Sp3

Summary

Gene Symbol: Sp3
Description: trans-acting transcription factor 3
Alias: D130027J01Rik, transcription factor Sp3
Species: mouse
Products:     Sp3

Top Publications

  1. Van Loo P, Mahtab E, Wisse L, Hou J, Grosveld F, Suske G, et al. Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007;27:8571-82 pubmed
    Mice lacking the zinc finger transcription factor specificity protein 3 (Sp3) die prenatally in the C57BL/6 background. To elucidate the cause of mortality we analyzed the potential role of Sp3 in embryonic heart development...
  2. Van Loo P, Bouwman P, Ling K, Middendorp S, Suske G, Grosveld F, et al. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood. 2003;102:858-66 pubmed
    As the zinc-finger transcription factor specificity protein 3 (Sp3) has been implicated in the regulation of many hematopoietic-specific genes, we analyzed the role of Sp3 in hematopoiesis. At embryonic day 18.5 (E18...
  3. Bouwman P, Gollner H, Elsasser H, Eckhoff G, Karis A, Grosveld F, et al. Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000;19:655-61 pubmed
    b>Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination...
  4. Krüger I, Vollmer M, Simmons D, Simmons D, Elsässer H, Philipsen S, et al. Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects. Dev Dyn. 2007;236:2235-44 pubmed
    The ubiquitously expressed zinc finger transcription factors Sp1 and Sp3 play critical roles in embryonic development. Sp1 knockout mice die around embryonic day 10.5. Mice lacking Sp3 are postnatal lethal...
  5. Tone Y, Kojima Y, Furuuchi K, Brady M, Yashiro Ohtani Y, Tykocinski M, et al. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites. J Immunol. 2007;179:1760-7 pubmed
    ..We have shown in this study that basal OX40 promoter activity is regulated by constitutively expressed Sp1/Sp3 and YY1 transcription factors...
  6. Gollner H, Dani C, Phillips B, Philipsen S, Suske G. Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev. 2001;106:77-83 pubmed
    b>Sp3 is a ubiquitously expressed member of the Sp family of transcription factors. Recently, the mouse Sp3 gene has been disrupted by homologous recombination. Sp3 null mice die immediately after birth due to respiratory failure...
  7. Ma W, Horvath G, Kistler M, Kistler W. Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts. Biol Reprod. 2008;79:289-300 pubmed publisher
    ..of gene expression, it is important to understand how levels of Krüpple-like transcription factors SP1 and SP3 change in germ cells during spermatogenesis...
  8. Stielow B, Krüger I, Diezko R, Finkernagel F, Gillemans N, Kong A San J, et al. Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3. PLoS Genet. 2010;6:e1001203 pubmed publisher
    ..We have employed the ubiquitously expressed murine transcription factor Sp3 to analyze the role of SUMOylation in vivo...
  9. Lin S, Perl A, Shannon J. Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. J Biol Chem. 2006;281:16716-26 pubmed
    ..Taken together, these results demonstrate that Erm is involved in SP-C regulation, which results from an interaction with TTF-1. ..
  10. Roder K, Kim K, Sul H. Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box. Biochem Biophys Res Commun. 2002;294:63-70 pubmed
    ..for H-rev107 induction by TSA and growth arrest, although there were no changes in the pattern and intensity of Sp1/Sp3-binding after induction...

Detail Information

Publications67

  1. Van Loo P, Mahtab E, Wisse L, Hou J, Grosveld F, Suske G, et al. Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007;27:8571-82 pubmed
    Mice lacking the zinc finger transcription factor specificity protein 3 (Sp3) die prenatally in the C57BL/6 background. To elucidate the cause of mortality we analyzed the potential role of Sp3 in embryonic heart development...
  2. Van Loo P, Bouwman P, Ling K, Middendorp S, Suske G, Grosveld F, et al. Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood. 2003;102:858-66 pubmed
    As the zinc-finger transcription factor specificity protein 3 (Sp3) has been implicated in the regulation of many hematopoietic-specific genes, we analyzed the role of Sp3 in hematopoiesis. At embryonic day 18.5 (E18...
  3. Bouwman P, Gollner H, Elsasser H, Eckhoff G, Karis A, Grosveld F, et al. Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000;19:655-61 pubmed
    b>Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination...
  4. Krüger I, Vollmer M, Simmons D, Simmons D, Elsässer H, Philipsen S, et al. Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects. Dev Dyn. 2007;236:2235-44 pubmed
    The ubiquitously expressed zinc finger transcription factors Sp1 and Sp3 play critical roles in embryonic development. Sp1 knockout mice die around embryonic day 10.5. Mice lacking Sp3 are postnatal lethal...
  5. Tone Y, Kojima Y, Furuuchi K, Brady M, Yashiro Ohtani Y, Tykocinski M, et al. OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites. J Immunol. 2007;179:1760-7 pubmed
    ..We have shown in this study that basal OX40 promoter activity is regulated by constitutively expressed Sp1/Sp3 and YY1 transcription factors...
  6. Gollner H, Dani C, Phillips B, Philipsen S, Suske G. Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev. 2001;106:77-83 pubmed
    b>Sp3 is a ubiquitously expressed member of the Sp family of transcription factors. Recently, the mouse Sp3 gene has been disrupted by homologous recombination. Sp3 null mice die immediately after birth due to respiratory failure...
  7. Ma W, Horvath G, Kistler M, Kistler W. Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts. Biol Reprod. 2008;79:289-300 pubmed publisher
    ..of gene expression, it is important to understand how levels of Krüpple-like transcription factors SP1 and SP3 change in germ cells during spermatogenesis...
  8. Stielow B, Krüger I, Diezko R, Finkernagel F, Gillemans N, Kong A San J, et al. Epigenetic silencing of spermatocyte-specific and neuronal genes by SUMO modification of the transcription factor Sp3. PLoS Genet. 2010;6:e1001203 pubmed publisher
    ..We have employed the ubiquitously expressed murine transcription factor Sp3 to analyze the role of SUMOylation in vivo...
  9. Lin S, Perl A, Shannon J. Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. J Biol Chem. 2006;281:16716-26 pubmed
    ..Taken together, these results demonstrate that Erm is involved in SP-C regulation, which results from an interaction with TTF-1. ..
  10. Roder K, Kim K, Sul H. Induction of murine H-rev107 gene expression by growth arrest and histone acetylation: involvement of an Sp1/Sp3-binding GC-box. Biochem Biophys Res Commun. 2002;294:63-70 pubmed
    ..for H-rev107 induction by TSA and growth arrest, although there were no changes in the pattern and intensity of Sp1/Sp3-binding after induction...
  11. Golonzhka O, Metzger D, Bornert J, Bay B, Gross M, Kioussi C, et al. Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Proc Natl Acad Sci U S A. 2009;106:4278-83 pubmed publisher
    ..These results suggest that Ctip2 functions as a critical regulator of epithelial cell fate and differentiation during tooth morphogenesis...
  12. Okumura K, Hosoe Y, Nakajima N. c-Jun and Sp1 family are critical for retinoic acid induction of the lamin A/C retinoic acid-responsive element. Biochem Biophys Res Commun. 2004;320:487-92 pubmed
    ..as a model system, that the lamin A/C promoter has a retinoic acid-responsive element (L-RARE), and that Sp1 and Sp3 bind the CACCC box of the L-RARE...
  13. Valin A, Cook J, Ross S, Saklad C, Gill G. Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells. Biochim Biophys Acta. 2009;1789:204-11 pubmed
    ..Electrophoretic mobility shift assays revealed that Sp1 and Sp3 bound to sequences required for p39 promoter function and chromatin immunoprecipitation assays confirmed binding of ..
  14. Rojvirat P, Chavalit T, Muangsawat S, Thonpho A, Jitrapakdee S. Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes. Biochim Biophys Acta. 2011;1809:541-8 pubmed publisher
    ..Three GC boxes were identified within this region and shown by gel shift and ChIP assays to bind Sp1/Sp3. Over-expression of Sp1/Sp3 in AML12 and NIH3T3 cells increased P1-promoter activity, with Sp1 being a stronger ..
  15. Völkel S, Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G. Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3. PLoS Genet. 2015;11:e1005102 pubmed publisher
    ..The Specificity proteins Sp1, Sp2 and Sp3 are paradigmatic of closely related transcription factors...
  16. Wilmanski J, Siddiqi M, Deitch E, Spolarics Z. Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J Leukoc Biol. 2005;78:85-94 pubmed
    ..Alterations in signaling pathways and associated changes in cytokine production may play a role in modulating the inflammatory responses following bacterial or malarial infections in G6PD deficiency. ..
  17. Tsika G, Ji J, Tsika R. Sp3 proteins negatively regulate beta myosin heavy chain gene expression during skeletal muscle inactivity. Mol Cell Biol. 2004;24:10777-91 pubmed
    ..This study demonstrates that increased binding of Sp3 to GC-rich elements in the betaMyHC promoter is a critical event in down-regulation of betaMyHC gene expression ..
  18. Itoh T, Miyake K, Yamaguchi T, Tsuge M, Kaneoka H, Iijima S. Constitutive expression of the brg1 gene requires GC-boxes near to the transcriptional start site. J Biochem. 2011;149:301-9 pubmed publisher
    ..A gel-shift assay showed that YY1 but not Sp1/3 bound to this sequence and that Sp3 but not Sp1 bound to the other three predicted binding sites...
  19. Pan L, Glenn S, Jones C, Gronostajski R, Gross K. Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3. Biochim Biophys Acta. 2003;1625:280-90 pubmed
    ..mobility shift and supershift assays have identified four nuclear factor I (NFI)-binding sites, an Sp1/Sp3 site and an unidentified transcription factor-binding site (Ei) located upstream of the CRE and E-box...
  20. Armstrong L, Lako M, van Herpe I, Evans J, Saretzki G, Hole N. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mech Dev. 2004;121:1509-22 pubmed
    ..This analysis indicated that Sp1, Sp3 and c-Myc bind to the GC-boxes and E-boxes, respectively, within the promoter and help activate the transcription ..
  21. Kawachi Y, Ishitsuka Y, Maruyama H, Fujisawa Y, Furuta J, Nakamura Y, et al. The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3. Arch Dermatol Res. 2013;305:371-8 pubmed publisher
    ..in vitro experiments indicated that the Oct-6 and Oct-11 can physically associate with both AP-1 factors and Sp1/Sp3. These findings indicate that Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via ..
  22. Liu M, Mendicino M, Ning Q, Ghanekar A, He W, McGilvray I, et al. Cytokine-induced hepatic apoptosis is dependent on FGL2/fibroleukin: the role of Sp1/Sp3 and STAT1/PU.1 composite cis elements. J Immunol. 2006;176:7028-38 pubmed
    ..of fgl2 by IFN-gamma in macrophages involved a STAT1-dependent pathway, involving the composite cis elements Sp1/Sp3 and GAS/PU.1...
  23. Gilmour J, Assi S, Jaegle U, Kulu D, van de Werken H, Clarke D, et al. A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification. Development. 2014;141:2391-401 pubmed publisher
    ..In addition, our global side-by-side analysis of the response of the transcriptional network to perturbation sheds a new light on the regulatory hierarchy of hematopoietic specification. ..
  24. Wang G, Wei L, Loh H. Transcriptional regulation of mouse delta-opioid receptor gene by CpG methylation: involvement of Sp3 and a methyl-CpG-binding protein, MBD2, in transcriptional repression of mouse delta-opioid receptor gene in Neuro2A cells. J Biol Chem. 2003;278:40550-6 pubmed
    ..promoter fragment formed a MeCP1-like protein complex that contained methyl-CpG-binding domain protein 2 (MBD2) and Sp3. Furthermore, the expression level of Sp3 was decreased when Neuro2A cells were demethylated with 5-aza-2'-..
  25. Subramanian S, Polikandriotis J, Kelm R, David J, Orosz C, Strauch A. Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell. 2004;15:4532-43 pubmed
    ..Interplay between Pur repressor isoforms and Sp1 and Smad coactivators may regulate SMA enhancer output in TGFbeta1-activated myofibroblasts during episodes of wound repair and tissue remodeling. ..
  26. Morales Lázaro S, González Ramírez R, Gomez P, Tapia Ramírez V, de León M, Cisneros B. Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity. J Neurochem. 2010;112:474-85 pubmed publisher
  27. de León M, Montañez C, Gomez P, Morales Lázaro S, Tapia Ramírez V, Valadez Graham V, et al. Dystrophin Dp71 expression is down-regulated during myogenesis: role of Sp1 and Sp3 on the Dp71 promoter activity. J Biol Chem. 2005;280:5290-9 pubmed
    ..Electrophoretic mobility shift and chromatin immunoprecipitation assays indicated that Sp1 and Sp3 transcription factors specifically bind to the Sp-binding sites in the minimal Dp71 promoter region...
  28. Wu C, Zhao W, Kishi H, Dokan J, Jin Z, Wei X, et al. Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Biochem Biophys Res Commun. 2004;317:1096-102 pubmed
    ..Furthermore, we show that MAZ synergistically activates the murine RAG-2 promoter with Pax-5/c-Myb/LEF-1 complex. These results first demonstrate that MAZ participates in activation of mouse RAG-2 promoter. ..
  29. Perera E, Bao Y, Kos L, BERKOVITZ G. Structural and functional characterization of the mouse tescalcin promoter. Gene. 2010;464:50-62 pubmed publisher
    ..Electrophoresis mobility shift assays, supershift assays, and mutation studies demonstrated that Sp1 and Sp3 bind to the GC-rich motifs, a CACCC box and three GC boxes, located within the Tesc proximal promoter...
  30. Ji J, Tsika G, Rindt H, Schreiber K, McCarthy J, Kelm R, et al. Puralpha and Purbeta collaborate with Sp3 to negatively regulate beta-myosin heavy chain gene expression during skeletal muscle inactivity. Mol Cell Biol. 2007;27:1531-43 pubmed
    ..Our previous work showed that Sp3 contributes to decreased betaMyHC gene expression under NWB conditions...
  31. Sack M, Disch D, Rockman H, Kelly D. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997;94:6438-43 pubmed
    ..Antibody "supershift" studies demonstrated that members of the Sp (Sp1, Sp3) and nuclear hormone receptor [chicken ovalbumin upstream promoter transcription factor (COUP-TF)/erbA-related ..
  32. Wang L, Zheng A, Yi L, Xu C, Ding M, Deng H. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Biochem Biophys Res Commun. 2004;325:302-7 pubmed
    ..The method can be used to study epigenetic modification of chromatin during nuclear reprogramming, cell differentiation, and transdifferentiation. ..
  33. van Rooij E, Quiat D, Johnson B, Sutherland L, Qi X, Richardson J, et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009;17:662-73 pubmed publisher
  34. Kim C, Choi H, Hwang C, Song K, Lee B, Law P, et al. Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene. Nucleic Acids Res. 2006;34:6392-403 pubmed
    ..In the co-immunoprecipitation experiment, NRSF interacted with the full-length Sp3 factor, but not with Sp1 or two short Sp3 isoforms...
  35. Li M, Kellems R. Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription. Biol Reprod. 2003;69:1220-30 pubmed
    ..Electrophoretic mobility shift assays demonstrated that Sp1 and Sp3 bind to three sites in the promoter region of the mouse AP-2gamma gene...
  36. Steinke J, Hodsdon W, Parenti S, Ostraat R, Lutz R, Borish L, et al. Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells. Mol Immunol. 2004;41:1145-53 pubmed
    ..The site binds Spl and Sp3 in nuclear extracts and recombinant Spl in vitro, and is required for full promoter function in transient promoter ..
  37. Hekmatnejad B, Gauthier C, St Arnaud R. Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts. J Cell Biochem. 2013;114:1863-70 pubmed publisher
    ..assays (EMSA) with MC3T3-E1 osteoblastic cells nuclear extracts indicated that the transcription factors Sp1 and Sp3, but not Sp7/OSTERIX, bound this proximal GC-box...
  38. Zhao M, Gupta V, Raj L, Roussel M, Bei M. A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol. 2013;33:3099-112 pubmed publisher
    ..Here, we show that Msx1, Snail, Lhx6, Lhx8, Sp3, and Lef1 interact in vitro and in vivo, revealing the existence of a novel context-specific protein network...
  39. Rajakumar A, Thamotharan S, Raychaudhuri N, Menon R, Devaskar S. Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons. J Biol Chem. 2004;279:26768-79 pubmed
    ..Dephosphorylated Sp1 and Sp3 proteins from the 1- and 21-day-old mouse brain nuclear extracts bound the repressor elements, whereas both ..
  40. Suttamanatwong S, Jensen E, Schilling J, Franceschi R, Carlson A, Mansky K, et al. Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone. J Cell Biochem. 2009;107:284-92 pubmed publisher
    ..Using gel-mobility shift assays we found that Sp1/Sp3, and Runx2 bind to distinct sites within this region...
  41. Chen X, Yang J, Sung D, Thompson W, Walker W, Thomas K. Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis. Mol Cell Endocrinol. 2008;295:10-7 pubmed publisher
    ..These studies suggest that the expression of the ldh2 gene in spermatogonia and early spermatocytes are regulated by SP-mediated transcriptional mechanisms. ..
  42. Zelko I, Folz R. Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. Free Radic Biol Med. 2004;37:1256-71 pubmed
    ..Binding of Sp1 and Sp3 transcription factors to this region was confirmed by DNase I footprinting, electrophoretic mobility shift assay, ..
  43. Bu Y, Gelman I. v-Src-mediated down-regulation of SSeCKS metastasis suppressor gene promoter by the recruitment of HDAC1 into a USF1-Sp1-Sp3 complex. J Biol Chem. 2007;282:26725-39 pubmed
    ..proximal promoter as the minimal v-Src-responsive element, which contains E- and GC-boxes bound by USF1 and Sp1/Sp3, respectively. Both E- and GC-boxes are crucial for v-Src-responsive and basal promoter activities...
  44. Lian S, Potula H, Pillai M, Van Stry M, Koyanagi M, Chung L, et al. Transcriptional activation of Mina by Sp1/3 factors. PLoS ONE. 2013;8:e80638 pubmed publisher
    ..These results set the stage for comprehensive analysis of Mina gene regulation from the context of tissue specificity, the impact of inherited genetic variation and the nature of upstream signaling pathways. ..
  45. Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M. Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. J Neurochem. 2017;140:245-256 pubmed publisher
    ..Previous in vitro work had pointed to a role of the zinc finger containing specificity proteins Sp1 and Sp3 as major regulators of glial differentiation and myelination...
  46. Peñuelas Urquides K, Becerril Esquivel C, Mendoza de León L, Silva Ramirez B, Davila Velderrain J, Cisneros B, et al. Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells. Biochem J. 2016;473:1967-76 pubmed publisher
    ..Using EMSAs and ChIP, we showed that the Sp1 (specificity protein 1), Sp3 (specificity protein 3) and YY1 (Yin and Yang 1) transcription factors bind to the Dp71 promoter region...
  47. Meinders M, Kulu D, van de Werken H, Hoogenboezem M, Janssen H, Brouwer R, et al. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood. 2015;125:1957-67 pubmed publisher
    Sp1 and Sp3 belong to the specificity proteins (Sp)/Krüppel-like transcription factor family. They are closely related, ubiquitously expressed, and recognize G-rich DNA motifs...
  48. Liu M, Leibowitz J, Clark D, Mendicino M, Ning Q, Ding J, et al. Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3. Eur J Biochem. 2003;270:2274-86 pubmed
    ..cells revealed that the nucleoprotein complexes that form on this positive regulatory domain (PRD) contain Sp1/Sp3 family members, Oct-1, and Ets-1...
  49. Zhu L, Michel V, Bakovic M. Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis. Gene. 2009;447:51-9 pubmed publisher
    ..Transcription factors Sp1 and Sp3 bind to regions A (-508/-378 bp) and C (-157/-111 bp), and muscle-specific differentiation factor MyoD targets the ..
  50. Liu J, Yang H, Liu W, Cao X, Feng X. Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. J Cell Biochem. 2005;96:716-27 pubmed
    ..Computer analysis revealed that Probes 1 and 2 contain a putative Sp1-binding site. Supershift assays with Sp1 and Sp3 antibodies confirmed that the nuclear proteins binding to Probes 1 and 2 are Sp1 and Sp3...
  51. Gollner H, Bouwman P, Mangold M, Karis A, Braun H, Rohner I, et al. Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes Cells. 2001;6:689-97 pubmed
    Sp4 is a zinc finger transcription factor which is closely related to Sp1 and Sp3. All three proteins recognize the same DNA elements and can act as transcriptional activators through glutamine-rich activation domains...
  52. Gartel A, Ye X, Goufman E, Shianov P, Hay N, Najmabadi F, et al. Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A. 2001;98:4510-5 pubmed
    ..and glutathione S-transferase pull-down experiments demonstrate that c-Myc may form complexes with Sp1/Sp3. We found that the central region of c-Myc interacts with the zinc finger domain of Sp1...
  53. Carver B, Plosa E, Stinnett A, Blackwell T, Prince L. Interactions between NF-?B and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013;288:15318-25 pubmed publisher
    ..Here, we show that interactions between the RELA subunit of NF-?B and SP3 suppress SP1-mediated FGF-10 expression...
  54. Clem B, Clark B. Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene. Mol Endocrinol. 2006;20:100-13 pubmed
    ..We now report that Sp3, CAGA element binding proteins, and a corepressor complex consisting of mSin3A, histone deacetylase (HDAC)1, and ..
  55. Ma L, Song L, Radoi G, Harrison N. Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor. J Biol Chem. 2004;279:40451-61 pubmed
    ..Both Sp3 and Sp4 transcription factors can interact with the two Sp1 binding sites within the minimal promoter and are ..
  56. Li H, Melford K, Judson A, Bensadoun A. Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells. Biochim Biophys Acta. 2004;1679:141-55 pubmed
    ..mobility shift and supershift assays identified a cluster of nine functional GC boxes binding Sp1 and Sp3 in this region...
  57. Yao D, Taguchi T, Matsumura T, Pestell R, Edelstein D, Giardino I, et al. High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem. 2007;282:31038-45 pubmed
    ..of mSin3A results in increased recruitment of O-GlcNAc-transferase, with consequent increased modification of Sp3 by O-linked N-acetylglucosamine...
  58. Xu J, Rogers M. Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors. Gene. 2007;392:221-9 pubmed
    ..We present data indicating that the ratio of Sp1 and Sp3 isoforms varies in cells that express or do not express BMP2...
  59. Jensen J, Heller R, Funder Nielsen T, Pedersen E, Lindsell C, Weinmaster G, et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes. 2000;49:163-76 pubmed
    ..Dynamic expression of Notch1 in PDX+ epithelial cells suggests that Notch signaling could inhibit a Ngn-NeuroD cascade as seen in the nervous system and thus prevent premature differentiation of endocrine cells. ..
  60. Das S, Ward S, Tacke R, Suske G, Samuel C. Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins. J Biol Chem. 2006;281:3244-53 pubmed
    ..We found that Sp1 and Sp3 of the Sp family of transcription factors bind at the KCS element...
  61. Thakur B, Dasgupta N, Ta A, Das S. Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms. Nucleic Acids Res. 2016;44:5658-72 pubmed publisher
    ..protein kinase C isoforms to dephosphorylate/acetylate Sp1 by serine/threonine phosphatases and phosphorylate Sp3 by ERK-MAPK, respectively...
  62. Yajima S, Lee S, Minowa T, Mouradian M. Sp family transcription factors regulate expression of rat D2 dopamine receptor gene. DNA Cell Biol. 1998;17:471-9 pubmed
    ..In the present investigation employing the in situ filter detection method, we identified this factor as Sp3. Anti-Sp3 antiserum used in gel-shift assays also revealed that Sp3 binds to the D2Neg-B sequence...
  63. Giatzakis C, Papadopoulos V. Differential utilization of the promoter of peripheral-type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity. Endocrinology. 2004;145:1113-23 pubmed
    ..absence of TATA or CCAAT boxes, but the presence of many putative transcription factor-binding sites, including Sp1/Sp3, AP2, Ik2, AP1, SOX, GATA, and SRY...
  64. Pichel J, Fernández Moreno C, Vicario Abejón C, Testillano P, Patterson P, de Pablo F. Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1. Mech Dev. 2003;120:349-61 pubmed
    ..5 mice were exacerbated by the absence of LIF. The transcription factor Sp3 was decreased in the skeleton of the double null mice...
  65. Ferguson M, Henry P, Currie R. Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene. Nucleic Acids Res. 2003;31:3123-33 pubmed
    ..immunoprecipitation (X-ChIP) analysis revealed a 5-6-fold decrease in endogenous Hmga2 promoter bound Sp1 and Sp3 proteins following TSA treatment in parallel with observed loss of acetylated histone H3 and H4...
  66. Cavanaugh E, DiMario J. Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation. Gene. 2017;617:24-31 pubmed publisher
    ..b>Sp3 also displayed a transient expression pattern with peak expression occurring after 6h of differentiation...