Gene Symbol: Sntb2
Description: syntrophin, basic 2
Alias: Snt2, beta-2-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 2, SNT3, SNTL, syntrophin-3
Species: mouse
Products:     Sntb2

Top Publications

  1. Adams M, Butler M, Dwyer T, Peters M, Murnane A, Froehner S. Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993;11:531-40 pubmed
    ..Syntrophin-2 mRNAs (2.2, 5.0, and 10 kb) are expressed in all mouse tissues examined. These patterns of expression suggest that syntrophin-1 and syntrophin-2 may associate with different members of the dystrophin family. ..
  2. Ahn A, Yoshida M, Anderson M, Feener C, Selig S, Hagiwara Y, et al. Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. Proc Natl Acad Sci U S A. 1994;91:4446-50 pubmed
    ..We have mapped the human basic component of A1 and EST25263 genes to chromosomes 8q23-24 and 16, respectively. ..
  3. Adams M, Dwyer T, Dowler L, White R, Froehner S. Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain. J Biol Chem. 1995;270:25859-65 pubmed
    ..The first pleckstrin homology domain is interrupted by a domain homologous to repeated sequences originally found in the Drosophila discs-large protein. ..
  4. Ahn A, Freener C, Gussoni E, Yoshida M, Ozawa E, Kunkel L. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem. 1996;271:2724-30 pubmed
  5. Gee S, Madhavan R, Levinson S, Caldwell J, Sealock R, Froehner S. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J Neurosci. 1998;18:128-37 pubmed
    ..Collectively, our data suggest that syntrophins link NaChs to the actin cytoskeleton and the extracellular matrix via dystrophin and the DAPC. ..
  6. Peters M, Adams M, Froehner S. Differential association of syntrophin pairs with the dystrophin complex. J Cell Biol. 1997;138:81-93 pubmed
    ..Since individual syntrophins do not have intrinsic binding specificity for dystrophin, dystrobrevin, or utrophin, the observed preferential pairing of syntrophins must depend on extrinsic regulatory mechanisms. ..
  7. Lumeng C, Phelps S, Crawford G, Walden P, Barald K, Chamberlain J. Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. Nat Neurosci. 1999;2:611-7 pubmed
    ..Our data suggest that MAST205 and SAST link the dystrophin/utrophin network with microtubule filaments via the syntrophins. ..
  8. Hebel T, Eisinger K, Neumeier M, Rein Fischboeck L, Pohl R, Meier E, et al. Lipid abnormalities in alpha/beta2-syntrophin null mice are independent from ABCA1. Biochim Biophys Acta. 2015;1851:527-36 pubmed publisher
    The syntrophins alpha (SNTA) and beta 2 (SNTB2) are molecular adaptor proteins shown to stabilize ABCA1, an essential regulator of HDL cholesterol. Furthermore, SNTB2 is involved in glucose stimulated insulin release...
  9. Sakaguchi A, Padalecki S, Mattern V, Rodriguez A, Leach R, McGill J, et al. Chromosomal sublocalization of the transcribed human telomere repeat binding factor 2 gene and comparative mapping in the mouse. Somat Cell Mol Genet. 1998;24:157-63 pubmed
    ..gene is situated by itself in a newly defined "bin" on chromosome 8 one crossover distal to Psm10 and Sntb2. Human TERF2 and mouse Terf2 are therefore part of a large evolutionarily conserved linkage group comprised of at ..

More Information


  1. Kim M, Froehner S, Adams M, Kim H. ?-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res. 2011;317:2914-24 pubmed publisher
    ..Phosphorylation of Akt was reduced in the ?-syntrophin siRNA-treated C2 cells. These results suggest that ?-syntrophin is required for HGF-induced migration of myoblasts and for proper PI3-kinase/Akt signaling. ..
  2. Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkr├╝ger A, Solimena M. Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem. 2008;283:33719-29 pubmed publisher
    ..Pharmacological modulation of these feedback loops may alleviate deficient insulin release in diabetes. ..
  3. Willmroth F, Beaudet A. Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to Chromosome 8. Mamm Genome. 1999;10:1085-8 pubmed
    ..It maps to murine Chromosome (Chr) 8 in a region homologous to human Chr 16q where the GLG1 locus maps, further indicating that Selel and GLG1 are mouse and human equivalents of the same gene. ..
  4. Abramovici H, Gee S. Morphological changes and spatial regulation of diacylglycerol kinase-zeta, syntrophins, and Rac1 during myoblast fusion. Cell Motil Cytoskeleton. 2007;64:549-67 pubmed
    ..Moreover, our findings provide a potential link between changes in the lipid content of the membrane bilayer and reorganization of the actin cytoskeleton during myoblast fusion. ..
  5. Riu E, Ferre T, Mas A, Hidalgo A, Franckhauser S, Bosch F. Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism. Biochem J. 2002;368:931-7 pubmed
  6. Albrecht D, Sherman D, Brophy P, Froehner S. The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells. Glia. 2008;56:611-8 pubmed publisher
    ..Specifically, the cholesterol transporter ABCA1, associates with the Dp116/syntrophin complex in Cajal bands and is excluded from the DRP2/periaxin rich plaques...
  7. Adams M, Kramarcy N, Krall S, Rossi S, Rotundo R, Sealock R, et al. Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol. 2000;150:1385-98 pubmed
    ..Thus, alpha-syntrophin has an important role in synapse formation and in the organization of utrophin, acetylcholine receptor, and acetylcholinesterase at the neuromuscular synapse. ..
  8. Mills K, Sunada Y, Campbell K, Mathews K. A syntrophin gene maps to mouse chromosome 8 and is not the myodystrophy gene. Mamm Genome. 1995;6:664-5 pubmed
  9. Hayashi M, Ishibashi T, Tanaka K, Kasahara M. The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter. J Immunol. 1997;159:2760-70 pubmed
    ..Besides the Psmb7 gene previously mapped to chromosome 2, a truncated processed pseudogene, designated Psmb7-ps, was identified and mapped to chromosome X. ..
  10. Xu X, Rich E, Seldin D. Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping. Genomics. 1998;48:79-86 pubmed
    ..A polymorphic dinucleotide repeat in the fifth intron allowed us to map the CK2 alpha' gene to murine Chromosome 8. ..
  11. Johnson E, Zhang L, Adams M, Phillips A, Freitas M, Froehner S, et al. Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS ONE. 2012;7:e43515 pubmed publisher
    ..In addition, our findings support the existence of cardiac-specific functions of dystrophin and may guide studies into early triggers of cardiac disease in Duchenne and Becker muscular dystrophies. ..
  12. Gorecki D, Abdulrazzak H, Lukasiuk K, Barnard E. Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain. Eur J Neurosci. 1997;9:965-76 pubmed
  13. Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y. Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. J Biol Chem. 2004;279:44065-73 pubmed
    ..D'Adamo, M. C., and Pessia, M. (2000) J. Biol. Chem. 275, 16404-16407), it is plausible that these channels play differential physiological roles in the K+ -buffering action of brain astrocytes in a region-specific manner. ..
  14. Adams M, Kramarcy N, Fukuda T, Engel A, Sealock R, Froehner S. Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. J Neurosci. 2004;24:10302-9 pubmed
    ..We conclude that both alpha-syntrophin and beta2-syntrophin play distinct roles in forming and maintaining NMJ structure and that each syntrophin can partially compensate for the loss of the other. ..
  15. Makris G, Samuelson L, Lomax M. The gene encoding subunit IV of cytochrome c oxidase maps to mouse chromosome 8. Mamm Genome. 1996;7:789-90 pubmed