Sox11

Summary

Gene Symbol: Sox11
Description: SRY (sex determining region Y)-box 11
Alias: 1110038H03Rik, 6230403H02Rik, AI836553, end1, transcription factor SOX-11, SRY-box containing gene 11
Species: mouse
Products:     Sox11

Top Publications

  1. Stock D, Buchanan A, Zhao Z, Weiss K. Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996;37:234-7 pubmed
    ..The expression of Sox genes during tooth development has not been reported previously and further experiments will be required to determine their role in this process. ..
  2. Bergsland M, Ramsköld D, Zaouter C, Klum S, Sandberg R, Muhr J. Sequentially acting Sox transcription factors in neural lineage development. Genes Dev. 2011;25:2453-64 pubmed publisher
    ..Here we characterize the genome-wide binding for Sox2, Sox3, and Sox11, which have vital functions in ES cells, neural precursor cells (NPCs), and maturing neurons, respectively...
  3. Hargrave M, Wright E, Kun J, Emery J, Cooper L, Koopman P. Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. Dev Dyn. 1997;210:79-86 pubmed
    ..We report here the cloning and characterisation of one of these genes, Sox11, in mice...
  4. Jankowski M, Cornuet P, McIlwrath S, Koerber H, Albers K. SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Neuroscience. 2006;143:501-14 pubmed
    The transcription factor Sox11 is expressed at high levels in developing sensory neurons and injured adult neurons but little is known about its transcriptional targets and function...
  5. Hoser M, Potzner M, Koch J, Bösl M, Wegner M, Sock E. Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol. 2008;28:4675-87 pubmed publisher
    The transcription factors Sox4 and Sox11 are important regulators of diverse developmental processes including heart, lung, pancreas, spleen, and B-cell development...
  6. Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 1999;27:1409-20 pubmed
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other. ..
  7. Wurm A, Sock E, Fuchshofer R, Wegner M, Tamm E. Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp Eye Res. 2008;86:895-907 pubmed publisher
    We describe that Sox11, a member of the group C of the Sox transcription factor family, is critically required during the morphogenetic processes of early eye development, and that lack of Sox11 results in ocular anterior segment ..
  8. Potzner M, Griffel C, Lütjen Drecoll E, Bösl M, Wegner M, Sock E. Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol. 2007;27:5316-26 pubmed
    The highly related transcription factors Sox4 and Sox11 are both expressed in oligodendrocyte precursors. Yet whether they have a function in oligodendrocyte development is unknown. By overexpressing Sox4 under the control of 3...
  9. Sock E, Rettig S, Enderich J, Bösl M, Tamm E, Wegner M. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol. 2004;24:6635-44 pubmed
    The high-mobility-group domain-containing transcription factor Sox11 is expressed transiently during embryonic development in many tissues that undergo inductive remodeling...

More Information

Publications76

  1. Haslinger A, Schwarz T, Covic M, Lie D. Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci. 2009;29:2103-14 pubmed publisher
    ..Here we report that Sox11, a member of the group C Sox transcription factor family, is prominently expressed in the neurogenic areas of the ..
  2. Cheung M, Abu Elmagd M, Clevers H, Scotting P. Roles of Sox4 in central nervous system development. Brain Res Mol Brain Res. 2000;79:180-91 pubmed
    ..Sox4 shows a high degree of sequence homology with another group C Sox gene, Sox11, which is predominantly expressed in the CNS...
  3. Dy P, Penzo Méndez A, Wang H, Pedraza C, Macklin W, Lefebvre V. The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res. 2008;36:3101-17 pubmed publisher
    ..Sry-related high-mobility group (HMG) box (Sox) transcription factors has three members in most vertebrates: Sox4, Sox11 and Sox12...
  4. Jing X, Wang T, Huang S, Glorioso J, Albers K. The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a. Exp Neurol. 2012;233:221-32 pubmed publisher
    ..b>Sox11 is a developmentally expressed transcription factor that is significantly induced in adult neurons in response to ..
  5. Lioubinski O, Müller M, Wegner M, Sander M. Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003;227:402-8 pubmed
    ..We detected transcripts for Sox11, Sox4, Sox13, Sox5, Sox9, Sox8, Sox10, Sox7, Sox17, Sox18, Sox15, and Sox30 in embryonic pancreas and found Sox4, ..
  6. Yuan H, Corbi N, Basilico C, Dailey L. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995;9:2635-45 pubmed
  7. Jay P, Goze C, Marsollier C, Taviaux S, Hardelin J, Koopman P, et al. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. Genomics. 1995;29:541-5 pubmed
    ..We have cloned and characterized the human SOX11 gene using the partial cloning of both human and mouse SOX11 genes and mapped it to chromosome 1p25...
  8. Bhattaram P, Penzo Méndez A, Sock E, Colmenares C, Kaneko K, Vassilev A, et al. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9 pubmed publisher
    ..study, we show that their survival critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 and Sox12...
  9. Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T. Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res. 2009;69:7953-9 pubmed publisher
    ..the gene expression profiles of tumorigenic and nontumorigenic clones showed that the tumorigenic clones had lost Sox11 expression...
  10. Wilson M, Yang K, Kalousova A, Lau J, Kosaka Y, Lynn F, et al. The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes. 2005;54:3402-9 pubmed
    ..We show here that several Sox transcription factors are expressed in the developing pancreas and in the islet, and that one of these factors, Sox4, is required for the normal development of pancreatic islets. ..
  11. Salerno K, Jing X, Diges C, Cornuet P, Glorioso J, Albers K. Sox11 modulates brain-derived neurotrophic factor expression in an exon promoter-specific manner. J Neurosci Res. 2012;90:1011-9 pubmed publisher
    b>Sox11 is a high-mobility group (HMG)-containing transcription factor that is significantly elevated in peripheral neurons in response to nerve injury...
  12. Gadi J, Jung S, Lee M, Jami A, Ruthala K, Kim K, et al. The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. J Biol Chem. 2013;288:25400-13 pubmed publisher
    b>Sox11 deletion mice are known to exhibit developmental defects of craniofacial skeletal malformations, asplenia, and hypoplasia of the lung, stomach, and pancreas...
  13. Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans Borgmeyer I, Wegner M. Cooperative function of POU proteins and SOX proteins in glial cells. J Biol Chem. 1998;273:16050-7 pubmed
    ..Sox10, cells of the oligodendrocyte lineage contain significant amounts of the related SRY box proteins Sox4 and Sox11. During development, Sox11 was strongly expressed in the central nervous system...
  14. Price K, Woolf A, Long D. Unraveling the genetic landscape of bladder development in mice. J Urol. 2009;181:2366-74 pubmed publisher
    ..These data provide novel insights into molecules that orchestrate bladder development and highlight genes that may be involved in diseases associated with abnormal differentiation. ..
  15. Hoshiba Y, Toda T, Ebisu H, Wakimoto M, Yanagi S, Kawasaki H. Sox11 Balances Dendritic Morphogenesis with Neuronal Migration in the Developing Cerebral Cortex. J Neurosci. 2016;36:5775-84 pubmed publisher
    ..Here we found that the expression levels of the transcription factor Sox11 decreased dramatically during dendritic morphogenesis...
  16. Ayoub A, Oh S, Xie Y, Leng J, Cotney J, Dominguez M, et al. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Proc Natl Acad Sci U S A. 2011;108:14950-5 pubmed publisher
    ..Additionally, we found intergenic transcriptionally active regions that possibly encode unique zone-specific transcripts. Finally, we present a high-resolution transcriptome map of transient zones in the embryonic mouse forebrain. ..
  17. Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, et al. The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells. Development. 2013;140:740-50 pubmed publisher
    Sry-related HMG box (Sox) proteins, Sox11 and Sox4 are members of the SoxC subtype...
  18. Shaham O, Gueta K, Mor E, Oren Giladi P, Grinberg D, Xie Q, et al. Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet. 2013;9:e1003357 pubmed publisher
    ..A number of new targets of miR-204 were revealed, among them Sox11, a member of the SoxC family of pro-neuronal transcription factors, and an important regulator of eye development...
  19. Guo D, Kassiri Z, Basu R, Chow F, Kandalam V, Damilano F, et al. Loss of PI3K? enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res. 2010;107:1275-89 pubmed publisher
    ..Loss of phosphoinositide 3-kinase (PI3K)?, the isoform linked to G protein-coupled receptor signaling, results in increased myocardial contractility, but the response to pressure overload is controversial...
  20. Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, Kondoh H. Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol. 2004;24:8834-46 pubmed
    ..and was utilized in assessing the specificity of the synergism; combinations of either group B1 or group C SOX (SOX11) with class III POU proved effective. In embryonic day 13...
  21. Wang Y, Lin L, LAI H, Parada L, Lei L. Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Dev Dyn. 2013;242:638-53 pubmed publisher
    ..In this study, we generated a Sox11 floxed allele and a Sox11 null allele in mice using the Cre-loxP technology...
  22. Pamnani M, Sinha P, Nara S, Sachan M. Study of promoter DNA methylation of Sox11 and its correlation with tissue-specific expression in the laboratory mouse. Gene. 2014;552:133-9 pubmed publisher
    b>Sox11, a member of the group C Sox transcription factor family, is predominantly expressed in the neurogenic areas of the adult brain. In the embryo, Sox11 is expressed in the developing nervous system in both glial and neuronal lineages...
  23. Thein D, Thalhammer J, Hartwig A, Crenshaw E, Lefebvre V, Wegner M, et al. The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. J Neurochem. 2010;115:131-41 pubmed publisher
    Development of the mouse CNS was reported to be normal in the absence of either Sox4 or its close relative Sox11 despite strong and widespread expression of both transcription factors...
  24. Mu L, Berti L, Masserdotti G, Covic M, Michaelidis T, Doberauer K, et al. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. J Neurosci. 2012;32:3067-80 pubmed publisher
    ..Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons...
  25. Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, et al. Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016;291:7107-18 pubmed publisher
    Mouse gene inactivation has shown that the transcription factor Sox11 is required for mouse palatogenesis. However, whether Sox11 is primarily involved in the regulation of palatogenesis still remains elusive...
  26. Stoller J, Huang L, Tan C, Huang F, Zhou D, Yang J, et al. Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood). 2010;235:569-76 pubmed publisher
    ..Furthermore, our finding of a physical interaction between Tbx1 and Ash2l suggest that at least some functions of Tbx1 may be mediated by direct interactions with a histone methyltransferase complex. ..
  27. Gnedeva K, Hudspeth A. SoxC transcription factors are essential for the development of the inner ear. Proc Natl Acad Sci U S A. 2015;112:14066-71 pubmed publisher
    ..Here we show that two members of the SoxC family of transcription factors, Sox4 and Sox11, are down-regulated after the epoch of hair cell development...
  28. Kato K, Bhattaram P, Penzo Méndez A, Gadi A, Lefebvre V. SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015;30:1560-71 pubmed publisher
    ..We investigated here the importance of the SoxC genes, which encode the SOX4, SOX11 and SOX12 transcription factors, in growth plates...
  29. Welsbie D, Mitchell K, Jaskula Ranga V, Sluch V, Yang Z, Kim J, et al. Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. Neuron. 2017;94:1142-1154.e6 pubmed publisher
    ..JUN, activating transcription factor 2 (ATF2), myocyte-specific enhancer factor 2A (MEF2A), and SRY-Box 11 (SOX11), as being the major downstream mediators through which DLK/LZK activation leads to RGC cell death...
  30. Kocabas A, Duarte T, Kumar S, Hynes M. Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues. Neuron. 2015;88:1149-1156 pubmed publisher
    ..Our findings raise questions about the role of isolated 3' UTR sequences in regulation of protein expression and highlight the importance of separately examining 3' UTR and CDS sequences in gene expression analyses. ..
  31. Kim H, Choe H, Chung S, Kim M, Seong J, Son G, et al. Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer. Mol Endocrinol. 2011;25:1184-96 pubmed publisher
    ..The class-C SOX member proteins (SOX-C) (SOX4 and SOX11) specifically augment this transcriptional activation by binding to these SOX-binding sites...
  32. Lin L, Lee V, Wang Y, Lin J, Sock E, Wegner M, et al. Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn. 2011;240:52-64 pubmed publisher
    ..We demonstrated that the transcription factor Sox11 was highly expressed in the developing sensory neurons...
  33. Bain G, Mansergh F, Wride M, Hance J, Isogawa A, Rancourt S, et al. ES cell neural differentiation reveals a substantial number of novel ESTs. Funct Integr Genomics. 2000;1:127-39 pubmed
    ..Given the recent identification of human ES cells, further characterization of these novel and uncharacterized ESTs has the potential to identify genes that may be important in nervous system development, physiology and disease. ..
  34. Wright E, Snopek B, Koopman P. Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993;21:744 pubmed
  35. Aubert J, Stavridis M, Tweedie S, O Reilly M, Vierlinger K, Li M, et al. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A. 2003;100 Suppl 1:11836-41 pubmed
    ..Whole mount in situ hybridization against two genes of previously unknown embryonic expression, Lrrn1 and Musashi2, confirmed the selectivity of this screen for early neuroectodermal markers. ..
  36. Bhattaram P, Penzo Méndez A, Kato K, Bandyopadhyay K, Gadi A, Taketo M, et al. SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014;207:657-71 pubmed publisher
    ..We here identify the SOXC proteins as potent amplifiers of this pathway. The SOXC genes, i.e., Sox4, Sox11, and Sox12, are coexpressed in skeletogenic mesenchyme, including presumptive joints and perichondrium, but not in ..
  37. Sanosaka T, Namihira M, Asano H, Kohyama J, Aisaki K, Igarashi K, et al. Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells. Neuroscience. 2008;155:780-8 pubmed publisher
    ..Taken together, our data suggest that astrocyte differentiation of NPCs is regulated not only by DNA methylation but also by genes whose expression is controlled spatio-temporally during brain development. ..
  38. Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013;288:18429-38 pubmed publisher
    ..The highly related group C Sox genes Sox4 and Sox11 are widely expressed in the development of mouse retina and share a similar expression pattern with each other in ..
  39. Conrotto P, Andréasson U, Kuci V, Borrebaeck C, Ek S. Knock-down of SOX11 induces autotaxin-dependent increase in proliferation in vitro and more aggressive tumors in vivo. Mol Oncol. 2011;5:527-37 pubmed publisher
    The transcription factor SOX11 is a novel diagnostic marker for mantle cell lymphoma (MCL), distinguishing this aggressive tumor from potential simulators...
  40. Sessa A, Ciabatti E, Drechsel D, Massimino L, Colasante G, Giannelli S, et al. The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways. Cereb Cortex. 2017;27:3378-3396 pubmed publisher
    ..These data identify TBR2 as a major determinant of the INP-specific traits by regulating both genetic and epigenetic pathways. ..
  41. Aubert J, Dunstan H, Chambers I, Smith A. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol. 2002;20:1240-5 pubmed
    ..These findings reveal the importance of Wnt signaling in regulating ES-cell lineage diversification. More generally, this study establishes a path for rapid and direct validation of candidate genes in ES cells. ..
  42. Huang J, Arsenault M, Kann M, Lopez Mendez C, Saleh M, Wadowska D, et al. The transcription factor Sry-related HMG box-4 (SOX4) is required for normal renal development in vivo. Dev Dyn. 2013;242:790-9 pubmed publisher
    ..We discovered that all three members of the SoxC subfamily, namely, Sox4, Sox11, and Sox12, are bound by Wt1 in mouse embryonic kidneys in vivo...
  43. Norsworthy M, Bei F, Kawaguchi R, Wang Q, Tran N, Li Y, et al. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017;94:1112-1120.e4 pubmed publisher
    ..From a screen of transcription factors, we identified Sox11 as one that could induce substantial axon regeneration...
  44. Jankowski M, McIlwrath S, Jing X, Cornuet P, Salerno K, Koerber H, et al. Sox11 transcription factor modulates peripheral nerve regeneration in adult mice. Brain Res. 2009;1256:43-54 pubmed publisher
    ..Previous in vitro evidence had suggested that the transcription factor Sox11, a HMG-domain containing protein that is highly expressed in developing sensory neurons, is an important component ..
  45. Yang W, Wang Y, Yu Z, Li Z, An G, Liu W, et al. SOX11 regulates the pro-apoptosis signal pathway and predicts a favorable prognosis of mantle cell lymphoma. Int J Hematol. 2017;106:212-220 pubmed publisher
    Sex-determining region Y-box 11 (SOX11) is an important diagnostic marker in mantle cell lymphoma (MCL)...
  46. Potzner M, Tsarovina K, BINDER E, Penzo Méndez A, Lefebvre V, Rohrer H, et al. Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development. 2010;137:775-84 pubmed publisher
    The highly related transcription factors Sox4 and Sox11 are expressed in the developing sympathetic nervous system. In the mouse, Sox11 appears first, whereas Sox4 is prevalent later...
  47. Ninkovic J, Steiner Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, et al. The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell. 2013;13:403-18 pubmed publisher
    ..Downstream of the Pax6-BAF complex, we find that Sox11, Nfib, and Pou3f4 form a transcriptional cross-regulatory network that drives neurogenesis and can convert ..
  48. Gaber Z, Butler S, Novitch B. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013;11:e1001676 pubmed publisher
    ..Together, these findings reveal a novel transcriptional strategy for spatially tuning the responsiveness of distinct neural progenitor groups to broadly distributed mitogenic signals in the embryonic environment. ..
  49. Kuwajima T, Soares C, Sitko A, Lefebvre V, Mason C. SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017;93:1110-1125.e5 pubmed publisher
    ..These data implicate SoxC transcription factors in the regulation of contralateral RGC differentiation and axon guidance. ..
  50. Shim S, Kwan K, Li M, Lefebvre V, Sestan N. Cis-regulatory control of corticospinal system development and evolution. Nature. 2012;486:74-9 pubmed publisher
    ..We find that SOX4 and SOX11 functionally compete with the repressor SOX5 in the transactivation of E4...
  51. Xu E, Krentz N, Tan S, Chow S, Tang M, Nian C, et al. SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models. Diabetologia. 2015;58:1013-23 pubmed publisher
    ..In conclusion, these studies position Sox4 temporally in the endocrine differentiation programme and provide a new target for improving in vitro differentiation of glucose-responsive pancreatic beta cells. ..
  52. Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan S, et al. LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J Neurosci. 2017;37:194-203 pubmed publisher
    ..deep layer neurogenesis, we show that transcription factor LHX2 binds to distal regulatory elements of Fezf2 and Sox11, critical determinants of neuron subtype identity in the mouse neocortex...
  53. Paul M, Harvey R, Wegner M, Sock E. Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types. Cell Mol Life Sci. 2014;71:2931-45 pubmed publisher
    ..Here we assess the contribution of the closely related high-mobility-group transcription factors Sox4 and Sox11 to outflow tract development and determine their function...
  54. Chang K, Hertz J, Zhang X, Jin X, Shaw P, Derosa B, et al. Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development. J Neurosci. 2017;37:4967-4981 pubmed publisher
    ..cell (RGC) fate in the developing retina? Here we report on mechanisms by which a molecular pathway involving Sox4/Sox11 is required for RGC differentiation and for optic nerve formation in mice in vivo, and is sufficient to ..
  55. Sun Y, Wang Y, Hu Y, Chen G, Ma H. Comparative analysis of neural transcriptomes and functional implication of unannotated intronic expression. BMC Genomics. 2011;12:494 pubmed publisher
    ..Our findings provide new insights into potentially novel genes, gene functions and regulatory mechanisms in early brain development. ..
  56. Wang Z, Reynolds A, Kirry A, Nienhaus C, Blackmore M. Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery. J Neurosci. 2015;35:3139-45 pubmed publisher
    ..b>Sox11 is a transcription factor whose expression is common to a many types of regenerating neurons, but it is unknown ..
  57. Tanabe K, Bonilla I, Winkles J, Strittmatter S. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J Neurosci. 2003;23:9675-86 pubmed
    ..Dozens of genes are differentially expressed after sciatic nerve injury by microarray analysis. Induction of SOX11, FLRT3, myosin-X, and fibroblast growth factor-inducible-14 (Fn14) mRNA in axotomized DRG neurons was verified by ..
  58. Li Y, Wang J, Zheng Y, Zhao Y, Guo M, Li Y, et al. Sox11 modulates neocortical development by regulating the proliferation and neuronal differentiation of cortical intermediate precursors. Acta Biochim Biophys Sin (Shanghai). 2012;44:660-8 pubmed publisher
    ..b>Sox11, one of SoxC family members, has been reported to be essential for embryonic and adult neurogenesis...
  59. Cameron T, Belluoccio D, Farlie P, Brachvogel B, Bateman J. Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20 pubmed publisher
    ..was validated by quantitative PCR for Agc1, Bmp8a, Col2a1, Fgfr4, Foxa3, Gdf5, Klf2, Klf4, Lepre1, Ncad, Sox11, and Trpv4...
  60. Mukhopadhyay P, Brock G, Webb C, Pisano M, Greene R. Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol. 2012;94:162-75 pubmed publisher
  61. Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung U, et al. SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol. 2013;13:4 pubmed publisher
    ..In this study, we focused on SOX11, and its contribution to the regulation of GDF5, a secreted signal necessary for proper joint formation and ..
  62. Choi M, Seong I, Kang S, Kim J. Down-regulation of Sox11 is required for efficient osteogenic differentiation of adipose-derived stem cells. Mol Cells. 2014;37:337-44 pubmed publisher
    ..a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process...
  63. Chen C, Lee G, Pourmorady A, Sock E, Donoghue M. Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes. J Neurosci. 2015;35:10629-42 pubmed publisher
    ..In several neural systems, the SoxC transcriptional regulators, particularly Sox11 and Sox4, have been characterized as functioning exclusively and redundantly in promoting neuronal differentiation...
  64. Murugan S, Shan J, Kühl S, Tata A, Pietilä I, Kuhl M, et al. WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. Exp Cell Res. 2012;318:1134-45 pubmed publisher
    ..We addressed the upstream regulators of the Wnt4 gene and describe here the transcription factors WT1 and Sox11 as candidate molecules in the control of gene expression...
  65. Sone M, Hayashi T, Tarui H, Agata K, Takeichi M, Nakagawa S. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci. 2007;120:2498-506 pubmed
    ..We propose that Gomafu RNA represents a novel family of mRNA-like noncoding RNA that constitutes a cell-type-specific component of the nuclear matrix. ..
  66. Salerno K, Jing X, Diges C, Davis B, Albers K. TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11. Neuroscience. 2013;231:28-37 pubmed publisher
    ..this goal we found that nerve injury induces a rapid and significant up-regulation of the transcription factor Sox11 in dorsal root ganglia (DRG) neurons...
  67. Usui A, Iwagawa T, Mochizuki Y, Iida A, Wegner M, Murakami A, et al. Expression of Sox4 and Sox11 is regulated by multiple mechanisms during retinal development. FEBS Lett. 2013;587:358-63 pubmed publisher
    b>Sox11 and Sox4 play critical roles in retinal development, during which they display specific and unique expression patterns...