Gene Symbol: Sp2
Description: Sp2 transcription factor
Alias: 4930480I16Rik, mKIAA0048, transcription factor Sp2
Species: mouse
Products:     Sp2

Top Publications

  1. Moorefield K, Fry S, Horowitz J. Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells. J Biol Chem. 2004;279:13911-24 pubmed
    Previous studies have indicated that Sp2 binds poorly to GC-rich sequences bound by Sp1 and Sp3, and further functional analyses of Sp2 have been limited...
  2. Baur F, Nau K, Sadic D, Allweiss L, Elsässer H, Gillemans N, et al. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS ONE. 2010;5:e9587 pubmed publisher
    The zinc finger protein Sp2 (specificity protein 2) is a member of the glutamine-rich Sp family of transcription factors...
  3. Kim T, Chiera S, Linder K, Trempus C, Smart R, Horowitz J. Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis. Cancer Res. 2010;70:8507-16 pubmed publisher
    ..Here, we report that Sp2 protein abundance in mice increases in concert with the progression of carcinogen-induced murine squamous cell ..
  4. Terrados G, Finkernagel F, Stielow B, Sadic D, Neubert J, Herdt O, et al. Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Nucleic Acids Res. 2012;40:7844-57 pubmed publisher
    The transcription factor Sp2 is essential for early mouse development and for proliferation of mouse embryonic fibroblasts in culture. Yet its mechanisms of action and its target genes are largely unknown...
  5. Liang H, Xiao G, Yin H, Hippenmeyer S, Horowitz J, Ghashghaei H. Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development. 2013;140:552-61 pubmed publisher
    ..and intermediate neural progenitor cells (NPCs) employ a zinc-finger transcription factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially distinct progenitor domains...
  6. Hammer F, Compagnone N, Vigne J, Bair S, Mellon S. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Endocrinology. 2004;145:901-12 pubmed
    ..Members of the Sp family of transcription factors also bind to the same DNA sequence as Ku. Sp4 and Sp2 colocalize with P450scc in the nervous system early in development, whereas Sp1 and Sp4 colocalize later in ..
  7. Wu J, Lim R. Regulation of inhibitor of differentiation gene 3 (Id3) expression by Sp2-motif binding factor in myogenic C2C12 cells: downregulation of DNA binding activity following skeletal muscle differentiation. Biochim Biophys Acta. 2005;1731:13-22 pubmed
    ..Two of these sites interacted, respectively, in vitro with Sp2 and Egr-1 proteins present in muscle cell nuclear extracts...
  8. Nishiguchi S, Sakuma R, Nomura M, Zou Z, Jearanaisilavong J, Joh T, et al. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996;119:749-67 pubmed
    ..Cataloguing of the genes expressed in the F9 cells paves the way for isolating genes involved in early mammalian development. ..
  9. Yin H, Nichols T, Horowitz J. Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion. Biochim Biophys Acta. 2010;1799:520-31 pubmed publisher
    ..b>Sp2 is a poorly characterized member of this transcription factor family that is widely expressed in murine and human ..

More Information


  1. Zschemisch N, Brüsch I, Hambusch A, Bleich A. Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir. PLoS ONE. 2016;11:e0155821 pubmed publisher
    ..a T to C exchange at position -259 replaced putative STAT1 and CDX1 sites in the Cd14 promoter from B6 by a SP2 site in C3Bir. Ablation of the Sp2 site through truncation was associated with a decreased promoter activity...
  2. Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M. Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. J Neurochem. 2017;140:245-256 pubmed publisher
    ..We also studied glia-specific conditional Sp2- and constitutive Sp4-deficient mice to include all related glutamine-rich Sp factors into our analysis...
  3. Bakovic M, Waite K, Vance D. Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter. J Lipid Res. 2000;41:583-94 pubmed
    ..expression of the CTalpha gene is controlled in part by the binding of three trans-acting nuclear factors, Sp1, Sp2, and Sp3...
  4. Wu Q, Chen D, Zuscik M, O Keefe R, Rosier R. Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008;23:552-63 pubmed
  5. Völkel S, Stielow B, Finkernagel F, Stiewe T, Nist A, Suske G. Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3. PLoS Genet. 2015;11:e1005102 pubmed publisher
    ..The Specificity proteins Sp1, Sp2 and Sp3 are paradigmatic of closely related transcription factors...