Gene Symbol: SMIF
Description: decapping mRNA 1A
Alias: 1110066A22Rik, 4930568L04Rik, AU019772, D14Ertd817e, Mitc1, SMIF, mRNA-decapping enzyme 1A, DCP1 decapping enzyme homolog A, MAD homolog 4 interacting transcription coactivator 1, Smad4-interacting transcriptional co-activator, decapping enzyme, transcription factor SMIF
Species: mouse
Products:     SMIF

Top Publications

  1. Suzuki A, Igarashi K, Aisaki K, Kanno J, Saga Y. NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs. Proc Natl Acad Sci U S A. 2010;107:3594-9 pubmed publisher
    ..We propose from our current findings that NANOS2-interacting RNAs may be recruited to P-bodies and degraded by the enzymes contained therein through NANOS2-mediated deadenylation. ..
  2. Bai R, Koester C, Ouyang T, Hahn S, Hammerschmidt M, Peschel C, et al. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. Nat Cell Biol. 2002;4:181-90 pubmed
    ..Here, we report the cloning of SMIF, a ubiquitously expressed, Smad4-interacting transcriptional co-activator...
  3. Suzuki A, Saba R, Miyoshi K, Morita Y, Saga Y. Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. PLoS ONE. 2012;7:e33558 pubmed publisher
  4. Blumenthal J, Behar L, Elliott E, Ginzburg I. Dcp1a phosphorylation along neuronal development and stress. FEBS Lett. 2009;583:197-201 pubmed publisher
    ..These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues. ..
  5. Swetloff A, Conne B, Huarte J, Pitetti J, Nef S, Vassalli J. Dcp1-bodies in mouse oocytes. Mol Biol Cell. 2009;20:4951-61 pubmed publisher
    ..Moreover, this disassembly of hDcp1a-bodies is concomitant with the posttranslational modification of EGFP-hDcp1a. ..
  6. Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010;139:381-93 pubmed publisher
    ..These findings unveil the presence of distinct posttranscriptional regulations in PGCs soon after their specification, for which RNA-binding proteins such as NANOS3 and TIAL1 would play critical functions. ..
  7. Bailey A, Batista P, Gold R, Chen Y, de Rooij D, Chang H, et al. The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. elife. 2017;6: pubmed publisher
  8. Kato Y, Katsuki T, Kokubo H, Masuda A, Saga Y. Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells. Nat Commun. 2016;7:11272 pubmed publisher
    ..We propose a dual system of NANOS2-mediated suppression of Dazl expression as a pivotal molecular mechanism promoting sexual differentiation of XY germ cells. ..
  9. Mehlmann L. Losing mom's message: requirement for DCP1A and DCP2 in the degradation of maternal transcripts during oocyte maturation. Biol Reprod. 2013;88:10 pubmed publisher

More Information


  1. De Fazio S, Bartonicek N, Di Giacomo M, Abreu Goodger C, Sankar A, Funaya C, et al. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature. 2011;480:259-63 pubmed publisher
    ..In addition, the hallmarks of piRNA amplification are observed in Miwi2-deficient gonadocytes. We conclude that cycles of intra-Mili secondary piRNA biogenesis fuel piRNA amplification that is absolutely required for LINE1 silencing. ..
  2. Flemr M, Ma J, Schultz R, Svoboda P. P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes. Biol Reprod. 2010;82:1008-17 pubmed publisher
    ..We propose that the cortex of growing oocytes serves as an mRNA storage compartment, which contains a novel type of RNA granule related to P-bodies. ..
  3. Aravin A, van der Heijden G, Castañeda J, Vagin V, Hannon G, Bortvin A. Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 2009;5:e1000764 pubmed publisher
    ..Cumulatively, our data reveal elaborate cytoplasmic compartmentalization of the fetal piRNA pathway that relies on MAEL function. ..
  4. Zheng D, Ezzeddine N, Chen C, Zhu W, He X, Shyu A. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol. 2008;182:89-101 pubmed publisher
    ..These results support a dynamic interplay among deadenylation, mRNP remodeling, and P-body formation in selective decay of mammalian mRNA...
  5. Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher
    ..These findings demonstrate a role for RGs in vertebrate organogenesis. ..
  6. Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn E, Michel G, et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009;11:1411-20 pubmed publisher
    ..Furthermore, mLin41 cooperated with the pluripotency factor Lin-28 in suppressing let-7 activity, revealing a dual control mechanism regulating let-7 in stem cells. ..
  7. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, et al. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109:11770-5 pubmed publisher
    ..These findings suggest that LSm14A is a sensor for both viral RNA and DNA and plays an important role in initiating IFN-? induction in the early phase of viral infection. ..
  8. Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y. Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016;17:37-46 pubmed publisher
    ..We also present the first evidence that the zinc finger domain of Nanos acts as a protein-interacting domain for another RBP, providing a novel insight into Nanos-mediated germ cell development. ..
  9. Usui H, Ichikawa T, Kobayashi K, Kumanishi T. Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. Gene. 2000;248:127-35 pubmed
    ..Northern blot analysis showed that the Sfmbt mRNAs were expressed most abundantly in the adult testis, and less intensively in all other tissues examined. ..
  10. Chiang P, Shen Y, Su Y, Kao C, Lin N, Hsu P, et al. Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes. PLoS ONE. 2013;8:e61697 pubmed publisher
    ..Our findings suggest that ERK-phosphorylated Dcp1a enhances its interaction with the decapping enzyme Dcp2 during early differentiation of 3T3-L1 cells.
  11. Suzuki A, Niimi Y, Saga Y. Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3:1207-16 pubmed publisher
    ..This alternate interaction might account for the molecular basis of the functional redundancy and differences in NANOS2 and NANOS3 functions. ..
  12. Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, et al. RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells. Dev Cell. 2015;34:96-107 pubmed publisher
    ..This mechanism links mRNA turnover to mTORC1 signaling through Nanos2-containing mRNPs and establishes a post-transcriptional buffering system to facilitate SSC homeostasis in the fluctuating environment within the seminiferous tubule. ..
  13. Ma J, Flemr M, Strnad H, Svoboda P, Schultz R. Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse. Biol Reprod. 2013;88:11 pubmed publisher
  14. Cougot N, Bhattacharyya S, Tapia Arancibia L, Bordonné R, Filipowicz W, Bertrand E, et al. Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J Neurosci. 2008;28:13793-804 pubmed publisher
    ..Thus, dlP-bodies may regulate local translation by storing repressed mRNPs in unstimulated cells, and releasing them on synaptic activation. ..
  15. Dougherty J, Reineke L, Lloyd R. mRNA decapping enzyme 1a (Dcp1a)-induced translational arrest through protein kinase R (PKR) activation requires the N-terminal enabled vasodilator-stimulated protein homology 1 (EVH1) domain. J Biol Chem. 2014;289:3936-49 pubmed publisher
    ..The translation blockade induced by Dcp1a expression suggests novel signaling linking RNA degradation/decapping and regulation of translation. ..