Gene Symbol: Spon1
Description: spondin 1, (f-spondin) extracellular matrix protein
Alias: AI666765, AW455831, BC020531, D330035F22Rik, FSP, spondin-1, F-spondin
Species: mouse
Products:     Spon1

Top Publications

  1. Miyamoto K, Morishita Y, Yamazaki M, Minamino N, Kangawa K, Matsuo H, et al. Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. Arch Biochem Biophys. 2001;390:93-100 pubmed
  2. Feinstein Y, Borrell V, Garcia C, Burstyn Cohen T, Tzarfaty V, Frumkin A, et al. F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. Development. 1999;126:3637-48 pubmed
    ..We have also demonstrated that the two proteins bind to a putative receptor(s) expressed on both hippocampal and sensory neurons. ..
  3. HOE H, Wessner D, Beffert U, Becker A, Matsuoka Y, Rebeck G. F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol Cell Biol. 2005;25:9259-68 pubmed
    ..These studies suggest that the extracellular matrix molecule F-spondin can cluster APP and ApoEr2 together on the cell surface and affect the processing of each, resulting in decreased production of Abeta. ..
  4. Palmer G, Piton A, Thant L, Oliveira S, D ANGELO M, Attur M, et al. F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation. J Orthop Res. 2010;28:1323-9 pubmed publisher
    ..Our findings indicate that F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization via interactions in its TSR domain and TGF-? dependent pathways. ..
  5. Chen T, Liao C, Cheng Y, Chen Y, Hsu Y, Liang C, et al. Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent. PLoS ONE. 2015;10:e0128926 pubmed publisher
    ..These findings demonstrated novel roles for F-spondin and IL-1Ra in CpG-B ODNs-mediated cell proliferation and migration of macrophages. ..
  6. Joksimovic M, Yun B, Kittappa R, Anderegg A, Chang W, Taketo M, et al. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci. 2009;12:125-31 pubmed publisher
    ..These findings demonstrate how the dynamic interplay of canonical Wnt/beta-catenin signaling and Shh may orchestrate floor plate neurogenesis or a lack thereof. ..
  7. Lee G, Wu J, Yeh C, Kuo C. TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration. Biochem Biophys Res Commun. 2016;473:1205-1210 pubmed publisher
    ..These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis. ..
  8. Palmer G, Attur M, Yang Q, Liu J, Moon P, Beier F, et al. F-spondin deficient mice have a high bone mass phenotype. PLoS ONE. 2014;9:e98388 pubmed publisher
    ..address its function in bone and cartilage in vivo, we generated mice that were deficient for the F-spondin gene, Spon1. Spon1-/- mice were viable and developed normally to adulthood with no major skeletal abnormalities...
  9. Yan L, Wei X, Tang Q, Feng J, Zhang Y, Liu C, et al. Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3? and TGF-?1-Smad signalling. Cardiovasc Res. 2011;92:85-94 pubmed publisher
    ..The present study demonstrates for the first time that mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3? and TGF-?1-Smad signalling. ..

More Information


  1. Fan C, Kuwana E, Bulfone A, Fletcher C, Copeland N, Jenkins N, et al. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996;7:1-16 pubmed
    ..Our data suggest that the Sim genes play roles in directing the regionalization of tissues where they are expressed. Moreover, the expression pattern documented for Sim2 may provide insights into its potential roles in Down syndrome. ..
  2. Joksimovic M, Anderegg A, Roy A, Campochiaro L, Yun B, Kittappa R, et al. Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. Proc Natl Acad Sci U S A. 2009;106:19185-90 pubmed publisher
    ..This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD. ..
  3. Svensson P, Williams C, Lundeberg J, Ryden P, Bergqvist I, Edlund H. Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC Dev Biol. 2007;7:129 pubmed
    ..5 pancreatic buds of Ipf1/Pdx1-/- embryos. The expression of one of these, Spondin 1, which encodes an extracellular matrix protein, has not previously been described in the pancreas...
  4. Blackburn A, Hill L, Roberts A, Wang J, Aud D, Jung J, et al. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol. 2007;170:2030-41 pubmed
    ..The results identify a novel mammary tumor susceptibility locus in mice and support a role for DMBT1 in suppression of mammary tumors in both mice and women. ..
  5. Serafini T, Colamarino S, Leonardo E, Wang H, Beddington R, Skarnes W, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 1996;87:1001-14 pubmed
    ..These results establish netrin-1 as a guidance cue that likely collaborates with other diffusible cues to guide axons in vivo. ..
  6. Nouri N, Patel M, Joksimovic M, Poulin J, Anderegg A, Taketo M, et al. Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci. 2015;68:131-42 pubmed publisher
    ..Our findings will impact embryonic stem cell protocols that utilize Wnt pathway reagents to derive mDA neuron models and therapeutics for Parkinson's disease. ..
  7. Guillemot F, Lo L, Johnson J, Auerbach A, Anderson D, Joyner A. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993;75:463-76 pubmed
    ..These observations suggest that Mash-1, like its Drosophila homologs of the AS-C, controls a basic operation in development of neuronal progenitors in distinct neural lineages. ..
  8. Gewies A, Castineiras Vilarino M, Ferch U, Jährling N, Heinrich K, Hoeckendorf U, et al. Prdm6 is essential for cardiovascular development in vivo. PLoS ONE. 2013;8:e81833 pubmed publisher
    ..We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development. ..