phenomenon are largely unknown, osteopontin (OPN) is one of the critical mediators required for unloading-induced bone loss [M. Ishijima, S.R. Rittling, T...
  8. Lenga Y, Koh A, Perera A, McCulloch C, Sodek J, Zohar R. Osteopontin expression is required for myofibroblast differentiation. Circ Res. 2008;102:319-27 pubmed
    b>Osteopontin (OPN) is a multifunctional cytokine that is strongly expressed in healing wounds and fibrotic lesions, both of which are characterized by the formation of myofibroblasts...
  9. Gao C, Guo H, Mi Z, Grusby M, Kuo P. Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. J Immunol. 2007;178:1870-81 pubmed
    ..we have previously demonstrated that NO feedback inhibits its own synthesis by increasing transcription of osteopontin (OPN), a potent transrepressor of inducible NO synthase expression...
  10. Uaesoontrachoon K, Yoo H, Tudor E, Pike R, Mackie E, Pagel C. Osteopontin and skeletal muscle myoblasts: association with muscle regeneration and regulation of myoblast function in vitro. Int J Biochem Cell Biol. 2008;40:2303-14 pubmed publisher
    b>Osteopontin is a secreted glycoprotein expressed by many cell types including osteoblasts and lymphocytes; it is a constituent of the extracellular matrix (ECM) in bone, and a mitogen for lymphocytes...
  11. Sahai A, Malladi P, Pan X, Paul R, Melin Aldana H, Green R, et al. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol. 2004;287:G1035-43 pubmed
    ..type 2 diabetic db/db mice in a nutritional model of NASH and determined the relationship of the expressions of osteopontin (OPN) and leptin receptors to the pathogenesis of NASH...
  12. Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, et al. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity. 2004;21:539-50 pubmed
    Both osteopontin (OPN) and natural killer T (NKT) cells play a role in the development of immunological disorders. We examined a functional link between OPN and NKT cells...
  13. Hu H, Hilton M, Tu X, Yu K, Ornitz D, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005;132:49-60 pubmed
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development. ..
  14. Nyström T, Dunér P, Hultgårdh Nilsson A. A constitutive endogenous osteopontin production is important for macrophage function and differentiation. Exp Cell Res. 2007;313:1149-60 pubmed
    ..in the pathological process underlying atherosclerosis and constitutively express the multifunctional protein osteopontin which has important exogenous effects on these cells...
  15. Schneider D, Lindsay J, Zhou Y, Molina J, Blackburn M. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J. 2010;24:70-80 pubmed publisher
    ..An established model of adenosine-mediated lung injury is the adenosine deaminase-deficient (Ada(-/-)) mouse. Osteopontin (OPN) is a chemokine that is produced following injury and is implicated in a variety of human pathologies, but ..
  16. Irita J, Okura T, Jotoku M, Nagao T, Enomoto D, Kurata M, et al. Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney. Am J Physiol Renal Physiol. 2011;301:F833-44 pubmed publisher
    b>Osteopontin (OPN) has been implicated in the pathology of several renal conditions...
  17. Holmes G, Rothschild G, Roy U, Deng C, Mansukhani A, Basilico C. Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol. 2009;328:273-84 pubmed publisher
  18. Marcondes M, Poling M, Watry D, Hall D, Fox H. In vivo osteopontin-induced macrophage accumulation is dependent on CD44 expression. Cell Immunol. 2008;254:56-62 pubmed publisher
    In order to assess the role of osteopontin (OPN) in leukocyte accumulation in inflammatory conditions, native OPN and its thrombin cleaved form (OPN+Thr) were studied in vivo using a rodent subcutaneous air pouch model (AP)...
  19. Lai C, Seshadri V, Huang K, Shao J, Cai J, Vattikuti R, et al. An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circ Res. 2006;98:1479-89 pubmed
    b>Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease...
  20. Kohan M, Breuer R, Berkman N. Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthma. Am J Respir Cell Mol Biol. 2009;41:290-6 pubmed publisher
    ..We have demonstrated that osteopontin, an inflammatory cytokine and an extracellular matrix glycoprotein with profibrotic properties, is up-regulated ..
  21. Eswarakumar V, Horowitz M, Locklin R, Morriss Kay G, Lonai P. A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A. 2004;101:12555-60 pubmed
    ..mice are viable and fertile with shortened face, protruding eyes, premature fusion of cranial sutures, and enhanced Spp1 expression in the calvaria...
  22. Kon S, Ikesue M, Kimura C, Aoki M, Nakayama Y, Saito Y, et al. Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin. J Exp Med. 2008;205:25-33 pubmed
    b>Osteopontin (OPN) is a T helper type 1 immunoregulatory cytokine that plays a critical role in various inflammatory disorders. OPN exerts proinflammatory reactions through interaction with integrin receptors...
  23. Lee Y, Petkova A, Granneman J. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 2013;18:355-67 pubmed publisher
    ..Recruited macrophages express high levels of osteopontin (OPN), which attracts a subpopulation of PDGFR?+ progenitors expressing CD44, a receptor for OPN...
  24. Akiyama H, Lyons J, Mori Akiyama Y, Yang X, Zhang R, Zhang Z, et al. Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 2004;18:1072-87 pubmed
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway. ..
  25. Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, et al. Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes. 2011;60:2424-33 pubmed publisher
    ..GIP stimulated osteopontin (OPN) mRNA and protein expression. OPN expression was lower in carriers of the A allele...
  26. Chakraborty G, Jain S, Patil T, Kundu G. Down-regulation of osteopontin attenuates breast tumour progression in vivo. J Cell Mol Med. 2008;12:2305-18 pubmed publisher
    ..Elevated expression of osteopontin (OPN) in higher grades of breast carcinoma correlates with enhanced expressions of several oncogenic molecules (..
  27. Koh A, Da Silva A, Bansal A, Bansal M, Sun C, Lee H, et al. Role of osteopontin in neutrophil function. Immunology. 2007;122:466-75 pubmed
    b>Osteopontin (OPN) is important for the function of fibroblasts, macrophages and lymphocytes during inflammation and wound healing...
  28. Duvall C, Taylor W, Weiss D, Wojtowicz A, Guldberg R. Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J Bone Miner Res. 2007;22:286-97 pubmed
    ..b>Osteopontin (OPN) is an extracellular matrix (ECM) protein with diverse localization and functionality that has been ..
  29. Nishimichi N, Hayashita Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem. 2011;286:11170-8 pubmed publisher
    b>Osteopontin (OPN) is an integrin-binding inflammatory cytokine that undergoes polymerization catalyzed by transglutaminase 2...
  30. Lu C, Wan Y, Cao J, Zhu X, Yu J, Zhou R, et al. Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013;53:566-74 pubmed publisher
  31. Mori R, Shaw T, Martin P. Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. J Exp Med. 2008;205:43-51 pubmed publisher
    Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis...
  32. Matsui Y, Jia N, Okamoto H, Kon S, Onozuka H, Akino M, et al. Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Hypertension. 2004;43:1195-201 pubmed
    b>Osteopontin (OPN) is upregulated in several experimental models of cardiac fibrosis and remodeling. However, its direct effects remain unclear...
  33. Hur E, Youssef S, Haws M, Zhang S, Sobel R, Steinman L. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol. 2007;8:74-83 pubmed
    Relapses and disease exacerbations are vexing features of multiple sclerosis. Osteopontin (Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma during relapses...
  34. Maetzler W, Berg D, Schalamberidze N, Melms A, Schott K, Mueller J, et al. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiol Dis. 2007;25:473-82 pubmed
    ..e., processes in which osteopontin (OPN) may also play a role...
  35. Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, et al. Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice. Arthritis Rheum. 2009;60:2362-71 pubmed publisher
    To investigate the role of osteopontin (OPN) in the development of osteoarthritis (OA) under in vivo and in vitro conditions...
  36. Thurner P, Chen C, Ionova Martin S, Sun L, Harman A, Porter A, et al. Osteopontin deficiency increases bone fragility but preserves bone mass. Bone. 2010;46:1564-73 pubmed publisher
    ..and collagen have been investigated in greater detail, the contribution of noncollagenous proteins such as osteopontin to bone matrix material properties remains unclear...
  37. Grassinger J, Haylock D, Storan M, Haines G, Williams B, Whitty G, et al. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood. 2009;114:49-59 pubmed publisher
    b>Osteopontin (OPN), a multifunctional acidic glycoprotein, expressed by osteoblasts within the endosteal region of the bone marrow (BM) suppresses the proliferation of hemopoietic stem and progenitor cells and also regulates their ..
  38. Giacopelli F, Marciano R, Pistorio A, Catarsi P, Canini S, Karsenty G, et al. Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol Genomics. 2004;20:87-96 pubmed
    Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis,..
  39. Wang Y, Chen B, Shen D, Xue S. Osteopontin protects against cardiac ischemia-reperfusion injury through late preconditioning. Heart Vessels. 2009;24:116-23 pubmed publisher
    b>Osteopontin (OPN) has been considered as a proinflammatory cytokine. A protective role for OPN in ischemic injury was demonstrated recently...
  40. Mi Z, Guo H, Wai P, Gao C, Kuo P. Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis. 2006;27:1134-45 pubmed
    ..b>Osteopontin (OPN) overexpression may represent a key molecular event in cancer metastasis...
  41. Monfoulet L, Malaval L, Aubin J, Rittling S, Gadeau A, Fricain J, et al. Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing. Bone. 2010;46:447-52 pubmed publisher
    ..femur, a lesion that triggers intramembranous repair, and compared the roles of bone sialoprotein (BSP) and osteopontin (OPN), two proteins of the extracellular matrix, in the repair process...
  42. Kilic G, Wang J, Sosa Pineda B. Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice. Dev Dyn. 2006;235:1659-67 pubmed
    ..In this study, we found that the matricellular protein osteopontin (Opn) is a novel marker of undifferentiated pancreatic precursors and pancreatic ductal tissues in mice...
  43. Craig Mylius K, Weber G, Coburn J, Glickstein L. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. J Leukoc Biol. 2005;77:710-8 pubmed
    ..T helper cell type 1 (TH1) response directed against intracellular pathogens includes the cytokine osteopontin, which acts predominantly on macrophages, where it induces the secretion of interleukin (IL)-12 and suppresses ..
  44. Kiefer F, Neschen S, Pfau B, Legerer B, Neuhofer A, Kahle M, et al. Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia. 2011;54:2132-42 pubmed publisher
    Obesity is strongly associated with the development of non-alcoholic fatty liver disease (NAFLD). The cytokine osteopontin (OPN) was recently shown to be involved in obesity-induced adipose tissue inflammation and reduced insulin ..
  45. Abel B, Freigang S, Bachmann M, Boschert U, Kopf M. Osteopontin is not required for the development of Th1 responses and viral immunity. J Immunol. 2005;175:6006-13 pubmed
    b>Osteopontin (OPN) has been defined as a key cytokine promoting the release of IL-12 and hence inducing the development of protective cell-mediated immunity to viruses and intracellular pathogens...
  46. Morimoto J, Sato K, Nakayama Y, Kimura C, Kajino K, Matsui Y, et al. Osteopontin modulates the generation of memory CD8+ T cells during influenza virus infection. J Immunol. 2011;187:5671-83 pubmed publisher
    ..In this study, we report that the inflammatory cytokine osteopontin (Opn) modulates memory CD8(+) T cell generation during influenza virus infection...
  47. Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, et al. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 2005;201:1781-91 pubmed
    ..We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment...
  48. Harmey D, Johnson K, Zelken J, Camacho N, Hoylaerts M, Noda M, et al. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res. 2006;21:1377-86 pubmed
    ..elevated levels of ePP(i) induce Opn gene expression, the Akp2(-/-) mice also display increased levels of osteopontin (OPN), another inhibitor of mineralization. Akp2(-/-) mice were bred into the Opn(-/-) line...
  49. Arafat H, Katakam A, Chipitsyna G, Gong Q, Vancha A, Gabbeta J, et al. Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide. Endocrinology. 2007;148:575-84 pubmed
    b>Osteopontin (OPN), a phosphorylated glycoprotein that binds to an integrin-binding motif, has been shown to regulate nitric oxide (NO) production via inhibition of induced NO synthase (iNOS) synthesis...
  50. Chapman J, Miles P, Ofrecio J, Neels J, Yu J, Resnik J, et al. Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice. PLoS ONE. 2010;5:e13959 pubmed publisher
    ..We initially observed osteopontin (OPN) mRNA over-expression in adipose tissue of obese, insulin resistant humans and rats which was normalized ..
  51. Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, et al. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS ONE. 2010;5:e9633 pubmed publisher
    Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function...
  52. Shen Q, Christakos S. The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin. J Biol Chem. 2005;280:40589-98 pubmed
    b>Osteopontin (OPN), a glycosylated phosphoprotein that binds calcium, is present in bone extracellular matrix and has been reported to modulate both mineralization and bone resorption...
  53. Christensen B, Kazanecki C, Petersen T, Rittling S, Denhardt D, Sørensen E. Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties. J Biol Chem. 2007;282:19463-72 pubmed
    b>Osteopontin (OPN) is a highly modified integrin-binding protein found in all body fluids...
  54. Nilsson S, Johnston H, Whitty G, Williams B, Webb R, Denhardt D, et al. Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood. 2005;106:1232-9 pubmed
    ..The studies described herein examine the role in hematopoiesis of Osteopontin (Opn), a multidomain, phosphorylated glycoprotein, synthesized by osteoblasts, with well-described roles in ..
  55. Maeno Y, Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka K, et al. Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infect Immun. 2006;74:2423-7 pubmed
    b>Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasmodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection...
  56. Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, et al. Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS ONE. 2012;7:e48933 pubmed publisher
    ..g. formation of adhesion complexes) rather than de novo integrin synthesis. Osteopontin (OPN) was identified as an estrogen-dependent uterine endometrial gland secretory factor responsible for ..
  57. Tu X, Joeng K, Nakayama K, Nakayama K, Rajagopal J, Carroll T, et al. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007;12:113-27 pubmed
    ..Together, these results reveal a Wnt-dependent osteogenic mechanism, and they provide a potential target pathway for designing therapeutics to promote bone formation. ..
  58. Zohar R, Zhu B, Liu P, Sodek J, McCulloch C. Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway. Am J Physiol Heart Circ Physiol. 2004;287:H1730-9 pubmed
    ..b>Osteopontin (OPN) is a proinflammatory cytokine that is upregulated after reperfusion...
  59. Wang Y, Xiao R, Yang F, Karim B, Iacovelli A, Cai J, et al. Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005;132:3537-48 pubmed
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  60. van der Windt G, Wieland C, Wiersinga W, Florquin S, van der Poll T. Osteopontin is not crucial to protective immunity during murine tuberculosis. Immunology. 2009;128:e766-76 pubmed publisher
    ..b>Osteopontin (OPN) is a phosphorylated glycoprotein that is chemotactic for inflammatory cells and has been implicated in ..
  61. Ishijima M, Tsuji K, Rittling S, Yamashita T, Kurosawa H, Denhardt D, et al. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells. J Endocrinol. 2007;193:235-43 pubmed
    ..The presence of osteopontin (OPN), which is one of the abundant proteins in bone matrix, is required for the effects of mechanical stress ..
  62. Yang H, Guo H, Fan K, Zhang B, Zhao L, Hou S, et al. Clearance of Propionibacterium acnes by kupffer cells is regulated by osteopontin through modulating the expression of p47phox. Mol Immunol. 2011;48:2019-26 pubmed publisher
    b>Osteopontin (OPN) is a cytokine with multiple functions, including the regulation of innate immune response. However, the detailed function and mechanism of OPN in host defense against invaded microorganisms remain unclear...
  63. Dahiya S, Givvimani S, Bhatnagar S, Qipshidze N, Tyagi S, Kumar A. Osteopontin-stimulated expression of matrix metalloproteinase-9 causes cardiomyopathy in the mdx model of Duchenne muscular dystrophy. J Immunol. 2011;187:2723-31 pubmed publisher
    ..Finally, our experiments have revealed that osteopontin, an important immunomodulator, contributes to the increased amounts of MMP-9 in cardiac and skeletal muscle of ..
  64. Sato K, Iwai A, Nakayama Y, Morimoto J, Takada A, Maruyama M, et al. Osteopontin is critical to determine symptom severity of influenza through the regulation of NK cell population. Biochem Biophys Res Commun. 2012;417:274-9 pubmed publisher
    b>Osteopontin (OPN) is involved in exacerbating various inflammatory diseases. A severe pulmonary inflammation is frequently found in lethal influenza A virus (IAV) infection...
  65. Lorena D, Darby I, Gadeau A, Leen L, Rittling S, Porto L, et al. Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice. J Hepatol. 2006;44:383-90 pubmed
    b>Osteopontin has been implicated in numerous physiopathological events. Osteopontin expression in normal and fibrotic liver and liver fibrogenesis in osteopontin-deficient mice were studied...
  66. Hattori T, Müller C, Gebhard S, Bauer E, Pausch F, Schlund B, et al. SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development. 2010;137:901-11 pubmed publisher
    ..high levels of Sox9 misexpression in hypertrophic chondrocytes but deficiencies of Vegfa, Mmp13, RANKL and osteopontin expression in the non-resorbed hypertrophic cartilage, indicating that Sox9 misexpression in hypertrophic ..
  67. Jacob A, Smith C, Partanen J, Ornitz D. Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Dev Biol. 2006;296:315-28 pubmed
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation. ..
  68. Nagasaka A, Matsue H, Matsushima H, Aoki R, Nakamura Y, Kambe N, et al. Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. Eur J Immunol. 2008;38:489-99 pubmed publisher
    b>Osteopontin (OPN), originally discovered in bone as an extracellular matrix protein, was identified in many cell types in the immune system, presumably being involved in many aspects of pathogenesis of inflammatory and immune diseases...
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    b>Osteopontin (Opn) is important for T helper type 1 (T(H)1) immunity and autoimmunity...
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    The observation that the T-bet transcription factor allows tissue-specific upregulation of intracellular osteopontin (Opn-i) in plasmacytoid dendritic cells (pDCs) suggests that Opn might contribute to the expression of interferon-alpha (..