Sort1

Summary

Gene Symbol: Sort1
Description: sortilin 1
Alias: 2900053A11Rik, AI852375, Ntr3, Ntsr3, sortilin, mNTR3, neurotensin receptor 3
Species: mouse
Products:     Sort1

Top Publications

  1. Shi J, Kandror K. The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles. J Biol Chem. 2007;282:9008-16 pubmed
    ..To test this hypothesis, we have studied targeting of sortilin, one of the major IRV constituents...
  2. Jansen P, Giehl K, Nyengaard J, Teng K, Lioubinski O, Sjoegaard S, et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci. 2007;10:1449-57 pubmed
    ..and p75 neurotrophin receptor (p75(NTR)), pro-neurotrophins induce apoptosis in cultured neurons by engaging sortilin and p75(NTR) in a death-signaling receptor complex...
  3. Strong A, Ding Q, Edmondson A, Millar J, Sachs K, Li X, et al. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J Clin Invest. 2012;122:2807-16 pubmed publisher
    ..infarction, reduced plasma levels of LDL cholesterol (LDL-C), and markedly increased expression of the gene sortilin-1 (SORT1) in liver...
  4. Kim J, Kandror K. The first luminal loop confers insulin responsiveness to glucose transporter 4. Mol Biol Cell. 2012;23:910-7 pubmed publisher
    ..The faithful targeting of the chimera depends on the expression of the sorting receptor sortilin, which interacts with the unique amino acid residues in the first luminal loop of GLUT4...
  5. Musunuru K, Strong A, Frank Kamenetsky M, Lee N, Ahfeldt T, Sachs K, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466:714-9 pubmed publisher
    ..C/EBP (CCAAT/enhancer binding protein) transcription factor binding site and alters the hepatic expression of the SORT1 gene...
  6. Gustafsen C, Kjolby M, Nyegaard M, Mattheisen M, Lundhede J, Buttenschøn H, et al. The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion. Cell Metab. 2014;19:310-8 pubmed publisher
    ..We here identify sortilin, encoded by the hypercholesterolemia-risk gene SORT1, as a high-affinity sorting receptor for PCSK9...
  7. Prudencio M, Jansen West K, Lee W, Gendron T, Zhang Y, Xu Y, et al. Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proc Natl Acad Sci U S A. 2012;109:21510-5 pubmed publisher
    b>Sortilin 1 regulates the levels of brain progranulin (PGRN), a neurotrophic growth factor that, when deficient, is linked to cases of frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43)-positive inclusions (FTLD-TDP)..
  8. Dicou E, Vincent J, Mazella J. Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line. J Neurosci Res. 2004;78:92-9 pubmed
    We show that the type I neurotensin receptor-3 (also called sortilin) is the only known neurotensin receptor expressed in a murine microglial cell line and that its activation leads to phosphorylation of both extracellular signaling-..
  9. Hu F, Padukkavidana T, Vægter C, Brady O, Zheng Y, Mackenzie I, et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010;68:654-67 pubmed publisher
    ..PGRN binds to cortical neurons via its C terminus, and unbiased expression cloning identifies Sortilin (Sort1) as a binding site. Sort1?/? neurons exhibit reduced PGRN binding...

More Information

Publications73

  1. Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
    ..The mechanism responsible for this trafficking remains poorly understood. Here we show that the sorting receptor sortilin interacts with TrkA, TrkB and TrkC and enables their anterograde axonal transport, thereby enhancing neurotrophin ..
  2. Kjolby M, Andersen O, Breiderhoff T, Fjorback A, Pedersen K, Madsen P, et al. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab. 2010;12:213-23 pubmed publisher
    ..3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100...
  3. Morris N, Ross S, Lane W, Moestrup S, Petersen C, Keller S, et al. Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. J Biol Chem. 1998;273:3582-7 pubmed
    ..This revealed that the protein is sortilin, a novel membrane protein that was cloned in another context from a human source while this work was in progress...
  4. Carlo A, Gustafsen C, Mastrobuoni G, Nielsen M, Burgert T, Hartl D, et al. The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-? peptide in the brain. J Neurosci. 2013;33:358-70 pubmed publisher
    ..Here, we identified the pro-neurotrophin receptor sortilin as major endocytic pathway for clearance of APOE/A? complexes in neurons. Sortilin binds APOE with high affinity...
  5. Gustafsen C, Glerup S, Pallesen L, Olsen D, Andersen O, Nykjær A, et al. Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor protein. J Neurosci. 2013;33:64-71 pubmed publisher
    ..We here identify sortilin as a novel APP interaction partner...
  6. Tauris J, Gustafsen C, Christensen E, Jansen P, Nykjaer A, Nyengaard J, et al. Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons. Eur J Neurosci. 2011;33:622-31 pubmed publisher
    ..its mature counterpart as it induces neuronal apoptosis through activation of a p75 NT receptor (p75(NTR) ) and Sortilin death-signalling complex...
  7. Kaddai V, Jager J, Gonzalez T, Najem Lendom R, Bonnafous S, Tran A, et al. Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabetologia. 2009;52:932-40 pubmed publisher
    ..b>Sortilin mRNA and protein were downregulated in adipose tissue from obese db/db and ob/ob mice, and also in muscle...
  8. Nielsen M, Jacobsen C, Olivecrona G, Gliemann J, Petersen C. Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem. 1999;274:8832-6 pubmed
    ..We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin/neurotensin receptor-3...
  9. Gass J, Lee W, Cook C, Finch N, Stetler C, Jansen West K, et al. Progranulin regulates neuronal outgrowth independent of sortilin. Mol Neurodegener. 2012;7:33 pubmed publisher
    ..In light of recent reports suggesting PGRN functions as a protective neurotrophic factor and that sortilin (SORT1) is a neuronal receptor for PGRN, we used a Sort1-deficient (Sort1-/-) murine primary hippocampal neuron ..
  10. Shi J, Kandror K. Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes. Dev Cell. 2005;9:99-108 pubmed
    ..Here, we report that GSVs are formed in differentiating 3T3-L1 adipocytes upon induction of sortilin on day 2 of differentiation...
  11. Botta R, Lisi S, Pinchera A, Giorgi F, Marcocci C, Taddei A, et al. Sortilin is a putative postendocytic receptor of thyroglobulin. Endocrinology. 2009;150:509-18 pubmed publisher
    The Vps10p family member sortilin is involved in various cell processes, including protein trafficking...
  12. Lebrun Julien F, Bertrand M, De Backer O, Stellwagen D, Morales C, Di Polo A, et al. ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway. Proc Natl Acad Sci U S A. 2010;107:3817-22 pubmed publisher
    ..Mice rendered null for p75(NTR), its coreceptor sortilin, or the adaptor protein NRAGE were defective in proNGF-induced glial TNFalpha production and did not undergo ..
  13. Ariga M, Nedachi T, Katagiri H, Kanzaki M. Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes. J Biol Chem. 2008;283:10208-20 pubmed publisher
    b>Sortilin has been implicated in the formation of insulin-responsive GLUT4 storage vesicles in adipocytes by regulating sorting events between the trans-Golgi-network and endosomes...
  14. Ruan C, Yang C, Li J, Luo H, Bobrovskaya L, Zhou X. Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior. Exp Neurol. 2016;281:99-108 pubmed publisher
    ..P75(NTR) and sortilin are co-receptors of proBDNF, however, the role of these receptors in mood regulation is not established...
  15. Li J, Matye D, Wang Y, Li T. Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett. 2017;591:1018-1028 pubmed publisher
    b>Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the regulation of plasma cholesterol in humans and mice...
  16. Zhou X, Sun L, Bastos de Oliveira F, Qi X, Brown W, Smolka M, et al. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. J Cell Biol. 2015;210:991-1002 pubmed publisher
    ..pathway is independent of, but complementary to, the previously identified PGRN lysosomal trafficking mediated by sortilin. Collectively, our results provide new understanding on PGRN trafficking and shed light on the molecular ..
  17. Boggild S, Molgaard S, Glerup S, Nyengaard J. Spatiotemporal patterns of sortilin and SorCS2 localization during organ development. BMC Cell Biol. 2016;17:8 pubmed publisher
    b>Sortilin and SorCS2 are part of the Vps10p receptor family...
  18. Gürgör P, Pallesen L, Johnsen L, Ulrichsen M, de Jong I, Vaegter C. Neuronal death in the dorsal root ganglion after sciatic nerve injury does not depend on sortilin. Neuroscience. 2016;319:1-8 pubmed publisher
    ..studies have suggested the involvement of the neurotrophin receptors p75 neurotrophin receptor (p75(NTR)) and sortilin, proposing that sensory neuron subpopulations undergo proneurotrophin-induced apoptosis in a similar manner to ..
  19. Pirault J, Polyzos K, Petri M, Ketelhuth D, Bäck M, Hansson G. The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway. Eur J Immunol. 2017;47:1918-1924 pubmed publisher
    b>Sortilin-1, a receptor of the VPS10p family, has been associated with cardiovascular disease in genome-wide association studies...
  20. Siao C, Lorentz C, Kermani P, Marinic T, Carter J, McGrath K, et al. ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. J Exp Med. 2012;209:2291-305 pubmed publisher
    ..ProNGF activates p75 neurotrophin receptor (p75(NTR)) and sortilin receptors to mediate proapoptotic responses...
  21. Kim E, Lee Y, Lee H, Kim J, Song B, Huh J, et al. Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem Biophys Res Commun. 2010;403:167-71 pubmed publisher
    ..Relatively, the amount of sortilin was increased approximately 20% in the Vps26b-deficient mice, whereas the sorLA was normal...
  22. Beaton N, Rudigier C, Moest H, Müller S, Mrosek N, Röder E, et al. TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Mol Metab. 2015;4:795-810 pubmed publisher
  23. Bi L, Chiang J, Ding W, Dunn W, Roberts B, Li T. Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J Lipid Res. 2013;54:2754-62 pubmed publisher
    ..Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma ..
  24. Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, et al. ?1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci. 2014;127:3477-87 pubmed publisher
    Here, we describe altered sorting of sortilin in adipocytes deficient for the ?1B-containing AP-1 complex, leading to the inhibition of adipogenesis. The AP-1 complex mediates protein sorting between the trans-Golgi network and endosomes...
  25. Xiang J, Yang H, Zhao T, Sun M, Xu X, Zhou X, et al. Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. J Clin Invest. 2014;124:85-98 pubmed publisher
    ..HAP1 stabilized the association of TRKB with the intracellular sorting protein sortilin, prevented TRKB degradation, and promoted its anterograde transport...
  26. Goettsch C, Hutcheson J, Aikawa M, Iwata H, Pham T, Nykjaer A, et al. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016;126:1323-36 pubmed publisher
    ..Here, we have demonstrated that sortilin is a key regulator of smooth muscle cell (SMC) calcification via its recruitment to extracellular vesicles...
  27. Zeng J, Racicott J, Morales C. The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. Exp Cell Res. 2009;315:3112-24 pubmed publisher
    ..We have identified a novel sorting receptor, sortilin, which is involved in the lysosomal trafficking of the sphingolipid activator proteins, prosaposin and GM(2)AP, ..
  28. Vincent J, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol Sci. 1999;20:302-9 pubmed
    ..receptors, whereas the third one is an entirely new type of neuropeptide receptor and is identical to gp95/sortilin, a 100 kDa-protein with a single transmembrane domain...
  29. Kim T, Hempstead B. NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. EMBO J. 2009;28:1612-23 pubmed publisher
    Proneurotrophins mediate neuronal apoptosis using a dual receptor complex of sortilin and p75(NTR)...
  30. Kim J, Weiss H, Evers B. Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells. Int J Oncol. 2017;50:2200-2206 pubmed publisher
    ..We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined...
  31. Bose A, Guilherme A, Robida S, Nicoloro S, Zhou Q, Jiang Z, et al. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002;420:821-4 pubmed
    ..Thus, myosin Myo1c functions in a PI(3)K-independent insulin signalling pathway that controls the movement of intracellular GLUT4-containing vesicles to the plasma membrane. ..
  32. Hashiramoto M, James D. Characterization of insulin-responsive GLUT4 storage vesicles isolated from 3T3-L1 adipocytes. Mol Cell Biol. 2000;20:416-27 pubmed
    ..and Rab4, and peak 2a was enriched in TGN markers (syntaxin 6, the cation-dependent mannose 6-phosphate receptor, sortilin, and sialyltransferase)...
  33. Reuter E, Weber J, Paterka M, Ploen R, Breiderhoff T, van Horssen J, et al. Role of Sortilin in Models of Autoimmune Neuroinflammation. J Immunol. 2015;195:5762-9 pubmed publisher
    The proneurotrophin receptor sortilin is a protein with dual functions, being involved in intracellular protein transport, as well as cellular signal transduction...
  34. Mohagheghi F, Prudencio M, Stuani C, Cook C, Jansen West K, Dickson D, et al. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. Hum Mol Genet. 2016;25:534-45 pubmed publisher
    ..into the complexity of the RNA-binding protein network by demonstrating that the inclusion of exon 17b in the SORT1 mRNA, a pathologically relevant splicing event known to be regulated by TDP-43, is also considerably affected by ..
  35. Patel K, Strong A, Tohyama J, Jin X, Morales C, Billheimer J, et al. Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res. 2015;116:789-96 pubmed publisher
    ..SORT1 encodes a protein called sortilin, and hepatic sortilin modulates LDL metabolism by targeting apolipoprotein B-containing lipoproteins to the ..
  36. Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, et al. Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival. Genes Dev. 2012;26:816-29 pubmed publisher
    ..Our findings therefore indicate that Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness. ..
  37. Li J, Wang Y, Matye D, Chavan H, Krishnamurthy P, Li F, et al. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem. 2017;292:146-160 pubmed publisher
    ..b>Sortilin 1 (SORT1) is a lysosomal trafficking receptor that was identified by genome-wide association studies (GWAS) as a ..
  38. Glerup S, Olsen D, Vaegter C, Gustafsen C, Sjoegaard S, Hermey G, et al. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014;82:1074-87 pubmed publisher
    ..In conclusion, we have demonstrated that two-chain processing of SorCS2 enables neurons and glia to respond differently to proneurotrophins. ..
  39. Hubel E, Saroha A, Park W, Pewzner Jung Y, Lavoie E, Futerman A, et al. Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury. Am J Pathol. 2017;187:122-133 pubmed publisher
    b>Sortilin, a member of the vacuolar protein sorting 10 domain receptor family, traffics newly synthesized proteins from the trans-Golgi network to secretory pathways, endosomes, and cell surface...
  40. Ruan C, Liu J, Yang M, Saadipour K, Zeng Y, Liao H, et al. Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP. Exp Neurol. 2018;299:75-85 pubmed publisher
    ..b>Sortilin (encoded by the gene Sort1) is a vacuolar protein sorting 10 protein domain-containing receptor, which is up-..
  41. Driessen T, Zhao C, Whittlinger A, Williams H, Gammie S. Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice. PLoS ONE. 2014;9:e83098 pubmed publisher
    ..In the medial preoptic area (MPOA), which is critical for maternal behaviors, mRNA of NT and NT receptor 3 (Sort1) were significantly up-regulated in postpartum mice compared to virgins...
  42. Huang G, Buckler Pena D, Nauta T, Singh M, Asmar A, Shi J, et al. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell. 2013;24:3115-22 pubmed publisher
    ..Coexpression of sortilin increased targeting of myc7-Glut4 to the IRVs, and its insulin responsiveness rose to the maximal levels observed ..
  43. Capsoni S, Amato G, Vignone D, Criscuolo C, Nykjaer A, Cattaneo A. Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation. Biochem Biophys Res Commun. 2013;431:579-85 pubmed publisher
    b>Sortilin is a member of the family of vacuolar protein sorting 10 protein domain receptors which has emerged as a co-receptor in cell death and neurodegeneration processes mediated by proneurotrophins...
  44. Mazella J, Petrault O, Lucas G, Deval E, Béraud Dufour S, Gandin C, et al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010;8:e1000355 pubmed publisher
    ..effects of spadin, a secreted peptide derived from the propeptide generated by the maturation of the neurotensin receptor 3 (NTSR3/Sortilin) and acting through TREK-1 inhibition...
  45. Wähe A, Kasmapour B, Schmaderer C, Liebl D, Sandhoff K, Nykjaer A, et al. Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin. J Cell Sci. 2010;123:2502-11 pubmed publisher
    Sortilin, also known as neurotensin receptor 3 (NTR3), is a transmembrane protein with a dual function...
  46. Lee W, Almeida S, Prudencio M, Caulfield T, Zhang Y, Tay W, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014;23:1467-78 pubmed publisher
    ..Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocytosis and a determinant of plasma PGRN levels portend the ..
  47. Seaman M. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol. 2004;165:111-22 pubmed
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin. ..
  48. Zeng J, Hassan A, Morales C. Study of the mouse sortilin gene: Effects of its transient silencing by RNA interference in TM4 Sertoli cells. Mol Reprod Dev. 2004;68:469-75 pubmed
    Using databases of the mouse genome in combination with a sequence deduced from a mouse sortilin cDNA originated in our laboratory, we found the sortilin gene to map to a region of chromosome 3...
  49. Hassan A, Zeng J, Ni X, Morales C. The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins. Mol Reprod Dev. 2004;68:476-83 pubmed
    ..cell line, we tested the hypothesis that prosaposin and GM2AP are targeted to the lysosomal compartment via the sortilin receptor, which has been recently shown to have a GGA binding motif...
  50. Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, et al. Glucose deprivation attenuates sortilin levels in skeletal muscle cells. Endocr J. 2017;64:255-268 pubmed publisher
    In skeletal muscle, sortilin plays a predominant role in the sorting of glucose transporter 4 (Glut4), thereby controlling glucose uptake...
  51. Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, et al. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A. 2008;105:7327-32 pubmed publisher
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis. ..
  52. Ai D, Baez J, Jiang H, Conlon D, Hernandez Ono A, Frank Kamenetsky M, et al. Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J Clin Invest. 2012;122:1677-87 pubmed publisher
    ..The SNPs are also associated with altered expression of hepatic sortilin-1 (SORT1), which encodes a protein thought to be involved in apoB trafficking and degradation...
  53. Yabe Wada T, Matsuba S, Takeda K, Sato T, Suyama M, Ohkawa Y, et al. TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin. Sci Rep. 2016;6:26566 pubmed publisher
    ..Here we report that the sorting receptor sortilin plays a key role in cytokine production...
  54. Hivelin C, Mazella J, Coppola T. Sortilin derived propeptide regulation during adipocyte differentiation and inflammation. Biochem Biophys Res Commun. 2017;482:87-92 pubmed publisher
    In this work, we aimed to correlate the expression of sortilin with the production of sortilin-derived propeptide (PE) during adipocyte differentiation, insulin resistance and inflammation...
  55. Santos A, López Sánchez N, Martín Oliva D, de la Villa P, Cuadros M, Frade J. Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS ONE. 2012;7:e36243 pubmed publisher
    ..ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR) co-receptor, suggesting that sortilin may participate in the photoreceptor degeneration ..
  56. Wagner N, Morrison H, Pagnotta S, Michiels J, Schwab Y, Tryggvason K, et al. The podocyte protein nephrin is required for cardiac vessel formation. Hum Mol Genet. 2011;20:2182-94 pubmed publisher
    ..Taken together, our data demonstrate that nephrin directly interacts with p75NTR and reveal an important role for nephrin in murine cardiac development by permitting survival of cardiovascular progenitor cells. ..
  57. Yang M, Virassamy B, Vijayaraj S, Lim Y, Saadipour K, Wang Y, et al. The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking. PLoS ONE. 2013;8:e63049 pubmed publisher
    ..To determine the interaction between sortilin and APP and the effect of sortilin on APP trafficking and processing, we studied the binding site and its ..
  58. Love K, Mahon K, Levins C, Whitehead K, Querbes W, Dorkin J, et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A. 2010;107:1864-9 pubmed publisher
    ..03 mg/kg. To our knowledge, this formulation facilitates gene silencing at orders-of-magnitude lower doses than required by any previously described siRNA liver delivery system. ..
  59. Orho Melander M. Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention. J Intern Med. 2015;278:433-46 pubmed publisher
    ..Together, these genetic findings are beginning to lead to promising new drug targets and novel interventional strategies and thus have great potential to improve prevention, prediction and therapy of CHD. ..
  60. Mortensen M, Kjolby M, Gunnersen S, Larsen J, Palmfeldt J, Falk E, et al. Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. J Clin Invest. 2014;124:5317-22 pubmed publisher
    ..3 and coronary artery disease. The gene encoding sortilin (SORT1) has been implicated as the causative gene within the locus, as sortilin regulates hepatic lipoprotein ..
  61. Hermans Borgmeyer I, Hermey G, Nykjaer A, Schaller C. Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Brain Res Mol Brain Res. 1999;65:216-9 pubmed
    Recently, sortilin a non G-protein-coupled receptor has been identified as the 100-kDa neurotensin receptor. In this paper we describe the expression of its gene during mouse embryonal development...
  62. Campbell C, Beug S, Nickerson P, Peng J, Mazerolle C, Bassett E, et al. Sortilin regulates sorting and secretion of Sonic hedgehog. J Cell Sci. 2016;129:3832-3844 pubmed
    ..We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor...
  63. Tsuchiya Y, Hatakeyama H, Emoto N, Wagatsuma F, Matsushita S, Kanzaki M. Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes. J Biol Chem. 2010;285:34371-81 pubmed publisher
    ..We herein demonstrate that palmitate induces down-regulation of sortilin, a sorting receptor implicated in the formation of insulin-responsive GLUT4 vesicles, via mechanisms involving ..
  64. Li J, Matye D, Li T. Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice. J Biol Chem. 2015;290:11526-36 pubmed publisher
    ..The cellular trafficking receptor sortilin 1 (Sort1) was recently identified to transport apoB100 to the lysosome for degradation in the liver and thus ..