Snca

Summary

Gene Symbol: Snca
Description: synuclein, alpha
Alias: NACP, alphaSYN, alpha-synuclein, non-A beta component of AD amyloid, non-A4 component of amyloid
Species: mouse

Top Publications

  1. ncbi Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development
    L J Hsu
    Department of Neuroscience, University of California San Diego, La Jolla 92093 0624, USA
    J Neurochem 71:338-44. 1998
  2. pmc Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    P J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, The Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 159:2215-25. 2001
  3. pmc Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies
    Deepak M Sampathu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 163:91-100. 2003
  4. ncbi Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 104:1504-25. 2008
  5. pmc Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
    J Clin Invest 118:777-88. 2008
  6. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
  7. pmc E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment
    Kristel L Emmer
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:35104-18. 2011
  8. pmc Lack of involvement of alpha-synuclein in unconditioned anxiety in mice
    Yolanda Peña-Oliver
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Behav Brain Res 209:234-40. 2010
  9. doi Lrrk2 and alpha-synuclein are co-regulated in rodent striatum
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 39:586-91. 2008
  10. doi Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Neurobiol Aging 33:1792-9. 2012

Research Grants

  1. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
  2. Robert A Rissman; Fiscal Year: 2015
  3. Models of Familial Parkinson's Disease: PINK1
    Ted Dawson; Fiscal Year: 2006
  4. The Role of Parkin in Parkinson's Disease
    Ted Dawson; Fiscal Year: 2009
  5. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
  6. DNA Damage/Repair and Cell Death
    Lee Martin; Fiscal Year: 2009
  7. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
  8. Characterization of the P5 Subfamily of P-type Transport ATPases in Mice
    PATRICK SCHULTHEIS; Fiscal Year: 2007
  9. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
  10. UBIQUINONE AND MITOCHONDRIAL OXIDATIVE DISORDERS OF AGIN
    Manuchair Ebadi; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications143 found, 100 shown here

  1. ncbi Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development
    L J Hsu
    Department of Neuroscience, University of California San Diego, La Jolla 92093 0624, USA
    J Neurochem 71:338-44. 1998
    The non-Abeta component of Alzheimer's disease amyloid precursor protein (NACP) is predominantly a neuron-specific presynaptic protein that may play a central role in neurodegeneration because NACP fragments are found in Alzheimer's ..
  2. pmc Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    P J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, The Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 159:2215-25. 2001
    ..In conclusion, the specific accumulation of detergent-insoluble alpha-SYN in transgenic mice recapitulates a pivotal feature of human LB diseases...
  3. pmc Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies
    Deepak M Sampathu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 163:91-100. 2003
    ..These results suggest that ubiquitination of alpha-synuclein is not required for inclusion formation and follows the fibrillization of alpha-synuclein...
  4. ncbi Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease
    Ashley D Reynolds
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 104:1504-25. 2008
    ..Taken together, the transcriptome and proteome of nitrated alpha-syn activated microglia, shown herein, provide new potential insights into disease mechanisms...
  5. pmc Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    Marta Martinez-Vicente
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, New York, New York 10461, USA
    J Clin Invest 118:777-88. 2008
    ..As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons...
  6. pmc Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    Venu M Nemani
    Departments of Neurology and Physiology, Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 65:66-79. 2010
    ..Increased levels of alpha-synuclein thus produce a specific, physiological defect in synaptic vesicle recycling that precedes detectable neuropathology...
  7. pmc E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment
    Kristel L Emmer
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:35104-18. 2011
    ..Collectively, these findings provide insights in the mechanisms of formation of these aberrant proteinaceous inclusions and support the notion that α-syn aggregates are involved in the pathogenesis of human diseases...
  8. pmc Lack of involvement of alpha-synuclein in unconditioned anxiety in mice
    Yolanda Peña-Oliver
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Behav Brain Res 209:234-40. 2010
    ..Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice...
  9. doi Lrrk2 and alpha-synuclein are co-regulated in rodent striatum
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, Retzius väg 8 B2 4, S 17177 Stockholm, Sweden
    Mol Cell Neurosci 39:586-91. 2008
    ..Because striatal Lrrk2 and alpha-synuclein levels were not changed by dopamine depletion, we conclude that Lrrk2 and alpha-synuclein mRNA levels are possibly co-regulated, but they are not influenced by striatal dopamine levels...
  10. doi Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Neurobiol Aging 33:1792-9. 2012
    The interactions between certain α-synuclein (SNCA) conformations and dopamine (DA) metabolism cause selective DA neuron degeneration in Parkinson's disease (PD)...
  11. ncbi The synuclein family
    C Lavedan
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genome Res 8:871-80. 1998
    ..The present review offers a synopsis of the current state of knowledge of all synuclein family members in different species...
  12. pmc Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
    Manuela Neumann
    Department of Neuropathology, Ludwig Maximilians University, Munich, Germany
    J Clin Invest 110:1429-39. 2002
    ..The transgenic mice showed a progressive deterioration of locomotor function. Thus, misfolding and hyperphosphorylation of alphaS may cause dysfunction of affected brain regions...
  13. pmc Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
    Sreeganga Chandra
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:14966-71. 2004
    ..These results show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function...
  14. pmc Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons
    Eugene V Mosharov
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 62:218-29. 2009
    ..Thus, an interaction between Ca2+, DA(cyt), and alpha-synuclein may underlie the susceptibility of SN neurons in PD, suggesting multiple therapeutic targets...
  15. doi Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology
    Masaki Ikeda
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Brain Res 1250:232-41. 2009
    Missense point mutations, duplication and triplication in the alpha-synuclein (alphaSYN) gene have been identified in familial Parkinson's disease (PD). Familial and sporadic PD show common pathological features of alphaSYN pathologies, e...
  16. pmc Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    Tereza Vogiatzi
    Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, Athens, Greece
    J Biol Chem 283:23542-56. 2008
    ..These results indicate that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system...
  17. pmc Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
    Wenxue Li
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:2162-7. 2005
    ..Collectively, our results indicate that the biology behind the generation and accumulation of alpha-SynDeltaC is likely to have relevance for the initiation and the progression of alpha-Syn aggregation in vivo...
  18. doi Decreased reuptake of dopamine in the dorsal striatum in the absence of α-synuclein
    Heramb Chadchankar
    School of Pharmacy, Faculty of Health Sciences, P O Box 1627, University of Eastern Finland, Kuopio Campus, Kuopio 70211, Finland
    Brain Res 1382:37-44. 2011
    ..We show that α-syn deletion produces significant adaptive changes in the striatal dopaminergic system via modulation of reuptake...
  19. ncbi Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
    O M Schlüter
    Center for Basic Neuroscience, Department of Molecular Genetics, and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Neuroscience 118:985-1002. 2003
    ....
  20. ncbi Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity
    Christophe Wersinger
    Department of Pediatrics, Georgetown University Medical Center, 3870 Reservoir Road NW, Washington, DC 20007, USA
    Mol Cell Neurosci 24:91-105. 2003
    ....
  21. ncbi Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    Xiangmin Peng
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Cell Sci 118:3523-30. 2005
    ..Together the data reveal a functional interaction between alpha-synuclein and PP2A that leads to PP2A activation and underscores a key role for alpha-synuclein in protein phosphorylation...
  22. pmc Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein
    Christopher E Ellis
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Dr, MSC 4472, Bethesda, Maryland 20892 4472, USA
    Mol Cell Biol 25:10190-201. 2005
    ..In mice lacking alpha-synuclein (Snca-/-), total brain steady-state mass of the mitochondria-specific phospholipid, cardiolipin, is reduced 22% and its ..
  23. ncbi Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders
    George K Tofaris
    Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom
    J Neurosci 26:3942-50. 2006
    ..These findings suggest that the C-terminal of alpha-synuclein is an important regulator of aggregation in vivo and will help to understand the mechanisms underlying the pathogenesis of Lewy body disorders and multiple system atrophy...
  24. ncbi Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis
    Kristin E Larsen
    Department of Neurology, Columbia University School of Medicine, New York, New York 10032, USA
    J Neurosci 26:11915-22. 2006
    ..We conclude that alpha-syn overexpression inhibits a vesicle "priming" step, after secretory vesicle trafficking to "docking" sites but before calcium-dependent vesicle membrane fusion...
  25. pmc Brain prostaglandin formation is increased by alpha-synuclein gene-ablation during global ischemia
    Mikhail Y Golovko
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 N Columbia Road, Grand Forks, ND 58202 9037, USA
    Neurosci Lett 432:243-7. 2008
    We have previously demonstrated that alpha-synuclein (Snca) gene ablation reduces brain arachidonic acid (20:4n-6) turnover rate in phospholipids through modulation of endoplasmic reticulum-localized acyl-CoA synthetase activity...
  26. doi Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain
    Heike Siebert
    Institute of Neuropathology, University Medical Centre Goettingen, Goettingen, Germany
    J Neurochem 114:1007-18. 2010
    ..alpha-Synuclein transgenic mice represent an appropriate model for investigations on axonal transport in neurodegenerative diseases...
  27. pmc beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    E Masliah
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 98:12245-50. 2001
    ..Therefore, treatments that block the production or accumulation of beta-amyloid peptides could benefit a broader spectrum of disorders than previously anticipated...
  28. ncbi alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells
    Makoto Hashimoto
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Biol Chem 277:11465-72. 2002
    ..Furthermore, interactions between alpha-synuclein and JIP-1b/IB1 may play a mutual role in the neuronal response to injury and neurodegeneration...
  29. ncbi Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    Eric K Richfield
    Department of Pathology and Lab Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Exp Neurol 175:35-48. 2002
    ..Expression of hm2alpha-SYN adversely affects the integrity of dopaminergic terminals and leads to age-related declines in motor coordination and dopaminergic markers...
  30. ncbi Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    Deborah E Cabin
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 4472, USA
    J Neurosci 22:8797-807. 2002
    ..These results reveal, for the first time, the normal function of endogenous alpha-synuclein in regulating synaptic vesicle mobilization at nerve terminals...
  31. ncbi Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration
    Robert E Drolet
    The Neuroscience Program, Michigan State University, B 436 Life Sciences Building, East Lansing, MI 48824, USA
    Neurotoxicology 25:761-9. 2004
    ....
  32. ncbi Phosphorylated alpha-synuclein in normal mouse brain
    Yu Hirai
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    FEBS Lett 572:227-32. 2004
    ..Relative prominence and age sensitivity of this phenomenon in the striatum may be relevant to the pathogenesis of Parkinson's disease...
  33. ncbi Peripheral sensory neurons survive in the absence of alpha- and gamma-synucleins
    Katerina Papachroni
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    J Mol Neurosci 25:157-64. 2005
    ..This suggests that other intraneuronal mechanisms and pathways effectively compensate the loss of synuclein function in null mutant animals...
  34. ncbi Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy
    Rainer von Coelln
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:3685-96. 2006
    ....
  35. ncbi Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
    Christian Freichel
    Pharma Research, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    Neurobiol Aging 28:1421-35. 2007
    Intraneuronal alpha-synuclein (alphaSYN) inclusions constitute the hallmark lesions of a number of neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies...
  36. ncbi Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
    Roya Tehranian
    Department of Neurology, University of Pittsburgh, School of Medicine, Pitttsburgh, Pennsylvania 15213, USA
    J Neurochem 99:1188-96. 2006
    ..These novel findings further support a role for alpha-synuclein in dopamine homeostasis and may explain, at least in part, the selective vulnerability of dopamine neurons that occurs in PD...
  37. ncbi Alpha-synuclein expression modulates microglial activation phenotype
    Susan A Austin
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota 58202 9037, USA
    J Neurosci 26:10558-63. 2006
    ..This has direct ramifications for the contribution of microglia to the pathophysiology of disease, particularly in familial cases linked to altered alpha-synuclein expression...
  38. ncbi Alpha-synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids
    Mikhail Y Golovko
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9037, USA
    J Neurochem 101:201-11. 2007
    Previously, we demonstrated that ablation of alpha-synuclein (Snca) reduces arachidonate (20:4n-6) turnover in brain phospholipids through modulation of an endoplasmic reticulum-localized acyl-CoA synthetase (Acsl)...
  39. ncbi Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice
    Gwendolyn Barcelo-Coblijn
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9037, USA
    J Neurochem 101:132-41. 2007
    Because alpha-synuclein (Snca) has a role in brain lipid metabolism, we determined the impact that Snca deletion had on whole brain lipid composition...
  40. ncbi Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice
    Daniel Alvarez-Fischer
    Department of Neurology, Philipps Universitat Marburg, Germany
    Exp Neurol 210:182-93. 2008
    ..In summary, we propose that the striatal 6-OHDA model may be a valuable addition and/or alternative in genetically modified mice models used in the study of PD pathophysiology...
  41. pmc Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
    Daniel Sevlever
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Biochemistry 47:9678-87. 2008
    ..Our findings suggest that upregulation of cathepsin D could be an additional therapeutic strategy to lessen alpha-synuclein burden in synucleinopathies...
  42. pmc Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice
    Natalia P Bondar
    Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia
    PLoS ONE 4:e4190. 2009
    ..The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently shown by male mice in special experimental settings...
  43. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  44. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
    ..These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission...
  45. ncbi Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 20:6365-73. 2000
    Mutations in the alpha-synuclein (alphaSYN) gene are associated with rare cases of familial Parkinson's disease, and alphaSYN is a major component of Lewy bodies and Lewy neurites...
  46. pmc Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element
    J W Touchman
    NIH Intramural Sequencing Center, National Institutes of Health, Gaithersburg, Maryland 20877, USA
    Genome Res 11:78-86. 2001
    The human alpha-synuclein gene (SNCA) encodes a presynaptic nerve terminal protein that was originally identified as a precursor of the non-beta-amyloid component of Alzheimer's disease plaques...
  47. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001
    ..However, the engrailed genes control the survival of midbrain dopaminergic neurons in a gene dose-dependent manner. Our findings also suggest a link between engrailed and Parkinson's disease...
  48. ncbi Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
    Y Matsuoka
    Dementia Research Group, Nathan Kline Institute New York University Medical School, 140 Old Orangeburg Road, Orangeburg, New York 10962, USA
    Neurobiol Dis 8:535-9. 2001
    ..These findings suggest that overexpression of alpha-synuclein within nigrostriatal dopaminergic neurons is not in itself sufficient to cause aggregation into Lewy body-like inclusions, nor does it trigger overt neurodegenerative changes...
  49. pmc Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
    C G Specht
    Laboratory for Molecular Pharmacology, UCL, Gower Street, London WC1E 6BT, UK
    BMC Neurosci 2:11. 2001
    ..Here we analyze potential compensatory mechanisms in alpha-synuclein null mutant mice. Furthermore, the findings reveal problems that may be associated with inbred mouse strains...
  50. ncbi Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
    Michael J Volles
    Center for Neurologic Diseases, Brigham and Women s Hospital, and Department of Neurology, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA
    Biochemistry 41:4595-602. 2002
    ..We conclude that the pathogenesis of Parkinson's disease may involve membrane permeabilization by protofibrillar alpha-synuclein, the extent of which will be strongly dependent on the in vivo conditions...
  51. ncbi Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, 3600 Spruce Street, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 34:521-33. 2002
    ..These mice demonstrate that A53T alpha-synuclein leads to the formation of toxic filamentous alpha-synuclein neuronal inclusions that cause neurodegeneration...
  52. pmc Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP
    William Dauer
    Department of Neurology, Columbia University, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 99:14524-9. 2002
    ....
  53. ncbi Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
    Leonard Petrucelli
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neuron 36:1007-19. 2002
    ..Therefore, parkin and alpha-synuclein are linked by common effects on a pathway associated with selective cell death in catecholaminergic neurons...
  54. ncbi Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
    Suzana Gispert
    Department of Anatomy II Experimental Neurobiology, University Frankfurt M, Frankfurt, Germany
    Mol Cell Neurosci 24:419-29. 2003
    ..Transgenic animals expressing mutant alpha-synuclein may be a valuable model to assess specific aspects of the pathogenesis of synucleinopathies...
  55. pmc Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene
    Natalia Ninkina
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, U K
    Mol Cell Biol 23:8233-45. 2003
    ..Nerve injury led to similar changes in sensory function in wild-type and mutant mice. Taken together, our data suggest that like alpha-synuclein, gamma-synuclein is dispensable for the development and function of the nervous system...
  56. ncbi The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain
    Susan Totterdell
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Brain Res 1004:61-72. 2004
    ..Nevertheless alpha-synuclein is also found in terminals of neurons which have not been reported to accumulate the protein in neurodegenerative disorders...
  57. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
    ....
  58. ncbi Deletion of multimerin-1 in alpha-synuclein-deficient mice
    Christian G Specht
    Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Genomics 83:1176-8. 2004
    A deletion of the murine Snca gene has been discovered in C57BL/6JOlaHsd, a population of the inbred strain C57BL/6J. We now characterize the exact nature of this deletion, Del(6)Snca1Slab...
  59. pmc alpha-Synuclein produces a long-lasting increase in neurotransmitter release
    Shumin Liu
    Department of Pathology, Columbia University, New York, NY, USA
    EMBO J 23:4506-16. 2004
    ..Thus, alpha-synuclein is involved in synaptic plasticity by augmenting transmitter release from the presynaptic terminal...
  60. ncbi Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background
    Deborah E Cabin
    National Human Genome Research Institute, 49 Convent Dr, Building 49, Room 4A72, NHGRI NIH, Bethesda, MD 20892, USA
    Neurobiol Aging 26:25-35. 2005
    ..Mice carrying an Ala53Thr human SNCA transgene driven by the mouse prion promoter show a mild movement disorder and only rarely develop severe pathology ..
  61. ncbi Role of alpha-synuclein in presynaptic dopamine recruitment
    Leonid Yavich
    Department of Pharmacology and Toxicology, Clinical Research Centre Mediteknia, University of Kuopio, Finland
    J Neurosci 24:11165-70. 2004
    ..Reducing capacity of the storage pool in transgenic A30P mice led to paradoxical effects of l-dopa, which elevated dopamine release in response to single stimulation but decreased the refilling rate of the RRP...
  62. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  63. ncbi A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease
    Chang wei Liu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    J Biol Chem 280:22670-8. 2005
    ..disease and other alpha-synucleinopathies are characterized by the deposition of intraneuronal alpha-synuclein (alphaSyn) inclusions...
  64. ncbi Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding
    Mikhail Y Golovko
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9037, USA
    Biochemistry 44:8251-9. 2005
    ..Thus, alpha-synuclein has effects on 16:0 uptake and metabolism similar to those of an FABP, but unlike FABP, it does not directly bind 16:0; hence, the mechanism underlying these effects is different from that of a classical FABP...
  65. ncbi Localization of alpha-synuclein to identified fibers and synapses in the normal mouse brain
    S Totterdell
    Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3QT, UK
    Neuroscience 135:907-13. 2005
    ....
  66. ncbi Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
    Sreeganga Chandra
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 123:383-96. 2005
    ....
  67. ncbi Mice lacking alpha-synuclein are resistant to mitochondrial toxins
    Peter Klivenyi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10021, USA
    Neurobiol Dis 21:541-8. 2006
    ..These findings implicate alpha-synuclein as a modulator of oxidative damage, which has been implicated in neuronal death produced by MPTP and other mitochondrial toxins...
  68. pmc Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism
    Mikhail Y Golovko
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, North Dakota 58202 9037, USA
    Biochemistry 45:6956-66. 2006
    Because alpha-synuclein (Snca) has a role in brain lipid metabolism, we determined the impact that the loss of alpha-synuclein had on brain arachidonic acid (20:4n-6) metabolism in vivo using Snca-/- mice...
  69. pmc Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation
    Joseph A Marsh
    Molecular Structure and Function, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Protein Sci 15:2795-804. 2006
    ....
  70. pmc Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity
    Michael J Volles
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    J Mol Biol 366:1510-22. 2007
    ..We hypothesize that yeast toxicity is caused by synuclein binding directly to membranes at levels sufficient to non-specifically disrupt homeostasis...
  71. ncbi Role of alpha-synuclein in synaptic glutamate release
    Irina Gureviciene
    Department Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, P O Box 1627 Neulaniementie 2, FIN 70211 Kuopio, Finland
    Neurobiol Dis 28:83-9. 2007
    ..However, transgenic expression of A30P mutated or wild type alpha-synuclein does not appear to prevent endogenous mouse alpha-synuclein to carry out this function...
  72. pmc In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
    Marie Francoise Chesselet
    Department of Neurology and Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 209:22-7. 2008
    ..The predictive value of all models of the disease, however, remains speculative in the absence of effective neuroprotective treatments for PD in humans...
  73. pmc Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    Steven L Senior
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Neurosci 27:947-57. 2008
    ..Rather, we propose that loss of both alpha- and gamma-synuclein causes an increase in release probability from dopaminergic synapses...
  74. pmc Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
    Hui Ming Gao
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:7687-98. 2008
    ..This study advances understanding of the role of neuroinflammation and abnormal SYN in the pathogenesis of PD and opens new avenues for the discovery of more effective therapies for PD...
  75. pmc Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
    Igor F Tsigelny
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 3:e3135. 2008
    ..However the molecular characteristics and consequences of these interactions are not completely clear...
  76. pmc Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system
    Kelly J Inglis
    Elan Pharmaceuticals Inc, South San Francisco, CA 94080, USA
    J Biol Chem 284:2598-602. 2009
    ..These results indicate that PLK2 plays a critical role in alpha-synuclein phosphorylation in central nervous system...
  77. pmc Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
    Liyan Qiao
    Department of Pathology, University of Alabama at Birmingham, USA
    Mol Brain 1:17. 2008
    ..Our data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics...
  78. doi Microarray expression analysis of human dopaminergic neuroblastoma cells after RNA interference of SNCA--a key player in the pathogenesis of Parkinson's disease
    Karina Häbig
    Department of Medical Genetics, Institute of Human Genetics, University of Tubingen, Germany
    Brain Res 1256:19-33. 2009
    ..Furthermore, both missense mutations and multiplications of the SNCA gene lead to autosomal dominant forms of familial PD...
  79. doi Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice
    H Schell
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, Tubingen, Germany
    Neuroscience 160:796-804. 2009
    ..Mutations in the alpha-synuclein (alphaSYN) gene cause Parkinson's disease, often associated with dementia...
  80. doi Alpha-synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP
    Seonghan Kim
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, Korea
    J Neurochem 109:1483-96. 2009
    ..With the recruitment of the microglial population into the SNpc during dopaminergic neurodegeneration, alpha-synuclein may play a role in accelerating the pathogenesis of PD...
  81. doi Alpha-synuclein deficiency affects brain Foxp1 expression and ultrasonic vocalization
    A Kurz
    Section Molecular Neurogenetics, Department Neurology, Goethe University Medical School, Frankfurt am Main, Germany
    Neuroscience 166:785-95. 2010
    ..Taken together, we identified an early behavioral consequence of alpha-synuclein deficiency and accompanying molecular changes, which supports the notion that the neural connectivity of sound or emotion control systems is affected...
  82. pmc Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    Xian Lin
    Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 64:807-27. 2009
    ....
  83. pmc Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration
    Elpida Tsika
    The Children s Hospital of Philadelphia Research Institute, Philadelphia Pennsylvania 19104, USA
    J Neurosci 30:3409-18. 2010
    ....
  84. pmc Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:9879-84. 2010
    ....
  85. pmc A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice
    Alexander Kurz
    Department of Neurology, Goethe University Medical School, Frankfurt, Germany
    PLoS ONE 5:e11464. 2010
    ..age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA)...
  86. pmc α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion
    Xuehui Geng
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 300:E276-86. 2011
    ..Synuclein might play similar roles in diabetes as it does in other degenerative diseases, including Alzheimer's and Parkinson's diseases...
  87. pmc αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
    Becket Greten-Harrison
    Program in Cellular Neuroscience, Neurodegeneration, and Repair and Department of Neurology, Yale University, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 107:19573-8. 2010
    ..Our results demonstrate that synucleins contribute importantly to the long-term operation of the nervous system and that alterations in their physiological function could contribute to the development of Parkinson's disease...
  88. pmc Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants
    Cintia Roodveldt
    CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine, Consejo Superior de Investigaciones Científicos, University of Seville UPO Junta de Andalucia, Seville, Spain
    PLoS ONE 5:e13481. 2010
    ..However, the effect of extracellular α-Syn on cellular activation and immune mediators, as well as the impact of familial PD-linked α-Syn mutants on this stimulation, are still largely unknown...
  89. pmc Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein
    Ken Nakamura
    Department of Neurology and Physiology, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:20710-26. 2011
    ..Synuclein thus exerts a primary and direct effect on the morphology of an organelle long implicated in the pathogenesis of Parkinson disease...
  90. pmc Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
    Sabina Anwar
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 31:7264-74. 2011
    ....
  91. pmc The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein
    Lijuan Kang
    Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854, United States
    J Am Chem Soc 133:13465-70. 2011
    ....
  92. pmc α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    Youngshin Lim
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 31:10076-87. 2011
    ..Furthermore, when α-syn expression was suppressed, we observed partial clearing of pre-existing α-syn pathology and reversal of structural synaptic defects, resulting in an improvement in memory function...
  93. pmc Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons
    Nadia Stefanova
    Division of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Am J Pathol 179:954-63. 2011
    ..The study supports TLR4 signaling as innate neuroprotective mechanism acting through clearance of α-synuclein...
  94. pmc Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
    Tiffany Kaul
    Department of Biochemistry and Molecular and Cell Biology, University of California San Diego, La Jolla, California, USA
    BMC Neurosci 12:79. 2011
    ..The current studies were undertaken to analyze the distribution of tauopathy in different brain regions in a widely used mouse model of PD, the α-Syn overexpressing mouse...
  95. pmc Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    Laura A Volpicelli-Daley
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
    Neuron 72:57-71. 2011
    ....
  96. pmc α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
    Bruno Fauvet
    Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Station 19, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 287:15345-64. 2012
    ..These results do not rule out the possibility that α-syn becomes structured upon interaction with other proteins and/or biological membranes...
  97. pmc Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    Kelvin C Luk
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 209:975-86. 2012
    ..These findings open up new avenues for understanding the progression of PD and for developing novel therapeutics...
  98. pmc Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
    Jacqueline Burré
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California 94305 5453, USA
    J Neurosci 32:15227-42. 2012
    ....
  99. pmc Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    Kelvin C Luk
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 4283, USA
    Science 338:949-53. 2012
    ..This recapitulation of a neurodegenerative cascade thus establishes a mechanistic link between transmission of pathologic α-Syn and the cardinal features of Parkinson's disease...
  100. pmc Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus
    Beate Winner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 32:16906-16. 2012
    ..The current work provides novel insights into the role of α-synuclein in adult hippocampal neurogenesis...
  101. pmc Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function
    Adam W Oaks
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC, USA
    PLoS ONE 8:e60378. 2013
    ..These findings highlight the involvement of the synuclein family of proteins and phosphorylation of Tau in the response to dopaminergic dysfunction of the nigrostriatal pathway...

Research Grants24

  1. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  2. Robert A Rissman; Fiscal Year: 2015
    ..abstract_text> ..
  3. Models of Familial Parkinson's Disease: PINK1
    Ted Dawson; Fiscal Year: 2006
    ....
  4. The Role of Parkin in Parkinson's Disease
    Ted Dawson; Fiscal Year: 2009
    ....
  5. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..Effective protocols for inactivating prions will protect the general public as well as laboratory scientists who are investigating prions. Rarely does a research study have such immediate and important implications. ..
  6. DNA Damage/Repair and Cell Death
    Lee Martin; Fiscal Year: 2009
    ....
  7. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    ..This work can define a new mitochondrial mechanism for target deprivation-induced neurodegeneration and can improve the understanding of the cellular and molecular mechanisms of neuronal apoptosis in vivo ..
  8. Characterization of the P5 Subfamily of P-type Transport ATPases in Mice
    PATRICK SCHULTHEIS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
    ..abstract_text> ..
  10. UBIQUINONE AND MITOCHONDRIAL OXIDATIVE DISORDERS OF AGIN
    Manuchair Ebadi; Fiscal Year: 2003
    ..The completion of these studies will undoubtedly provide additional items of information on reactive oxygen species-induced damage of mitochondrial DNA and the protective effects of coenzyme Q10(ubiquinol) to minimize it. ..
  11. Magnesium Deficiency: Global Gene Expression Study
    PATRICK SCHULTHEIS; Fiscal Year: 2002
    ..This combination of techniques should lead to the identification of all genes that are differentially expressed during magnesium deficiency. ..
  12. MECHANISMS OF AXONAL SPROUTING IN THE ADULT STRIATUM
    Marie Francoise Chesselet; Fiscal Year: 2003
    ..This has relevance for the treatment of stroke and neurodegenerative diseases, two major health concern and leading causes of disability. ..
  13. Models of Familial Parkinson's Disease: DJ-1 Knockouts
    Ted Dawson; Fiscal Year: 2005
    ....
  14. METABOLISM AND TRANSPORT OF MAMMALIAN GPIS
    Daniel Sevlever; Fiscal Year: 2003
    ..These studies will provide a better understanding of the role played by compart-mentalization on the regulation of the GPI pathway. ..
  15. Apoptosis Inducing Factor in Dopaminergic Cell Death
    Ted Dawson; Fiscal Year: 2003
    ....
  16. Center for Gene-Environment Studies in Parkinson Disease
    Marie Francoise Chesselet; Fiscal Year: 2006
    ..Cell lines, primary neuronal cultures from genetically altered mice, and human lymphoblasts will be examined. ..
  17. PLASTICITY OF GAD GENE EXPRESSION IN THE BASAL GANGLIA
    Marie Francoise Chesselet; Fiscal Year: 2007
    ..These studies will provide basic information on the mechanisms involved in the maturation of a crucial population of striatal GABAerglc neurons and provide new cues for striatal pathologies. ..
  18. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..
  19. Reversible and Temporally Inducible LRRK2 Knockout Mice
    Ted Dawson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  20. Role of Complement in Alzheimer's Disease
    Daniel Sevlever; Fiscal Year: 2007
    ..Since certain inflammation responses can be detrimental while others can be beneficial, modulation of complement activation may be one therapeutic approach for the treatment of AD. ..
  21. The mechanism of MPTP resistance in synuclein null mice.
    William Dauer; Fiscal Year: 2008
    ..This proposal exemplifies the type of clinically related fundamental neurobiological research I plan to pursue during my career. ..