Gene Symbol: Snord115
Description: small nucleolar RNA, C/D Box 115 cluster
Alias: MBII-52, snoRNA MBII-52
Kishore S, Khanna A, Zhang Z, Hui J, Balwierz P, Stefan M, et al
. The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet. 2010;19:1153-64 pubmed publisher
..This processed snoRNA functions in alternative splice-site selection. Its substitution could be a therapeutic principle for PWS. ..
Skryabin B, Gubar L, Seeger B, Pfeiffer J, Handel S, Robeck T, et al
. Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007;3:e235 pubmed publisher
..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype. ..
Watrin F, Le Meur E, Roeckel N, Ripoche M, Dandolo L, Muscatelli F. The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin gene. BMC Genet. 2005;6:1 pubmed
..However, we demonstrate that the IC, if required for imprinted regulation, is not involved in the spatio-temporal regulation of distantly located retrotransposed genes such as the Ndn gene in the PWS domain. ..
Doe C, Relkovic D, Garfield A, Dalley J, Theobald D, Humby T, et al
. Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour. Hum Mol Genet. 2009;18:2140-8 pubmed publisher
Nakagaki A, Osanai H, Kishino T. Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014;553:63-8 pubmed publisher
Stefan M, Simmons R, Bertera S, Trucco M, Esni F, Drain P, et al
. Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011;300:E909-22 pubmed publisher
Bortolin Cavaillé M, Cavaille J. The SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C/D snoRNAs. Nucleic Acids Res. 2012;40:6800-7 pubmed publisher
..two large arrays of tandemly repeated, paternally expressed box C/D small-nucleolar RNA (snoRNA) genes: the SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters believed to play key roles in the fine-tuning of serotonin ..