Gene Symbol: Sox17
Description: SRY (sex determining region Y)-box 17
Alias: transcription factor SOX-17, SRY-box containing gene 17
Species: mouse
Products:     Sox17

Top Publications

  1. Yang H, Lee S, Lee S, Kim K, Yang Y, Kim J, et al. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest. 2013;123:418-31 pubmed publisher
    ..Here, we studied the expression pattern of the transcription factor Sox17 in the vasculature of murine and human tumors and investigated the function of Sox17 during tumor angiogenesis ..
  2. Tam P, Khoo P, Lewis S, Bildsoe H, Wong N, Tsang T, et al. Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development. 2007;134:251-60 pubmed
    ..The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another. ..
  3. Kanai Azuma M, Kanai Y, Gad J, Tajima Y, Taya C, Kurohmaru M, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002;129:2367-79 pubmed
    ..The transcription factors, Sox17 (a Sry-related HMG box factor) and its upstream factors, Mixer (homeobox factor) and Casanova (a novel Sox factor),..
  4. Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu G, et al. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 2013;32:938-53 pubmed publisher
    ..We demonstrate here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification...
  5. Lorthongpanich C, Messerschmidt D, Chan S, Hong W, Knowles B, Solter D. Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 2013;27:1441-6 pubmed publisher
    ..We therefore conclude that precisely timed YAP localization in early morulae is essential to prevent trophectoderm marker expression in, and lineage specification of, the ICM. ..
  6. Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, et al. Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A. 2007;104:3859-64 pubmed
    ..Among genes associated temporally with this step was Sox17, encoding an endodermal HMG-box transcription factor...
  7. Niakan K, Ji H, Maehr R, Vokes S, Rodolfa K, Sherwood R, et al. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010;24:312-26 pubmed publisher
    ..Here, we show that Sox17 is a transcriptional regulator of differentiation in these pluripotent cells...
  8. Frum T, Halbisen M, Wang C, Amiri H, Robson P, Ralston A. Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell. 2013;25:610-22 pubmed publisher
    ..Finally, we show that Oct4 is required for the expression of multiple EPI and PE genes as well as multiple metabolic pathways essential for the continued growth of the preimplantation embryo. ..
  9. Kanai Y, Kanai Azuma M, Noce T, Saido T, Shiroishi T, Hayashi Y, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996;133:667-81 pubmed
    The different mRNA isoforms of the mouse Sox17 gene were isolated from adult mouse testis cDNAs...

More Information


  1. Corada M, Orsenigo F, Morini M, Pitulescu M, Bhat G, Nyqvist D, et al. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609 pubmed publisher
    ..Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, ..
  2. Serrano A, Gandillet A, Pearson S, Lacaud G, Kouskoff V. Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification. Blood. 2010;115:3895-8 pubmed publisher
    ..Here, we assessed, using embryonic stem cell differentiation as a model system, whether Sox17 and Sox18, 2 close homologs of Sox7, may act similarly to Sox7 at the onset of hematopoietic development...
  3. Lange A, Keiser A, Wells J, Zorn A, Whitsett J. Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS ONE. 2009;4:e5711 pubmed publisher
    The Sry-related high mobility group box transcription factor Sox17 is required for diverse developmental processes including endoderm formation, vascular development, and fetal hematopoietic stem cell maintenance...
  4. Artus J, Piliszek A, Hadjantonakis A. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol. 2011;350:393-404 pubmed publisher
    ..In this study we have investigated the localization of two transcriptional regulators of the SOX family, SOX17 and SOX7, within the PrE and its derivatives...
  5. Lioubinski O, Müller M, Wegner M, Sander M. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003;227:402-8 pubmed
    ..We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, Sox9, and Sox13 in adult pancreatic islets...
  6. Le Bin G, Muñoz Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, et al. Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development. 2014;141:1001-10 pubmed publisher
    ..b>Sox17, a marker of primitive endoderm, is not detected following prolonged culture of such embryos, but can be rescued ..
  7. Clarke R, Yzaguirre A, Yashiro Ohtani Y, Bondue A, Blanpain C, Pear W, et al. The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol. 2013;15:502-10 pubmed publisher
    ..Here we identify Sox17 as a key regulator of haemogenic endothelial development...
  8. Park K, Wells J, Zorn A, Wert S, Whitsett J. Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol. 2006;294:192-202 pubmed
    The Sry-related HMG box transcription factor, Sox17, is required for formation of definitive endoderm that gives rise to various organs, including thyroid, lung, liver, pancreas, and intestine...
  9. Matsui T, Kanai Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, et al. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006;119:3513-26 pubmed
    Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant mice...
  10. Sakamoto Y, Hara K, Kanai Azuma M, Matsui T, Miura Y, Tsunekawa N, et al. Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 2007;360:539-44 pubmed
    ..Here we characterized cardiovascular phenotypes of Sox17/Sox18-double and Sox17-single null embryos during early-somite stages...
  11. Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, et al. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 2010;24:1746-57 pubmed publisher
    ..of myocardial proliferation can be rescued by exogenous Fgf20, and is mediated, in part, by Foxp1 repression of Sox17. In contrast, myocardial-specific loss of Foxp1 results in increased cardiomyocyte proliferation and decreased ..
  12. Palasingam P, Jauch R, Ng C, Kolatkar P. The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J Mol Biol. 2009;388:619-30 pubmed publisher
    b>Sox17 regulates endodermal lineage commitment and is thought to function antagonistically to the pluripotency determinant Sox2...
  13. Uemura M, Ozawa A, Nagata T, Kurasawa K, Tsunekawa N, Nobuhisa I, et al. Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013;140:639-48 pubmed publisher
    ..Here, we show that during mouse organogenesis, insufficient SOX17 expression in the gallbladder and bile duct epithelia results in congenital biliary atresia and subsequent acute '..
  14. Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T, et al. Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development. 2009;136:2385-91 pubmed publisher
    ..Here we show that two closely related Group F Sox factors, SOX7 and SOX17, are able to functionally substitute for SOX18 in vitro and in vivo...
  15. Engert S, Liao W, Burtscher I, Lickert H. Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells. Genesis. 2009;47:603-10 pubmed publisher
    b>Sox17 encodes an SRY-related high-mobility group (HMG) box transcription factor that is essential for endoderm formation and fetal hematopoietic stem cell maintenance...
  16. Spence J, Lange A, Lin S, Kaestner K, Lowy A, Kim I, et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009;17:62-74 pubmed publisher
    ..These pancreatobiliary progenitor cells coexpress the transcription factors PDX1 and SOX17 at E8.5 and their segregation into a PDX1+ ventral pancreas and a SOX17+ biliary primordium is Sox17-dependent...
  17. Pfister S, Jones V, Power M, Truisi G, Khoo P, Steiner K, et al. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55:45-58 pubmed publisher
    b>Sox17 is a transcription factor that is required for maintenance of the definitive endoderm in mouse embryos...
  18. Kang M, Piliszek A, Artus J, Hadjantonakis A. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development. 2013;140:267-79 pubmed publisher
    ..Instead, depending on concentration, we noted no effect or conversion of all ICM cells to GATA6-positive PrE. We propose that heterogeneities in the availability of FGF produce the salt-and-pepper distribution of lineage-biased cells...
  19. Liao W, Uetzmann L, Burtscher I, Lickert H. Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries. Genesis. 2009;47:476-83 pubmed publisher
    The HMG-box transcription factor Sox17 has been shown to play important roles in both endoderm formation and cardiovascular development...
  20. Sinner D, Kordich J, Spence J, Opoka R, Rankin S, Lin S, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007;27:7802-15 pubmed
    ..We found that some Sox proteins antagonize while others enhance beta-catenin/T-cell factor (TCF) activity. Sox17, which is expressed in the normal gut epithelium but exhibits reduced expression in intestinal neoplasia, is ..
  21. Kim I, Saunders T, Morrison S. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007;130:470-83 pubmed
    ..the gene expression profiles of fetal versus adult hematopoietic stem cells (HSCs) and discovered that the Sox17 transcriptional regulator is specifically expressed in fetal and neonatal but not adult HSCs...
  22. Krawchuk D, Honma Yamanaka N, Anani S, Yamanaka Y. FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst. Dev Biol. 2013;384:65-71 pubmed publisher
    ..We conclude that the amount of FGF4 is limited and regulates PE/EPI proportions in the mouse embryo...
  23. Schrode N, Saiz N, Di Talia S, Hadjantonakis A. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014;29:454-67 pubmed publisher
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  24. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177-89 pubmed publisher
    ..These results suggest that Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in mouse development. ..
  25. Iwafuchi Doi M, Matsuda K, Murakami K, Niwa H, Tesar P, Aruga J, et al. Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012;139:3926-37 pubmed publisher
    ..The direct interaction of these factors with enhancers of Otx2, Hesx1 and Sox2 genes was demonstrated. Thus, a combination of regulatory processes that suppresses non-ANP lineages and promotes neural plate development determines the ANP...
  26. Lauriol J, Cabrera J, Roy A, Keith K, Hough S, Damilano F, et al. Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines. J Clin Invest. 2016;126:2989-3005 pubmed publisher
    ..Together, our data provide functional and disease-based evidence that aberrant SHP2 signaling during cardiac development leads to CHD and adult-onset heart hypertrophy. ..
  27. Saund R, Kanai Azuma M, Kanai Y, Kim I, Lucero M, Saijoh Y. Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012;139:2426-35 pubmed publisher
    ..Here we studied the role of endoderm cells in the transfer of the LR asymmetry signal by analyzing mouse Sox17 null mutant embryos, which possess endoderm-specific defects...
  28. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011;102:1313-21 pubmed publisher
    ..Microarray analysis showed that CD133(+) cells specifically expressed Sox17, a tumor suppressor in gastric carcinogenesis...
  29. Teo A, Arnold S, Trotter M, Brown S, Ang L, Chng Z, et al. Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25:238-50 pubmed publisher
    ..Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development. ..
  30. Du Y, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, et al. Induction and down-regulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis. Gastroenterology. 2009;137:1346-57 pubmed publisher
    The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer...
  31. Viotti M, Nowotschin S, Hadjantonakis A. SOX17 links gut endoderm morphogenesis and germ layer segregation. Nat Cell Biol. 2014;16:1146-56 pubmed publisher
    ..We show that the transcription factor SOX17, which is activated in prospective DE cells before intercalation, is necessary for gut endoderm morphogenesis and ..
  32. Jonatan D, Spence J, Method A, Kofron M, Sinagoga K, Haataja L, et al. Sox17 regulates insulin secretion in the normal and pathologic mouse β cell. PLoS ONE. 2014;9:e104675 pubmed publisher
    b>SOX17 is a key transcriptional regulator that can act by regulating other transcription factors including HNF1β and FOXA2, which are known to regulate postnatal β cell function...
  33. Zhou Y, Williams J, Smallwood P, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE. 2015;10:e0143650 pubmed publisher
    ..Here we study the roles of three closely related SoxF family transcription factors-Sox7, Sox17, and Sox18 -in the developing and mature mouse vasculature using targeted gene deletion on a mixed C57/129/CD1 ..
  34. Villani R, Hodgson S, Legrand J, Greaney J, Wong H, Pichol Thievend C, et al. Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development. 2017;144:1887-1895 pubmed publisher
    ..In conclusion, SOX18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types. ..
  35. Jin J, Ding J. Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol. 2013;381:170-8 pubmed publisher
    ..These results demonstrate a critical role for Cripto during mouse gastrulation, especially in mesoderm and endoderm formation and allocation. ..
  36. Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, et al. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells. 2014;32:1515-26 pubmed publisher
    ..2 mouse embryonic stem cells (mESCs), we identified the endodermal transcription factor Sox17 as essential for Mesp1 induction in primitive mesoderm and subsequent cardiac muscle differentiation...
  37. Harrelson Z, Kaestner K, Evans S. Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biol Open. 2012;1:173-81 pubmed publisher
    ..Loss of Foxa2 in ventral endoderm resulted in reduced expression of Sox17, Gata4, and ZO proteins, accounting at least in part for observed lack of foregut fusion, cardia bifida, and ..
  38. Messerschmidt D, de Vries W, Lorthongpanich C, Balu S, Solter D, Knowles B. ?-catenin-mediated adhesion is required for successful preimplantation mouse embryo development. Development. 2016;143:1993-9 pubmed publisher
  39. Wallingford M, Angelo J, Mager J. Morphogenetic analysis of peri-implantation development. Dev Dyn. 2013;242:1110-20 pubmed publisher
    ..We examined expression patterns of key transcription factors (Sox2, Oct4, Nanog, Cdx2, Gata6, Sox17, and Yy1) during pre- and postimplantation development...
  40. Thompson H, Tucker A. Dual origin of the epithelium of the mammalian middle ear. Science. 2013;339:1453-6 pubmed publisher
    ..A different process of cavitation appears evident in birds and reptiles, indicating that this dual epithelium may be unique to mammals. ..
  41. Misra C, Sachan N, McNally C, Koenig S, Nichols H, Guggilam A, et al. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012;8:e1002690 pubmed publisher
    ..In summary, the Gata4 G295S mutation functions as a hypomorph in vivo and leads to defects in cardiomyocyte proliferation during embryogenesis, which may contribute to the development of congenital heart defects in humans. ..
  42. Barratt K, Glanville Jones H, Arkell R. The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis. 2014;52:626-35 pubmed publisher
    ..Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation. ..
  43. Bonney S, Harrison Uy S, Mishra S, MacPherson A, Choe Y, Li D, et al. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016;36:7786-801 pubmed publisher
    ..inhibit WNT-?-catenin transcriptional activity and that this is required to moderate the expression of WNT target Sox17. From this, a model emerges in which RA acts upstream of the WNT pathway via non-cell-autonomous and cell-..
  44. Jiang X, Hawkins J, Lee J, Lizama C, Bos F, Zape J, et al. Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun. 2017;8:128 pubmed publisher
    ..Here, the authors show that changing miRNA biogenesis and leukotriene B4 signaling in mice modulates this switch in the niche. ..
  45. Cornett B, Snowball J, Varisco B, Lang R, Whitsett J, Sinner D. Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol. 2013;379:38-52 pubmed publisher
    ..These studies provide a new framework for understanding the molecular mechanisms underlying normal pulmonary vasculature formation and the dysmorphic pulmonary vasculature development associated with congenital lung disease. ..
  46. Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, et al. MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. J Biol Chem. 2016;291:12126-35 pubmed publisher
    ..Altogether, our results indicate that miR-127 accelerates mesendoderm differentiation of mouse embryonic stem cells through nodal signaling by targeting Lefty2. ..
  47. Tam P, Khoo P, Wong N, Tsang T, Behringer R. Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function. Dev Biol. 2004;274:171-87 pubmed
    ..The inefficient movement of the anterior endoderm, and the abnormal differentiation highlighted by the lack of Sox17 and Foxa2 expression, may underpin the malformation of the head of Lhx1 mutant embryos.
  48. Choi E, Kraus M, Lemaire L, Yoshimoto M, Vemula S, Potter L, et al. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012;30:2297-308 pubmed publisher
    b>Sox17 is essential for both endoderm development and fetal hematopoietic stem cell (HSC) maintenance...
  49. Rubel C, Lanz R, Kommagani R, Franco H, Lydon J, DeMayo F. Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus. Mol Endocrinol. 2012;26:1428-42 pubmed publisher
    ..Further mining of the ChIP-seq data revealed Sox17 as a direct transcriptional PR target gene in the uterus...
  50. Hoxha E, Lambers E, Wasserstrom J, Mackie A, Ramirez V, Abramova T, et al. Elucidation of a novel pathway through which HDAC1 controls cardiomyocyte differentiation through expression of SOX-17 and BMP2. PLoS ONE. 2012;7:e45046 pubmed publisher
    ..cardiovascular and more specifically cardiomyocyte differentiation in ES cells by controlling expression of SOX17 and BMP2 during early differentiation...
  51. Fiorenzano A, Pascale E, D Aniello C, Acampora D, Bassalert C, Russo F, et al. Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency. Nat Commun. 2016;7:12589 pubmed publisher
    ..All together, our studies provide novel insights into the current model of mammalian pluripotency and contribute to the understanding of the extrinsic regulation of the first cell lineage decision in the embryo. ..
  52. Viotti M, Niu L, Shi S, Hadjantonakis A. Role of the gut endoderm in relaying left-right patterning in mice. PLoS Biol. 2012;10:e1001276 pubmed publisher
    ..Noting that embryos lacking Sox17 exhibit defects in both gut endoderm formation and LR patterning, we investigated a potential connection between ..
  53. Hayashi M, Pluchinotta M, Momiyama A, Tanaka Y, Nishikawa S, Kataoka H. Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp Hematol. 2012;40:738-750.e11 pubmed publisher
    ..While promoting hematopoiesis/vasculogenesis, Etv2 expression should be tightly regulated to achieve normal vascular development and hematopoiesis. ..
  54. Koh F, Lizama C, Wong P, Hawkins J, Zovein A, Ramalho Santos M. Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription. Proc Natl Acad Sci U S A. 2015;112:E1734-43 pubmed publisher
    ..Our results reveal a new paradigm of regulation of a developmental transition by elevation of global transcriptional output that is critical for hemogenesis and may play roles in other contexts. ..
  55. Lilly A, Mazan A, Scott D, Lacaud G, Kouskoff V. SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mech Dev. 2017;146:31-41 pubmed publisher
    ..Together, our data reveal the unique role of SOX7 in vasculogenesis and angiogenesis during embryonic development. ..
  56. Cerdá Esteban N, Naumann H, Ruzittu S, Mah N, Pongrac I, Cozzitorto C, et al. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2. Nat Commun. 2017;8:14127 pubmed publisher
    ..This study uncovers the reprogramming activity of TGIF2 and suggests a stepwise reprogramming paradigm, whereby a 'lineage-restricted' dedifferentiation step precedes the identity switch. ..
  57. Abboud N, Moore Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi M, et al. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015;6:6749 pubmed publisher
    ..SALL4 concomitantly mobilizes the polycomb complexes at the Soxs loci. Thus, OCT4/SALL4-driven cohesin- and polycombs-mediated changes in higher-order chromatin structure mediate instruction of early cell fate in embryonic cells. ..
  58. Frame J, Fegan K, Conway S, McGrath K, Palis J. Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. Stem Cells. 2016;34:431-44 pubmed publisher
    ..These data illustrate the heterogeneity in hematopoietic output and spatiotemporal regulation of primary embryonic hemogenic endothelium. ..
  59. Lee S, Lee S, Yang H, Song S, Kim K, Saunders T, et al. Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circ Res. 2014;115:215-26 pubmed publisher
    ..Transcription factor Sox17 is specifically expressed in endothelial cells, but its expression and role at the vascular front remain largely ..
  60. Rommelaere S, Millet V, Vu Manh T, Gensollen T, Andreoletti P, Cherkaoui Malki M, et al. Sox17 regulates liver lipid metabolism and adaptation to fasting. PLoS ONE. 2014;9:e104925 pubmed publisher
    ..This mouse carries a mutation in the HMG domain of the Sox17 transcription factor...
  61. Guimarães Young A, Neff T, Dupuy A, Goodheart M. Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function. Dev Biol. 2016;414:219-27 pubmed publisher
    ..b>Sox17 is a transcription factor characterized in numerous tissues as an antagonist of Wnt signaling...
  62. Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, et al. Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development. 2017;144:3706-3718 pubmed publisher
    ..These data demonstrate that Klf5 suppresses Fgf4-Fgfr-ERK signalling, thus preventing precocious activation of the PrE specification programme. ..
  63. Costello I, Nowotschin S, Sun X, Mould A, Hadjantonakis A, Bikoff E, et al. Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015;29:2108-22 pubmed publisher
    ..These partnerships cooperatively regulate development of the anterior mesendoderm, node, and midline cell populations responsible for establishment of the left-right body axis and head formation. ..
  64. Johansson E, Andersson L, Örnros J, Carlsson T, Ingeson Carlsson C, Liang S, et al. Revising the embryonic origin of thyroid C cells in mice and humans. Development. 2015;142:3519-28 pubmed publisher
    ..With lineage tracing, we now provide direct evidence that Sox17+ anterior endoderm is the only source of differentiated C cells and their progenitors in mice...
  65. Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, et al. Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS ONE. 2012;7:e43857 pubmed publisher
    ..Our data suggest that SOXF transcription factors play a role in regulating formation of cytoplasmic plaque protein assembly, and that disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes. ..
  66. Kulinski T, Casari M, Guenzl P, Wenzel D, Andergassen D, Hladik A, et al. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015;402:291-305 pubmed publisher
    ..This explains why cystic EBs reproduce the imprinted expression seen in the embryo but not that seen in the ysE. ..
  67. Hou J, Wei W, Saund R, Xiang P, Cunningham T, Yi Y, et al. A regulatory network controls nephrocan expression and midgut patterning. Development. 2014;141:3772-81 pubmed publisher
    ..We observed that Nepn expression is dramatically reduced in Sox17(-/-) and Raldh2(-/-) embryos compared with wild-type embryos...
  68. Gregorieff A, Grosschedl R, Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J. 2004;23:1825-33 pubmed
    ..Our results reveal a novel role for Wnt signalling in early gut morphogenesis and suggest that specific Wnt-driven patterning events are determined by the unique tissue distribution of Tcf/Lef family members. ..
  69. Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, et al. Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014;34:1976-90 pubmed publisher
    ..Here we found that an endodermal transcription factor marker, Sox17, and other F-group (SoxF) proteins, Sox7 and Sox18, were expressed in E10.5 intra-aortic cell clusters...
  70. Willet S, Hale M, Grapin Botton A, Magnuson M, Macdonald R, Wright C. Dominant and context-specific control of endodermal organ allocation by Ptf1a. Development. 2014;141:4385-94 pubmed publisher
    ..We provide strong evidence, beyond previous Ptf1a inactivation or misexpression experiments in frog embryos, for spatiotemporally context-dependent activity of Ptf1a as a potent gain-of-function trigger of pro-pancreatic commitment. ..
  71. Geula S, Moshitch Moshkovitz S, Dominissini D, Mansour A, Kol N, Salmon Divon M, et al. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015;347:1002-6 pubmed publisher
    ..This study highlights a critical role for an mRNA epigenetic modification in vivo and identifies regulatory modules that functionally influence naïve and primed pluripotency in an opposing manner. ..
  72. Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, et al. Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017;144:1906-1917 pubmed publisher
    ..i>Sox17 haploinsufficiency causes biliary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos, ..
  73. Moll N, Hong E, Fauveau M, Naruse M, Kerninon C, Tepavcevic V, et al. SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis. Glia. 2013;61:1659-72 pubmed publisher
    We have previously demonstrated that Sox17 expression is prominent at developmental stages corresponding to oligodendrocyte progenitor cell (OPC) cycle exit and onset of differentiation, and that Sox17 promotes initiation of OPC ..
  74. Jackson A, Kasah S, Mansour S, Morrow B, Basson M. Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. Dev Dyn. 2014;243:1143-51 pubmed publisher
    ..Tbx1 deletion from the pharyngeal endoderm is sufficient to cause caudal pharyngeal arch segmentation defects by FGF-independent effectors that remain to be identified. ..
  75. Sharma B, Ho L, Ford G, Chen H, Goldstone A, Woo Y, et al. Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. Dev Cell. 2017;42:655-666.e3 pubmed publisher
    ..An upregulation of endocardial SOX17 accompanied compensation in Apj mutants, which was also seen in Ccbe1 knockouts, indicating that the endocardium ..