Sparc

Summary

Gene Symbol: Sparc
Description: secreted acidic cysteine rich glycoprotein
Alias: BM-40, SPARC, basement-membrane protein 40, osteonectin, secreted protein acidic and rich in cysteine
Species: mouse
Products:     Sparc

Top Publications

  1. Wang Y, Xiao R, Yang F, Karim B, Iacovelli A, Cai J, et al. Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005;132:3537-48 pubmed
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  2. Weaver M, Workman G, Sage E. The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. J Biol Chem. 2008;283:22826-37 pubmed publisher
    b>Secreted protein acidic and rich in cysteine (SPARC) is important for the normal growth and maintenance of the murine lens...
  3. Lehmann S, O Kelly J, Raynaud S, Funk S, Sage E, Koeffler H. Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice. Leukemia. 2007;21:1931-6 pubmed
    ..receptor-beta (PDGFRB; 73%), Nef-associated factor 1 (TNIP1; 72%), secreted protein, acidic and rich in cysteine (SPARC; 71%), annexin VI (ANAX6; 69%), NSDT (66%) and TIGD (60%)...
  4. Wang J, Lai S, Guo X, Zhang X, de Crombrugghe B, Sonnylal S, et al. Attenuation of fibrosis in vitro and in vivo with SPARC siRNA. Arthritis Res Ther. 2010;12:R60 pubmed publisher
    b>SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases...
  5. Arnold S, Mira E, Muneer S, Korpanty G, Beck A, Holloway S, et al. Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC. Exp Biol Med (Maywood). 2008;233:860-73 pubmed publisher
    ..These features are regulated in part by MMP9 and SPARC. To explore the interaction of SPARC and MMP9 in cancer, we first established orthotopic pancreatic tumors in ..
  6. Rempel S, Hawley R, Gutierrez J, Mouzon E, Bobbitt K, Lemke N, et al. Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response. Genes Immun. 2007;8:262-74 pubmed
    b>Sparc-null mice have been used as models to assess tumor-host immune cell interactions. However, it is not known if they have a competent immune system. In this study, the immune systems of Sparc wild-type and null mice were compared...
  7. Bassuk J, Birkebak T, Rothmier J, Clark J, Bradshaw A, Muchowski P, et al. Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation. Exp Eye Res. 1999;68:321-31 pubmed
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation...
  8. Yan Q, Weaver M, Perdue N, Sage E. Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells. J Cell Physiol. 2005;203:286-94 pubmed
    The matricellular glycoprotein, secreted protein acidic and rich in cysteine (SPARC), has complex biological activities and is important for lens epithelial cell function and regulation of cataract formation...
  9. Rivera L, Brekken R. SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-?1 activity. J Cell Biol. 2011;193:1305-19 pubmed publisher
    Pericytes migrate to nascent vessels and promote vessel stability. Recently, we reported that secreted protein acidic and rich in cysteine (SPARC)-deficient mice exhibited decreased pericyte-associated vessels in an orthotopic model of ..

More Information

Publications69

  1. Millecamps M, Tajerian M, Sage E, Stone L. Behavioral signs of chronic back pain in the SPARC-null mouse. Spine (Phila Pa 1976). 2011;36:95-102 pubmed publisher
    Secreted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice were examined for behavioral signs of chronic low back and/or radicular pain...
  2. Trombetta J, Bradshaw A. SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament. J Histochem Cytochem. 2010;58:871-9 pubmed publisher
    Expression of secreted protein acidic and rich in cysteine (SPARC)/osteonectin, a collagen-binding matricellular protein, is frequently associated with tissues with high rates of collagen turnover, such as bone...
  3. Gilmour D, Lyon G, Carlton M, Sanes J, Cunningham J, Anderson J, et al. Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998;17:1860-70 pubmed
    SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin/BM40) is a secreted Ca2+-binding glycoprotein that interacts with a range of extracellular matrix molecules, including collagen IV...
  4. Socha M, Manhiani M, Said N, Imig J, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Am J Pathol. 2007;171:1104-12 pubmed
    The matricellular protein secreted protein acidic and rich in cysteine (SPARC) modulates cell adhesion, proliferation, matrix deposition, and tissue remodeling...
  5. Bradshaw A, Baicu C, Rentz T, Van Laer A, Boggs J, Lacy J, et al. Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation. 2009;119:269-80 pubmed publisher
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-..
  6. Lane T, Sage E. The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J. 1994;8:163-73 pubmed
    An extracellular matrix-associated glycoprotein expressed in a variety of tissues during embryogenesis and repair, SPARC contains modular domains that can function independently to bind cells and matrix components...
  7. Francki A, Bradshaw A, Bassuk J, Howe C, Couser W, Sage E. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells. J Biol Chem. 1999;274:32145-52 pubmed
    The matricellular protein SPARC is expressed at high levels in cells that participate in tissue remodeling and is thought to regulate mesangial cell proliferation and extracellular matrix production in the kidney glomerulus in a rat ..
  8. Iseki S, Wilkie A, Morriss Kay G. Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999;126:5611-20 pubmed
    ..Following up-regulation of the differentiation marker osteopontin, Fgfr1, osteonectin and alkaline phosphatase are down-regulated, suggesting that they are involved in the osteogenic ..
  9. Bradshaw A, Baicu C, Rentz T, Van Laer A, Bonnema D, Zile M. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2010;298:H614-22 pubmed publisher
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in the changes in post-synthetic procollagen processing that occur in ..
  10. Gruber H, Sage E, Norton H, Funk S, Ingram J, Hanley E. Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse. J Histochem Cytochem. 2005;53:1131-8 pubmed
    b>SPARC (secreted protein, acidic, and rich in cysteine) is a matricellular protein that is present in the intervertebral disc; in man, levels of SPARC decrease with aging and degeneration...
  11. Soderling J, Reed M, Corsa A, Sage E. Cloning and expression of murine SC1, a gene product homologous to SPARC. J Histochem Cytochem. 1997;45:823-35 pubmed
    A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC (secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell adhesion, cell cycle, and matrix assembly and remodeling...
  12. Puolakkainen P, Brekken R, Muneer S, Sage E. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol Cancer Res. 2004;2:215-24 pubmed
    b>SPARC, a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix (ECM). Tumor growth and metastasis occur in the context of the ECM, the levels and deposition of which are controlled in part by SPARC...
  13. Yan Q, Clark J, Wight T, Sage E. Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice. J Cell Sci. 2002;115:2747-56 pubmed
    ..b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-..
  14. Bassett J, Gogakos A, White J, Evans H, Jacques R, Van der Spek A, et al. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet. 2012;8:e1002858 pubmed publisher
    ..Application of the approach to diseases affecting other physiological systems will help to realize the full potential of the International Mouse Phenotyping Consortium. ..
  15. Tripathi R, Mishra R. Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation. J Mol Neurosci. 2010;41:397-403 pubmed publisher
    ..Pax6 is known to be a nuclear protein, it is presumed that it may interact with matricelluar proteins like SPARC during transport and processing of Pax6...
  16. Bradshaw A, Reed M, Sage E. SPARC-null mice exhibit accelerated cutaneous wound closure. J Histochem Cytochem. 2002;50:1-10 pubmed
    Expression of SPARC (secreted protein acidic and rich in cysteine; osteonectin, BM-40), an extracellular matrix (ECM) associated protein, is coincident with matrix remodeling...
  17. Mansergh F, Wells T, Elford C, Evans S, Perry M, Evans M, et al. Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression. Physiol Genomics. 2007;32:64-73 pubmed
    b>Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low-turnover osteopenia in the 129Sv/C57BL/6 exon 4 knockout...
  18. Francki A, McClure T, Brekken R, Motamed K, Murri C, Wang T, et al. SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells. J Cell Biochem. 2004;91:915-25 pubmed
    b>Secreted protein acidic and rich in cysteine (SPARC), a member of the family of matricellular proteins, regulates the interaction of cells with pleiotropic factors and proteins of the extracellular matrix (ECM)...
  19. Kupprion C, Motamed K, Sage E. SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem. 1998;273:29635-40 pubmed
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and proliferation and is thought to function in tissue remodeling and angiogenesis...
  20. Brekken R, Puolakkainen P, Graves D, Workman G, Lubkin S, Sage E. Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM. J Clin Invest. 2003;111:487-95 pubmed
    b>SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions...
  21. Schellings M, Vanhoutte D, Swinnen M, Cleutjens J, Debets J, van Leeuwen R, et al. Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J Exp Med. 2009;206:113-23 pubmed publisher
    The matricellular protein SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin) mediates cell-matrix interactions during wound healing and regulates the production and/or assembly of the extracellular matrix (..
  22. Schiemann B, Neil J, Schiemann W. SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system. Mol Biol Cell. 2003;14:3977-88 pubmed
    Secreted protein, acidic and rich in cysteine (SPARC) is a multifunctional secreted protein that regulates cell-cell and cell-matrix interactions, leading to alterations in cell adhesion, motility, and proliferation...
  23. Delany A, Amling M, Priemel M, Howe C, Baron R, Canalis E. Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest. 2000;105:915-23 pubmed
    ..There is evidence that the extracellular matrix glycoprotein osteonectin or secreted protein acidic and rich in cysteine (BM-40) may be important in bone remodeling...
  24. Norose K, Lo W, Clark J, Sage E, Howe C. Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface. Exp Eye Res. 2000;71:295-307 pubmed
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein involved in cell-matrix interactions...
  25. Bhoopathi P, Chetty C, Gujrati M, Dinh D, Rao J, Lakka S. The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine. Br J Cancer. 2010;102:530-40 pubmed publisher
    b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix and is capable of altering the growth of various cancers...
  26. Engel J, Taylor W, Paulsson M, Sage H, Hogan B. Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. Biochemistry. 1987;26:6958-65 pubmed
    SPARC, BM-40, and osteonectin are identical or very closely related extracellular proteins of apparent Mr 43,000 (Mr 33,000 predicted from sequence)...
  27. Yan Q, Perdue N, Blake D, Sage E. Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule. Invest Ophthalmol Vis Sci. 2005;46:4652-60 pubmed
    To investigate the role of SPARC in the regulation of the expression and deposition of extracellular matrix (ECM) proteins in the lens capsule...
  28. Iruela Arispe M, Vernon R, Wu H, Jaenisch R, Sage E. Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996;207:171-83 pubmed
    ..g., fibronectin, secreted protein acidic and rich in cysteine (SPARC), decorin, and transforming growth factor-beta...
  29. Bradshaw A, Puolakkainen P, Dasgupta J, Davidson J, Wight T, Helene Sage E. SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol. 2003;120:949-55 pubmed
    ..We present evidence that SPARC (secreted protein acidic and rich in cysteine) contributes to collagen fibril formation in the dermis...
  30. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89:755-64 pubmed
  31. Sullivan M, Barker T, Funk S, Karchin A, Seo N, Hook M, et al. Matricellular hevin regulates decorin production and collagen assembly. J Biol Chem. 2006;281:27621-32 pubmed
    Matricellular proteins such as SPARC, thrombospondin 1 and 2, and tenascin C and X subserve important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix...
  32. Rentz T, Poobalarahi F, Bornstein P, Sage E, Bradshaw A. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem. 2007;282:22062-71 pubmed
    ..SPARC (secreted protein acidic and rich in cysteine) is a counter-adhesive protein that binds collagens...
  33. Strandjord T, Madtes D, Weiss D, Sage E. Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis. Am J Physiol. 1999;277:L628-35 pubmed
    b>Secreted protein acidic and rich in cysteine (SPARC) has been shown to be coexpressed with type I collagen in tissues undergoing remodeling and wound repair...
  34. Basu A, Kligman L, Samulewicz S, Howe C. Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40). BMC Cell Biol. 2001;2:15 pubmed
    b>SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing...
  35. Savani R, Zhou Z, Arguiri E, Wang S, Vu D, Howe C, et al. Bleomycin-induced pulmonary injury in mice deficient in SPARC. Am J Physiol Lung Cell Mol Physiol. 2000;279:L743-50 pubmed
    b>SPARC (secreted protein, acidic and rich in cysteine) is a component of the matrix that appears to regulate tissue remodeling...
  36. Arnold S, Rivera L, Miller A, Carbon J, Dineen S, Xie Y, et al. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Dis Model Mech. 2010;3:57-72 pubmed publisher
    Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition...
  37. Sangaletti S, Gioiosa L, Guiducci C, Rotta G, Rescigno M, Stoppacciaro A, et al. Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice. J Cell Sci. 2005;118:3685-94 pubmed
    ..The matricellular protein SPARC (secreted protein, acidic and rich in cysteine), which is induced during inflammation and tissue repair, organizes ..
  38. Kudo H, Hirayoshi K, Kitagawa Y, Imamura S, Nagata K. Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses. Exp Cell Res. 1994;212:219-24 pubmed
    ..It was sequenced and identified as a segment of mouse osteonectin (SPARC) cDNA. We found osteonectin to be heat-inducible in some cells...
  39. Harris B, Zhang Y, Card L, Rivera L, Brekken R, Bradshaw A. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol. 2011;301:H841-7 pubmed publisher
    Cardiac tissue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced amounts of insoluble collagen content at baseline and in response to pressure overload hypertrophy compared with wild-type (WT) ..
  40. Norose K, Clark J, Syed N, Basu A, Heber Katz E, Sage E, et al. SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci. 1998;39:2674-80 pubmed
    To determine the role of SPARC (secreted protein, acidic, and rich in cysteine) in cataractogenesis by examining mice deficient in a matricellular protein SPARC. Mice were rendered SPARC-deficient by a targeted disruption of the gene...
  41. Yan Q, Sage E. SPARC, a matricellular glycoprotein with important biological functions. J Histochem Cytochem. 1999;47:1495-506 pubmed
    b>SPARC (secreted protein, acidic and rich in cysteine) is a unique matricellular glycoprotein that is expressed by many different types of cells and is associated with development, remodeling, cell turnover, and tissue repair...
  42. Barker T, Baneyx G, Cardo Vila M, Workman G, Weaver M, Menon P, et al. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. J Biol Chem. 2005;280:36483-93 pubmed
    b>SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their extracellular matrix, and targeted deletion of Sparc results in compromised extracellular matrix in mice...
  43. Puolakkainen P, Bradshaw A, Kyriakides T, Reed M, Brekken R, Wight T, et al. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Am J Pathol. 2003;162:627-35 pubmed
    b>SPARC (secreted protein, acidic and rich in cysteine), a matricellular glycoprotein, modulates the interaction of cells with the extracellular matrix (ECM)...
  44. Francki A, Motamed K, McClure T, Kaya M, Murri C, Blake D, et al. SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling. J Cell Biochem. 2003;88:802-11 pubmed
    ..b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, has been shown to modulate the interaction of cells with ..
  45. Bradshaw A, Graves D, Motamed K, Sage E. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci U S A. 2003;100:6045-50 pubmed
    b>Secreted protein acidic and rich in cysteine/osteonectin/BM-40 (SPARC) is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM)...
  46. Boskey A, Moore D, Amling M, Canalis E, Delany A. Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res. 2003;18:1005-11 pubmed
    b>Osteonectin function in bone was investigated by infrared analysis of bones from osteonectin-null (KO) and wildtype mice (four each at 11, 17, and 36 weeks)...
  47. Rosset E, Bradshaw A. SPARC/osteonectin in mineralized tissue. Matrix Biol. 2016;52-54:78-87 pubmed publisher
    b>Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues...
  48. Sasaki T, Ito Y, Bringas P, Chou S, Urata M, Slavkin H, et al. TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006;133:371-81 pubmed
  49. Cheng L, Sage E, Yan Q. SPARC fusion protein induces cellular adhesive signaling. PLoS ONE. 2013;8:e53202 pubmed publisher
    Secreted protein, acidic and rich in cysteine (SPARC) has been described as a counteradhesive matricellular protein with a diversity of biological functions associated with morphogenesis, remodeling, cellular migration, and proliferation...
  50. Kucukdereli H, Allen N, Lee A, Feng A, Ozlu M, Conatser L, et al. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. Proc Natl Acad Sci U S A. 2011;108:E440-9 pubmed publisher
    ..Here we identified two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vitro and in vivo...
  51. Toba H, de Castro Brás L, Baicu C, Zile M, Lindsey M, Bradshaw A. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am J Physiol Cell Physiol. 2015;308:C972-82 pubmed publisher
    To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related cardiac inflammation, we studied six groups of mice: young (3-5 mo old), middle-aged (10-12 mo old), and old (18-29 mo old) C57BL/6 wild-type (..
  52. Trombetta eSilva J, Eadie E, Zhang Y, Norris R, Borg T, Bradshaw A. The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures. PLoS ONE. 2013;8:e79715 pubmed publisher
    ..b>SPARC is a collagen-binding protein previously shown to affect cardiac collagen deposition...
  53. Tripodo C, Sangaletti S, Guarnotta C, Piccaluga P, Cacciatore M, Giuliano M, et al. Stromal SPARC contributes to the detrimental fibrotic changes associated with myeloproliferation whereas its deficiency favors myeloid cell expansion. Blood. 2012;120:3541-54 pubmed publisher
    ..We show that the matricellular protein SPARC contributes to the BM stromal response to myeloproliferation...
  54. Mock B, Hilgers J, Huppi K, D Hoostelaere L. A TaqI restriction fragment length polymorphism at the Hox-2.1 locus cosegregates with the Dlb-1 locus on mouse chromosome 11. Nucleic Acids Res. 1987;15:2397 pubmed
  55. Lloyd Burton S, York E, Anwar M, Vincent A, Roskams A. SPARC regulates microgliosis and functional recovery following cortical ischemia. J Neurosci. 2013;33:4468-81 pubmed publisher
    Secreted protein acidic rich in cysteine (SPARC) is a matricellular protein that modulates the activity of growth factors, cytokines, and extracellular matrix to play multiple roles in tissue development and repair, such as cellular ..
  56. Barker T, Framson P, Puolakkainen P, Reed M, Funk S, Sage E. Matricellular homologs in the foreign body response: hevin suppresses inflammation, but hevin and SPARC together diminish angiogenesis. Am J Pathol. 2005;166:923-33 pubmed
    ..In this report we delineate functions of hevin and SPARC, two homologs of the SPARC family of matricellular proteins, in the foreign body response...
  57. Voss G, Jockusch H. New testis-specific expressed genes on mouse Chromosome 11. Mamm Genome. 1996;7:163 pubmed
  58. Ma C, Bampton E, Evans M, Taylor J. Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways. Neuroscience. 2010;165:463-74 pubmed publisher
    Our previous study identified osteonectin (ON) in a screen of factors made by Schwann cells (SCs) which promoted peripheral and central neurons survival and neuritogenesis, however, the mechanisms of ON promoting effects are largely ..
  59. Chlenski A, Guerrero L, Salwen H, Yang Q, Tian Y, Morales La Madrid A, et al. Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone. PLoS ONE. 2011;6:e23880 pubmed publisher
    b>Secreted Protein Acidic and Rich in Cysteine (SPARC) is one of the major non-structural proteins of the extracellular matrix (ECM) in remodeling tissues...
  60. Barlow J, Drynan L, Hewett D, Holmes L, Lorenzo Abalde S, Lane A, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010;16:59-66 pubmed publisher
    ..This mouse model suggests that a p53-dependent mechanism underlies the pathophysiology of the 5q- syndrome. ..