Gene Symbol: Sox21
Description: SRY (sex determining region Y)-box 21
Alias: Sox25, transcription factor SOX-21, DNA-binding protein SOX21, HMG-box protein SOX21, SRY-box containing gene 21
Species: mouse
Products:     Sox21

Top Publications

  1. Kuzmichev A, Kim S, D Alessio A, Chenoweth J, Wittko I, Campanati L, et al. Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells. Curr Biol. 2012;22:1705-10 pubmed publisher
    ..In vivo studies demonstrated that Sox21, another member of the SoxB gene family, was a specific, immediate, and cell-autonomous target of Sox2 in ..
  2. Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, et al. The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci U S A. 2009;106:9292-7 pubmed publisher
    ..We have established a mutant mouse with a cyclic alopecia phenotype resulting from the targeted disruption of Sox21, a gene that encodes a HMG-box protein...
  3. Mallanna S, Ormsbee B, Iacovino M, Gilmore J, Cox J, Kyba M, et al. Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate. Stem Cells. 2010;28:1715-27 pubmed publisher
    ..Using ESC engineered for inducible expression of Sox21, we show that ectopic expression of Sox21 in ESC induces their differentiation into specific cell types, including ..
  4. Chakravarthy H, Ormsbee B, Mallanna S, Rizzino A. Rapid activation of the bivalent gene Sox21 requires displacement of multiple layers of gene-silencing machinery. FASEB J. 2011;25:206-18 pubmed publisher
    ..In this study, we investigated the regulation of the bivalent gene Sox21, which is activated rapidly when ESCs differentiate in response to increases in Sox2...
  5. Cheung L, Okano H, Camper S. Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes. Mol Cell Endocrinol. 2017;439:213-223 pubmed publisher
    ..b>SOX21 is a protein that regulates hair, neural, and trophoblast stem cell differentiation...
  6. Goolam M, Scialdone A, Graham S, Macaulay I, Jedrusik A, Hupalowska A, et al. Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos. Cell. 2016;165:61-74 pubmed publisher
    ..regulators Oct4 and Sox2 as being highly heterogeneously expressed between blastomeres of the 4-cell embryo, with Sox21 showing one of the most heterogeneous expression profiles...
  7. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..Sox2, Sox14, Sox21 and Sox15 strongly cooperate on the canonical element but compete with Oct4 on a recently discovered compressed ..
  8. Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S, Nakagawa F, et al. Expression and function of Sox21 during mouse cochlea development. Neurochem Res. 2011;36:1261-9 pubmed publisher
    ..In this study, we examined the expression pattern of Sox21 in the developing and adult murine cochlea...
  9. Sennett R, Wang Z, Rezza A, Grisanti L, Roitershtein N, Sicchio C, et al. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin. Dev Cell. 2015;34:577-91 pubmed publisher
    ..Finally, we share all data in an interactive, searchable companion website. Our study provides an overarching view of signaling within the entire embryonic skin and captures a molecular snapshot of HF progenitors and their niche. ..

More Information


  1. Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, et al. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett. 2004;358:157-60 pubmed
    b>Sox21, a high-mobility group box transcription factor, is expressed throughout the immature neural stem/progenitor population in ventricular zone but not in the cortical plate in embryonic mouse brain and its expression is restricted to ..
  2. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam...
  3. Kurtsdotter I, Topcic D, Karlén A, Singla B, Hagey D, Bergsland M, et al. SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells. Cancer Res. 2017;77:4985-4997 pubmed publisher
    ..We show that the expression levels of SOX5, SOX6, and SOX21 (SOX5/6/21) transcription factors increase in stem cells of the subventricular zone (SVZ) upon oncogenic stress, ..
  4. Matsuda S, Kuwako K, Okano H, Tsutsumi S, Aburatani H, Saga Y, et al. Sox21 promotes hippocampal adult neurogenesis via the transcriptional repression of the Hes5 gene. J Neurosci. 2012;32:12543-57 pubmed
    ..Here, we demonstrate that another member of the SoxB (Sox1/Sox2/Sox3) transcription factor family, Sox21, is also a critical regulator of adult neurogenesis in mouse hippocampus...
  5. Hwang C, Wu X, Wang G, Kim C, Loh H. Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem. 2003;278:3742-50 pubmed
    ..These data indicate that SOX proteins might contribute to the transcriptional activity of the mor gene and suggest that mu opioid receptor could mediate some of the developmental processes in which SOX proteins are included. ..
  6. Kawaminami S, Breakspear S, Saga Y, Noecker B, Masukawa Y, Tsuchiya M, et al. Deletion of the Sox21 gene drastically affects hair lipids. Exp Dermatol. 2012;21:974-6 pubmed publisher
    The effects of Sox21 gene deletion on hair lipids have been studied...
  7. Fantauzzo K, Christiano A. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012;139:203-14 pubmed publisher
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle. ..
  8. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem. 2015;290:30152-62 pubmed publisher
    ..Our analysis revealed a high expression of Sox21 in TSCs compared with other cell types...
  9. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox genes thus showed a dynamic spatio-temporal expression during tooth development. ..
  10. Wilson M, Yang K, Kalousova A, Lau J, Kosaka Y, Lynn F, et al. The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes. 2005;54:3402-9 pubmed
    ..We show here that several Sox transcription factors are expressed in the developing pancreas and in the islet, and that one of these factors, Sox4, is required for the normal development of pancreatic islets. ..
  11. Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development. ..