Sorbs3

Summary

Gene Symbol: Sorbs3
Description: sorbin and SH3 domain containing 3
Alias: SCAM-1, SH3P3, Sh3d4, vinexin-g, vinexin, SH3 domain protein 4, SH3 domain-containing protein SH3P3, SH3-containing adapter molecule 1, vinexin alpha, vinexin beta
Species: mouse
Products:     Sorbs3

Top Publications

  1. Sparks A, Hoffman N, McConnell S, Fowlkes D, Kay B. Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996;14:741-4 pubmed
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs. ..
  2. Nagasato A, Yamashita H, Matsuo M, Ueda K, Kioka N. The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix. Biosci Biotechnol Biochem. 2017;81:1136-1147 pubmed publisher
    ..Our previous study has shown that the interaction of the focal adhesion protein vinculin with vinexin ? plays a critical role in sensing ECM stiffness and regulating stiffness-dependent cell migration...
  3. Umemoto T, Tanaka K, Ueda K, Kioka N. Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin. Biochem Biophys Res Commun. 2009;387:191-5 pubmed publisher
    ..Here, we report the tyrosine phosphorylation of vinexin alpha in v-Src-transformed NIH3T3 cells...
  4. Umemoto T, Inomoto T, Ueda K, Hamaguchi M, Kioka N. v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin. Cancer Lett. 2009;279:22-9 pubmed publisher
    Expression of focal adhesion protein vinexin is reported to be altered in several cancer tissues; however, the mechanism of expressional change in vinexin is not known...
  5. Takahashi H, Mitsushima M, Okada N, Ito T, Aizawa S, Akahane R, et al. Role of interaction with vinculin in recruitment of vinexins to focal adhesions. Biochem Biophys Res Commun. 2005;336:239-46 pubmed
    ..We also show that the interaction with vinculin is necessary for the efficient localization of vinexin alpha and beta at focal adhesions...
  6. Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, et al. A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005;10:421-34 pubmed
    ..In the present study, we identified a novel isoform of Vinexin, which is expressed in somatic cells but not germ cells of sexually indifferent stages of fetal gonads...
  7. Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, et al. The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. Exp Cell Res. 2004;298:239-48 pubmed
    ..We identified the cytoskeletal molecule vinexin as a partner interacting with SOCS-7...
  8. Wakabayashi M, Ito T, Mitsushima M, Aizawa S, Ueda K, Amachi T, et al. Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. J Biol Chem. 2003;278:21709-14 pubmed
    b>Vinexin is a recently identified cytoskeletal protein and plays a key role in the regulation of cytoskeletal organization and signal transduction...
  9. Bour G, Plassat J, Bauer A, Lalevée S, Rochette Egly C. Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. J Biol Chem. 2005;280:17027-37 pubmed
    ..Here, using a yeast two-hybrid system, we report the isolation of vinexin beta as a new cofactor that interacts with the N-terminal A/B domain of the RARgamma isotype...

Scientific Experts

More Information

Publications21

  1. Guan H, Cheng W, Guo J, Chao M, Zhang Y, Gong J, et al. Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis. J Am Heart Assoc. 2017;6: pubmed publisher
    b>Vinexin β is a novel adaptor protein that regulates cellular adhesion, cytoskeletal reorganization, signal transduction, and transcription; however, the exact role that vinexin β plays in atherosclerosis remains unknown...
  2. Suwa A, Mitsushima M, Ito T, Akamatsu M, Ueda K, Amachi T, et al. Vinexin beta regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor. J Biol Chem. 2002;277:13053-8 pubmed
    ..Here, we show that exogenous expression of vinexin beta, a novel focal adhesion protein, allows anchorage-independent ERK2 activation stimulated by epidermal growth ..
  3. Li M, Guo S, Zhang P, Gong J, Zheng A, Zhang Y, et al. Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. J Neurochem. 2015;134:211-21 pubmed publisher
    b>Vinexin-β is an adaptor protein that regulates cell adhesion, cytoskeletal organization and signal transduction. Our previous work showed that Vinexin-β protects against cardiac hypertrophy...
  4. Kawauchi T, Ikeya M, Takada S, Ueda K, Shirai M, Takihara Y, et al. Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal. Mech Dev. 2001;106:147-50 pubmed
    ..Using whole-mount in situ hybridization, we showed here that expression of vinexin alpha, the longer vinexin transcript, is strictly regulated, although the shorter transcript, vinexin beta, is ..
  5. Williams J, Kondo N, Okabe T, Takeshita N, Pilchak D, Koyama E, et al. Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol. 2009;328:315-27 pubmed publisher
    ..Since aggrecan is critical for growth plate function, its deficiency in RAR-mutant mice is likely to have contributed directly to their growth retardation. ..
  6. Liu X, Wan N, Zhang X, Zhao Y, Zhang Y, Hu G, et al. Vinexin-β exacerbates cardiac dysfunction post-myocardial infarction via mediating apoptotic and inflammatory responses. Clin Sci (Lond). 2015;128:923-36 pubmed publisher
    b>Vinexin-β is one of the adaptor proteins that are primarily involved in signal transduction and cytoskeletal organization under various pathological conditions, including cardiac hypertrophy...
  7. Lalevée S, Bour G, Quinternet M, Samarut E, Kessler P, Vitorino M, et al. Vinexinß, an atypical "sensor" of retinoic acid receptor gamma signaling: union and sequestration, separation, and phosphorylation. FASEB J. 2010;24:4523-34 pubmed publisher
    ..we determined that the N-terminal domain (NTD) also plays a role through its phosphorylation, and we isolated vinexin?, a cytoskeleton protein with three SH3 domains, as a new partner of the RAR? NTD...
  8. Paternotte N, Zhang J, Vandenbroere I, Backers K, Blero D, Kioka N, et al. SHIP2 interaction with the cytoskeletal protein Vinexin. FEBS J. 2005;272:6052-66 pubmed
    ..In addition, we showed the colocalization between Vinexin alpha and SHIP2 at the periphery of transfected COS-7 cells...
  9. Kioka N, Ito T, Yamashita H, Uekawa N, Umemoto T, Motoyoshi S, et al. Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. Exp Cell Res. 2010;316:1728-38 pubmed publisher
    In the process of tissue injury and repair, epithelial cells rapidly migrate and form epithelial sheets. Vinexin is a cytoplasmic molecule of the integrin-containing cell adhesion complex localized at focal contacts in vitro...
  10. Paz M, López Casas P, Mazo J. Changes in vinexin expression patterns in the mouse testis induced by developmental exposure to 17beta-estradiol. Biol Reprod. 2007;77:605-13 pubmed
    ..We found that the testicular vinexin (sorbin and SH3 domain-containing protein 3, encoded by the Sorbs3 gene) pattern underwent significant changes ..
  11. Mitsushima M, Suwa A, Amachi T, Ueda K, Kioka N. Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. J Biol Chem. 2004;279:34570-7 pubmed
    ..Site-directed mutagenesis revealed that ERK2 mainly phosphorylated the serine 189 residue of vinexin beta. Furthermore, vinexin beta interacted with ERK1/2 both in vitro and in vivo...
  12. Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama S, Okazaki K, et al. Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. J Cell Biol. 1999;144:59-69 pubmed
    ..full-length cDNA clones and sequencing indicated that the two mRNA encode 82- and 37-kD polypeptides termed vinexin alpha and beta, respectively...