Gene Symbol: Sox2ot
Description: SOX2 overlapping transcript (non-protein coding)
Amaral P, Neyt C, Wilkins S, Askarian Amiri M, Sunkin S, Perkins A, et al
. Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA. 2009;15:2013-27 pubmed publisher
..of pluripotency embedded within an intron of a long noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed in the same orientation. However, this ncRNA remains uncharacterized...
Mandalos N, Saridaki M, Harper J, Kotsoni A, Yang P, Economides A, et al
. Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2. PLoS ONE. 2012;7:e45768 pubmed publisher
..and coding region are entirely contained within a CpG island, and are also spanned by an overlapping transcript, Sox2Ot, which contains mmu-miR1897...
Askarian Amiri M, Seyfoddin V, Smart C, Wang J, Kim J, Hansji H, et al
. Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer. PLoS ONE. 2014;9:e102140 pubmed publisher
..but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called SOX2 overlapping transcript (SOX2OT)...
Li C, Wang S, Wang W, Song S, Liu X. Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury. Cell Mol Neurobiol. 2017;37:361-369 pubmed publisher
..Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high ..
Tosetti V, Sassone J, Ferri A, Taiana M, Bedini G, Nava S, et al
. Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis. PLoS ONE. 2017;12:e0180579 pubmed publisher
..Long non-coding RNA (lncRNA) Sox2 overlapping transcript (Sox2OT) plays a crucial role in gene expression control during development but its transcriptional regulation is still to ..
Messemaker T, van Leeuwen S, van den Berg P, t Jong A, Palstra R, Hoeben R, et al
. Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot. Sci Rep. 2018;8:386 pubmed publisher
..postulated that Sox2 regulation is partially controlled by the Sox2 overlapping long non-coding RNA (lncRNA) gene Sox2ot. Here we show that the RNA levels of Sox2ot and Sox2 are inversely correlated during neural differentiation of ..