Gene Symbol: Snrpd1
Description: small nuclear ribonucleoprotein D1
Alias: AA407109, AL023031, SMD1, small nuclear ribonucleoprotein Sm D1, sm-D autoantigen, sm-D1, snRNP core protein D1
Sundar K, Jacques S, Gottlieb P, Villars R, Benito M, Taylor D, et al
. Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. J Autoimmun. 2004;23:127-40 pubmed
..Our data suggest that the anti-Sm response arises as a consequence of antigenic cross-reactivity by anti-EBNA-1 antibodies. These results support a possible association between EBV infection and SLE. ..
Liu Q, Fischer U, Wang F, Dreyfuss G. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell. 1997;90:1013-21 pubmed
..These findings suggest a role for SMN and SIP1 in spliceosomal snRNP biogenesis and function and provide a likely molecular mechanism for the cause of SMA. ..
Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al
. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
We report a novel modification of spliceosome proteins Sm D1, Sm D3, and Sm B/B'. L292 mouse fibroblasts were labeled in vivo with [3H]methionine...
Charroux B, Pellizzoni L, Perkinson R, Yong J, Shevchenko A, Mann M, et al
. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. J Cell Biol. 2000;148:1177-86 pubmed
..Interestingly, Gemin4 is also detected in the nucleoli, suggesting that the SMN complex may also function in preribosomal RNA processing or ribosome assembly. ..
Mitsuda T, Eisenberg R, Cohen P. The murine Sm-D autoantigen: multiple genes, genetic polymorphism, evolutionary conservation and lack of intervening sequences in the coding region. J Autoimmun. 1992;5:277-87 pubmed
..The Sm-D protein is thus highly conserved in evolution, probably owing to its essential role in the physiology of the cell. ..
Riemekasten G, Langnickel D, Enghard P, Undeutsch R, Humrich J, Ebling F, et al
. Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells. J Immunol. 2004;173:5835-42 pubmed
..b>SmD1 83-119 (a D1 protein of the Smith (Sm) proteins, part of small nuclear ribonucleoprotein) was recently shown to ..