Gene Symbol: Smc2
Description: structural maintenance of chromosomes 2
Alias: 5730502P04Rik, AI255214, AW545314, CAP-E, CAPE, Fin16, SMC-2, Smc2l1, structural maintenance of chromosomes protein 2, FGF-inducible protein 16, SMC protein 2, SMC2 structural maintenance of chromosomes 2-like 1, XCAP-E homolog, chromosome-associated protein E, fibroblast growth factor inducible 16
Species: mouse
Products:     Smc2

Top Publications

  1. Cobbe N, Heck M. The evolution of SMC proteins: phylogenetic analysis and structural implications. Mol Biol Evol. 2004;21:332-47 pubmed
    ..Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution...
  2. Fazzio T, Panning B. Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. J Cell Biol. 2010;188:491-503 pubmed publisher
    ..Among these 62 genes were Smc2 and -4, which are core components of the two mammalian condensin complexes...
  3. Lee J, Ogushi S, Saitou M, Hirano T. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 2011;22:3465-77 pubmed publisher
  4. Guthridge M, Seldin M, Basilico C. Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996;12:1267-78 pubmed
    ..clones include a putative serine-threonine phosphatase (FIN13) and a gene with homology to NTP-binding proteins (FIN16)...
  5. Nagamori I, Yomogida K, Adams P, Sassone Corsi P, Nojima H. Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem. 2006;281:15073-81 pubmed
    ..Finally, we demonstrate that the Tisp40DeltaTM-CREMtau heterodimer acts as a recruiter of HIRA, a histone chaperone, to CRE. Taken together, we propose that Tisp40 is an important transcriptional regulator during spermiogenesis. ..
  6. Griese J, Witte G, Hopfner K. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Nucleic Acids Res. 2010;38:3454-65 pubmed publisher
    ..Cohesin (SMC1-SMC3) is involved in DNA double-strand break repair, condensin (SMC2-SMC4) participates in single-strand break (SSB) repair, and the SMC5-SMC6 complex functions in various DNA repair ..
  7. Pan X, Papasani M, Hao Y, Calamito M, Wei F, Quinn Iii W, et al. YY1 controls Ig? repertoire and B-cell development, and localizes with condensin on the Ig? locus. EMBO J. 2013;32:1168-82 pubmed publisher
    ..Knock-down of a condensin subunit protein or YY1 reduced rearrangement of Ig? V? genes suggesting a direct role for YY1-condensin complexes in Ig? locus structure and rearrangement. ..
  8. Kawakami Y, Yoshida K, Yang J, Suzuki T, Azuma N, Sakai K, et al. Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Neurosci Res. 2009;63:184-93 pubmed publisher
    ..The present integrative study provides in vivo evidence that normal cell cycle progression and subsequent neurogenesis of radial glia cells are severely impaired by serine deficiency. ..
  9. Nishide K, Hirano T. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. PLoS Genet. 2014;10:e1004847 pubmed publisher
    ..Our results demonstrate that condensins I and II have overlapping and non-overlapping functions in NSCs, and also provide evolutionary insight into intricate balancing acts of the two condensin complexes. ..