Gene Symbol: Smarce1
Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Alias: 2810417B20Rik, 5830412H02Rik, 9030408N19Rik, Baf27, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1, BAF57, BRG1-associated factor 57, SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1
Species: mouse
Products:     Smarce1

Top Publications

  1. Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree G. Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. Proc Natl Acad Sci U S A. 1998;95:492-8 pubmed
    ..However, we now describe the cloning of the 57-kDa subunit (BAF57), which is present only in higher eukaryotes but not in yeast...
  2. Chi T, Wan M, Zhao K, Taniuchi I, Chen L, Littman D, et al. Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature. 2002;418:195-9 pubmed
    ..We find that mutations in the high mobility group (HMG) domain of BAF57--a DNA-binding subunit of the mammalian SWI/SNF-like chromatin-remodelling BAF complexes--or in the BAF complex ..
  3. Wan M, Zhang J, Lai D, Jani A, Prestone Hurlburt P, Zhao L, et al. Molecular basis of CD4 repression by the Swi/Snf-like BAF chromatin remodeling complex. Eur J Immunol. 2009;39:580-8 pubmed publisher
    ..repression during T-cell development, because deletion of the ATPase subunit Brg1 or a dominant negative mutant of BAF57 each impairs CD4 repression in early thymocytes...
  4. Link K, Burd C, Williams E, Marshall T, Rosson G, Henry E, et al. BAF57 governs androgen receptor action and androgen-dependent proliferation through SWI/SNF. Mol Cell Biol. 2005;25:2200-15 pubmed
    ..However, the mechanisms underlying SWI/SNF regulation of the AR remained unsolved. We show here that the BAF57 subunit, an accessory component of the remodeling complex, is a critical regulator of AR function...
  5. Belandia B, Orford R, Hurst H, Parker M. Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J. 2002;21:4094-103 pubmed
    ..Here, we have identified an interaction between the estrogen receptor and BAF57, a subunit present only in mammalian SWI/SNF complexes, which is stimulated by estrogen and requires both a ..
  6. Bultman S, Gebuhr T, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005;19:2849-61 pubmed
    ..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling. ..
  7. Lomeli H, Castillo Robles J. The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin-remodeling complex. FEBS Lett. 2016;590:1555-69 pubmed publisher
    ..b>BAF57 is a subunit of the BAF complexes; it is encoded only in higher eukaryotes and is present in all mammalian ..
  8. Baker K, Wei G, Schaffner A, Ostrowski M. Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter. J Biol Chem. 2003;278:17876-84 pubmed
    ..Brg-1, the ATP-hydrolyzing component of the SWI/SNF complex, along with the BAF57/p50 and Ini1 subunits could be co-immunoprecipitated from cells with ets-2...
  9. Lessard J, Wu J, Ranish J, Wan M, Winslow M, Staahl B, et al. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007;55:201-15 pubmed
    ..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits. ..

More Information


  1. Kim S, Zhang S, Choi K, Reister R, Do C, Baykiz A, et al. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Biol Psychiatry. 2009;65:425-31 pubmed publisher
    ..The RNF41 and its binding partners suggest molecular pathways underlying behavior, highlighting a potential role for the ubiquitin proteasome system in psychiatric illness. ..
  2. Faralli H, Martin E, Coré N, Liu Q, Filippi P, Dilworth F, et al. Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. J Biol Chem. 2011;286:23498-510 pubmed publisher
    ..We identified the BRG1-associated factor 57 (BAF57), a subunit of the SWI/SNF complex, as a partner of TSHZ3...
  3. Rapicavoli N, Poth E, Zhu H, Blackshaw S. The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural Dev. 2011;6:32 pubmed publisher
  4. Dhar S, Thota A, Rao M. Insights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesis. J Biol Chem. 2012;287:6387-405 pubmed publisher
    ..Furthermore, Brdt interacts with Smarce1, a member of the SWI/SNF family...
  5. Olave I, Wang W, Xue Y, Kuo A, Crabtree G. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509-17 pubmed
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons. ..
  6. Ding L, Paszkowski Rogacz M, Nitzsche A, Slabicki M, Heninger A, de Vries I, et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell. 2009;4:403-15 pubmed publisher
    ..We propose that the Paf1C plays an important role in maintaining ESC identity. ..
  7. Jagani Z, Mora Blanco E, Sansam C, McKenna E, Wilson B, Chen D, et al. Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat Med. 2010;16:1429-33 pubmed publisher
    ..Therefore, our studies reveal that SNF5 is a key mediator of Hh signaling and that aberrant activation of GLI1 is a previously undescribed targetable mechanism contributing to the growth of MRT cells. ..
  8. He S, Pirity M, Wang W, Wolf L, Chauhan B, Cveklova K, et al. Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3:21 pubmed publisher
    ..Brg1 is directly or indirectly involved in processes that degrade lens fiber cell chromatin. The presence of nuclei and other organelles generates scattered light incompatible with the optical requirements for the lens. ..
  9. Pirotte D, Wislet Gendebien S, Cloes J, Rogister B. Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex. Mol Cell Neurosci. 2010;43:72-80 pubmed publisher
    ..Moreover, we showed that ICD physically interacted in cultured NSC with BRM and BAF57, two members of the Swi/Snf remodeling complex, and that ICD stimulation of neuronal cell differentiation is ..
  10. Chaiyachati B, Kaundal R, Zhao J, Wu J, Flavell R, Chi T. LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting. BMC Biol. 2012;10:96 pubmed publisher
    ..this study we proved the principle of LOFT in the context of T-cell development, at a hypomorphic allele of Baf57/Smarce1 encoding a subunit of the chromatin-remodeling Brg/Brahma-associated factor (BAF) complex...