Smarcd3

Summary

Gene Symbol: Smarcd3
Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Alias: 1500001J14Rik, 2210409C08Rik, BAF60C, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, 60 kDa BRG-1/Brm-associated factor subunit C, BRG1-associated factor 60C, mBAF60c
Species: mouse
Products:     Smarcd3

Top Publications

  1. Debril M, Gelman L, Fayard E, Annicotte J, Rocchi S, Auwerx J. Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. J Biol Chem. 2004;279:16677-86 pubmed
    ..BAF60c2 represents a new isoform of BAF60c, a component of the SWI/SNF (mating type switching/sucrose non-fermenting) chromatin remodeling complex...
  2. Ai D, Fu X, Wang J, Lu M, Chen L, Baldini A, et al. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007;104:9319-24 pubmed
    ..Our findings reveal that Wnt signaling plays a major positive role in promoting growth and diversification of SHF precursors into right ventricular and interventricular myocardium. ..
  3. Forcales S, Albini S, Giordani L, Malecova B, Cignolo L, Chernov A, et al. Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex. EMBO J. 2012;31:301-16 pubmed publisher
    ..We show that the muscle determination factor MyoD and the SWI/SNF subunit BAF60c interact on the regulatory elements of MyoD-target genes in myoblasts, prior to activation of transcription...
  4. Lee K, Singh M, Ussar S, Wetzel P, Hirshman M, Goodyear L, et al. Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054 pubmed publisher
    ..Thus, Tbx15 is one of a limited number of transcription factors to be identified with a critical role in regulating glycolytic fibre identity and muscle metabolism. ..
  5. Zhao R, Watt A, Battle M, Li J, Bondow B, Duncan S. Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008;317:614-9 pubmed publisher
    ..Our data support a model whereby GATA4 or GATA6 are essential for expression of the network of transcription factors that regulate the onset of cardiac myocyte gene expression during mammalian development. ..
  6. Nakamura R, Koshiba Takeuchi K, Tsuchiya M, Kojima M, Miyazawa A, Ito K, et al. Expression analysis of Baf60c during heart regeneration in axolotls and neonatal mice. Dev Growth Differ. 2016;58:367-82 pubmed publisher
    ..b>Baf60c (BRG1/BRM-associated factor 60c), a component of ATP-dependent chromatin-remodeling complexes, has an essential ..
  7. D Aniello C, Fiorenzano A, Iaconis S, Liguori G, Andolfi G, Cobellis G, et al. The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis. Cardiovasc Res. 2013;100:95-104 pubmed publisher
    ..differentiation, (ii) regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus and the Baf60c/Smarcd3 subunit of the Brg1/Brm-associated factors (BAF) chromatin-remodelling complex...
  8. Christoforou N, Chellappan M, Adler A, Kirkton R, Wu T, Addis R, et al. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PLoS ONE. 2013;8:e63577 pubmed publisher
    ..Overexpression of transcription factors MYOCD and SRF alone or in conjunction with Mesp1 and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4, TBX5, and MEF2C...
  9. Van Handel B, Montel Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd C, et al. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012;150:590-605 pubmed publisher
    ..These results reveal unexpected plasticity in embryonic endothelium such that loss of a single master regulator can induce ectopic cardiomyogenesis from endothelial cells. ..

More Information

Publications21

  1. Yu Z, Mannik J, Soto A, Lin K, Andersen B. The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J. 2009;28:1890-903 pubmed publisher
    ..These results show a crucial role for Get1 in urothelial differentiation and barrier formation. ..
  2. Lamba D, Hayes S, Karl M, Reh T. Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008;237:3016-23 pubmed publisher
    ..In this study, we show that Baf60c, another important part of this large complex, acts in a similar neural progenitor-specific manner...
  3. Lessard J, Wu J, Ranish J, Wan M, Winslow M, Staahl B, et al. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007;55:201-15 pubmed
    ..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits. ..
  4. Wang Y, Wong R, Tang T, Hudak C, Yang D, Duncan R, et al. Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Mol Cell. 2013;49:283-97 pubmed publisher
    ..In response to insulin, BAF60c is phosphorylated at S247 by atypical PKC?/?, which causes translocation of BAF60c to the nucleus and allows a ..
  5. Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
  6. Takeuchi J, Lickert H, Bisgrove B, Sun X, Yamamoto M, Chawengsaksophak K, et al. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007;104:846-51 pubmed
    ..In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF chromatin remodeling complex, is essential for establishment of LR asymmetry...
  7. Martini M, Dobrowolny G, Aucello M, Musarò A. Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation. Mediators Inflamm. 2015;2015:537853 pubmed publisher
    ..progenitors (FAPs) phenotype, upregulating HDAC4 protein and preventing the myogenic commitment complex BAF60C-SWI/SNF...
  8. Meng Z, Li S, Wang L, Ko H, Lee Y, Jung D, et al. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013;19:640-5 pubmed publisher
    ..Here we show that Baf60c (also called Smarcd3), a transcriptional cofactor enriched in fast-twitch muscle, promotes a switch from oxidative to glycolytic ..
  9. Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P. The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor. Mol Cell Endocrinol. 2007;270:23-32 pubmed
    ..This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process. ..
  10. Devine W, Wythe J, George M, Koshiba Takeuchi K, Bruneau B. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. elife. 2014;3: pubmed publisher
    ..We identify Smarcd3 as a marker of early specified cardiac precursors and identify within these precursors a compartment boundary at ..
  11. Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999;10:345-55 pubmed
    ..We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation. ..
  12. Meng Z, Tao W, Sun J, Wang Q, Mi L, Lin J. Uncoupling Exercise Bioenergetics From Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle. Diabetes. 2018;67:85-97 pubmed publisher
    ..In this study, we conditionally inactivated Baf60a, Baf60c, or both in mature skeletal myocytes to delineate their contribution to muscle bioenergetics and metabolic ..