Sox4

Summary

Gene Symbol: Sox4
Description: SRY (sex determining region Y)-box 4
Alias: AA682046, Sox-4, transcription factor SOX-4, SRY-box containing gene 4
Species: mouse
Products:     Sox4

Top Publications

  1. Lioubinski O, Müller M, Wegner M, Sander M. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003;227:402-8 pubmed
    ..We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, ..
  2. Bogani D, Willoughby C, Davies J, Kaur K, Mirza G, Paudyal A, et al. Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen. Proc Natl Acad Sci U S A. 2005;102:12477-82 pubmed
  3. Yuan H, Corbi N, Basilico C, Dailey L. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995;9:2635-45 pubmed
  4. Hoser M, Baader S, Bösl M, Ihmer A, Wegner M, Sock E. Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia. J Neurosci. 2007;27:5495-505 pubmed
    ..Here, we overexpressed the group C protein Sox4 in transgenic mice under the control of the human GFAP promoter...
  5. Dy P, Penzo Méndez A, Wang H, Pedraza C, Macklin W, Lefebvre V. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res. 2008;36:3101-17 pubmed publisher
    ..C of Sry-related high-mobility group (HMG) box (Sox) transcription factors has three members in most vertebrates: Sox4, Sox11 and Sox12...
  6. Penzo Méndez A, Dy P, Pallavi B, Lefebvre V. Generation of mice harboring a Sox4 conditional null allele. Genesis. 2007;45:776-80 pubmed
    b>Sox4 belongs to the family of Sry-related HMG box transcription factors, which specify cell fate and differentiation in many lineages...
  7. van de Wetering M, Oosterwegel M, van Norren K, Clevers H. Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J. 1993;12:3847-54 pubmed
    ..Our observations indicate that a detailed understanding of T cell-specific gene control must integrate the concerted activity of at least three tissue-specific HMG box genes. ..
  8. Arkell R, Cadman M, Marsland T, Southwell A, Thaung C, Davies J, et al. Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse. Mamm Genome. 2001;12:687-94 pubmed
    ..Both the heterozygous viability and the penetrance of the visible phenotypes vary with genetic background. ..
  9. Wilson M, Yang K, Kalousova A, Lau J, Kosaka Y, Lynn F, et al. The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes. 2005;54:3402-9 pubmed
    ..Sox family members in both the developing pancreas and mature islets and then focused on two factors, Sox2 and Sox4. The expression field of Sox2, which plays a role in the maintenance of some stem cell populations, included the ..

More Information

Publications86

  1. Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, et al. Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 2008;57:2234-44 pubmed publisher
    ..The function of the SRY-related high mobility group (HMG)-box 4 (Sox4) gene in insulin secretion was tested using another ENU allele and by small interfering RNA silencing in insulinoma ..
  2. Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans Borgmeyer I, Wegner M. Cooperative function of POU proteins and SOX proteins in glial cells. J Biol Chem. 1998;273:16050-7 pubmed
    ..addition to Sox10, cells of the oligodendrocyte lineage contain significant amounts of the related SRY box proteins Sox4 and Sox11. During development, Sox11 was strongly expressed in the central nervous system...
  3. Potzner M, Griffel C, Lütjen Drecoll E, Bösl M, Wegner M, Sock E. Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol. 2007;27:5316-26 pubmed
    The highly related transcription factors Sox4 and Sox11 are both expressed in oligodendrocyte precursors. Yet whether they have a function in oligodendrocyte development is unknown. By overexpressing Sox4 under the control of 3...
  4. Kamachi Y, Uchikawa M, Kondoh H. Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet. 2000;16:182-7 pubmed
  5. Schilham M, Oosterwegel M, Moerer P, Ya J, de Boer P, van de Wetering M, et al. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature. 1996;380:711-4 pubmed
    ..In line with this, the frequency and proliferative capacity of IL-7-responsive B cell progenitors in fetal liver were severely decreased in vitro. ..
  6. Hoser M, Potzner M, Koch J, Bösl M, Wegner M, Sock E. Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol. 2008;28:4675-87 pubmed publisher
    The transcription factors Sox4 and Sox11 are important regulators of diverse developmental processes including heart, lung, pancreas, spleen, and B-cell development...
  7. Ya J, Schilham M, de Boer P, Moorman A, Clevers H, Lamers W. Sox4-deficiency syndrome in mice is an animal model for common trunk. Circ Res. 1998;83:986-94 pubmed
    Embryonic mice lacking functional Sox4 transcription factor die from cardiac failure at embryonic day (ED) 14...
  8. Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 1999;27:1409-20 pubmed
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other. ..
  9. Sinner D, Kordich J, Spence J, Opoka R, Rankin S, Lin S, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007;27:7802-15 pubmed
    ..Sox17 and Sox4 are expressed in mutually exclusive domains in normal and neoplastic gut tissues, and gain- and loss-of-function ..
  10. Cheung M, Abu Elmagd M, Clevers H, Scotting P. Roles of Sox4 in central nervous system development. Brain Res Mol Brain Res. 2000;79:180-91 pubmed
    The transcription factor-encoding gene, Sox4, is expressed in a wide range of tissues and has been shown to be functionally involved in heart, B-cell and reproductive system development...
  11. Nissen Meyer L, Jemtland R, Gautvik V, Pedersen M, Paro R, Fortunati D, et al. Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice. J Cell Sci. 2007;120:2785-95 pubmed
    The transcription factor Sox4 is vital for fetal development, as Sox4(-/-) homozygotes die in utero...
  12. Schilham M, Moerer P, Cumano A, Clevers H. Sox-4 facilitates thymocyte differentiation. Eur J Immunol. 1997;27:1292-5 pubmed
    ..When Sox-4-deficient fetal liver cells were injected together with normal cells intrathymically, they did not compete efficiently for reconstitution. It is concluded that Sox-4 facilitates thymocyte development. ..
  13. Sandoval S, Kraus C, Cho E, Cho M, Bies J, Manara E, et al. Sox4 cooperates with CREB in myeloid transformation. Blood. 2012;120:155-65 pubmed publisher
    ..leukemic blasts from the majority of acute myeloid leukemia patients have higher CREB, phosphorylated CREB, and Sox 4 protein expression...
  14. Jang S, Kim J, Kim D, Kim C, An J, Choi K, et al. Sox4-mediated caldesmon expression facilitates differentiation of skeletal myoblasts. J Cell Sci. 2013;126:5178-88 pubmed publisher
    ..Promoter analysis of the caldesmon gene (Cald1) and gel mobility shift assays identified Sox4 as a major trans-acting factor for the regulation of Cald1 expression during myoblast differentiation...
  15. Stephen L, Fawkes A, Verhoeve A, Lemke G, Brown A. A critical role for the EphA3 receptor tyrosine kinase in heart development. Dev Biol. 2007;302:66-79 pubmed
    ..Thus our results indicate that EphA3 plays a crucial role in the development and morphogenesis of the cells that give rise to the atrioventricular valves and septa. ..
  16. Wang B, Weidenfeld J, Lu M, Maika S, Kuziel W, Morrisey E, et al. Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development. 2004;131:4477-87 pubmed
    ..5 and are similar to those observed in other mouse models of congenital heart disease, including Sox4 and Nfatc1 null embryos...
  17. Chang K, Hertz J, Zhang X, Jin X, Shaw P, Derosa B, et al. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017;37:4967-4981 pubmed publisher
    ..cell (RGC) fate in the developing retina? Here we report on mechanisms by which a molecular pathway involving Sox4/Sox11 is required for RGC differentiation and for optic nerve formation in mice in vivo, and is sufficient ..
  18. Rojas A, Schachterle W, Xu S, Martin F, Black B. Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer. Dev Biol. 2010;346:346-55 pubmed publisher
    ..These studies identify Gata4 as a direct transcriptional target of FoxA2 in the hierarchy of the transcriptional regulatory network that controls the development of the definitive endoderm. ..
  19. Huang J, Arsenault M, Kann M, Lopez Mendez C, Saleh M, Wadowska D, et al. The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013;242:790-9 pubmed publisher
    ..We discovered that all three members of the SoxC subfamily, namely, Sox4, Sox11, and Sox12, are bound by Wt1 in mouse embryonic kidneys in vivo...
  20. Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A. A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992;20:2887 pubmed
  21. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..In contrast, Sox17 and Sox4 cooperate more strongly on the compressed than on the canonical element...
  22. Okada A, Kushima K, Aoki Y, Bialer M, Fujiwara M. Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth Defects Res A Clin Mol Teratol. 2005;73:229-38 pubmed
    ..Annotation analysis revealed that the increased genes included gadd45b, ier5, per1, phfl3, pou3f1, and sox4, and the decreased genes included ccne2, ccnl, gas5, egr2, sirt1, and zfp105...
  23. Kuwajima T, Soares C, Sitko A, Lefebvre V, Mason C. SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017;93:1110-1125.e5 pubmed publisher
    ..Here we demonstrate that SoxC genes (Sox4, 11, and 12) act on the progenitor-to-postmitotic transition to implement contralateral, but not ipsilateral, RGC ..
  24. Ninkovic J, Steiner Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, et al. The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell. 2013;13:403-18 pubmed publisher
    ..Taken together, elements of our work identify a tripartite effector network activated by Pax6-BAF that programs neuronal fate. ..
  25. Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, et al. Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. FEBS Lett. 2013;587:358-63 pubmed publisher
    Sox11 and Sox4 play critical roles in retinal development, during which they display specific and unique expression patterns. The expression of Sox11 and Sox4 is temporally sequential, albeit spatially overlapping in some retinal subtypes...
  26. Nagai K. Molecular evolution of Sry and Sox gene. Gene. 2001;270:161-9 pubmed
    ..This rapid evolution of Sry might agree with the fact that the Srys are present not on the pseudoautosomal region but on the distal region with no recombination of the Y chromosomal short arm. ..
  27. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..5), the localized expression of six Sox genes (Sox2, 5, 6, 9, 12 and 13) was observed in the shelves, whereas Sox4 and Sox11 showed ubiquitious expression. During the down-growth of palatal shelves (E13...
  28. Castillo S, Matheu A, Mariani N, Carretero J, Lopez Rios F, Lovell Badge R, et al. Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer. Cancer Res. 2012;72:176-86 pubmed publisher
    The HMG box transcription factor SOX4 involved in neuronal development is amplified and overexpressed in a subset of lung cancers, suggesting that it may be a driver oncogene...
  29. Gyurján I, Sonderegger B, Naef F, Duboule D. Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol. 2011;11:47 pubmed publisher
    ..These datasets provide a valuable resource, either for research projects involving gene expression and regulation in developing mouse limbs, or as examples of tissue-specific, genome-wide transcriptional activities. ..
  30. Boogerd C, Wong L, van den Boogaard M, Bakker M, Tessadori F, Bakkers J, et al. Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43. Cell Mol Life Sci. 2011;68:3949-61 pubmed publisher
    ..Here, we identify Sox4 as an interacting partner of Tbx3...
  31. Collignon J, Sockanathan S, Hacker A, Cohen Tannoudji M, Norris D, Rastan S, et al. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996;122:509-20 pubmed
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties. ..
  32. Tiwari N, Tiwari V, Waldmeier L, Balwierz P, Arnold P, Pachkov M, et al. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell. 2013;23:768-83 pubmed publisher
    Gene expression profiling has uncovered the transcription factor Sox4 with upregulated activity during TGF-?-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells...
  33. Paul M, Harvey R, Wegner M, Sock E. Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cell Mol Life Sci. 2014;71:2931-45 pubmed publisher
    ..Here we assess the contribution of the closely related high-mobility-group transcription factors Sox4 and Sox11 to outflow tract development and determine their function...
  34. Song H, Mak K, Topol L, Yun K, Hu J, Garrett L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107:1431-6 pubmed publisher
  35. Stock D, Buchanan A, Zhao Z, Weiss K. Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996;37:234-7 pubmed
    ..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process. ..
  36. Brunskill E, Witte D, Yutzey K, Potter S. Novel cell lines promote the discovery of genes involved in early heart development. Dev Biol. 2001;235:507-20 pubmed
    ..The results show that the 1H and ECL-2 cell lines can be used to discover novel genes expressed in the early cardiomyocyte. ..
  37. Thein D, Thalhammer J, Hartwig A, Crenshaw E, Lefebvre V, Wegner M, et al. The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. J Neurochem. 2010;115:131-41 pubmed publisher
    Development of the mouse CNS was reported to be normal in the absence of either Sox4 or its close relative Sox11 despite strong and widespread expression of both transcription factors...
  38. Mehta A, Mann M, Zhao J, Marinov G, Majumdar D, Garcia Flores Y, et al. The microRNA-212/132 cluster regulates B cell development by targeting Sox4. J Exp Med. 2015;212:1679-92 pubmed publisher
    ..We find that Sox4 is a target of miR-132 in B cells...
  39. Cordi S, Godard C, Saandi T, Jacquemin P, Monga S, Colnot S, et al. Role of β-catenin in development of bile ducts. Differentiation. 2016;91:42-9 pubmed publisher
    ..Our work is expected to significantly impact on in vitro differentiation of stem cells to cholangiocytes for toxicology studies and disease modeling. ..
  40. Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, et al. The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development. 2013;140:740-50 pubmed publisher
    Sry-related HMG box (Sox) proteins, Sox11 and Sox4 are members of the SoxC subtype...
  41. Deneault E, Cellot S, Faubert A, Laverdure J, Fréchette M, Chagraoui J, et al. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137:369-79 pubmed publisher
    ..The utilization of this screening method together with the creation of a database enriched for potential determinants of hematopoietic stem cell self-renewal will serve as a resource to uncover regulatory networks in these cells. ..
  42. Hansen G, Skapura D, Justice M. Genetic profile of insertion mutations in mouse leukemias and lymphomas. Genome Res. 2000;10:237-43 pubmed
  43. Mu L, Berti L, Masserdotti G, Covic M, Michaelidis T, Doberauer K, et al. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. J Neurosci. 2012;32:3067-80 pubmed publisher
    ..Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons...
  44. Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, et al. Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016;291:7107-18 pubmed publisher
    ..Taken together, the palate defects presented in the Sox11 loss mutant mimic the clefting in the Pierre Robin sequence in humans. ..
  45. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox genes thus showed a dynamic spatio-temporal expression during tooth development. ..
  46. Gitler A, Lu M, Jiang Y, Epstein J, Gruber P. Molecular markers of cardiac endocardial cushion development. Dev Dyn. 2003;228:643-50 pubmed
  47. Gnedeva K, Hudspeth A. SoxC transcription factors are essential for the development of the inner ear. Proc Natl Acad Sci U S A. 2015;112:14066-71 pubmed publisher
    ..Here we show that two members of the SoxC family of transcription factors, Sox4 and Sox11, are down-regulated after the epoch of hair cell development...
  48. Sakhinia E, Byers R, Bashein A, Hoyland J, Buckle A, Brady G. Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis. Br J Haematol. 2006;135:105-16 pubmed
    ..In addition to providing baseline values for myeloid and lymphoid lineage markers during mouse haematopoiesis, these results highlight the importance of single-cell analysis in the study of complex tissues. ..
  49. Jauch R, Ng C, Narasimhan K, Kolatkar P. The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition. Biochem J. 2012;443:39-47 pubmed publisher
    ..In the present study we examine the crystal structure of the HMG (high-mobility group) domain of Sox4 [Sry (sex-determining region on the Y chromosome)-related HMG box 4] bound to DNA...
  50. Aue G, Du Y, Cleveland S, Smith S, DAVE U, Liu D, et al. Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia. Blood. 2011;118:4674-81 pubmed publisher
    ..leukemias induced by transducing wild-type bone marrow progenitors with a SRY sex determining region Y-box 4 (Sox4)-expressing retrovirus frequently carried proviral insertions at Sfpi1, decreasing its mRNA levels, suggesting that ..
  51. Ling K, Brautigan P, Moore S, Fraser R, Cheah P, Raison J, et al. Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain. Genomics. 2016;107:88-99 pubmed publisher
    ..Multiple NATs at the Sox4 gene locus are spatiotemporally regulated throughout murine cerebral corticogenesis...
  52. Kato K, Bhattaram P, Penzo Méndez A, Gadi A, Lefebvre V. SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015;30:1560-71 pubmed publisher
    ..We investigated here the importance of the SoxC genes, which encode the SOX4, SOX11 and SOX12 transcription factors, in growth plates...
  53. Bartesaghi L, Arnaud Gouttenoire E, Prunotto A, Médard J, Bergmann S, Chrast R. Sox4 participates in the modulation of Schwann cell myelination. Eur J Neurosci. 2015;42:1788-96 pubmed publisher
    ..This analysis revealed that Sox4, which encodes a member of the Sry-related high-mobility group box protein family, was consistently upregulated in ..
  54. Malhotra N, Narayan K, Cho O, Sylvia K, Yin C, Melichar H, et al. A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 2013;38:681-93 pubmed publisher
    ..by a gene regulatory network consisting of a quartet of high-mobility group (HMG) box transcription factors, SOX4, SOX13, TCF1, and LEF1, and not by conventional TCR signaling...
  55. Rex M, Uwanogho D, Cartwright E, Pearl G, Sharpe P, Scotting P. Sox gene expression during neuronal development. Biochem Soc Trans. 1994;22:252S pubmed
  56. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  57. Garside V, Cullum R, Alder O, Lu D, Vander Werff R, Bilenky M, et al. SOX9 modulates the expression of key transcription factors required for heart valve development. Development. 2015;142:4340-50 pubmed publisher
    ..of several transcription factors with previously identified roles in heart valve development, including Twist1, Sox4, Mecom and Pitx2...
  58. Pamilo P, O Neill R. Evolution of the Sry genes. Mol Biol Evol. 1997;14:49-55 pubmed
    ..We did not find good support for the hypothesis that the high evolutionary rate of Sry would be associated with a promiscuous mating system. ..
  59. Bilir B, Osunkoya A, Wiles W, Sannigrahi S, Lefebvre V, Metzger D, et al. SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation. Cancer Res. 2016;76:1112-21 pubmed publisher
    ..The transcription factor SOX4 is overexpressed in many human cancers, including prostate cancer, suggesting it may participate in prostate ..
  60. Collins S, Do H, Hastoy B, Hugill A, Adam J, Chibalina M, et al. Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion. Diabetes. 2016;65:1952-61 pubmed publisher
    The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1 In a mouse model expressing a mutant form of Sox4, glucose-induced insulin ..
  61. Reichling T, Goss K, Carson D, Holdcraft R, Ley Ebert C, Witte D, et al. Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors. Cancer Res. 2005;65:166-76 pubmed
    ..Real-time reverse transcription-PCR analysis of human colorectal cancer cell lines and adenocarcinomas revealed that altered expression levels were also observed for six of the genes Igfbp5, Lcn2, Ly6d, N4wbp4 (PMEPA1), S100c, and Sox4.
  62. Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Munsterberg A, et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature. 1990;346:245-50 pubmed
    ..This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains. ..
  63. Kato Y, Alavattam K, Sin H, Meetei A, Pang Q, Andreassen P, et al. FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis. Hum Mol Genet. 2015;24:5234-49 pubmed publisher
    ..Taken together, these results indicate that FANCB functions at critical stages of germ cell development and reveal a novel function of the FA pathway in the regulation of H3K9 methylation in the germline. ..
  64. Wiles W, Mou Z, Du Y, Long A, Scharer C, Bilir B, et al. Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality. In Vivo. 2014;28:709-18 pubmed
    b>Sox4 is an essential gene, and genetic deletion results in embryonic lethality...
  65. de la Pompa J, Timmerman L, Takimoto H, Yoshida H, Elia A, Samper E, et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature. 1998;392:182-6 pubmed
  66. Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013;288:18429-38 pubmed publisher
    ..The highly related group C Sox genes Sox4 and Sox11 are widely expressed in the development of mouse retina and share a similar expression pattern with each ..
  67. Seelan R, Mukhopadhyay P, Warner D, Webb C, Pisano M, Greene R. Epigenetic regulation of Sox4 during palate development. Epigenomics. 2013;5:131-46 pubmed publisher
    ..of the murine palate from gestational days 12-14 (GD12-14), a critical period in palate development, identified Sox4 as a differentially expressed gene...
  68. Bhattaram P, Penzo Méndez A, Kato K, Bandyopadhyay K, Gadi A, Taketo M, et al. SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014;207:657-71 pubmed publisher
    ..We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes, i.e., Sox4, Sox11, and Sox12, are coexpressed in skeletogenic mesenchyme, including presumptive joints and perichondrium, but ..
  69. Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X, et al. The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia. Haematologica. 2014;99:1591-8 pubmed publisher
    The transcription factor Sox4 plays an indispensable role in the development of early progenitor B cells from hematopoietic stem cells...
  70. Wright E, Snopek B, Koopman P. Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993;21:744 pubmed
  71. Kim H, Choe H, Chung S, Kim M, Seong J, Son G, et al. Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer. Mol Endocrinol. 2011;25:1184-96 pubmed publisher
    ..The class-C SOX member proteins (SOX-C) (SOX4 and SOX11) specifically augment this transcriptional activation by binding to these SOX-binding sites...
  72. Kagami Y, Furuichi T. Investigation of differentially expressed genes during the development of mouse cerebellum. Brain Res Gene Expr Patterns. 2001;1:39-59 pubmed
  73. Behlke M, Bogan J, Beer Romero P, Page D. Evidence that the SRY protein is encoded by a single exon on the human Y chromosome. Genomics. 1993;17:736-9 pubmed
    ..Within this CpG island lies the sequence CGCCCCGC, a potential binding site for the EGR-1/WT1 family of transcription factors, some of which appear to function in gonadal development. ..
  74. Mallampati S, Sun B, Lu Y, Ma H, Gong Y, Wang D, et al. Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1?. Blood. 2014;123:4064-76 pubmed publisher
    ..We found that Sox4 coordinates multilevel controls in the differentiation of early stage B cells...
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  76. Critcher R, Stitson R, Wade Martins R, Easty D, Farr C. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. Cytogenet Cell Genet. 1998;81:294-5 pubmed
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