Gene Symbol: Snrpb
Description: small nuclear ribonucleoprotein B
Alias: AL024368, AU018828, SM-B, SM11, SMB, SNRNP-B, small nuclear ribonucleoprotein-associated protein B, sm protein B
Species: mouse
Products:     Snrpb

Top Publications

  1. Griffith A, Schmauss C, Craft J. The murine gene encoding the highly conserved Sm B protein contains a nonfunctional alternative 3' splice site. Gene. 1992;114:195-201 pubmed
    The cDNA and partial genomic nucleotide (nt) sequences were derived for the mouse Sm B polypeptide and compared to the cDNA and genomic sequences encoding human Sm B...
  2. Gray T, Smithwick M, Schaldach M, Martone D, Graves J, McCarrey J, et al. Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci. Nucleic Acids Res. 1999;27:4577-84 pubmed
    The human small nuclear ribonucleoprotein SNRPB ' /B gene is alternatively spliced to produce the SmB or SmB' spliceosomal core proteins...
  3. Brunet C, Quan T, Craft J. Comparison of the Drosophila melanogaster, human and murine Sm B cDNAs: evolutionary conservation. Gene. 1993;124:269-73 pubmed
    To analyze the evolutionary stability of the Sm B polypeptides, the cDNA nucleotide (nt) sequence was derived for the Drosophila melanogaster Sm B polypeptide and compared to the cDNAs encoding human and murine Sm B...
  4. Miranda T, Khusial P, Cook J, Lee J, Gunderson S, Pestka S, et al. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochem Biophys Res Commun. 2004;323:382-7 pubmed
    We report a novel modification of spliceosome proteins Sm D1, Sm D3, and Sm B/B'. L292 mouse fibroblasts were labeled in vivo with [3H]methionine...
  5. Yang X, Torres M, Marzluff W, Dominski Z. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol Cell Biol. 2009;29:4045-56 pubmed publisher
    ..protein (SLBP), which interacts with the stem-loop structure upstream of the cleavage site, and both Lsm11 and SmB, which are components of the U7-specific Sm ring...
  6. Seraphin B. Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs. EMBO J. 1995;14:2089-98 pubmed
    ..These findings have implications for the structure of the Sm protein complex, spliceosomal snRNP evolution, snRNA transport and modification as well as the involvement of Sm proteins in systemic lupus erythematosus. ..
  7. Bedford M, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A. 1998;95:10602-7 pubmed
    ..Moreover, FBP21 interacts directly with the U1 snRNP protein U1C, the core snRNP proteins SmB and SmB', and the branchpoint binding protein SF1/mBBP...
  8. Gabanella F, Carissimi C, Usiello A, Pellizzoni L. The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation. Hum Mol Genet. 2005;14:3629-42 pubmed
    ..These results demonstrate that the SMN complex activity in snRNP assembly is regulated and point to a differential requirement for SMN function during development and cellular differentiation. ..
  9. Cheng D, Cote J, Shaaban S, Bedford M. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007;25:71-83 pubmed
    ..We developed a small-pool screening approach for this purpose and identified CA150, SAP49, SmB, and U1C as splicing factors that are specifically methylated by CARM1...

More Information


  1. Fronz K, Otto S, Kölbel K, Kuhn U, Friedrich H, Schierhorn A, et al. Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20 pubmed publisher
    ..Thus, arginine methylation might be relevant for oculopharyngeal muscular dystrophy. However, in two different types of assays we have been unable to detect any effect of arginine methylation on the aggregation of bovine PABPN1. ..