Gene Symbol: Sox14
Description: SRY (sex determining region Y)-box 14
Alias: transcription factor SOX-14, SRY-box containing gene 14
Species: mouse
Products:     Sox14

Top Publications

  1. Achim K, Peltopuro P, Lahti L, Tsai H, Zachariah A, Astrand M, et al. The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors. Biol Open. 2013;2:990-7 pubmed publisher
    ..The observed similarities and differences between Tal1/Tal2 and Gata2 mutants suggest both co-operative and unique roles for these factors in determination of midbrain GABAergic neuron identities. ..
  2. Hargrave M, Karunaratne A, Cox L, Wood S, Koopman P, Yamada T. The HMG box transcription factor gene Sox14 marks a novel subset of ventral interneurons and is regulated by sonic hedgehog. Dev Biol. 2000;219:142-53 pubmed
    ..Here we report the cloning and characterization of Sox14, a novel and highly conserved member of the Sry-related Sox transcription factor gene family, in mouse and chick...
  3. Kirby P, Waters P, Delbridge M, Svartman M, Stewart A, Nagai K, et al. Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Cytogenet Genome Res. 2002;98:96-100 pubmed
    ..The two SOX B genes SOX2 and SOX14 co-localize to chromosome 3q in humans...
  4. Song H, Lee B, Pyun D, Guimera J, Son Y, Yoon J, et al. Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015;398:280-91 pubmed publisher
    ..Taken together, our results suggest a model whereby the combined activity of two distinct bHLH factors plays a key role in the development of discrete classes of thalamic interneurons. ..
  5. Hargrave M, James K, Yamada T, Koopman P. Sox14 maps to mouse chromosome 9 and shows no mutations in the neurological mouse mutants ducky and tippy. Mamm Genome. 2000;11:231-3 pubmed
  6. Wilmore H, Smith M, Wilcox S, Bell K, Sinclair A. SOX14 is a candidate gene for limb defects associated with BPES and Möbius syndrome. Hum Genet. 2000;106:269-76 pubmed
    ..It is likely that mutations in other SOX genes are responsible for a variety of human genetic diseases. SOX14 has been identified from a human genomic library and the mouse and chicken sequences obtained by polymerase chain ..
  7. Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006;133:3993-4004 pubmed
    ..These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions. ..
  8. Crone S, Quinlan K, Zagoraiou L, Droho S, Restrepo C, Lundfald L, et al. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron. 2008;60:70-83 pubmed publisher
    ..Our findings imply that the neural substrate for left-right coordination consists of at least two components; commissural neurons and a class of ipsilateral interneurons that activate commissural pathways. ..
  9. Zagoraiou L, Akay T, Martin J, Brownstone R, Jessell T, Miles G. A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron. 2009;64:645-62 pubmed publisher
    ..Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior. ..

More Information


  1. Lee K, Tan J, Morris M, Rizzoti K, Hughes J, Cheah P, et al. Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice. PLoS ONE. 2012;7:e29041 pubmed publisher
    ..This study provides further evidence that SCO function is essential for the prevention of hydrocephalus and indicates that overexpression of Sox3 in the dorsal midline alters progenitor cell differentiation in a dose-dependent manner. ..
  2. Clovis Y, Seo S, Kwon J, Rhee J, Yeo S, Lee J, et al. Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016;16:1642-1652 pubmed publisher
    ..This dual activity enables Chx10 to effectively separate the V2a and MN pathways. Our study uncovers a widely applicable gene regulatory principle for segregating related cell fates. ..
  3. Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, et al. Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016;21:111-8 pubmed publisher
    ..Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis. ..
  4. Jeong Y, Dolson D, Waclaw R, Matise M, Sussel L, Campbell K, et al. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011;138:531-41 pubmed publisher
  5. Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, et al. Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59:471-8 pubmed publisher
    ..Sox genes thus showed a dynamic spatio-temporal expression during tooth development. ..
  6. Hashimoto Torii K, Motoyama J, Hui C, Kuroiwa A, Nakafuku M, Shimamura K. Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus. Mech Dev. 2003;120:1097-111 pubmed
    ..As a first step to this end, we focused on two transcription factors Sox14 and Gbx2 that are expressed in the specific brain nuclei in the chick DT...
  7. Hargrave M, James K, Nield K, Toomes C, Georgas K, Sullivan T, et al. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. Hum Genet. 2000;106:432-9 pubmed
    ..We have recently described the cloning of chick and mouse Sox14 and the expression of these genes in a population of ventral interneurons in the embryonic spinal cord...
  8. Jager P, Ye Z, Yu X, Zagoraiou L, Prekop H, Partanen J, et al. Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat Commun. 2016;7:13579 pubmed publisher
    ..interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs...
  9. Lee B, Lee M, Song S, Loi L, Lam D, Yoon J, et al. Specification of neurotransmitter identity by Tal1 in thalamic nuclei. Dev Dyn. 2017;246:749-758 pubmed publisher
    ..Our results demonstrate that Tal1 plays an essential role in regulating neurotransmitter phenotype in the developing thalamic nuclei. Developmental Dynamics 246:749-758, 2017. © 2017 Wiley Periodicals, Inc. ..
  10. Ng C, Li N, Chee S, Prabhakar S, Kolatkar P, Jauch R. Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012;40:4933-41 pubmed publisher
    ..Sox2, Sox14, Sox21 and Sox15 strongly cooperate on the canonical element but compete with Oct4 on a recently discovered ..
  11. Delogu A, Sellers K, Zagoraiou L, Bocianowska Zbrog A, Mandal S, Guimera J, et al. Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012;75:648-62 pubmed publisher
    ..We describe Sox14 as a marker to follow the ontogeny of the SVS and find that the complex forms from two narrow stripes of Dlx2-..
  12. Wright E, Snopek B, Koopman P. Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993;21:744 pubmed
  13. Bikoff J, Gabitto M, Rivard A, Drobac E, Machado T, Miri A, et al. Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits. Cell. 2016;165:207-219 pubmed publisher
    ..Moreover, V1 diversity indicates that different inhibitory microcircuits exist for motor pools controlling hip, ankle, and foot muscles, revealing a variable circuit architecture for interneurons that control limb movement. ..