Gene Symbol: Smc1a
Description: structural maintenance of chromosomes 1A
Alias: 5830426I24Rik, SMC-1A, Sb1.8, Smc1, Smc1alpha, Smc1l1, Smcb, mKIAA0178, structural maintenance of chromosomes protein 1A, SMC (segregation of mitotic chromosomes 1)-like 1, SMC protein 1A, SMC-1-alpha, chromosome segregation protein SmcB, segregation of mitotic chromosomes b
Species: mouse
Products:     Smc1a

Top Publications

  1. Prieto I, Suja J, Pezzi N, Kremer L, Martinez A C, Rufas J, et al. Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. Nat Cell Biol. 2001;3:761-6 pubmed
    ..STAG3 interacts with the structural maintenance chromosome proteins SMC1 and SMC3, which have been reported to be subunits of the mitotic cohesin complex...
  2. Revenkova E, Eijpe M, Heyting C, Gross B, Jessberger R. Novel meiosis-specific isoform of mammalian SMC1. Mol Cell Biol. 2001;21:6984-98 pubmed
    ..for a unique, basic, DNA binding C-terminal motif-is highly homologous to SMC1 (which may now be called SMC1alpha) and is not present in the yeast genome...
  3. Lee J, Iwai T, Yokota T, Yamashita M. Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci. 2003;116:2781-90 pubmed publisher
    ..transition by multisubunit protein complexes called cohesin, which include at least four proteins, SMC1alpha, SMC3, Rad21 and either SA1 or SA2, in mammalian somatic cells...
  4. Kagey M, Newman J, Bilodeau S, Zhan Y, Orlando D, van Berkum N, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010;467:430-5 pubmed publisher
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell. ..
  5. Kurze A, Michie K, Dixon S, Mishra A, Itoh T, Khalid S, et al. A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion. EMBO J. 2011;30:364-78 pubmed publisher
    Cohesin's structural maintenance of chromosome 1 (Smc1) and Smc3 are rod-shaped proteins with 50-nm long intra-molecular coiled-coil arms with a heterodimerization domain at one end and an ABC-like nucleotide-binding domain (NBD) at the ..
  6. Remeseiro S, Cuadrado A, Gomez Lopez G, Pisano D, Losada A. A unique role of cohesin-SA1 in gene regulation and development. EMBO J. 2012;31:2090-102 pubmed publisher
    Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth...
  7. Stracker T, Williams B, Deriano L, Theunissen J, Adelman C, Roth D, et al. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol. 2009;29:503-14 pubmed publisher
    ..Our results reveal a role for DNA-PKcs in the maintenance of S/G(2)-phase chromosome stability and in the induction of cell cycle checkpoint responses. ..
  8. Sultana R, Adler D, Edelhoff S, Carrel L, Lee K, Chapman V, et al. The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Hum Mol Genet. 1995;4:257-63 pubmed
    ..spretus X chromosome is inactivated. The Sb1.8 gene is a new member of a group of genes that escape X inactivation in human, but are inactivated in mouse. ..
  9. Tsuchiya K, Willard H. Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human. Mamm Genome. 2000;11:849-54 pubmed
    ..Possible mechanisms responsible for the differing inactivation status between genes in the escape domain in human Xp11. 21-p11.22 and the corresponding mouse region are discussed. ..

Scientific Experts

More Information


  1. James R, Schmiesing J, Peters A, Yokomori K, Disteche C. Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice. Chromosome Res. 2002;10:549-60 pubmed
    SMC proteins are components of cohesin complexes that function in chromosome cohesion. We determined that SMC1alpha and SMC3 localized to wild-type mouse meiotic chromosomes, but with distinct differences in their patterns...
  2. Kitagawa R, Bakkenist C, McKinnon P, Kastan M. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004;18:1423-38 pubmed
    ..sites of DNA breaks after ionizing irradiation, and that this recruitment is required for the phosphorylation of SMC1 by ATM...
  3. Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher
    ..These results suggest that ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage. ..
  4. Demare L, Leng J, Cotney J, Reilly S, Yin J, Sarro R, et al. The genomic landscape of cohesin-associated chromatin interactions. Genome Res. 2013;23:1224-34 pubmed publisher
    ..Here we performed chromatin interaction analysis with paired-end tag sequencing (ChIA-PET) of the cohesin subunit SMC1A in developing mouse limb...
  5. Li T, Wang Z. Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage. Mech Ageing Dev. 2011;132:382-8 pubmed publisher
    ..MEFs reveals no obvious defects in the Chk2 phosphorylation at 1Gy, but a delayed phosphorylation of Chk2 and Smc1 only at intermediate (4.5Gy) and high (10Gy) doses, respectively...
  6. Biswas U, Hempel K, Llano E, Pendas A, Jessberger R. Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis. PLoS Genet. 2016;12:e1006389 pubmed publisher
    ..functions of the two meiosis-specific kleisins, REC8 or RAD21L, together with the only meiosis-specific SMC protein SMC1?, we generated Smc1?-/-Rec8-/- and Smc1?-/-Rad21L-/- mouse mutants...
  7. Remeseiro S, Cuadrado A, Kawauchi S, Calof A, Lander A, Losada A. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013;1832:2097-102 pubmed publisher
    ..These results provide further support for the idea that developmental defects in CdLS are caused by deregulated transcription and not by malfunction of cohesion-related processes. ..
  8. Tomaz R, Harman J, Karimlou D, Weavers L, Fritsch L, Bou Kheir T, et al. Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation. Development. 2017;144:567-579 pubmed publisher
    ..Jmjd2c abrogates G9a recruitment and further destabilises loading of the mediator and cohesin components Med1 and Smc1a at newly activated and poised enhancers in ESC-derived epiblast-like cells...
  9. Chatzinikolaou G, Apostolou Z, Aid Pavlidis T, Ioannidou A, Karakasilioti I, Papadopoulos G, et al. ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes. Nat Cell Biol. 2017;19:421-432 pubmed publisher
    ..endonuclease ERCC1-XPF complex interacts with the insulator binding protein CTCF, the cohesin subunits SMC1A and SMC3 and with MBD2; the factors co-localize with ATRX at the promoters and control regions (ICRs) of imprinted ..
  10. Gutiérrez Caballero C, Herrán Y, Sanchez Martin M, Suja J, Barbero J, Llano E, et al. Identification and molecular characterization of the mammalian ?-kleisin RAD21L. Cell Cycle. 2011;10:1477-87 pubmed
    ..RAD21L interacts with other cohesin subunits such as SMC1?, SMC1b, SMC3 and with the meiosis-specific STAG3 protein...
  11. Kernohan K, Jiang Y, Tremblay D, Bonvissuto A, Eubanks J, Mann M, et al. ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Dev Cell. 2010;18:191-202 pubmed publisher
    ..We propose that ATRX, cohesin, and MeCP2 cooperate to silence a subset of imprinted genes in the postnatal mouse brain. ..
  12. Blewitt M, Gendrel A, Pang Z, Sparrow D, Whitelaw N, Craig J, et al. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Nat Genet. 2008;40:663-9 pubmed publisher
    ..This finding links a group of proteins normally associated with structural aspects of chromosome biology with epigenetic gene silencing. ..
  13. Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, et al. In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Hum Mol Genet. 2006;15:1847-57 pubmed
    ..Our findings suggest a critical function for CEP290 in ciliary transport and provide insights into the mechanism of early-onset photoreceptor degeneration. ..
  14. Morales M, Theunissen J, Kim C, Kitagawa R, Kastan M, Petrini J. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 2005;19:3043-54 pubmed
  15. Darwiche N, Freeman L, Strunnikov A. Characterization of the components of the putative mammalian sister chromatid cohesion complex. Gene. 1999;233:39-47 pubmed
    ..Overexpression of a PW29-GFP fusion protein in mouse fibroblasts leads to inhibition of proliferation, implicating this protein and its complex with SMC proteins in the control of mitotic cycle progression. ..
  16. Ding C, Li Y, Kim B, Malovannaya A, Jung S, Wang Y, et al. Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions. J Proteome Res. 2011;10:3652-9 pubmed publisher
    ..vertebrate cohesin complex consists of four core components including structure maintenance of chromosomes proteins SMC1 and SMC3, RAD21, and SA2/SA1...
  17. Stedman W, Kang H, Lin S, Kissil J, Bartolomei M, Lieberman P. Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators. EMBO J. 2008;27:654-66 pubmed publisher
    ..RAD21 and SMC1 also associate with the cellular CTCF sites at mammalian c-myc promoter and H19/Igf2 imprinting control region...
  18. Houlihan S, Feng Y. The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. elife. 2014;3:e03297 pubmed publisher
    ..These findings suggest that NDE1-mediated heterochromatin replication is indispensible for neuronal differentiation, and that the loss of NDE1 function may lead to genomic neurological disorders. ..
  19. Fazio G, Gaston Massuet C, Bettini L, Graziola F, Scagliotti V, Cereda A, et al. CyclinD1 Down-Regulation and Increased Apoptosis Are Common Features of Cohesinopathies. J Cell Physiol. 2016;231:613-22 pubmed publisher
    Genetic variants within components of the cohesin complex (NIPBL, SMC1A, SMC3, RAD21, PDS5, ESCO2, HDAC8) are believed to be responsible for a spectrum of human syndromes known as "cohesinopathies" that includes Cornelia de Lange ..
  20. Lee J, Hirano T. RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J Cell Biol. 2011;192:263-76 pubmed publisher
    ..RAD21L associates with SMC3, STAG3, and either SMC1? or SMC1?...
  21. Guan J, Ekwurtzel E, Kvist U, Yuan L. Cohesin protein SMC1 is a centrosomal protein. Biochem Biophys Res Commun. 2008;372:761-4 pubmed publisher
    Structural maintenance of chromosome protein 1 (SMC1) is well known for its roles in sister chromatid cohesion and DNA repair...