Gene Symbol: Spn
Description: sialophorin
Alias: A630014B01Rik, Cd43, Galgp, Ly-48, Ly48, leukosialin, 3E8 antigen, B-cell differentiation antigen LP-3, leukocyte sialoglycoprotein, lymphocyte antigen 48
Species: mouse
Products:     Spn

Top Publications

  1. Carlow D, Corbel S, Ziltener H. Absence of CD43 fails to alter T cell development and responsiveness. J Immunol. 2001;166:256-61 pubmed
    Genetic elimination of CD43 has been associated with increased T cell adhesiveness and T cell hyperresponsiveness to mitogens and alloantigens...
  2. Onami T, Harrington L, Williams M, Galvan M, Larsen C, Pearson T, et al. Dynamic regulation of T cell immunity by CD43. J Immunol. 2002;168:6022-31 pubmed
    ..We investigated the contribution of CD43 expression to 1B11 and PNA binding as well as its role in generation and maintenance of a CD8 T cell response...
  3. Randhawa A, Ziltener H, Merzaban J, Stokes R. CD43 is required for optimal growth inhibition of Mycobacterium tuberculosis in macrophages and in mice. J Immunol. 2005;175:1805-12 pubmed
    We explored the role of macrophage (Mphi) CD43, a transmembrane glycoprotein, in the pathogenesis of Mycobacterium tuberculosis...
  4. Montufar Solis D, Garza T, Klein J. Selective upregulation of immune regulatory and effector cytokine synthesis by intestinal intraepithelial lymphocytes following CD43 costimulation. Biochem Biophys Res Commun. 2005;338:1158-63 pubmed
    The involvement of the CD43 molecule in the activation of mouse small intestinal intraepithelial lymphocytes (IELs) has been studied using a panel of twenty-two regulatory and effector immune response analytes...
  5. Takai Y, Kitano K, Terawaki S, Maesaki R, Hakoshima T. Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins. J Mol Biol. 2008;381:634-44 pubmed publisher
    CD43/leukosialin/sialophorin is the major adhesion molecule in most hematopoietic cells and belongs to the sialomucin superfamily...
  6. Mody P, Cannon J, Bandukwala H, Blaine K, Schilling A, Swier K, et al. Signaling through CD43 regulates CD4 T-cell trafficking. Blood. 2007;110:2974-82 pubmed
    The mucin-like protein CD43 is excluded from the immune synapse, and regulates T-cell proliferation as well as T-cell migration...
  7. Manjunath N, Correa M, Ardman M, Ardman B. Negative regulation of T-cell adhesion and activation by CD43. Nature. 1995;377:535-8 pubmed
    b>CD43 is a cell-surface sialoglycoprotein expressed by a variety of haematopoietically derived cells, including T lymphocytes...
  8. Todeschini A, Nunes M, Pires R, Lopes M, Previato J, Mendonça Previato L, et al. Costimulation of host T lymphocytes by a trypanosomal trans-sialidase: involvement of CD43 signaling. J Immunol. 2002;168:5192-8 pubmed
    ..cruzi-infected mice. By flow cytometry, inactive trans-sialidase bound the highly sialylated surface Ag CD43 on host CD4+ T cells. Both costimulatory and antiapoptotic effects of trans-sialidases required CD43 signaling...
  9. Thurman E, Walker J, Jayaraman S, Manjunath N, Ardman B, Green J. Regulation of in vitro and in vivo T cell activation by CD43. Int Immunol. 1998;10:691-701 pubmed
    ..CD43 (leukosialin, sialophorin) has been suggested to influence cell activation by steric hindrance based upon the large size and ..

More Information


  1. Merzaban J, Zuccolo J, Corbel S, Williams M, Ziltener H. An alternate core 2 beta1,6-N-acetylglucosaminyltransferase selectively contributes to P-selectin ligand formation in activated CD8 T cells. J Immunol. 2005;174:4051-9 pubmed
    ..of P-selectin ligand correlated with altered cell surface binding of the core 2-sensitive mAb 1B11, indicating that CD43 and CD45 are also physiological targets for this alternate C2GlcNAcT enzyme...
  2. van den Berg T, Nath D, Ziltener H, Vestweber D, Fukuda M, Van Die I, et al. Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J Immunol. 2001;166:3637-40 pubmed
    ..The 130- and 240-kDa sialoadhesin-binding glycoproteins were identified as the sialomucins CD43 and P-selectin glycoprotein ligand 1 (CD162), respectively...
  3. Fratazzi C, Manjunath N, Arbeit R, Carini C, Gerken T, Ardman B, et al. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med. 2000;192:183-92 pubmed
    We studied the role of CD43 (leukosialin/sialophorin), the negatively charged sialoglycoprotein of leukocytes, in the binding of mycobacteria to host cells...
  4. Matsumoto M, Atarashi K, Umemoto E, Furukawa Y, Shigeta A, Miyasaka M, et al. CD43 functions as a ligand for E-Selectin on activated T cells. J Immunol. 2005;175:8042-50 pubmed
    ..The mAb 1B11, which recognizes the 130-kDa glycoform of CD43, recognized the 130-kDa band in the E-selectin-IgG precipitate...
  5. Tong J, Allenspach E, Takahashi S, Mody P, Park C, Burkhardt J, et al. CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. J Exp Med. 2004;199:1277-83 pubmed
    b>CD43 is a large heavily glycosylated protein highly expressed on T cells and actively excluded from the immunological synapse through interactions with ezrin-radixin-moesin proteins...
  6. Cannon J, Collins A, Mody P, Balachandran D, Henriksen K, Smith C, et al. CD43 regulates Th2 differentiation and inflammation. J Immunol. 2008;180:7385-93 pubmed
    b>CD43 is a highly glycosylated transmembrane protein that regulates T cell activation...
  7. Carlow D, Corbel S, Williams M, Ziltener H. IL-2, -4, and -15 differentially regulate O-glycan branching and P-selectin ligand formation in activated CD8 T cells. J Immunol. 2001;167:6841-8 pubmed
    ..Through analysis of C2GnT1-dependent epitopes on CD43 and CD45RB we have found that in activated CD8(+) T cells expression of C2GnT1 was dependent upon exposure to ..
  8. Savage N, Kimzey S, Bromley S, Johnson K, Dustin M, Green J. Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J Immunol. 2002;168:3740-6 pubmed
    ..This model predicts the topological seclusion of large molecules such as CD43 from the site of closest contact between the T cell and APC, allowing for the close apposition of cell membranes ..
  9. Allenspach E, Cullinan P, Tong J, Tang Q, Tesciuba A, Cannon J, et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001;15:739-50 pubmed
    The large mucin CD43 is actively excluded from T cell/APC interaction sites, concentrating in a membrane domain distal to the site of TCR engagement. The cytoplasmic region of CD43 was necessary and sufficient for this antipodal movement...
  10. Sperling A, Green J, Mosley R, Smith P, DiPaolo R, Klein J, et al. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995;182:139-46 pubmed
    ..Expression cloning of the R2/60 antigen identified the ligand as murine CD43. Together, these data demonstrate that CD43 can serve as a receptor on T cells that can provide CD28-independent ..
  11. Seo W, Ziltener H. CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis. Blood. 2009;114:3567-77 pubmed publisher
    The sialomucin CD43 is highly expressed on most hematopoietic cells. In this study, we show that the CD43 ectodomain is shed from murine granulocytes, mast cells, and T cells, but not from macrophages...
  12. Cyster J, Somoza C, Killeen N, Williams A. Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur J Immunol. 1990;20:875-81 pubmed
    A partial cDNA clone for mouse leukosialin was isolated by use of a rat leukosialin cDNA probe. The mouse cDNA was then used to isolate genomic clones that corresponded to the two mouse genes detected in Southern blots...
  13. Chappel M, Hough M, Mittel A, Takei F, Kay R, Humphries R. Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med. 1996;184:1639-49 pubmed
    ..Taken together, these data implicate HSA as a potent negative regulator of B cell development and activation. ..
  14. Dorfman K, Litaker W, Baecher C, Frelinger J. The nucleotide sequence of Ly 48 (mouse leukosialin, sialophorin): the mouse homolog of CD43. Nucleic Acids Res. 1990;18:4932 pubmed
  15. Ford M, Onami T, Sperling A, Ahmed R, Evavold B. CD43 modulates severity and onset of experimental autoimmune encephalomyelitis. J Immunol. 2003;171:6527-33 pubmed
    ..This study investigated the role of CD43 in the induction and progression of EAE...
  16. Veerman K, Williams M, Uchimura K, Singer M, Merzaban J, Naus S, et al. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol. 2007;8:532-9 pubmed
    ..Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule. ..
  17. Carlow D, Ziltener H. CD43 deficiency has no impact in competitive in vivo assays of neutrophil or activated T cell recruitment efficiency. J Immunol. 2006;177:6450-9 pubmed
    Using noncompetitive methodologies comparing CD43(+/+) and CD43(-/-) mice, it has been reported that CD43(-/-) leukocytes exhibit reduced recruitment efficiency to sites of inflammation...
  18. Cannon J, Mody P, Blaine K, Chen E, Nelson A, Sayles L, et al. CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Mol Biol Cell. 2011;22:954-63 pubmed publisher
    Cell polarization is a key feature of cell motility, driving cell migration to tissues. CD43 is an abundantly expressed molecule on the T-cell surface that shows distinct localization to the migrating T-cell uropod and the distal pole ..
  19. Bagriacik E, Tang M, Wang H, Klein J. CD43 potentiates CD3-induced proliferation of murine intestinal intraepithelial lymphocytes. Immunol Cell Biol. 2001;79:303-7 pubmed
    The involvement of CD43 in cell proliferation of murine intestinal intraepithelial lymphocytes (IEL) has been studied in in vitro CD3-stimulated cell cultures...
  20. Matsumoto M, Shigeta A, Furukawa Y, Tanaka T, Miyasaka M, Hirata T. CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. J Immunol. 2007;178:2499-506 pubmed
    ..We show in this study that CD43-deficient Th1 cells, like PSGL-1-deficient cells, exhibited reduced E-selectin-binding activity compared with wild-..
  21. Guimaraes M, Peterson D, Vicari A, Cocks B, Copeland N, Gilbert D, et al. Identification of a novel selD homolog from eukaryotes, bacteria, and archaea: is there an autoregulatory mechanism in selenocysteine metabolism?. Proc Natl Acad Sci U S A. 1996;93:15086-91 pubmed
    ..This mechanism is likely to have been present in ancient life forms and conserved in a variety of living organisms from all domains of life. ..
  22. Shiota J, Nishimura H, Okamoto H, Yu B, Hattori S, Abe M, et al. A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell Immunol. 1994;155:402-13 pubmed
    ..purified 132-kDa Lp-3 molecules and the nucleotide sequence of the cDNA clones, we found that Lp-3 is an epitope of CD43. Thus, the monoclonal antibody (mAb) Lp-3 may be the first mAb to murine CD43 defined by primary target structure ..
  23. Van Dyken S, Green R, Marth J. Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis. Mol Cell Biol. 2007;27:1096-111 pubmed
    ..The mechanism does not involve the ST3Gal-I substrate CD43 or core 2 O-glycan induction and overcomes the ability of Bcl-2 to inhibit the contraction phase in vivo...
  24. Hickey T, Ziltener H, Speert D, Stokes R. Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cell Microbiol. 2010;12:1634-47 pubmed publisher
    b>CD43 is a large sialylated glycoprotein found on the surface of haematopoietic cells and has been previously shown to be necessary for efficient macrophage binding and immunological responsiveness to Mycobacterium tuberculosis...
  25. Cheng A, Rowley B, Pao W, Hayday A, Bolen J, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 1995;378:303-6 pubmed
  26. Dopp J, Breneman S, Olschowka J. Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis. J Neuroimmunol. 1994;54:129-44 pubmed
    ..Expression of the adhesion molecules ICAM-1 (CD54), VCAM-1 (CD106), L-selectin (CD62L), and leukosialin (CD43) was analyzed via immunocytochemistry 4-28 days after the injection of encephalitogen into EAE-..
  27. Pathak B, Shaughnessy J, Meneton P, Greeb J, Shull G, Jenkins N, et al. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Genomics. 1996;33:124-7 pubmed
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping. ..
  28. Alcaide P, King S, Dimitroff C, Lim Y, Fuhlbrigge R, Luscinskas F. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007;127:1964-72 pubmed
    ..Here, we report that the glycosylated form of CD43 expressed in Th1 cells is a functional E-selectin-specific ligand in vitro...
  29. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002;31:320-5 pubmed
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  30. Garcia G, Sadighi Akha A, Miller R. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J Immunol. 2007;179:6403-9 pubmed
    ..CD4 T cells in several aspects of ERM biochemistry, including ERM phosphorylation and ERM associations with CD44, CD43, and EBP50...
  31. Zhou H, Yan H, Cannon J, Springer L, Green J, Pham C. CD43-mediated IFN-? production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013;190:5078-85 pubmed publisher
    b>CD43 is a glycosylated surface protein abundantly expressed on lymphocytes. Its role in immune responses has been difficult to clearly establish, with evidence supporting both costimulatory and inhibitory functions...
  32. Matsumoto M, Shigeta A, Miyasaka M, Hirata T. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J Immunol. 2008;181:3628-35 pubmed
    ..Recently, we reported that CD43 on activated T cells functions as an E-selectin ligand and thereby mediates T cell migration to inflamed sites, in ..
  33. Tsuruyama T, Imai Y, Takeuchi H, Hiratsuka T, Maruyama Y, Kanaya K, et al. Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas. J Leukoc Biol. 2010;88:107-16 pubmed publisher
    IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM...
  34. Berger S, Sadighi Akha A, Miller R, Garcia G. CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymes. Immunology. 2006;119:178-86 pubmed
    ..mouse CD4+ T cells can be augmented by an enzyme, O-sialoglycoprotein endopeptidase (OSGE), which cleaves surface CD43, suggesting the idea that the high levels of glycosylated CD43 found on T cells from aged mice may contribute to ..
  35. Molina Pinelo S, Ferrer I, Blanco Aparicio C, Peregrino S, Pastor M, Alvarez Vega J, et al. Down-regulation of spinophilin in lung tumours contributes to tumourigenesis. J Pathol. 2011;225:73-82 pubmed publisher
    The scaffold protein spinophilin (Spn, PPP1R9B) is one of the regulatory subunits of phosphatase-1a (PP1), targeting it to distinct subcellular locations and to its target...
  36. Tribulatti M, Cattaneo V, Hellman U, Mucci J, Campetella O. Galectin-8 provides costimulatory and proliferative signals to T lymphocytes. J Leukoc Biol. 2009;86:371-80 pubmed publisher
    ..Taken together, our findings support a distinctive role for locally produced Gal-8 as an enhancer of otherwise borderline immune responses and also suggest that Gal-8 might fuel the reactivity at inflammatory foci. ..
  37. Yago T, Fu J, McDaniel J, Miner J, McEver R, Xia L. Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. Proc Natl Acad Sci U S A. 2010;107:9204-9 pubmed publisher
    ..These defects were more severe than those of neutrophils lacking PSGL-1, CD44, and the mucin CD43. Our results demonstrate that core 1-derived O-glycans are essential E-selectin ligands; that some of these O-..
  38. Wang W, Link V, Green J. Identification and cloning of a CD43-associated serine/threonine kinase. Cell Immunol. 2000;205:34-9 pubmed
    b>CD43 is expressed on most hematopoetic cells and has been shown to regulate the activation and adhesion of T cells. We have cloned a serine/threonine kinase that can interact with the cytoplasmic domain of CD43...
  39. Hernandez J, Nguyen J, He J, Wang W, Ardman B, Green J, et al. Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. J Immunol. 2006;177:5328-36 pubmed
    ..thymocytes and activated peripheral T cells by binding to glycans on T cell glycoproteins including CD7, CD45, and CD43. Although roles for CD7 and CD45 in regulating galectin-1-induced death have been described, the requirement for ..
  40. Carlow D, Williams M, Ziltener H. Modulation of O-glycans and N-glycans on murine CD8 T cells fails to alter annexin V ligand induction by galectin 1. J Immunol. 2003;171:5100-6 pubmed
  41. Kidder D, Richards H, Ziltener H, Garden O, Crocker P. Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. J Immunol. 2013;190:2593-602 pubmed publisher
    ..T cells was dependent on N-glycan rather than O-glycan biosynthesis and independent of the mucin-like molecules CD43 and P-selectin glycoprotein ligand-1, previously implicated in Sn interactions...
  42. Mathieu C, Beltra J, Charpentier T, Bourbonnais S, Di Santo J, Lamarre A, et al. IL-2 and IL-15 regulate CD8+ memory T-cell differentiation but are dispensable for protective recall responses. Eur J Immunol. 2015;45:3324-38 pubmed publisher
    ..Globally, these results indicate that lack of IL-2 and IL-15 signaling modulates the CD8(+) T-cell differentiation program but does not impede adequate effector functions. ..
  43. Meiler S, Baumer Y, McCurdy S, Lee B, Kitamoto S, Boisvert W. Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report. Arterioscler Thromb Vasc Biol. 2015;35:309-11 pubmed publisher
    The aim of this study was to investigate the role of cluster of differentiation 43 (CD43), an integral membrane glycoprotein with both proadhesive and antiadhesive activities, in atherosclerosis...
  44. Baecher C, Dorfman K, Mattei M, Frelinger J. cDNA cloning and localization of the mouse leukosialin gene (Ly48) to chromosome 7. Immunogenetics. 1990;31:307-14 pubmed
    Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules...
  45. Wang H, Montufar Solis D, Teng B, Klein J. Maximum immunobioactivity of murine small intestinal intraepithelial lymphocytes resides in a subpopulation of CD43+ T cells. J Immunol. 2004;173:6294-302 pubmed
    b>CD43 has been linked to many function-associated T cell activities...
  46. Shworak N, Liu J, Petros L, Zhang L, Kobayashi M, Copeland N, et al. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999;274:5170-84 pubmed
    ..Moreover, the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-OST-1, regulate important biologic properties of heparan sulfate proteoglycans. ..
  47. Ford M, Evavold B. Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. Cell Immunol. 2006;240:53-61 pubmed
    ..We have previously demonstrated reduced disease incidence and severity in CD43(-/-) mice following MOG immunization, and attributed this attenuation in disease progression to the effects of CD43 ..
  48. Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, et al. Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis. PLoS ONE. 2016;11:e0152326 pubmed publisher
    ..The antigens recognized by these mAbs were identified by expression cloning as the same protein, CD43, although their binding patterns to subsets of hematopoietic cells differed significantly from each other and from ..
  49. Randhawa A, Ziltener H, Stokes R. CD43 controls the intracellular growth of Mycobacterium tuberculosis through the induction of TNF-alpha-mediated apoptosis. Cell Microbiol. 2008;10:2105-17 pubmed publisher
    ..We previously showed that macrophage CD43 is required for optimal uptake and growth inhibition of Mycobacterium tuberculosis both in vitro and in vivo...
  50. Misawa Y, Shibuya M. Amplification and rearrangement of melF/mouse CD43 (leukosialin) gene encoding a highly glycosylated membrane protein gp120 in Friend erythroleukemia cells. Oncogene. 1992;7:919-26 pubmed
    ..revealed that the melF cDNA encodes a membrane protein of 395 amino acids that is the couterpart to human CD43 (leukosialin) surface antigen of lymphocytes in mice...
  51. Kishimoto H, Sprent J. Several different cell surface molecules control negative selection of medullary thymocytes. J Exp Med. 1999;190:65-73 pubmed
    ..In support of this idea, we show here that at least three cell surface molecules, namely CD28, CD5, and CD43, contribute to Fas-independent negative selection of the tolerance-susceptible population of heat-stable antigen (..
  52. Cedeno Laurent F, Opperman M, Barthel S, Kuchroo V, Dimitroff C. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012;188:3127-37 pubmed publisher
    ..Collectively, these findings show how Gal-1 functions as a major glycome determinant regulating Th cell development, inflammation, and tumor immunity. ..
  53. Dragone L, Barth R, Sitar K, Disbrow G, Frelinger J. Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival. Proc Natl Acad Sci U S A. 1995;92:626-30 pubmed
    b>Leukosialin (also known as Ly48, CD43, and sialophorin) is a major cell surface sialoglycoprotein found on a variety of hematopoietically derived cells...
  54. Fuzii H, Travassos L. Transient resistance to B16F10 melanoma growth and metastasis in CD43-/- mice. Melanoma Res. 2002;12:9-16 pubmed
    b>CD43, the major transmembrane sialoglycoprotein of neutrophils, monocytes, T lymphocytes and platelets, is highly glycosylated and its high sialic acid content contributes to the strongly negative charge of cells...
  55. Velázquez F, Grodecki Pena A, Knapp A, Salvador A, NEVERS T, Croce K, et al. CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol. 2016;196:1305-1316 pubmed publisher
    ..the expression and functionality of E-selectin ligands in Th type 17 lymphocytes (Th17 cells) and report that CD43 functions as a Th17 cell E-selectin ligand in vitro that mediates Th17 cell rolling on the vascular endothelium and ..
  56. Garcia G, Miller R. Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. Eur J Immunol. 2003;33:3464-72 pubmed
    ..CD4(+) T cells from old mice express unusually high levels of glycosylated forms of the bulky T cell glycoprotein CD43, particularly on a subset of functionally anergic cells expressing P-glycoprotein...
  57. Mullaly S, Oudhoff M, Min P, Burrows K, Antignano F, Rattray D, et al. Requirement for core 2 O-glycans for optimal resistance to helminth infection. PLoS ONE. 2013;8:e60124 pubmed publisher
    ..Similarly, loss of CD34, CD43, CD44 or PSGL-1 had no effect on resistance to infection...
  58. Koneru M, Schaer D, Monu N, Ayala A, Frey A. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40 pubmed
    ..LFA-1, lipid rafts, ZAP70, and linker for activation of T cells localize at the TIL:tumor cell contact site, and CD43 and CD45 are excluded...
  59. Stockton B, Cheng G, Manjunath N, Ardman B, von Andrian U. Negative regulation of T cell homing by CD43. Immunity. 1998;8:373-81 pubmed
    We report that the cell surface mucin CD43 acts as an anti-adhesin on T lymphocytes. CD43-deficient murine lymphocytes homed significantly more frequently to secondary lymphoid organs than wild-type cells...
  60. Wenger R, Kopf M, Nitschke L, Lamers M, Kohler G, Nielsen P. B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Res. 1995;4:173-83 pubmed
    ..However, a reduction in immature B-cells in the bone marrow and an altered degree of bone marrow and blood chimaerism suggest that HSA expression influences the maturation of B-cells. ..