Sox8

Summary

Gene Symbol: Sox8
Description: SRY (sex determining region Y)-box 8
Alias: transcription factor SOX-8, SRY-box containing gene 8
Species: mouse
Products:     Sox8

Top Publications

  1. Chaboissier M, Kobayashi A, Vidal V, Lützkendorf S, van de Kant H, Wegner M, et al. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development. 2004;131:1891-901 pubmed
    ..knock-out approach, we show that Sox9 is involved in Sertoli cell differentiation, the activation of Mis and Sox8, and the inactivation of Sry...
  2. Barrionuevo F, Georg I, Scherthan H, Lecureuil C, Guillou F, Wegner M, et al. Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Dev Biol. 2009;327:301-12 pubmed publisher
    Sox9 and Sox8 are transcription factors expressed in embryonic and postnatal Sertoli cells of the mouse testis. Sox9 inactivation prior to the sex determination stage leads to complete XY sex reversal...
  3. Gao F, Maiti S, Alam N, Zhang Z, Deng J, Behringer R, et al. The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006;103:11987-92 pubmed
    ..Our data, along with previous work demonstrating the role of Wt1 at early stages of gonadal development, thus indicate that Wt1 is essential at multiple steps in testicular development. ..
  4. Pfeifer D, Poulat F, Holinski Feder E, Kooy F, Scherer G. The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. Genomics. 2000;63:108-16 pubmed
    ..We describe the 5. 4-kb human SOX8 gene that codes for a 446-amino-acid protein and that is expressed strongly in brain and less abundantly in other ..
  5. Schepers G, Bullejos M, Hosking B, Koopman P. Cloning and characterisation of the Sry-related transcription factor gene Sox8. Nucleic Acids Res. 2000;28:1473-80 pubmed
    ..Several SOX genes have been implicated in human congenital diseases. We report here the isolation of Sox8 and its characterisation in mice and humans...
  6. Polanco J, Wilhelm D, Davidson T, Knight D, Koopman P. Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development. Hum Mol Genet. 2010;19:506-16 pubmed publisher
    ..1, our results functionally implicate SOX10 in the etiology of these DSDs. ..
  7. Sock E, Schmidt K, Hermanns Borgmeyer I, Bösl M, Wegner M. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol Cell Biol. 2001;21:6951-9 pubmed
    b>Sox8, Sox9, and Sox10 constitute subgroup E within the Sox family of transcription factors. Many Sox proteins are essential regulators of development...
  8. Lavery R, Lardenois A, Ranc Jianmotamedi F, Pauper E, Gregoire E, Vigier C, et al. XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes. Dev Biol. 2011;354:111-22 pubmed publisher
    ..Taken together, we found that XY Sf1:Cre(Tg/+); Sox9(flox/flox) females are capable of producing viable offspring albeit at a reduced level. ..
  9. Yuan H, Corbi N, Basilico C, Dailey L. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995;9:2635-45 pubmed

More Information

Publications62

  1. Schepers G, Wilson M, Wilhelm D, Koopman P. SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem. 2003;278:28101-8 pubmed
    b>Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a key gene in the testis determination pathway in mammals...
  2. Kim G, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, et al. Dicer is required for Sertoli cell function and survival. Int J Dev Biol. 2010;54:867-75 pubmed publisher
    ..Taken together, the results of this study show that Dicer is required for Sertoli cell function and survival and for spermatogenesis in mice. ..
  3. Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves A, et al. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet. 2011;20:1143-53 pubmed publisher
    ..Here we show that SOX9, a gene involved in campomelic dysplasia (CD) in humans, together with its close homologue SOX8, plays an essential role in RET signalling...
  4. Scott C, Wynn S, Sesay A, Cruz C, Cheung M, Gomez Gaviro M, et al. SOX9 induces and maintains neural stem cells. Nat Neurosci. 2010;13:1181-9 pubmed publisher
    ..These data identify a functional link between extrinsic and intrinsic mechanisms of NSCs specification and maintenance, and establish a central role for SOX9 in the process. ..
  5. Kellerer S, Schreiner S, Stolt C, Scholz S, Bösl M, Wegner M. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006;133:2875-86 pubmed
    b>Sox8 and Sox10 are two closely related transcription factors of the Sox protein family with overlapping expression patterns during development...
  6. Maka M, Stolt C, Wegner M. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Dev Biol. 2005;277:155-69 pubmed
    ..Here, we show that the closely related Sox8 functions as a modifier gene for Sox10-dependent enteric nervous system defects as it increases both penetrance and ..
  7. Anderson R, Stewart A, Young H. Phenotypes of neural-crest-derived cells in vagal and sacral pathways. Cell Tissue Res. 2006;323:11-25 pubmed
  8. Schmidt K, Glaser G, Wernig A, Wegner M, Rosorius O. Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis. J Biol Chem. 2003;278:29769-75 pubmed
    b>Sox8 belongs to a family of transcription regulators characterized by a unique DNA-binding domain known as the high mobility group box. Many Sox proteins play fundamental roles in vertebrate development and differentiation processes...
  9. Guth S, Schmidt K, Hess A, Wegner M. Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor. J Lipid Res. 2009;50:1269-80 pubmed publisher
    Although the transcription factor Sox8 is broadly expressed during embryogenesis in developing ectodermal and mesodermal tissues, mice develop surprisingly normally in the absence of Sox8...
  10. Turnescu T, Arter J, Reiprich S, Tamm E, Waisman A, Wegner M. Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia. 2018;66:279-294 pubmed publisher
    ..As Sox10 is co-expressed with the related Sox8, we also analyzed oligodendrocytes and myelination in Sox8-deficient mice...
  11. Merchan Sala P, Nardini D, Waclaw R, Campbell K. Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain. J Comp Neurol. 2017;525:2805-2819 pubmed publisher
    ..We show here that the SoxE family member, Sox8, is co-expressed with the dSPN markers, Isl1 and Ebf1, in the developing striatum...
  12. Stolt C, Schmitt S, Lommes P, Sock E, Wegner M. Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol. 2005;281:309-17 pubmed
    The myelin-forming oligodendrocytes of the mouse embryonic spinal cord express the three group E Sox proteins Sox8, Sox9, and Sox10...
  13. de Melo J, Zibetti C, Clark B, Hwang W, Miranda Angulo A, Qian J, et al. Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016;36:2391-405 pubmed publisher
    ..of Notch pathway genes including Notch1, Dll1, and Dll3 and gliogenic transcription factors such as Hes1, Hes5, Sox8, and Rax...
  14. Nicol B, Yao H. Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice. Biol Reprod. 2015;93:35 pubmed publisher
    ..underlying the XY-specific masculinization involve the expression of Sry and 21 SRY direct target genes, such as Sox8 and Cyp26b1...
  15. Kataruka S, Akhade V, Kayyar B, Rao M. Mrhl Long Noncoding RNA Mediates Meiotic Commitment of Mouse Spermatogonial Cells by Regulating Sox8 Expression. Mol Cell Biol. 2017;37: pubmed publisher
    ..In our present study, we identified the transcription factor Sox8 as the regulatory link between mrhl RNA expression, Wnt signaling activation, and meiotic progression...
  16. Georg I, Barrionuevo F, Wiech T, Scherer G. Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice. Biol Reprod. 2012;87:99 pubmed publisher
    ..Of the related Sox genes Sox8, Sox9, and Sox10, all expressed during Sertoli cell differentiation, only inactivation of Sox9 before the sex ..
  17. Lavery R, Chassot A, Pauper E, Gregoire E, Klopfenstein M, de Rooij D, et al. Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet. 2012;8:e1003170 pubmed publisher
    ..Molecular analyses show expression of both Sox8 and Sox10, suggesting that activation of Sox genes other than Sox9 can induce male differentiation in Rspo1(KO)Sox9(..
  18. Lake J, Avetisyan M, Zimmermann A, Heuckeroth R. Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton. Dev Biol. 2016;409:152-165 pubmed publisher
    ..These data suggest that IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the ENS and other neural crest derivatives. ..
  19. Wright E, Snopek B, Koopman P. Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993;21:744 pubmed
  20. Kennedy C, Koopman P, Mishina Y, O Bryan M. Sox8 and Sertoli-cell function. Ann N Y Acad Sci. 2007;1120:104-13 pubmed
    b>SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) superfamily of genes...
  21. O Bryan M, Takada S, Kennedy C, Scott G, Harada S, Ray M, et al. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol. 2008;316:359-70 pubmed publisher
    b>Sox8 encodes a high-mobility group transcription factor that is widely expressed during development. Sox8, -9 and -10 form group E of the Sox gene family which has been implicated in several human developmental disorders...
  22. Shen J, Ingraham H. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002;16:529-40 pubmed
    ..Among the approximately 20 known members of the Sox gene family, we focused on Sox3, Sox8, and Sox9, based on their coexpression with SF-1 in the embryonic testis...
  23. Schepers G, Koopman -. Mouse Sox8 is located between, not within,the t-complex deletions t(w18) and t(h20) on chromosome 17. Cytogenet Cell Genet. 2001;93:91-3 pubmed
    ..b>SOX8 is broadly expressed during development and is located on human chromosome 16p and within the t-complex on mouse ..
  24. Wilson M, Yang K, Kalousova A, Lau J, Kosaka Y, Lynn F, et al. The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes. 2005;54:3402-9 pubmed
    ..We show here that several Sox transcription factors are expressed in the developing pancreas and in the islet, and that one of these factors, Sox4, is required for the normal development of pancreatic islets. ..
  25. Muto A, Iida A, Satoh S, Watanabe S. The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina. Exp Eye Res. 2009;89:549-58 pubmed publisher
    ..We found that two group E Sox genes, Sox8 and Sox9, are expressed in proliferating progenitors and then exclusively in Müller glial cells in mouse retina...
  26. Lioubinski O, Müller M, Wegner M, Sander M. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003;227:402-8 pubmed
    ..We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, and Sox13 in adult ..
  27. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis. ..
  28. Gonen N, Quinn A, O Neill H, Koopman P, Lovell Badge R. Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet. 2017;13:e1006520 pubmed publisher
    ..Our results demonstrate that TES/TESCO is a crucial enhancer regulating Sox9 expression in the gonad, but point to the existence of additional enhancers that act redundantly. ..
  29. Schlierf B, Werner T, Glaser G, Wegner M. Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor. J Mol Biol. 2006;361:11-21 pubmed
  30. Fulp C, Cho G, Marsh E, Nasrallah I, Labosky P, Golden J. Identification of Arx transcriptional targets in the developing basal forebrain. Hum Mol Genet. 2008;17:3740-60 pubmed publisher
  31. Wilson M, Jeyasuria P, Parker K, Koopman P. The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. J Biol Chem. 2005;280:5917-23 pubmed
    ..Our findings account for the sex- and cell-type-specific expression of Vanin-1 in the developing mouse gonad in vivo, which we suggest is required to provide an appropriate environment for male germ cell development. ..
  32. Singh A, Harada S, Mishina Y. Downstream genes of Sox8 that would affect adult male fertility. Sex Dev. 2009;3:16-25 pubmed publisher
    Sertoli cells provide nutritional and physical support to germ cells during spermatogenesis. Sox8 encodes a high mobility group transcription factor closely related to Sox9 and Sox10...
  33. Chalmel F, Lardenois A, Georg I, Barrionuevo F, Demougin P, Jegou B, et al. Genome-wide identification of Sox8-, and Sox9-dependent genes during early post-natal testis development in the mouse. Andrology. 2013;1:281-92 pubmed publisher
    The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis...
  34. Cossais F, Sock E, Hornig J, Schreiner S, Kellerer S, Bösl M, et al. Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Dev Biol. 2010;341:267-81 pubmed publisher
    ..regulated by complex regulatory networks, of which the SoxE-type high-mobility-group domain transcription factors Sox8, Sox9 and Sox10 are essential components...
  35. Schmidt K, Schinke T, Haberland M, Priemel M, Schilling A, Mueldner C, et al. The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation. J Cell Biol. 2005;168:899-910 pubmed
    ..In this study, we identify the high mobility group transcription factor Sox8 as a physiologic regulator of bone formation...
  36. Wolf M, Lommes P, Sock E, Reiprich S, Friedrich R, Kriesch J, et al. Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Dev Biol. 2009;332:418-28 pubmed publisher
    ..The extent of functional equivalence between related transcription factors is thus strongly dependent on the analyzed tissue. ..
  37. Brunskill E, Potter A, Distasio A, Dexheimer P, Plassard A, Aronow B, et al. A gene expression atlas of early craniofacial development. Dev Biol. 2014;391:133-46 pubmed publisher
  38. Seward D, Koh A, Boyer J, Ballatori N. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003;278:27473-82 pubmed
    ..Interestingly, OSTalpha and OSTbeta mRNAs were highly expressed and widely distributed in human tissues, with the highest levels occurring in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland. ..
  39. Barrionuevo F, Naumann A, Bagheri Fam S, Speth V, Taketo M, Scherer G, et al. Sox9 is required for invagination of the otic placode in mice. Dev Biol. 2008;317:213-24 pubmed publisher
  40. Stolt C, Lommes P, Friedrich R, Wegner M. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development. 2004;131:2349-58 pubmed
    ..We show that oligodendrocytes in the spinal cord additionally express the highly related Sox8. In Sox8-deficient mice, oligodendrocyte development proceeded normally until birth...
  41. Guth S, Bösl M, Sock E, Wegner M. Evolutionary conserved sequence elements with embryonic enhancer activity in the vicinity of the mammalian Sox8 gene. Int J Biochem Cell Biol. 2010;42:465-71 pubmed publisher
    The transcription factor Sox8 is widely and dynamically expressed during embryonic development similar to its close relatives Sox9 and Sox10...
  42. Barrionuevo F, Hurtado A, Kim G, Real F, Bakkali M, Kopp J, et al. Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. elife. 2016;5: pubmed publisher
    ..Sox9 and Sox8 are required for postnatal male fertility, but their role in the adult testis has not been investigated...
  43. Vong K, Leung C, Behringer R, Kwan K. Sox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellum. Mol Brain. 2015;8:25 pubmed publisher
  44. Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development. ..
  45. Mashimo T, Erven A, Spiden S, Guenet J, Steel K. Two quantitative trait loci affecting progressive hearing loss in 101/H mice. Mamm Genome. 2006;17:841-50 pubmed
    ..Finally, we found some evidence of epistatic interaction between Phl1 and Phl2. ..
  46. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..Sox5 and Sox18 show some cooperation on both elements, whereas Sox8 and Sox9 compete on both elements...
  47. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in ..
  48. Takada S, Koopman P. Origin and possible roles of the Sox8 transcription factor gene during sexual development. Cytogenet Genome Res. 2003;101:212-8 pubmed
    b>Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a critical gene involved in mammalian sex determination and differentiation...
  49. Singh A, Cummings C, Mishina Y, Archer T. SOX8 regulates permeability of the blood-testes barrier that affects adult male fertility in the mouse. Biol Reprod. 2013;88:133 pubmed publisher
    Sertoli cells provide nutritional and physical support to germ cells during spermatogenesis. Sox8 encodes a member of the high mobility group of transcription factors closely related to Sox9 and Sox10...
  50. Taylor M, Yeager K, Morrison S. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development. 2007;134:2435-47 pubmed
    ..These results demonstrate that physiological Notch signaling is required for gliogenesis in vivo, independent of the role of Notch in the maintenance of undifferentiated neural progenitors. ..
  51. Stolt C, Lommes P, Sock E, Chaboissier M, Schedl A, Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003;17:1677-89 pubmed
    ..numbers recovered at later stages of development, probably owing to compensatory actions of the related Sox10 and Sox8, both of which overlap with Sox9 in the oligodendrocyte lineage...
  52. Kordes U, Cheng Y, Scotting P. Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse. Brain Res Dev Brain Res. 2005;157:209-13 pubmed
    The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development...
  53. Stock D, Buchanan A, Zhao Z, Weiss K. Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996;37:234-7 pubmed
    ..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process. ..