Sox18

Summary

Gene Symbol: Sox18
Description: SRY (sex determining region Y)-box 18
Alias: AI385749, Ragl, transcription factor SOX-18, SRY-box containing gene 18, Sry-related HMG-box gene 18, ragged
Species: mouse
Products:     Sox18

Top Publications

  1. James K, Hosking B, Gardner J, Muscat G, Koopman P. Sox18 mutations in the ragged mouse alleles ragged-like and opossum. Genesis. 2003;36:1-6 pubmed
    The ragged (Ra) spontaneous mouse mutant is characterised by abnormalities in its coat and cardiovascular system...
  2. Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, et al. Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008;456:643-7 pubmed publisher
    ..4). Defects in the transcription factor gene SOX18 (SRY (sex determining region Y) box 18) cause lymphatic dysfunction in the human syndrome hypotrichosis-..
  3. Pennisi D, Bowles J, Nagy A, Muscat G, Koopman P. Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol. 2000;20:9331-6 pubmed
    ..and that point mutations in Sox18 are the underlying cause of cardiovascular and hair follicle defects in ragged (Ra) mice. Here we describe the analysis of Sox18(-/-) mice produced by gene targeting...
  4. Pennisi D, Gardner J, Chambers D, Hosking B, Peters J, Muscat G, et al. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice. Nat Genet. 2000;24:434-7 pubmed
    ..This region contains a known mouse mutation, ragged (Ra), that affects the coat and vasculature. Here we have directly evaluated Sox18 as a candidate for Ra...
  5. Clarke R, Yzaguirre A, Yashiro Ohtani Y, Bondue A, Blanpain C, Pear W, et al. The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol. 2013;15:502-10 pubmed publisher
    ..Taken together, these findings position Sox17 as a key regulator of haemogenic endothelial and haematopoietic development. ..
  6. Durkin M, Loechel F, Mattei M, Gilpin B, Albrechtsen R, Wewer U. Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. FEBS Lett. 1997;411:296-300 pubmed
    ..2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.
  7. Downes M, Koopman P. SOX18 and the transcriptional regulation of blood vessel development. Trends Cardiovasc Med. 2001;11:318-24 pubmed
    b>SOX18 is a transcription factor that is transiently expressed in nascent endothelial cells during embryonic development and adult neovascularization...
  8. Matsui T, Kanai Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, et al. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006;119:3513-26 pubmed
    ..Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant mice...
  9. Sakamoto Y, Hara K, Kanai Azuma M, Matsui T, Miura Y, Tsunekawa N, et al. Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 2007;360:539-44 pubmed
    ..Here we characterized cardiovascular phenotypes of Sox17/Sox18-double and Sox17-single null embryos during early-somite stages...

More Information

Publications71

  1. Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T, et al. Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development. 2009;136:2385-91 pubmed publisher
    ..Mutations in Sox18 cause a variable phenotype in the human congenital syndrome hypotrichosis-lymphedema-telangiectasia, and the ..
  2. Hwang C, Wu X, Wang G, Kim C, Loh H. Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem. 2003;278:3742-50 pubmed
    ..These data indicate that SOX proteins might contribute to the transcriptional activity of the mor gene and suggest that mu opioid receptor could mediate some of the developmental processes in which SOX proteins are included. ..
  3. Miner J, Cunningham J, Sanes J. Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain. J Cell Biol. 1998;143:1713-23 pubmed
    ..Other laminin alpha chains accumulate in these BLs, but this compensation is apparently functionally inadequate. Our results identify new roles for laminins and BLs in diverse developmental processes. ..
  4. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis. ..
  5. Hogan M, King L, Sundberg J. Defects of pelage hairs in 20 mouse mutations. J Invest Dermatol. 1995;104:31S-32S pubmed
  6. Young N, Hahn C, Poh A, Dong C, Wilhelm D, Olsson J, et al. Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J Natl Cancer Inst. 2006;98:1060-7 pubmed
    ..The SOX18 transcription factor is a key regulator of murine and human blood vessel formation...
  7. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox genes thus showed a dynamic spatio-temporal expression during tooth development. ..
  8. Forsthoefel P, Shenk T. Linkage relationships of Strong's luxoid gene in the mouse. J Hered. 1970;61:64-6 pubmed
  9. Zhou Y, Williams J, Smallwood P, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE. 2015;10:e0143650 pubmed publisher
    ..Here we study the roles of three closely related SoxF family transcription factors-Sox7, Sox17, and Sox18 -in the developing and mature mouse vasculature using targeted gene deletion on a mixed C57/129/CD1 genetic ..
  10. Lilly A, Mazan A, Scott D, Lacaud G, Kouskoff V. SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mech Dev. 2017;146:31-41 pubmed publisher
    ..Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development. ..
  11. Dunn T, Mynett Johnson L, Wright E, Hosking B, Koopman P, Muscat G. Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. Gene. 1995;161:223-5 pubmed
    ..We have determined the full cDNA sequence of Sox-18 which encodes a protein of 378 aa. Sox-18 mRNA transcripts were restricted to heart, lung and skeletal muscle in the adult mouse. ..
  12. Serrano A, Gandillet A, Pearson S, Lacaud G, Kouskoff V. Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood. 2010;115:3895-8 pubmed publisher
    ..Here, we assessed, using embryonic stem cell differentiation as a model system, whether Sox17 and Sox18, 2 close homologs of Sox7, may act similarly to Sox7 at the onset of hematopoietic development...
  13. Greenfield A, Dunn T, Muscat G, Koopman P. The Sry-related gene Sox18 maps to distal mouse chromosome 2. Genomics. 1996;36:558-9 pubmed
  14. Duong T, Proulx S, Luciani P, Leroux J, Detmar M, Koopman P, et al. Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res. 2012;72:3105-14 pubmed publisher
    ..Developmental biology studies have identified the transcription factor SOX18 as a critical switch for lymphangiogenesis in the mouse embryo...
  15. Corada M, Orsenigo F, Morini M, Pitulescu M, Bhat G, Nyqvist D, et al. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609 pubmed publisher
    ..Mechanistically, Sox17 acts upstream of the Notch system and downstream of the canonical Wnt system. These data introduce Sox17 as a component of the complex signalling network that orchestrates arterial/venous specification. ..
  16. Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, et al. Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS ONE. 2012;7:e43857 pubmed publisher
    ..Previous studies have established that the mouse mutant ragged-opossum (Ra(op)) expresses a dominant-negative form of the SOX18 transcription factor that interferes with the ..
  17. Cermenati S, Moleri S, Neyt C, Bresciani E, Carra S, Grassini D, et al. Sox18 genetically interacts with VegfC to regulate lymphangiogenesis in zebrafish. Arterioscler Thromb Vasc Biol. 2013;33:1238-47 pubmed publisher
    ..We addressed this issue in zebrafish. Mutations in the transcription factor-coding gene SOX18 and in VEGFR3 cause lymphedema, and the VEGFR3/Flt4 ligand VEGFC plays an evolutionarily conserved role in ..
  18. Peters J, Beechey C, Ball S, Evans E. Mapping studies of the distal imprinting region of mouse chromosome 2. Genet Res. 1994;63:169-74 pubmed
    ..Ada, adenosine deaminase, lies very near the proximal boundary and Ra, ragged, maps very close to the distal boundary, and is less than 0.2 cM from wasted, wst...
  19. Wallace M. Analysis of genetic control of chylous ascites in ragged mice. Heredity (Edinb). 1979;43:9-18 pubmed
    ..An initial genetic study showed it to be a pleiotropic effect of ragged, Ra. There were four main studies. These involved seven major mutants segregating with ragged...
  20. Duong T, Koltowska K, Pichol Thievend C, Le Guen L, Fontaine F, Smith K, et al. VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 2014;123:1102-12 pubmed publisher
    ..Vegf/Vegf-receptor pathway and SoxF transcription factors and identified a specific interaction between Vegfd and Sox18. Double knockdown zebrafish embryos for Sox18/Vegfd and Sox7/Vegfd exhibit defects in arteriovenous ..
  21. Swailes N, Colegrave M, Knight P, Peckham M. Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse. J Cell Sci. 2006;119:3561-70 pubmed
  22. Kartopawiro J, Bower N, Karnezis T, Kazenwadel J, Betterman K, Lesieur E, et al. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. 2014;23:1286-97 pubmed publisher
    ..To identify novel modulators of lymphangiogenesis, we used a mouse model of HLT (Ragged Opossum) and performed gene expression profiling of aberrant dermal lymphatic vessels...
  23. Abbott C, Malas S, Pilz A, Pate L, Ali R, Peters J. Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2. Genomics. 1994;20:94-8 pubmed
    Mice that are heterozygous for the ragged (Ra) mutation, which is semidominant, have ragged coats caused by an absence of certain hair types. Ra/Ra homozygous mice usually die soon after birth, are naked, and have edema...
  24. Sennett R, Wang Z, Rezza A, Grisanti L, Roitershtein N, Sicchio C, et al. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin. Dev Cell. 2015;34:577-91 pubmed publisher
    ..Finally, we share all data in an interactive, searchable companion website. Our study provides an overarching view of signaling within the entire embryonic skin and captures a molecular snapshot of HF progenitors and their niche. ..
  25. Davisson M, Cattanach B. The mouse mutation ulnaless on chromosome 2. J Hered. 1990;81:151-3 pubmed
    ..Penetrance appears to be complete, but the homozygote is not known, as heterozygous males do not breed. We report the linkage of the Ul gene on Chromosome 2, 18 cM proximal to pallid (pa), and describe its phenotypic effects. ..
  26. Lioubinski O, Müller M, Wegner M, Sander M. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003;227:402-8 pubmed
    ..We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, and Sox13 in adult pancreatic islets...
  27. Abbott C, Evans E, Burtenshaw M, Ball S, Skidmore C, Jones J, et al. Adenosine deaminase, Ada, is in mouse chromosome 2H3, and is not allelic with wasted, wst. Biochem Genet. 1991;29:537-44 pubmed
    ..Linkage analysis of backcross data has shown that Ada is 13.8 +/- 2.7 cM from the coat texture mutant, ragged, Ra. From the results of earlier work (Abbott, C. M., et al., Proc. Natl. Acad. Sci...
  28. Little M, Brennan J, Georgas K, Davies J, Davidson D, Baldock R, et al. A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns. 2007;7:680-99 pubmed
    ..Visual examples of how terms appear in different specimen types are also provided...
  29. Olsson J, Kamachi Y, Penning S, Muscat G, Kondoh H, Koopman P. Sox18 expression in blood vessels and feather buds during chicken embryogenesis. Gene. 2001;271:151-8 pubmed
    b>Sox18 encodes a transcription factor known to be important for the development of blood vessels and hair follicles in mice...
  30. Slee J. Developmental morphology of the skin and hair follicles in normal and in 'ragged' mice. J Embryol Exp Morphol. 1962;10:507-29 pubmed
  31. Stock D, Buchanan A, Zhao Z, Weiss K. Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996;37:234-7 pubmed
    ..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process. ..
  32. Fitch K, McGowan K, Van Raamsdonk C, Fuchs H, Lee D, Puech A, et al. Genetics of dark skin in mice. Genes Dev. 2003;17:214-28 pubmed
    ..histology of 10 new Dsk and 2 new dark coat (Dcc) mutations, and identified mutations in Agouti (Met1Leu, Dcc4), Sox18 (Leu220ter, Dcc1), Keratin 2e (Thr500Pro, Dsk2), and Egfr (Leu863Gln, Dsk5)...
  33. Su H, Trombly M, Chen J, Wang X. Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009;23:304-17 pubmed publisher
    ..Thus, our results demonstrate that mammalian Agos all contribute to miRNA silencing, and individual Agos have largely overlapping functions in this process. ..
  34. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..In contrast, Sox17 and Sox4 cooperate more strongly on the compressed than on the canonical element. Sox5 and Sox18 show some cooperation on both elements, whereas Sox8 and Sox9 compete on both elements...
  35. Wallace M. Mapping with mimic genes in the mouse. J Hered. 1979;70:216 pubmed
  36. Hosking B, Muscat G, Koopman P, Dowhan D, Dunn T. Trans-activation and DNA-binding properties of the transcription factor, Sox-18. Nucleic Acids Res. 1995;23:2626-8 pubmed
    ..Furthermore, Sox-18 was capable of trans-activating gene expression through the AACAAA motif. Our results suggest that Sox-18 functions as a classical trans-activator of gene expression. ..
  37. Srinivasan R, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, et al. The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010;24:696-707 pubmed publisher
    ..The SRY-related gene Sox18 is required to induce Prox1 expression in venous LEC progenitors...
  38. Pennisi D, James K, Hosking B, Muscat G, Koopman P. Structure, mapping, and expression of human SOX18. Mamm Genome. 2000;11:1147-9 pubmed
  39. Hosking B, Wyeth J, Pennisi D, Wang S, Koopman P, Muscat G. Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Gene. 2001;262:239-47 pubmed
    ..mutations in the Sox18 activation domain underlie cardiovascular and hair follicle defects in the mouse mutation, ragged (Ra) (Pennisi et al., 2000. Mutations in Sox18 underlie cardiovascular and hair follicle defecs in ragged mice...
  40. Villani R, Hodgson S, Legrand J, Greaney J, Wong H, Pichol Thievend C, et al. Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development. 2017;144:1887-1895 pubmed publisher
    SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear...
  41. Sandholzer J, Hoeth M, Piskacek M, Mayer H, de Martin R. A novel 9-amino-acid transactivation domain in the C-terminal part of Sox18. Biochem Biophys Res Commun. 2007;360:370-4 pubmed
    ..as well as the blood and lymphatic vasculature, due to the identification of mutations that result in the ragged phenotype in mice, and in the hypotrichosis lymphedema telangiectasia syndrome in humans...
  42. Green M, Sweet H, Bunker L. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am J Pathol. 1976;82:493-512 pubmed
  43. Hosking B, Wang S, Chen S, Penning S, Koopman P, Muscat G. SOX18 directly interacts with MEF2C in endothelial cells. Biochem Biophys Res Commun. 2001;287:493-500 pubmed
    ..in the Sry-related HMG box gene Sox18 underlie vascular and hair follicle defects in the mouse allelic mutants ragged (Ra) and RaJ...
  44. Lauriol J, Cabrera J, Roy A, Keith K, Hough S, Damilano F, et al. Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines. J Clin Invest. 2016;126:2989-3005 pubmed publisher
    ..Together, our data provide functional and disease-based evidence that aberrant SHP2 signaling during cardiac development leads to CHD and adult-onset heart hypertrophy. ..
  45. Chiang I, Fritzsche M, Pichol Thievend C, Neal A, Holmes K, Lagendijk A, et al. SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development. 2017;144:2629-2639 pubmed publisher
    ..binding sites established a clear requirement for members of this group of transcription factors (SOX7, SOX17 and SOX18) to drive the activity of these enhancers in vivo Endogenous deletion of the notch1b enhancer led to ..
  46. Dickerman R, Feinstein R, Grahn D. Position of the acatalasemia gene in linkage group V of the mouse. J Hered. 1968;59:177-8 pubmed
  47. Legrand J, Roy E, Ellis J, Francois M, Brooks A, Khosrotehrani K. STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction. J Invest Dermatol. 2016;136:1781-1791 pubmed publisher
    ..found that conditional knockout of STAT5A/B in the DP targeted through Cre-recombinase under the control of the Sox18 promoter resulted in delayed anagen entry compared with control...
  48. Basílio J, Hoeth M, Holper Schichl Y, Resch U, Mayer H, Hofer Warbinek R, et al. TNF?-induced down-regulation of Sox18 in endothelial cells is dependent on NF-?B. Biochem Biophys Res Commun. 2013;442:221-6 pubmed publisher
    The transcription factor Sox18 plays a role in angiogenesis, including lymphangiogenesis, where it is upregulated by growth factors and directs the expression of genes encoding, e.g., guidance molecules and a matrix metalloproteinase...
  49. Azuma T, Seki N, Yoshikawa T, Saito T, Masuho Y, Muramatsu M. cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18. J Hum Genet. 2000;45:192-5 pubmed
    ..with an open reading frame encoding a putative protein of 384 amino acids, which shared 83% identity to the mouse Sox18 protein. Northern blot analysis revealed that a 1...
  50. Fantauzzo K, Christiano A. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development. 2012;139:203-14 pubmed publisher
    ..Our findings identify Trps1 as a novel regulator of the Wnt signaling pathway and of early hair follicle progenitors in the developing vibrissa follicle. ..
  51. Stanojcic S, Stevanovic M. The human SOX18 gene: cDNA cloning and high resolution mapping. Biochim Biophys Acta. 2000;1492:237-41 pubmed
    ..We report here cloning and characterisation of the human SOX18 gene...
  52. Nagai K. Molecular evolution of Sry and Sox gene. Gene. 2001;270:161-9 pubmed
    ..This rapid evolution of Sry might agree with the fact that the Srys are present not on the pseudoautosomal region but on the distal region with no recombination of the Y chromosomal short arm. ..
  53. Hardie W, Korfhagen T, Sartor M, Prestridge A, Medvedovic M, Le Cras T, et al. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007;37:309-21 pubmed
    ..These studies support a role for epithelial cell-derived TGF-alpha in the regulation of processes that alter the airway and vascular architecture and function. ..
  54. Maltais L, Lane P, Beamer W. Anorexia, a recessive mutation causing starvation in preweanling mice. J Hered. 1984;75:468-72 pubmed
    ..Data suggest that the mutant mice are not ingesting the levels of nutrients necessary to sustain life. This mutation may provide an important tool for studying the neurobiology of suckling behavior in the preweanling animal. ..
  55. Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen V, Zarkada G, et al. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest. 2014;124:3975-86 pubmed publisher
  56. Xie J, Wu T, Xu K, Huang I, Cleaver O, Huang C. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol. 2009;175:1315-27 pubmed publisher
  57. Azizoglu D, Chong D, Villasenor A, Magenheim J, Barry D, Lee S, et al. Vascular development in the vertebrate pancreas. Dev Biol. 2016;420:67-78 pubmed publisher
    ..This study constitutes a first-time in-depth cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium. ..
  58. Hosking B, Wang S, Downes M, Koopman P, Muscat G. The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. J Biol Chem. 2004;279:5314-22 pubmed
    ..We use biochemical techniques, cell culture systems, and the ragged opossum (RaOP) mouse model with a naturally occurring mutation in Sox18 to demonstrate that VCAM-1 is an important ..
  59. Brouillard P, Boon L, Vikkula M. Genetics of lymphatic anomalies. J Clin Invest. 2014;124:898-904 pubmed publisher
    ..Most of the corresponding murine knockouts are homozygous lethal, while heterozygotes are healthy, which suggests differences in human and murine physiology and the influence of other factors. ..
  60. Ren X, Ustiyan V, Pradhan A, Cai Y, Havrilak J, Bolte C, et al. FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells. Circ Res. 2014;115:709-20 pubmed publisher
    ..FOXF1 is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling. ..
  61. Durkin M, Albrechtsen R, Chambers D, Abbott C, Wewer U. Evaluation of Lama5 as a candidate for the mouse ragged (Ra) mutation. Biochem Biophys Res Commun. 1998;250:125-30 pubmed
    ..The mouse laminin alpha5 chain gene (Lama5) has been mapped close to the locus of the semidominant ragged (Ra) mutation on distal chromosome 2...
  62. Downes M, Francois M, Ferguson C, Parton R, Koopman P. Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet. 2009;18:2839-50 pubmed publisher
    ..and functional analysis of vascular anomalies in embryos of the naturally occurring Sox18-mutant mouse strain ragged-opossum (Ra(Op))...