Sparc

Summary

Gene Symbol: Sparc
Description: secreted acidic cysteine rich glycoprotein
Alias: AA517111, BM-40, SPARC, basement-membrane protein 40, osteonectin, secreted protein acidic and rich in cysteine
Species: mouse

Top Publications

  1. ncbi SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    C Kupprion
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    J Biol Chem 273:29635-40. 1998
  2. ncbi Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
  3. ncbi Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA
    J Histochem Cytochem 53:1131-8. 2005
  4. ncbi Behavioral signs of chronic back pain in the SPARC-null mouse
    Magali Millecamps
    Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 36:95-102. 2011
  5. ncbi SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    Barbara J Schiemann
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Biol Cell 14:3977-88. 2003
  6. ncbi Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM
    Rolf A Brekken
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Clin Invest 111:487-95. 2003
  7. ncbi Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice
    Sabina Sangaletti
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milano, Italy
    J Cell Sci 118:3685-94. 2005
  8. ncbi Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface
    K Norose
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Exp Eye Res 71:295-307. 2000
  9. ncbi Osteopenia and decreased bone formation in osteonectin-deficient mice
    A M Delany
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    J Clin Invest 105:915-23. 2000
  10. ncbi Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault
    S Iseki
    Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Development 126:5611-20. 1999

Research Grants

  1. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY DODD BRADSHAW; Fiscal Year: 2010
  2. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY BRADSHAW; Fiscal Year: 2009
  3. SPARC Modulates Extracellular Matrix Dynamics in Skin
    AMY BRADSHAW; Fiscal Year: 2004
  4. Lens Basement Membrane in SPARC-Null Cataractogenesis
    Qi Yan; Fiscal Year: 2005
  5. IN VIVO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2005
  6. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele Boskey; Fiscal Year: 2005
  7. FT-IR MICROSCOPY OF MINERAL STRUCTURE IN OSTEOPOROSIS
    Adele Boskey; Fiscal Year: 2004
  8. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
  9. FT-IR Microscopy of Mineral Structure
    Adele L Boskey; Fiscal Year: 2010
  10. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications90

  1. ncbi SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    C Kupprion
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    J Biol Chem 273:29635-40. 1998
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and proliferation and is thought to function in tissue remodeling and angiogenesis...
  2. ncbi Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
    Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition...
  3. ncbi Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA
    J Histochem Cytochem 53:1131-8. 2005
    b>SPARC (secreted protein, acidic, and rich in cysteine) is a matricellular protein that is present in the intervertebral disc; in man, levels of SPARC decrease with aging and degeneration...
  4. ncbi Behavioral signs of chronic back pain in the SPARC-null mouse
    Magali Millecamps
    Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 36:95-102. 2011
    Secreted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice were examined for behavioral signs of chronic low back and/or radicular pain.
  5. ncbi SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    Barbara J Schiemann
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Biol Cell 14:3977-88. 2003
    Secreted protein, acidic and rich in cysteine (SPARC) is a multifunctional secreted protein that regulates cell-cell and cell-matrix interactions, leading to alterations in cell adhesion, motility, and proliferation...
  6. ncbi Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM
    Rolf A Brekken
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Clin Invest 111:487-95. 2003
    b>SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions...
  7. ncbi Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice
    Sabina Sangaletti
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milano, Italy
    J Cell Sci 118:3685-94. 2005
    ..The matricellular protein SPARC (secreted protein, acidic and rich in cysteine), which is induced during inflammation and tissue repair, organizes ..
  8. ncbi Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface
    K Norose
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Exp Eye Res 71:295-307. 2000
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein involved in cell-matrix interactions...
  9. ncbi Osteopenia and decreased bone formation in osteonectin-deficient mice
    A M Delany
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    J Clin Invest 105:915-23. 2000
    ..There is evidence that the extracellular matrix glycoprotein osteonectin or secreted protein acidic and rich in cysteine (BM-40) may be important in bone remodeling...
  10. ncbi Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault
    S Iseki
    Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Development 126:5611-20. 1999
    ..Following up-regulation of the differentiation marker osteopontin, Fgfr1, osteonectin and alkaline phosphatase are down-regulated, suggesting that they are involved in the osteogenic ..
  11. ncbi Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis
    T P Strandjord
    Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
    Am J Physiol 277:L628-35. 1999
    b>Secreted protein acidic and rich in cysteine (SPARC) has been shown to be coexpressed with type I collagen in tissues undergoing remodeling and wound repair...
  12. ncbi Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation
    J A Bassuk
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA, USA
    Exp Eye Res 68:321-31. 1999
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation...
  13. ncbi Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)
    A Basu
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    BMC Cell Biol 2:15. 2001
    b>SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing...
  14. ncbi The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase
    Matt S Weaver
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    J Biol Chem 283:22826-37. 2008
    b>Secreted protein acidic and rich in cysteine (SPARC) is important for the normal growth and maintenance of the murine lens...
  15. ncbi SPARC-null mice exhibit accelerated cutaneous wound closure
    Amy D Bradshaw
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 50:1-10. 2002
    Expression of SPARC (secreted protein acidic and rich in cysteine; osteonectin, BM-40), an extracellular matrix (ECM) associated protein, is coincident with matrix remodeling...
  16. ncbi Matricellular hevin regulates decorin production and collagen assembly
    Millicent M Sullivan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 281:27621-32. 2006
    Matricellular proteins such as SPARC, thrombospondin 1 and 2, and tenascin C and X subserve important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix...
  17. ncbi SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
    Thomas H Barker
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 280:36483-93. 2005
    b>SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their extracellular matrix, and targeted deletion of Sparc results in compromised extracellular matrix in mice...
  18. ncbi Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension
    Matthew J Socha
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB 3306, Augusta, GA 30912, USA
    Am J Pathol 171:1104-12. 2007
    The matricellular protein secreted protein acidic and rich in cysteine (SPARC) modulates cell adhesion, proliferation, matrix deposition, and tissue remodeling...
  19. ncbi SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    Amy D Bradshaw
    The Hope Heart Institute, Seattle, Washington 98104, USA
    J Invest Dermatol 120:949-55. 2003
    ..We present evidence that SPARC (secreted protein acidic and rich in cysteine) contributes to collagen fibril formation in the dermis...
  20. ncbi SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts
    Tyler J Rentz
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29412, USA
    J Biol Chem 282:22062-71. 2007
    ..SPARC (secreted protein acidic and rich in cysteine) is a counter-adhesive protein that binds collagens...
  21. ncbi Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials
    Pauli Puolakkainen
    Department of Vascular Biology, The Hope Heart Institute, University of Washington, Seattle, Washington 98104, USA
    Am J Pathol 162:627-35. 2003
    b>SPARC (secreted protein, acidic and rich in cysteine), a matricellular glycoprotein, modulates the interaction of cells with the extracellular matrix (ECM)...
  22. ncbi Cloning and expression of murine SC1, a gene product homologous to SPARC
    J A Soderling
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    J Histochem Cytochem 45:823-35. 1997
    A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC (secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell adhesion, cell cycle, and matrix assembly and remodeling...
  23. ncbi SPARC deficiency leads to early-onset cataractogenesis
    K Norose
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 39:2674-80. 1998
    To determine the role of SPARC (secreted protein, acidic, and rich in cysteine) in cataractogenesis by examining mice deficient in a matricellular protein SPARC.
  24. ncbi Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis
    Pauli A Puolakkainen
    Department of Vascular Biology, Hope Heart Institute, University of Washington, Seattle, Washington, USA
    Mol Cancer Res 2:215-24. 2004
    b>SPARC, a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix (ECM). Tumor growth and metastasis occur in the context of the ECM, the levels and deposition of which are controlled in part by SPARC...
  25. ncbi SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 88:802-11. 2003
    ..b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, has been shown to modulate the interaction of cells with ..
  26. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    b>Secreted protein acidic and rich in cysteine (SPARC), a member of the family of matricellular proteins, regulates the interaction of cells with pleiotropic factors and proteins of the extracellular matrix (ECM)...
  27. ncbi The biology of SPARC, a protein that modulates cell-matrix interactions
    T F Lane
    Department of Genetics, Howard Hughes Medical Institute, Harvard University School of Medicine, Boston, Massachusetts 02115
    FASEB J 8:163-73. 1994
    An extracellular matrix-associated glycoprotein expressed in a variety of tissues during embryogenesis and repair, SPARC contains modular domains that can function independently to bind cells and matrix components...
  28. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  29. ncbi SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells
    A Francki
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Biol Chem 274:32145-52. 1999
    The matricellular protein SPARC is expressed at high levels in cells that participate in tissue remodeling and is thought to regulate mesangial cell proliferation and extracellular matrix production in the kidney glomerulus in a rat ..
  30. ncbi Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction
    Mark W M Schellings
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6229 HX Maastricht, The Netherlands
    J Exp Med 206:113-23. 2009
    The matricellular protein SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin) mediates cell-matrix interactions during wound healing and regulates the production and/or assembly of the extracellular matrix (..
  31. ncbi Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function
    M L Iruela-Arispe
    Department of Biological Structure, University of Washington School of Medicine, Seattle 98195, USA
    Dev Dyn 207:171-83. 1996
    ..g., fibronectin, secreted protein acidic and rich in cysteine (SPARC), decorin, and transforming growth factor-beta...
  32. ncbi Mutations in the RNA granule component TDRD7 cause cataract and glaucoma
    Salil A Lachke
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 331:1571-6. 2011
    ..These findings demonstrate a role for RGs in vertebrate organogenesis...
  33. ncbi Inactivation of SPARC enhances high-fat diet-induced obesity in mice
    Jing Nie
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Connect Tissue Res 52:99-108. 2011
    Secreted protein, acidic and rich in cysteine (SPARC), a matricellular protein, modulates extracellular matrix assembly and turnover in many physiological processes. SPARC-null mice exhibit an increased accumulation of adipose tissue...
  34. ncbi LPS induces greater bone and PDL loss in SPARC-null mice
    J Trombetta-Esilva
    Department of Craniofacial Biology and Center for Oral Health Research, Medical University of South Carolina, Charleston, SC, USA
    J Dent Res 90:477-82. 2011
    ..Collagen I is the primary component of bone and PDL extracellular matrix. SPARC/Osteonectin (SP/ON) is implicated in the regulation of collagen content in healthy PDL...
  35. ncbi Expression in SPARC-null mice of collagen type I lacking the globular domain of the α1(I) N-propeptide results in abdominal hernias and loss of dermal collagen
    Lauren Card
    Gazes Cardiac Research Institute, Division of Cardiology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, United States
    Matrix Biol 29:559-64. 2010
    ..To determine whether the N-propeptide contributed to decreased collagen content in SPARC-null mice, mice carrying a deletion of exon 2, which encodes the globular domain of the N-propeptide of collagen I,..
  36. ncbi Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response
    S A Rempel
    Department of Neurosurgery, Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA
    Genes Immun 8:262-74. 2007
    b>Sparc-null mice have been used as models to assess tumor-host immune cell interactions. However, it is not known if they have a competent immune system. In this study, the immune systems of Sparc wild-type and null mice were compared...
  37. ncbi Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    Owen J Sansom
    Beatson Institute of Cancer Research, Glasgow, Scotland, UK
    Gut 56:1410-4. 2007
    b>SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human cancers. More recently, it has been shown to be upregulated in human gastric and colorectal cancer...
  38. ncbi The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development
    Kyoko Oka
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 303:391-404. 2007
    ..Collectively, our data suggest that there are differential signal cascades in response to TGF-beta to control chondrogenesis and osteogenesis during mandibular development...
  39. ncbi Proteomic analysis of soluble factors secreted by limbal fibroblasts
    Shigeto Shimmura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 12:478-84. 2006
    ..To identify soluble factors selectively secreted by limbal fibroblasts as possible regulators of limbal basal epithelium...
  40. ncbi SPARC interacts with AMPK and regulates GLUT4 expression
    Haiyan Song
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, XueFu Road 246, Harbin 150080, China
    Biochem Biophys Res Commun 396:961-6. 2010
    ..We show that secreted protein acidic and rich in cysteine (SPARC) is an AMPK-interacting protein, and the two proteins enhance each other...
  41. ncbi Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
    b>SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases...
  42. ncbi Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis
    Sabina Sangaletti
    Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Universita degli Studi di Milano, Milan, Italy
    Cancer Res 68:9050-9. 2008
    ..b>Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular matrix (ECM) deposition and ..
  43. ncbi Recombinant mouse SPARC promotes parietal endoderm differentiation and cardiomyogenesis in embryoid bodies
    Christopher Hrabchak
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S, Canada
    Biochem Cell Biol 86:487-99. 2008
    ..Cardiomyogenesis in embryoid bodies was recently demonstrated to be promoted by PYS-2-derived native SPARC (secreted protein, acidic and rich in cysteine), whose expression is upregulated in parietal endoderm at the onset ..
  44. ncbi SPARC accelerates disease progression in experimental crescentic glomerulonephritis
    Amy N Sussman
    Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Am J Pathol 174:1827-36. 2009
    ..b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, is normally expressed at low ..
  45. ncbi The first draft of the endostatin interaction network
    Clément Faye
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS, University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    J Biol Chem 284:22041-7. 2009
    ..include glycosaminoglycans (chondroitin and dermatan sulfate), matricellular proteins (thrombospondin-1 and SPARC), collagens (I, IV, and VI), the amyloid peptide Abeta-(1-42), and transglutaminase-2...
  46. ncbi Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways
    C H E Ma
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroscience 165:463-74. 2010
    Our previous study identified osteonectin (ON) in a screen of factors made by Schwann cells (SCs) which promoted peripheral and central neurons survival and neuritogenesis, however, the mechanisms of ON promoting effects are largely ..
  47. ncbi Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice
    Luciene Machado do Reis
    University of Sao Paulo, Sao Paulo, Brazil
    Bone 43:264-73. 2008
    ..proteins play a unique role in the skeleton as regulators of bone remodeling, and the matricellular protein osteonectin (SPARC, BM-40) is the most abundant non-collagenous protein in bone...
  48. ncbi SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament
    Jessica M Trombetta
    Department of Craniofacial Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Histochem Cytochem 58:871-9. 2010
    Expression of secreted protein acidic and rich in cysteine (SPARC)/osteonectin, a collagen-binding matricellular protein, is frequently associated with tissues with high rates of collagen turnover, such as bone...
  49. ncbi SPARC is expressed by macroglia and microglia in the developing and mature nervous system
    Adele J Vincent
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:1449-62. 2008
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair...
  50. ncbi Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing
    Amy D Bradshaw
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 298:H614-22. 2010
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in the changes in post-synthetic procollagen processing that occur in ..
  51. ncbi Identification of SPARC as a candidate target antigen for immunotherapy of various cancers
    Mitsuhiro Inoue
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 127:1393-403. 2010
    ..A genome-wide cDNA microarray analysis identified that secreted protein acidic and rich in cysteine (SPARC) gene is overexpressed in the gastric, pancreatic and colorectal cancer tissues but not ..
  52. ncbi Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 205:657-67. 2008
    ..We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response...
  53. ncbi Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci
    Clifton M Ramsdell
    Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
    Mamm Genome 17:37-48. 2006
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
  54. ncbi Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro
    Martina Stary
    Max F Perutz Laboratories, University Institutes at the Vienna Biocenter, Department of Medical Biochemistry, Division of Molecular Cell Biology, Medical University of Vienna, Dr Bohrgasse 9, A1030 Vienna, Austria
    Exp Cell Res 310:331-43. 2005
    ..Here, we demonstrate that Secreted Protein, Acidic, Rich in Cysteine, SPARC, predominantly secreted by mesenchymal parietal endoderm specifically promotes early myocardial cell ..
  55. ncbi A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:454-62. 1989
    ....
  56. ncbi In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
    I M Clauss
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
    Dev Dyn 197:146-56. 1993
    ..observations suggest that hXBP-1 may play a role in regulating the expression of tissue specific genes (TIMP, osteonectin, osteopontin, osteocalcin) expressed in osteoblasts...
  57. ncbi Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 51:503-11. 2003
    b>SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a matricellular glycoprotein that modulates cell proliferation, adhesion, migration, and extracellular matrix (ECM) production...
  58. ncbi Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls
    Adele L Boskey
    Research Division, Hospital for Special Surgery, New York, New York 10021, USA
    J Bone Miner Res 18:1005-11. 2003
    b>Osteonectin function in bone was investigated by infrared analysis of bones from osteonectin-null (KO) and wildtype mice (four each at 11, 17, and 36 weeks)...
  59. ncbi mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11
    K Kuwabara
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    Genomics 20:337-8. 1994
  60. ncbi The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re
    C P Hart
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genetics 118:319-27. 1988
    ..The results place the Hoax-2 locus approximately 1 cM from the rex (Re) locus on mouse chromosome 11...
  61. ncbi Genetic mapping of members of the polyubiquitin gene subfamily coding for UbB
    G C Voss
    Developmental Biology Unit, University of Bielefeld, Germany
    Mamm Genome 7:169. 1996
  62. ncbi SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges
    Pauli A Puolakkainen
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Ave, Seattle, WA 98101, USA
    J Histochem Cytochem 53:571-81. 2005
    b>Secreted protein acidic and rich in cysteine (SPARC) and thrombospondin-2 (TSP-2) are structurally unrelated matricellular proteins that have important roles in cell-extracellular matrix (ECM) interactions and tissue repair...
  63. ncbi Chromosomal assignment of the recoverin gene and cancer-associated retinopathy
    J F McGinnis
    Department of Anatomy and Cell Biology, University of California Los Angeles 90024
    Mamm Genome 4:43-5. 1993
    ..length variants in recombinant inbred strains of mice assigned Rcvrn to mouse Chromosome (Chr) 11, between Sparc (3.7 map units) and Zfp-3 (2.3 map units)...
  64. ncbi Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein
    M Nomura
    Department of Medical Genetics, Osaka University, Japan
    Differentiation 57:39-50. 1994
    ..As the Drosophila polyhomeotic gene is involved in regulating morphogenesis, the rae-28 gene may participate in regulating early mammalian development...
  65. ncbi Somatic cell hybrid mapping on mouse chromosome 11 (MMU11): assignment of markers relative to two breakpoints in band D
    D J Morris
    Mammal Research Institute, University of Pretoria, South Africa
    Genomics 15:323-31. 1993
    ....
  66. ncbi Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain
    D B Mendis
    Department of Zoology, University of Toronto, Ont, Canada
    Brain Res Mol Brain Res 24:11-9. 1994
    The pattern of expression of the SPARC gene was examined during postnatal development of the mouse brain using in situ hybridization...
  67. ncbi Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5
    I Kalcheva
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffallo, NY 14263
    Cytogenet Cell Genet 68:19-24. 1995
    ..The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31...
  68. ncbi Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13
    M L Roller
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618, USA
    Mamm Genome 6:305-6. 1995
  69. ncbi Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)
    B Lankat-Buttgereit
    Dermatologische Klinik der Universität München, FRG
    FEBS Lett 236:352-6. 1988
    ..The sequences showed 92% identity and were also essentially identical to those of bone osteonectin and of the parietal endoderm protein SPARC...
  70. ncbi Expression of SPARC/osteonectin transcript in murine embryos and gonads
    C C Howe
    Wistar Institute, Philadelphia, Pennsylvania 19104
    Differentiation 37:20-5. 1988
    ..Nucleotide-sequence analysis revealed extensive homology between this clone and SPARC/osteonectin cDNA cloned from mouse parietal endoderm and bovine bone cells...
  71. ncbi Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker
    S V Cheng
    Neurogenetics Laboratory, Massachusetts General Hospital, Boston
    DNA 6:401-7. 1987
    ..The mouse locus was mapped to the central region of chromosome 11 at 1 centiMorgan from the SPARC gene, a locus whose human counterpart is on human chromosome 5.
  72. ncbi Chromosomal localization of zinc finger protein genes in man and mouse
    A Ashworth
    Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Genomics 4:323-7. 1989
    ..In humans ZFP3 has been localized to chromosome 17p12-17pter and thus is part of the conserved linkage group between this chromosome and the distal half of mouse chromosome 11...
  73. ncbi The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene
    P J McKinnon
    Genome Res 6:1077-83. 1996
    Sc1 and Sparc are two extracellular proteins sharing similarity in their carboxyl terminus, with 63% identity over a 232-amino-acid region. We have cloned and mapped the genomic locus of mouse Sc1...
  74. ncbi The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11
    P A Baldacci
    Unite de Genetique des Mammiferes, Institut Pasteur, Paris, France
    Mamm Genome 2:100-5. 1992
    ..Our results indicate that a single locus, Om, is responsible for the DDK syndrome and is located on Chromosome (Chr) 11, very close to the Sigje locus...
  75. ncbi Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice
    Shelli L Kirstein
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Pharmacol Exp Ther 302:1238-45. 2002
    ..These results suggest that although ethanol sensitivity and cAMP signaling are determined by multiple genes, they may share certain genetic codetermination...
  76. ncbi Murine inner cell mass-derived lineages depend on Sall4 function
    Ulrich Elling
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:16319-24. 2006
    ..These data establish Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages...
  77. ncbi SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
    ..We now report a novel interaction between VCAM-1 and secreted protein acidic and rich in cysteine (SPARC), which induces actin cytoskeletal rearrangement and intercellular gaps, physiological ..
  78. ncbi Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98104 2046, USA
    J Cell Physiol 203:286-94. 2005
    The matricellular glycoprotein, secreted protein acidic and rich in cysteine (SPARC), has complex biological activities and is important for lens epithelial cell function and regulation of cataract formation...
  79. ncbi SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
    Akira Murakami
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:28564-73. 2004
    ..This Fgf-3 expression was virtually abolished when Sox7 expression was suppressed by RNA interference. These results show that SOX7 is a potent activator of Fgf-3 transcription...
  80. ncbi Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    S Lehmann
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Leukemia 21:1931-6. 2007
    ..receptor-beta (PDGFRB; 73%), Nef-associated factor 1 (TNIP1; 72%), secreted protein, acidic and rich in cysteine (SPARC; 71%), annexin VI (ANAX6; 69%), NSDT (66%) and TIGD (60%)...
  81. ncbi Osteonectin-null mutation compromises osteoblast formation, maturation, and survival
    Anne M Delany
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    Endocrinology 144:2588-96. 2003
    Osteonectin, also known as SPARC (secreted protein acidic and rich in cysteine) or BM-40, is one of the most abundant noncollagenous proteins in bone...
  82. ncbi Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression
    Fiona C Mansergh
    School of Biosciences, Cardiff University, Cardiff
    Physiol Genomics 32:64-73. 2007
    b>Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low-turnover osteopenia in the 129Sv/C57BL/6 exon 4 knockout...
  83. ncbi Gene mapping of sperm quality parameters in recombinant inbred strains of mice
    Aniela Golas
    Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Int J Dev Biol 52:287-93. 2008
    ..A detailed analysis of the genes located in these regions enabled us to prepare a list of candidate genes. We discuss the basis of the correlation between the measured parameters...
  84. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
  85. ncbi Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development
    T Nikaido
    Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Histochem Cell Biol 116:141-8. 2001
    ..Spatiotemporal patterns of OASIS partly overlapped that of osteopontin, osteonectin, and alpha1 type I procollagen genes...
  86. ncbi Shared gene expression profiles in developing heart valves and osteoblast progenitor cells
    Santanu Chakraborty
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, Ohio 45229, USA
    Physiol Genomics 35:75-85. 2008
    ..Together, these data support shared gene expression profiles of the developing valves and osteoblast bone precursor cells in normal valve development and homeostasis with potential functions in calcific valve disease...
  87. ncbi Entorhinal deafferentation induces upregulation of SPARC in the mouse hippocampus
    Xin Liu
    Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Science, 320 Yue Yang Road, Shanghai 200031, PR China
    Brain Res Mol Brain Res 141:58-65. 2005
    b>SPARC is a matricellular protein that modulates cell-cell and cell-matrix interactions by virtue of its antiproliferative and counteradhesive properties...
  88. ncbi Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98104 2046, USA
    J Cell Sci 115:2747-56. 2002
    ..b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-..
  89. ncbi Derivation and characterization of a somatic cell hybrid containing the portion of mouse chromosome 11 (MMU11) homologous to human chromosome 17q
    D J Morris-Rosendahl
    Department of Zoology and Entomology, University of Pretoria, South Africa
    J Hered 87:252-8. 1996
    ..Loci for D11Mit5, Rpo2-1, Trp53, Glut4, Acrb, and Atplb2 could all be localized proximal to the T16Ad breakpoint in band B5, between bands B1 and B5 on MMU11...
  90. ncbi Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing
    Amy D Bradshaw
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 119:269-80. 2009
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-..

Research Grants62

  1. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY DODD BRADSHAW; Fiscal Year: 2010
    ..in vitro, using murine primary cardiac fibroblast culture studies, whether a change in SPARC (Secreted Protein Acidic and Rich in Cysteine) expression or procollagen binding results in an isolated change in procollagen processing and ..
  2. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY BRADSHAW; Fiscal Year: 2009
    ..in vitro, using murine primary cardiac fibroblast culture studies, whether a change in SPARC (Secreted Protein Acidic and Rich in Cysteine) expression or procollagen binding results in an isolated change in procollagen processing and ..
  3. SPARC Modulates Extracellular Matrix Dynamics in Skin
    AMY BRADSHAW; Fiscal Year: 2004
    This research proposal addresses the function of SPARC (secreted protein acidic and rich in cysteine) in the maintenance and repair of collagenous matrices in the skin...
  4. Lens Basement Membrane in SPARC-Null Cataractogenesis
    Qi Yan; Fiscal Year: 2005
    SPARC (secreted protein acidic and rich in cysteine), also termed osteonectin and BM-40, is a matricellular glycoprotein which has been shown to regulate cell functions such as cell cycle, cell shape change, migration, adhesion, gene ..
  5. IN VIVO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2005
    ..Results of these proposed should provide new insights in calcification mechanisms in general, and new information on how to treat conditions in which cartilage calcification is aberrant. ..
  6. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele Boskey; Fiscal Year: 2005
    ..g. OPN and osteocalcin; OPN and collagen; OPN and BSP; OPN and fibronectin). ..
  7. FT-IR MICROSCOPY OF MINERAL STRUCTURE IN OSTEOPOROSIS
    Adele Boskey; Fiscal Year: 2004
    ..Emphasis will be placed on those properties identified in Aim 1 that are most predictive of fracture. ..
  8. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  9. FT-IR Microscopy of Mineral Structure
    Adele L Boskey; Fiscal Year: 2010
    ..This information should lead to improved diagnosis and new approaches to prevention and treatment of osteoporosis, the "silent epidemic". ..
  10. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  11. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  12. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele Boskey; Fiscal Year: 2007
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  13. Stretch-Induced Podocyte Injury
    Raghu Durvasula; Fiscal Year: 2007
    ..abstract_text> ..
  14. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2007
    ....
  15. THE ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2007
    ..b>Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in gliomas...
  16. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  17. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 1993
    ..growth disorders, rickets) and of accelerated or dystrophic calcification (eg. osteoarthritis)...
  18. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 1991
    ..Their clinical significance comes from the basic information on calcification mechanisms they will provide as well as from the specific data they will generate on the effect of certain therapies on these mechanisms...
  19. ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2003
    ..We have demonstrated that SPARC is highly expressed in gliomas and that it functionally contributes to invasion in vitro...
  20. FT-IR MICROSCOPY OF MINERAL STRUCTURE IN OSTEOPOROSIS
    Adele Boskey; Fiscal Year: 2000
    ..Results of these FTIRM analyses will provide insight into the basis for the loss of bone strength in osteoporosis, and may suggest which treatments are most desirable. ..
  21. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 1999
    ....