Smarcc2

Summary

Gene Symbol: Smarcc2
Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Alias: 5930405J04Rik, SWI/SNF complex subunit SMARCC2, BAF170, BRG1-associated factor 170, SWI/SNF complex 170 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2
Species: mouse
Products:     Smarcc2

Top Publications

  1. Lessard J, Wu J, Ranish J, Wan M, Winslow M, Staahl B, et al. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007;55:201-15 pubmed
    ..More broadly, these studies suggest that SWI/SNF-like complexes in vertebrates achieve biological specificity by combinatorial assembly of their subunits. ..
  2. Jagani Z, Mora Blanco E, Sansam C, McKenna E, Wilson B, Chen D, et al. Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Nat Med. 2010;16:1429-33 pubmed publisher
    ..Therefore, our studies reveal that SNF5 is a key mediator of Hh signaling and that aberrant activation of GLI1 is a previously undescribed targetable mechanism contributing to the growth of MRT cells. ..
  3. Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev A, et al. Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning. Mol Neurobiol. 2017;54:4618-4635 pubmed publisher
    ..Here, we show that in postnatal dentate gyrus (DG), the BAF170 subunit of the complex is expressed in radial glial-like (RGL) progenitors and in cell types involved in ..
  4. Miller S, Mohn S, Weinmann A. Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell. 2010;40:594-605 pubmed publisher
    ..This function for H3K27 demethylase proteins may explain their presence in differentiated cells where the epigenetic profile is already established. ..
  5. Harmacek L, Watkins Chow D, Chen J, Jones K, Pavan W, Salbaum J, et al. A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 2014;74:483-97 pubmed publisher
    ..These results shed light on the role of the BAF complex in the process of neural tube closure and highlight the importance of studying missense alleles to understand epigenetic regulation during critical phases of development. ..
  6. Jiang Z, Tang Y, Zhao X, Zhang M, Donovan D, Tian X. Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells. Stem Cells Dev. 2015;24:2328-36 pubmed publisher
    ..For example, in embryonic stem cells, esBAF contains Brg1 and Baf155, while their homologs, Brm and Baf170, are present in BAF of somatic cells...
  7. Narayanan R, Pirouz M, Kerimoglu C, Pham L, Wagener R, Kiszka K, et al. Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development. Cell Rep. 2015;13:1842-54 pubmed publisher
    ..Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in ..
  8. Nguyen H, Sokpor G, Pham L, Rosenbusch J, Stoykova A, Staiger J, et al. Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development. Cell Cycle. 2016;15:1317-24 pubmed publisher
    ..Importantly, we recently reported that double conditional knock-out (dcKO) of the BAF155 and BAF170 core subunits in mice abolished the presence of the other BAF subunits in the developing cortex...
  9. Bachmann C, Nguyen H, Rosenbusch J, Pham L, Rabe T, Patwa M, et al. mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium. PLoS Genet. 2016;12:e1006274 pubmed publisher
    ..We demonstrated that BAF155 subunit is highly expressed in both oNSCs and ORNs, whereas high expression of BAF170 subunit is observed only in ORNs...

More Information

Publications14

  1. Olave I, Wang W, Xue Y, Kuo A, Crabtree G. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509-17 pubmed
    ..We speculate that bBAF complexes create neuronal-specific patterns of chromatin accessibility, thereby imparting new regulatory characteristics to ubiquitous sequence-specific transcription factors in neurons. ..
  2. Ahmed M, Xu J, Xu P. EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development. 2012;139:1965-77 pubmed publisher
    ..We demonstrate that EYA1 and SIX1 interact directly with the SWI/SNF chromatin-remodeling subunits BRG1 and BAF170 to drive neurogenesis cooperatively in 3T3 cells and cochlear nonsensory epithelial cells, and that SOX2 ..
  3. Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
  4. Tuoc T, Narayanan R, Stoykova A. BAF chromatin remodeling complex: cortical size regulation and beyond. Cell Cycle. 2013;12:2953-9 pubmed publisher
    ..Using cortex-specific conditional knockout and overexpression mouse models, we have recently reported that BAF170, a subunit of the vertebrate BAF chromatin remodeling complex, interacts with transcription factor (TF) Pax6 to ..
  5. Cajigas I, Leib D, Cochrane J, Luo H, Swyter K, Chen S, et al. Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development. 2015;142:2641-52 pubmed publisher
    ..SWI/SNF-related chromatin remodelers Brahma-related gene 1 (BRG1, SMARCA4) and Brahma-associated factor (BAF170, SMARCC2) in the developing mouse forebrain...