Gene Symbol: Son
Description: Son DNA binding protein
Alias: 2900011L12Rik, AA409051, AU067731, C81487, mKIAA1019, nrebp, protein SON, NRE-binding protein, Son cell proliferation protein, negative regulatory element-binding protein
Species: mouse
Products:     Son

Top Publications

  1. Soteriou B, Fisher R, Khan I, Kessling A, Archard L, Buluwela L. Conserved gene sequences for species identification: PCR analysis of the 3' UTR of the SON gene distinguishes human and other mammalian DNAs. Forensic Sci Int. 1995;73:171-81 pubmed
    ..reaction (PCR) can be used on regions of highly conserved genes, such as the 3' untranslated region (3' UTR) of the SON gene, to identify the mammalian origin of a sample...
  2. Cheng S, Lutfalla G, Uze G, Chumakov I, Gardiner K. GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm Genome. 1993;4:338-42 pubmed
  3. Yu J, Farjo R, MacNee S, Baehr W, Stambolian D, Swaroop A. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Genome Biol. 2003;4:R65 pubmed
    ..Our studies present a large number of potentially interesting genes for biological investigation, and the annotated EST set provides a useful resource for microarray and functional genomic studies. ..
  4. Ahn E, Yan M, Malakhova O, Lo M, Boyapati A, Ommen H, et al. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Proc Natl Acad Sci U S A. 2008;105:17103-8 pubmed publisher
    ..Furthermore, we identified SON, a DNA/RNA-binding domain containing protein, as a novel NHR4-interacting protein...
  5. Kai N, Mishina M, Yagi T. Molecular cloning of Fyn-associated molecules in the mouse central nervous system. J Neurosci Res. 1997;48:407-24 pubmed
    ..Sequence analyses revealed that three of them are previously reported molecules, SON, tctex-1, and hnRNP K, and that two clones encode novel sequences...
  6. Wynn S, Fisher R, Pagel C, Price M, Liu Q, Khan I, et al. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Genomics. 2000;68:57-62 pubmed
    The SON gene, which maps to human chromosome 21q22.1-q22.2, encodes a novel regulatory protein. Here we describe the organization of the Son locus in the mouse genome. The mouse Son gene spans a region of approximately 35 kb...
  7. Cazalla D, Newton K, Caceres J. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005;25:2969-80 pubmed
    ..SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing. ..
  8. Komori T, Doi A, Furuta H, Wakao H, Nakao N, Nakazato M, et al. Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. J Biol Chem. 2010;285:37884-94 pubmed publisher
    ..One of the genes isolated was a mouse homolog of human negative regulatory element-binding protein (NREBP)...
  9. Ahn E, Higashi T, Yan M, Matsuura S, Hickey C, Lo M, et al. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster. J Biol Chem. 2013;288:5381-8 pubmed publisher
    b>SON is a DNA- and RNA-binding protein localized in nuclear speckles...

More Information


  1. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..