Gene Symbol: Sorbs2
Description: sorbin and SH3 domain containing 2
Alias: 2010203O03Rik, 9430041O17Rik, A530071H08, Argbp2, mKIAA0777, nArgBP2, sorbin and SH3 domain-containing protein 2, Arg/Abl-binding protein 2, Arg/Abl-interacting protein ArgBP2, arg-binding protein 2, arg/Abl-interacting protein 2
Species: mouse
Products:     Sorbs2

Top Publications

  1. Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, et al. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Biochem Biophys Res Commun. 2007;355:47-53 pubmed
    ..5-10.5. Based on our results, we consider that the present profiling method may be useful to identify novel genes important for cardiac development. ..
  2. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..contained sorbin, a polypeptide of 153 amino acids present in SH3 domain-containing adaptor proteins, such as SORBS2. This interaction was also assessed by Western blot on immunoprecipitate from mouse embryo or H1355 cell lysates ..
  3. Fouillade C, Baron Menguy C, Domenga Denier V, Thibault C, Takamiya K, Huganir R, et al. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013;33:76-86 pubmed publisher
    ..Notch3-regulated transcriptome provides potential for modulating myogenic response in the cerebrovasculature. ..
  4. Wang H, Bei Y, Shen S, Huang P, Shi J, Zhang J, et al. miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2. J Mol Cell Cardiol. 2016;94:43-53 pubmed publisher
    ..Meanwhile, our data showed that SH3 domain-containing protein 2 (SORBS2) was inversely correlated with miR-21-3p expression level in mice hearts, and was repressed in hearts challenged ..
  5. Sanger J, Wang J, Gleason L, Chowrashi P, Dube D, Mittal B, et al. Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules. Cytoskeleton (Hoboken). 2010;67:808-23 pubmed publisher
    b>ArgBP2 (Arg/Abl-Binding Protein) is expressed at high levels in the heart and is localized in the Z-bands of mature myofibrils...
  6. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011;359:163-75 pubmed publisher
    ..As an initial step in this direction we describe a regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development. ..
  7. Zhang Q, Gao X, Li C, Feliciano C, Wang D, Zhou D, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36:2247-60 pubmed publisher
    ..kinase binding protein 2) protein in non-neuronal tissues and is alternatively spliced in the brain to encode nArgBP2 protein...
  8. Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, et al. A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005;10:421-34 pubmed
    ..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads. ..
  9. Hallock P, Chin S, Blais S, Neubert T, Glass D. Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Mol Cell Biol. 2016;36:262-70 pubmed publisher
    ..the roles of Crk/CrkL, we identified CrkL binding proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two functionally redundant proteins that associate with the initiating MuSK/Dok-7/Crk/CrkL complex, regulate ..

More Information


  1. Lee S, Chang S. nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders. BMB Rep. 2016;49:457-8 pubmed
    ..Neural Abelson-related gene-binding protein 2 (nArgBP2) was originally identified as a protein that interacts with SAPAP3 and Shank3...