Gene Symbol: Sorbs1
Description: sorbin and SH3 domain containing 1
Alias: 2310065E01Rik, 9530001P15Rik, CAP, SH3P12, Sh3d5, mKIAA1296, sorbin and SH3 domain-containing protein 1, SH3 domain protein 5, c-Cbl-associated protein, ponsin, sorbs1
Species: mouse
Products:     Sorbs1

Top Publications

  1. Ribon V, Printen J, Hoffman N, Kay B, Saltiel A. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998;18:872-9 pubmed
    ..Here we describe the isolation and the characterization of a novel protein that we termed CAP for c-Cbl-associated protein...
  2. Ribon V, Herrera R, Kay B, Saltiel A. A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. J Biol Chem. 1998;273:4073-80 pubmed
    c-Cbl-associated protein, CAP, was originally cloned from a 3T3-L1 adipocyte cDNA expression library using full-length c-Cbl as a bait...
  3. Chiang S, Baumann C, Kanzaki M, Thurmond D, Watson R, Neudauer C, et al. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature. 2001;410:944-8 pubmed
    ..tyrosine phosphorylation of Cbl, which is recruited to the insulin receptor by the adapter protein CAP. On phosphorylation, Cbl is translocated to lipid rafts...
  4. Sparks A, Hoffman N, McConnell S, Fowlkes D, Kay B. Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996;14:741-4 pubmed
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs. ..
  5. Baumann C, Ribon V, Kanzaki M, Thurmond D, Mora S, Shigematsu S, et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000;407:202-7 pubmed
    ..Cbl is recruited to the insulin receptor by interaction with the adapter protein CAP, through one of three adjacent SH3 domains in the carboxy terminus of CAP...
  6. Liu J, Kimura A, Baumann C, Saltiel A. APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002;22:3599-609 pubmed
    ..APS also interacted directly with the c-Cbl-associated protein (CAP) and colocalized with the protein in cells...
  7. Limpert A, Karlo J, Landreth G. Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein. Mol Cell Biol. 2007;27:5686-98 pubmed intrinsic constituent of these membrane microdomains, via the adapter protein, c-Cbl associated protein (CAP)...
  8. Zhang M, Liu J, Cheng A, Deyoung S, Chen X, Dold L, et al. CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006;25:5284-93 pubmed
    CAP/Ponsin belongs to the SoHo family of adaptor molecules that includes ArgBP2 and Vinexin...
  9. Cowan C, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001;413:174-9 pubmed
    ..set of other proteins that are implicated in cytoskeletal regulation, including the Cbl-associated protein (CAP/ponsin), the Abl-interacting protein-1 (Abi-1), dynamin, PAK1, hnRNPK and axin...

More Information


  1. Tomasovic A, Traub S, Tikkanen R. Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS ONE. 2012;7:e29739 pubmed publisher
    ..We have here identified flotillin-1 and the cbl-associated protein/ponsin (CAP) as novel interaction partners of FRS2...
  2. Liu J, Wang T, Zhao M. Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda). 2016;6:2929-35 pubmed publisher
    ..The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1 (sorbin and SH3 domain containing 1)...
  3. Valaperti A, Nishii M, Liu Y, Yang H, Naito K, Liu P, et al. The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity. Basic Res Cardiol. 2014;109:411 pubmed publisher
    c-Cbl-associated protein (CAP), also called Sorbs1 or ponsin, has been described as an essential adapter protein in the insulin-signalling pathway. Here, we describe for the first time a unique protective role for CAP in viral myocarditis...
  4. Li D, Wang G, Shan M, Liu J, Wang L, Zhu D. [Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance]. Zhong Xi Yi Jie He Xue Bao. 2012;10:886-93 pubmed
    ..used to detect the effects of UA on expressions of adipocyte lipid binding protein (aP2), c-Cbl-associated protein (CAP) and matrix metalloproteinase-1 (MMP-1) in 3T3-L1 cells with insulin resistance...
  5. Gehmlich K, Hayess K, Legler C, Haebel S, van der Ven P, Ehler E, et al. Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells. Eur J Cell Biol. 2010;89:351-64 pubmed publisher
    ..The expression and localisation of the protein ponsin at cell-matrix contacts marks the establishment of costameres...
  6. Zhang M, Liu J, Cheng A, Deyoung S, Saltiel A. Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007;18:4731-40 pubmed
    Cbl-associated protein (CAP) is an adaptor protein that interacts with both signaling and cytoskeletal proteins. Here, we characterize the expression, localization and potential function of CAP in striated muscle...
  7. Lesniewski L, Hosch S, Neels J, De Luca C, Pashmforoush M, Lumeng C, et al. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007;13:455-62 pubmed
    ..positive role of Cap in glucose uptake, here we show that deletion of the gene encoding Cap (official gene name: Sorbs1) protects against high-fat diet (HFD)-induced insulin resistance in mice while also having an opposite, insulin-..
  8. Nunes S, Ferralli J, Choi K, Brown Luedi M, Minet A, Chiquet Ehrismann R. The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. Exp Cell Res. 2005;305:122-32 pubmed
    ..One of the proteins identified is the c-Cbl-associated protein CAP/ponsin, an adaptor protein containing SH3 domains...
  9. Alcazar O, Ho R, Fujii N, Goodyear L. cDNA cloning and functional characterization of a novel splice variant of c-Cbl-associated protein from mouse skeletal muscle. Biochem Biophys Res Commun. 2004;317:285-93 pubmed
    ..fragment encodes a peptide sequence that shows very high similarity with exon 25 of the human homologue of CAP (SORBS1)...
  10. Zhang M, Kimura A, Saltiel A. Cloning and characterization of Cbl-associated protein splicing isoforms. Mol Med. 2003;9:18-25 pubmed
    ..Alternative splicing of the gene SORBS1 results in multiple isoforms of CAP protein...
  11. Buck K, Rademacher B, Metten P, Crabbe J. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002;160:398-407 pubmed
    ..Syntenic homology between human and mouse chromosomes suggests that genes related to physical dependence on ethanol may localize to human chromosome regions 10q23-q26, 1q21-q43, 2q11-q32, 5p15/5q14-q21, and 9p24-p22. ..
  12. Mandai K, Nakanishi H, Satoh A, Takahashi K, Satoh K, Nishioka H, et al. Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. J Cell Biol. 1999;144:1001-17 pubmed
    ..Both the two variants had three Src homology 3 (SH3) domains and turned out to be splicing variants of SH3P12. The third proline-rich region of l-afadin bound to the region of ponsin containing the second and third SH3 ..
  13. Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, et al. A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005;10:421-34 pubmed
    ..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads. ..
  14. Liu J, Deyoung S, Hwang J, O Leary E, Saltiel A. The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003;278:36754-62 pubmed
    ..of glucose transport by insulin involves the tyrosine phosphorylation of c-Cbl and the translocation of the c-Cbl/CAP complex to lipid raft subdomains of the plasma membrane...
  15. Tosoni D, Cestra G. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. FEBS Lett. 2009;583:293-300 pubmed publisher
    CAP (c-Cbl associated protein)/ponsin belongs to a family of adaptor proteins implicated in cell adhesion and signaling. Here we show that CAP binds to and co-localizes with the essential endocytic factor dynamin...
  16. Hallock P, Chin S, Blais S, Neubert T, Glass D. Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation. Mol Cell Biol. 2016;36:262-70 pubmed publisher
    ..understand the roles of Crk/CrkL, we identified CrkL binding proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two functionally redundant proteins that associate with the initiating MuSK/Dok-7/Crk/CrkL complex, ..
  17. Hoffman N, Sparks A, Carter J, Kay B. Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries. Mol Divers. 1996;2:5-12 pubmed
  18. Vosseller K, Trinidad J, Chalkley R, Specht C, Thalhammer A, Lynn A, et al. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2006;5:923-34 pubmed
  19. Mitra P, Zheng X, Czech M. RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin. J Biol Chem. 2004;279:37431-5 pubmed
    ..of a PI 3-kinase-independent pathway leading to activation of the TC10 GTPase, the putative intermediates CAP, c-Cbl, Cbl-b, and CrkII were selectively depleted in 3T3-L1 adipocytes using highly efficient small interfering (..
  20. Xie J, Cai T, Zhang H, Lan M, Notkins A. The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. Genomics. 2002;80:54-61 pubmed
    ..that interacted with INSM1 by the yeast two-hybrid system and the binding of one of them, Cbl-associated protein (CAP), to INSM1 was confirmed by in vitro pull-down experiments, nuclear colocalization, and co-immunoprecipitation ..
  21. Chamberlain C, Ranum L. Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise. Hum Mol Genet. 2012;21:4645-54 pubmed publisher
    ..In summary, MBNL1 overexpression may be a valuable strategy for treating the skeletal muscle features of DM...
  22. Nedelko T, Kollmus H, Klawonn F, Spijker S, Lu L, Heßman M, et al. Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. BMC Genomics. 2012;13:411 pubmed publisher
    ..We highlight candidate genes in the respective intervals and review their possible biological function during infection. ..