Gene Symbol: Smc4
Description: structural maintenance of chromosomes 4
Alias: 2500002A22Rik, C79747, SMC-4, Smc4l1, structural maintenance of chromosomes protein 4, SMC protein 4, SMC4 structural maintenance of chromosomes 4-like 1, XCAP-C homolog, chromosome-associated polypeptide C
Species: mouse
Products:     Smc4

Top Publications

  1. Cobbe N, Heck M. The evolution of SMC proteins: phylogenetic analysis and structural implications. Mol Biol Evol. 2004;21:332-47 pubmed
    ..Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution...
  2. Griese J, Witte G, Hopfner K. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res. 2010;38:3454-65 pubmed publisher
    ..Cohesin (SMC1-SMC3) is involved in DNA double-strand break repair, condensin (SMC2-SMC4) participates in single-strand break (SSB) repair, and the SMC5-SMC6 complex functions in various DNA repair ..
  3. Strunnikov A, Jessberger R. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem. 1999;263:6-13 pubmed
    ..The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types...
  4. Losada A, Hirano T. Shaping the metaphase chromosome: coordination of cohesion and condensation. Bioessays. 2001;23:924-35 pubmed
    ..We argue that, in different eukaryotic organisms, the balance of cohesion and condensation is adjusted in such a way that the size and shape of the resulting chromosomes are best suited for their accurate segregation. ..
  5. Lee J, Ogushi S, Saitou M, Hirano T. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 2011;22:3465-77 pubmed publisher
  6. Pan X, Papasani M, Hao Y, Calamito M, Wei F, Quinn Iii W, et al. YY1 controls Ig? repertoire and B-cell development, and localizes with condensin on the Ig? locus. EMBO J. 2013;32:1168-82 pubmed publisher
    ..Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Ig? V? genes suggesting a direct role for YY1-condensin complexes in Ig? locus structure and rearrangement. ..
  7. Hwang G, Sun F, O Brien M, Eppig J, Handel M, Jordan P. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 2017;144:1648-1660 pubmed publisher