Gene Symbol: Sox6
Description: SRY (sex determining region Y)-box 6
Alias: AI987981, SOX-LZ, transcription factor SOX-6, SRY-box containing gene 6
Species: mouse
Products:     Sox6

Top Publications

  1. Lefebvre V, Li P, de Crombrugghe B. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998;17:5718-33 pubmed
    Transcripts for a new form of Sox5, called L-Sox5, and Sox6 are coexpressed with Sox9 in all chondrogenic sites of mouse embryos...
  2. Dumitriu B, Dy P, Smits P, Lefebvre V. Generation of mice harboring a Sox6 conditional null allele. Genesis. 2006;44:219-24 pubmed
    b>Sox6 belongs to the family of Sry-related HMG box transcription factors, which determine cell fate and differentiation in various lineages...
  3. Snyder M, Huang X, Zhang J. Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene. FEBS Lett. 2011;585:148-52 pubmed publisher
    ..We show that the SRY-box containing gene 6 (Sox6) gene, important for neuronal differentiation, is a direct target gene of Stat3...
  4. Smits P, Dy P, Mitra S, Lefebvre V. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004;164:747-58 pubmed
    Sox5 and Sox6 encode Sry-related transcription factors that redundantly promote early chondroblast differentiation...
  5. Murakami A, Ishida S, Thurlow J, Revest J, Dickson C. SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter. Nucleic Acids Res. 2001;29:3347-55 pubmed
    ..To identify the transcription factor(s), we used a yeast one-hybrid screen and obtained a novel Sox6 cDNA (SOX6D)...
  6. Fernández Lloris R, Vinals F, Lopez Rovira T, Harley V, Bartrons R, Rosa J, et al. Induction of the Sry-related factor SOX6 contributes to bone morphogenetic protein-2-induced chondroblastic differentiation of C3H10T1/2 cells. Mol Endocrinol. 2003;17:1332-43 pubmed
    ..high-mobility group (HMG) box proteins (SOX) transcription factors demonstrated a time-dependent induction of Sox6 expression by BMP-2 that correlated with the appearance of BMP-2- induced protein complexes bound to the ..
  7. Cohen Barak O, Erickson D, Badowski M, Fuchs D, Klassen C, Harris D, et al. Stem cell transplantation demonstrates that Sox6 represses epsilon y globin expression in definitive erythropoiesis of adult mice. Exp Hematol. 2007;35:358-67 pubmed
    b>Sox6, a member of the Sox transcription factor family, is essential for the silencing of epsilon y globin gene expression in definitive erythropoiesis of mice...
  8. Connor F, Wright E, Denny P, Koopman P, Ashworth A. The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Nucleic Acids Res. 1995;23:3365-72 pubmed
    We have cloned and sequenced a full-length cDNA for the HMG box-containing, SRY-related gene Sox6 from mouse. The deduced protein sequence of Sox6 has considerable homology with that of the previously determined Sox5 sequence...
  9. Hagiwara N, Klewer S, Samson R, Erickson D, Lyon M, Brilliant M. Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000;97:4180-5 pubmed
    ..We demonstrate here that the p(100H) chromosomal inversion disrupts both the p gene and the Sox6 gene...

More Information


  1. Hagiwara N, Ma B, Ly A. Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H. Dev Dyn. 2005;234:301-11 pubmed
    We have previously demonstrated that p100H mutant mice, which lack a functional Sox6 gene, exhibit skeletal and cardiac muscle degeneration and develop cardiac conduction abnormalities soon after birth...
  2. Ikeda T, Kamekura S, Mabuchi A, Kou I, Seki S, Takato T, et al. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum. 2004;50:3561-73 pubmed
    ..No single factor induced fluorescence. Among various combinations examined, only the SOX5, SOX6, and SOX9 combination (the SOX trio) induced fluorescence within 3 days...
  3. Quiat D, Voelker K, Pei J, Grishin N, Grange R, Bassel Duby R, et al. Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6. Proc Natl Acad Sci U S A. 2011;108:10196-201 pubmed publisher
    ..Here, we identify Sox6 as a fast myofiber-enriched repressor of slow muscle gene expression in vivo...
  4. Ohe K, Lalli E, Sassone Corsi P. A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc Natl Acad Sci U S A. 2002;99:1146-51 pubmed
    ..Here we show that SRY and the Sox protein SOX6 colocalize with splicing factors in the nucleus and are dynamically redistributed following the blockage of ..
  5. Hagiwara N, Yeh M, Liu A. Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice. Dev Dyn. 2007;236:2062-76 pubmed
    b>Sox6, a member of the Sox family of transcription factors, is highly expressed in skeletal muscle. Despite its abundant expression, the role of Sox6 in muscle development is not well understood...
  6. Yi Z, Cohen Barak O, Hagiwara N, Kingsley P, Fuchs D, Erickson D, et al. Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet. 2006;2:e14 pubmed
    b>Sox6 is a member of the Sox transcription factor family that is defined by the conserved high mobility group (HMG) DNA binding domain, first described in the testis determining gene, Sry...
  7. Takamatsu N, Kanda H, Tsuchiya I, Yamada S, Ito M, Kabeno S, et al. A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein. Mol Cell Biol. 1995;15:3759-66 pubmed
    ..Thus, the repressed transactivation of the intact SOX-LZ in CHO cells was primarily attributable to the low level of DNA binding of SOX-LZ homodimers...
  8. Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 1999;27:1409-20 pubmed
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other. ..
  9. Smits P, Li P, Mandel J, Zhang Z, Deng J, Behringer R, et al. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001;1:277-90 pubmed
    L-Sox5 and Sox6 are highly identical Sry-related transcription factors coexpressed in cartilage...
  10. Han Y, Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol. 2008;28:4999-5013 pubmed publisher
    The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear...
  11. Azim E, Jabaudon D, Fame R, Macklis J. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009;12:1238-47 pubmed publisher
    ..We found that the transcription factor SOX6 controls the molecular segregation of dorsal (pallial) from ventral (subpallial) telencephalic progenitors and the ..
  12. Lefebvre V. The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators. Int J Biochem Cell Biol. 2010;42:429-32 pubmed publisher
    Sox5, Sox6, and Sox13 constitute the group D of sex-determining region (Sry)-related transcription factors...
  13. Batista Brito R, Rossignol E, Hjerling Leffler J, Denaxa M, Wegner M, Lefebvre V, et al. The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron. 2009;63:466-81 pubmed publisher
    We describe the role of Sox6 in cortical interneuron development, from a cellular to a behavioral level...
  14. Cohen Barak O, Yi Z, Hagiwara N, Monzen K, Komuro I, Brilliant M. Sox6 regulation of cardiac myocyte development. Nucleic Acids Res. 2003;31:5941-8 pubmed
    ..The gene that is disrupted in this mutation encodes the transcription factor Sox6. P19CL6 cells were used as an in vitro cardiomyocyte differentiation system and revealed that Sox6 is expressed ..
  15. Hamada Kanazawa M, Ishikawa K, Nomoto K, Uozumi T, Kawai Y, Narahara M, et al. Sox6 overexpression causes cellular aggregation and the neuronal differentiation of P19 embryonic carcinoma cells in the absence of retinoic acid. FEBS Lett. 2004;560:192-8 pubmed
    The Sox6 gene is a member of the Sox gene family that encodes transcription factors. Previous studies have suggested that Sox6 plays an important role in the development of the central nervous system...
  16. Smits P, Lefebvre V. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003;130:1135-48 pubmed
    ..Sox5 and Sox6 encode Sry-related HMG box transcription factors that act redundantly to promote chondroblast differentiation in ..
  17. van Rooij E, Quiat D, Johnson B, Sutherland L, Qi X, Richardson J, et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009;17:662-73 pubmed publisher
  18. Hagiwara N. Sox6, jack of all trades: a versatile regulatory protein in vertebrate development. Dev Dyn. 2011;240:1311-21 pubmed publisher
    ..Uncovering the versatile roles of Sox6 in vertebrate development sheds some light on how an organism efficiently utilizes the limited resources of ..
  19. Kamachi Y, Uchikawa M, Kondoh H. Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet. 2000;16:182-7 pubmed
  20. Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, et al. Identification and characterization of the human SOX6 promoter. Biochem Biophys Res Commun. 2007;357:383-90 pubmed
    The present study attempted to identify and characterize the embryonic promoter of Sox6, a determinant regulator of chondrogenic differentiation...
  21. Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed
    ..Here, we show that the group D Sox transcription factors Sox5 and Sox6 jointly and cell-autonomously regulate several stages of oligodendrocyte development in the mouse spinal cord...
  22. Hamada Kanazawa M, Ishikawa K, Ogawa D, Kanai M, Kawai Y, Narahara M, et al. Suppression of Sox6 in P19 cells leads to failure of neuronal differentiation by retinoic acid and induces retinoic acid-dependent apoptosis. FEBS Lett. 2004;577:60-6 pubmed
    The Sox6 gene is a member of the Sox gene family, which encodes transcription factors, and previous studies have suggested that it plays an important role in the development of the central nervous system...
  23. Dumitriu B, Patrick M, Petschek J, Cherukuri S, Klingmuller U, Fox P, et al. Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development. Blood. 2006;108:1198-207 pubmed
    ..Here we identify the Sry-related high-mobility-group (HMG) box transcription factor Sox6 as an important enhancer of definitive erythropoiesis...
  24. Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, et al. SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation. J Biol Chem. 2007;282:19052-61 pubmed
    ..To determine the contribution of SOX6 to insulin resistance, we analyzed the effects of SOX6 on cell proliferation...
  25. Brent A, Braun T, Tabin C. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development. 2005;132:515-28 pubmed
    ..Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the two ..
  26. Jaglin X, Hjerling Leffler J, Fishell G, Batista Brito R. The origin of neocortical nitric oxide synthase-expressing inhibitory neurons. Front Neural Circuits. 2012;6:44 pubmed publisher
    ..Finally, we show that conditional removal of the transcription factor Sox6 in MGE-derived GABAergic cortical neurons results in an absence of SST and CR expression, as well as reduced ..
  27. Yamashita S, Miyaki S, Kato Y, Yokoyama S, Sato T, Barrionuevo F, et al. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem. 2012;287:22206-15 pubmed publisher
    ..Fellow Sox family members L-Sox5 and Sox6 also function as regulators of cartilage development by boosting Sox9 activation of chondrocyte-specific genes such ..
  28. Nagai K. Molecular evolution of Sry and Sox gene. Gene. 2001;270:161-9 pubmed
    ..This rapid evolution of Sry might agree with the fact that the Srys are present not on the pseudoautosomal region but on the distal region with no recombination of the Y chromosomal short arm. ..
  29. Arora R, Metzger R, Papaioannou V. Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system. PLoS Genet. 2012;8:e1002866 pubmed publisher
    ..Finally, we show that Tbx4 and Tbx5 interact with Fgf10 during the process of lung growth and branching but not during tracheal/bronchial cartilage development. ..
  30. Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, et al. Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010;137:1159-67 pubmed publisher
    ..analyses demonstrated that the expression of alpha1(II) collagen (Col2a1 - Mouse Genome Informatics), Sox5 and Sox6 in the prospective sternum of Prx1 DKO mice was severely attenuated, whereas Sox9 expression was unchanged...
  31. HUANG A, Riordan T, Pryce B, Weibel J, Watson S, Long F, et al. Musculoskeletal integration at the wrist underlies the modular development of limb tendons. Development. 2015;142:2431-41 pubmed publisher
    ..Subsequent individuation of these tendons depends on muscle activity. These results establish an integrated model for limb tendon development that provides a framework for future analyses of tendon and musculoskeletal phenotypes. ..
  32. Bommireddy R, Ormsby I, Yin M, Boivin G, Babcock G, Doetschman T. TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol. 2003;170:3645-52 pubmed
    ..Consequently, TGFbeta1 prevents autoimmune disease through a Ca(2+) regulatory pathway that maintains the activation threshold above that inducible by self-MHC-TCR interactions. ..
  33. Akiyama H, Stadler H, Martin J, Ishii T, Beachy P, Nakamura T, et al. Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol. 2007;26:224-33 pubmed
    ..The mutant mouse embryos exhibited polydactyly in limb buds in association with ectopic expression of Sox5 and Sox6 although markers for the different axes of limb bud development showed a normal pattern of expression...
  34. Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, et al. SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. J Biol Chem. 2005;280:37669-80 pubmed
    ..Here, we report the identification of sex-determining region Y-box 6 (SOX6), a member of the high mobility group box superfamily of transcription factors, as a co-repressor for pancreatic-..
  35. Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A. A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992;20:2887 pubmed
  36. Baroti T, Schillinger A, Wegner M, Stolt C. Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes. J Neurochem. 2016;136:316-28 pubmed publisher
    The role of transcription factor Sox13, which together with Sox5 and Sox6 belongs to the SoxD family, is only poorly characterized in central nervous system development...
  37. Ueda R, Ohkusu Tsukada K, Fusaki N, Soeda A, Kawase T, Kawakami Y, et al. Identification of HLA-A2- and A24-restricted T-cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy. Int J Cancer. 2010;126:919-29 pubmed publisher
    ..We previously identified SOX6 as a human glioma antigen and demonstrated that vaccination with SOX6 DNA induced cytotoxic T lymphocytes (CTLs) ..
  38. Tang L, Wu X, Zhang H, Lu S, Wu M, Shen C, et al. A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome. Hum Mol Genet. 2017;26:1280-1293 pubmed publisher
    ..shows that Fgf9 inhibits mesenchymal cell differentiation into chondrocytes by downregulating the expression of Sox6 and Sox9. However, the mutant protein does not exhibit the same inhibitory effect...
  39. Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg H, et al. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol. 2007;177:451-64 pubmed
    ..In addition, mutant mice show a striking impairment of joint development. Our study demonstrates a crucial, and previously unrecognized, role of Hif-1alpha in early chondrogenesis and joint formation. ..
  40. Aza Carmona M, Shears D, Yuste Checa P, Barca Tierno V, Hisado Oliva A, Belinchón A, et al. SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer. Hum Mol Genet. 2011;20:1547-59 pubmed publisher
    ..Two transcription factors, SOX5 and SOX6, were identified...
  41. Stolt C, Lommes P, Hillgärtner S, Wegner M. The transcription factor Sox5 modulates Sox10 function during melanocyte development. Nucleic Acids Res. 2008;36:5427-40 pubmed publisher
    ..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage. ..
  42. Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, et al. Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016;31:1391-404 pubmed publisher
    ..Although only Cbfb2 loss generated overt skeletal phenotypes, both may play major roles in skeletal development with functional redundancy. © 2016 American Society for Bone and Mineral Research. ..
  43. Akiyama H, Chaboissier M, Behringer R, Rowitch D, Schedl A, Epstein J, et al. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004;101:6502-7 pubmed
    ..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation. ..
  44. Uusitalo H, Hiltunen A, Ahonen M, Gao T, Lefebvre V, Harley V, et al. Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. J Bone Miner Res. 2001;16:1837-45 pubmed
    ..progenitor cells during fracture repair, we have investigated the participation of transcription factors L-Sox5, Sox6, and Sox9 in this process...
  45. Storbeck M, Hupperich K, Gaspar J, Meganathan K, Mart nez Carrera L, Wirth R, et al. Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain. PLoS ONE. 2014;9:e89020 pubmed publisher
    ..Apoptotic events triggered via p21 might not be restricted to the developing brain but could possibly be generalized to the whole organism and explain early embryonic lethality in Tra2b-depleted mice...
  46. Yamashita A, Ito M, Takamatsu N, Shiba T. Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. FEBS Lett. 2000;481:147-51 pubmed
    SoxLZ/Sox6, a member of the Sox protein family, contains a leucine zipper motif in addition to an HMG box, which is its DNA binding domain...
  47. Cardelli M, Zirngibl R, Boetto J, McKenzie K, Troy T, Turksen K, et al. Cartilage-specific overexpression of ERR? results in Chondrodysplasia and reduced chondrocyte proliferation. PLoS ONE. 2013;8:e81511 pubmed publisher
  48. Taglietti V, Maroli G, Cermenati S, Monteverde S, Ferrante A, Rossi G, et al. Nfix Induces a Switch in Sox6 Transcriptional Activity to Regulate MyHC-I Expression in Fetal Muscle. Cell Rep. 2016;17:2354-2366 pubmed publisher
    b>Sox6 belongs to the Sox gene family and plays a pivotal role in fiber type differentiation, suppressing transcription of slow-fiber-specific genes during fetal development...
  49. Li X, Wang J, Jia Z, Cui Q, Zhang C, Wang W, et al. MiR-499 regulates cell proliferation and apoptosis during late-stage cardiac differentiation via Sox6 and cyclin D1. PLoS ONE. 2013;8:e74504 pubmed publisher
    ..b>Sox6 is believed to be one of its targets, and is also believed to play a role in cardiac differentiation...
  50. Dy P, Han Y, Lefebvre V. Generation of mice harboring a Sox5 conditional null allele. Genesis. 2008;46:294-9 pubmed publisher
    ..Moreover, the chondrodysplasia of Sox5(fl+/fl+)Sox6(fl+/fl+)Prx1Cre mice demonstrates that the two redundant chondrogenic Sox genes can be efficiently inactivated in a ..
  51. Ma T, Zhang Q, Cai Y, You Y, Rubenstein J, Yang Z. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012;22:2120-30 pubmed publisher
    ..In contrast to MGE-derived interneurons, dLGE/dCGE-derived Sp8+ interneurons follow an outside-in layering pattern, preferentially occupying superficial cortical layers. ..
  52. Hu J, Vogt D, Lindtner S, Sandberg M, Silberberg S, Rubenstein J. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017;144:2837-2851 pubmed publisher
    ..and Coup-TF2 autonomously repress PV+ fate in MGE progenitors, in part through directly driving Sox6 expression. These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate.
  53. Liu C, Zhang Y, Xu K, Parsons D, Alfonso D, Di Cesare P. Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators. Front Biosci. 2007;12:3899-910 pubmed
    ..addition, activation of COMP gene expression by Sox9 requires the participation of transcription factors Sox5 and Sox6 as well as the coactivators CBP and p300 histone acetylase...
  54. Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, et al. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. PLoS ONE. 2014;9:e115169 pubmed publisher
    Transcription factors SOX9, SOX5 and SOX6 are indispensable for generation and differentiation of chondrocytes. However, molecular mechanisms to induce the SOX genes are poorly understood...
  55. Pandey P, Qin S, Ho J, Zhou J, Kreidberg J. Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol. 2011;5:56 pubmed publisher
    ..miRNAs are small, regulatory non-coding RNAs, implicated in a wide spectrum of biological processes. Their expression levels are altered in several diseases including kidney cancer, diabetic nephropathy and PKD...
  56. Bai C, Li X, Gao Y, Wang K, Fan Y, Zhang S, et al. Role of microRNA-21 in the formation of insulin-producing cells from pancreatic progenitor cells. Biochim Biophys Acta. 2016;1859:280-93 pubmed publisher a bidirectional switch in the formation of IPCs by regulating the expression of target and downstream genes (SOX6, RPBJ and HES1)...
  57. Ueda R, Kinoshita E, Ito R, Kawase T, Kawakami Y, Toda M. Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6. Int J Cancer. 2008;122:2274-9 pubmed publisher
    We previously reported identifying SOX6 as a glioma antigen by serological screening using a testis cDNA library...
  58. Liu C, Lefebvre V. The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic Acids Res. 2015;43:8183-203 pubmed publisher
    SOX9 is a transcriptional activator required for chondrogenesis, and SOX5 and SOX6 are closely related DNA-binding proteins that critically enhance its function...
  59. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis. ..
  60. Rutkowski T, Kohn A, Sharma D, Ren Y, Mirando A, Hilton M. HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci. 2016;129:2145-55 pubmed publisher
    ..This work identifies important candidates that might function as downstream mediators of Notch signaling both during normal skeletal development and in Notch-related skeletal disorders. ..
  61. An C, Ganio E, Hagiwara N. Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells. Skelet Muscle. 2013;3:11 pubmed publisher
    ..We have previously shown that the transcription factor Sox6 plays an essential role in coordinating muscle fiber type differentiation by acting as a transcriptional suppressor ..
  62. Purcell P, Joo B, Hu J, Tran P, Calicchio M, O Connell D, et al. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Proc Natl Acad Sci U S A. 2009;106:18297-302 pubmed publisher
    ..Thus, these experiments establish that Hh signaling acts at two distinct steps in disk morphogenesis, condyle initiation, and disk-condyle separation and provide a molecular framework for future studies of the TMJ. ..
  63. Rudrabhatla P, Utreras E, Jaffe H, Kulkarni A. Regulation of Sox6 by cyclin dependent kinase 5 in brain. PLoS ONE. 2014;9:e89310 pubmed publisher
    ..Here, we show that nuclear transcription factor Sox6 is a direct nuclear target of Cdk5...
  64. Hwang C, Wu X, Wang G, Kim C, Loh H. Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem. 2003;278:3742-50 pubmed
    ..These data indicate that SOX proteins might contribute to the transcriptional activity of the mor gene and suggest that mu opioid receptor could mediate some of the developmental processes in which SOX proteins are included. ..
  65. Takigawa Y, Hata K, Muramatsu S, Amano K, Ono K, Wakabayashi M, et al. The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9. J Cell Sci. 2010;123:3780-8 pubmed publisher
    ..Our results suggest that Znf219 plays an important role in the regulation of chondrocyte differentiation as a transcriptional partner of Sox9. ..
  66. Hormuzdi S, Pais I, LeBeau F, Towers S, Rozov A, Buhl E, et al. Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron. 2001;31:487-95 pubmed
    ..2001), unaffected. Thus, specific connexins differentially deployed throughout cortical networks are likely to regulate different functional aspects of neuronal information processing in the mature brain. ..
  67. Baroti T, Zimmermann Y, Schillinger A, Liu L, Lommes P, Wegner M, et al. Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain. Glia. 2016;64:122-38 pubmed publisher
    ..Using mice with specific deletion of the SoxD proteins Sox5 and Sox6 in the central nervous system, we now show that SoxD proteins additionally influence migration of oligodendrocyte ..
  68. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium...
  69. Tuncdemir S, Fishell G, Batista Brito R. miRNAs are Essential for the Survival and Maturation of Cortical Interneurons. Cereb Cortex. 2015;25:1842-57 pubmed publisher
    ..Thus, our results indicate that cIN progenitors require Dicer-dependent mechanisms to fine-tune the migration and maturation of cINs. ..
  70. Le N, Binh N, Takarada T, Takarada Iemata M, Hinoi E, Yoneda Y. Negative correlation between Per1 and Sox6 expression during chondrogenic differentiation in pre-chondrocytic ATDC5 cells. J Pharmacol Sci. 2013;122:318-25 pubmed
    ..but transient increase in Per1 expression was seen only 1 h after addition together with a prolonged decrease in Sox6 levels. However, no significant changes were induced in Sox5 and Runx2 levels in cells exposed to PTH...