Gene Symbol: Smap2
Description: small ArfGAP 2
Alias: 1810031K02Rik, AA408614, Smap1l, stromal membrane-associated protein 2, stromal membrane-associated GTPase-activating protein 2
Natsume W, Tanabe K, Kon S, Yoshida N, Watanabe T, Torii T, et al
. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. Mol Biol Cell. 2006;17:2592-603 pubmed
..Here, we identified a SMAP1 homologue that we named SMAP2. Like SMAP1, SMAP2 exhibits GAP activity and interacts with clathrin heavy chain (CHC)...
Funaki T, Kon S, Ronn R, Henmi Y, Kobayashi Y, Watanabe T, et al
. Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport. Cell Struct Funct. 2011;36:83-95 pubmed
b>SMAP2 is an Arf GTPase-activating protein that is located and functions on early endosome membranes...
Rorick N, Kinoshita A, Weirather J, Peyrard Janvid M, de Lima R, Dunnwald M, et al
. Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Am J Med Genet A. 2011;155A:1314-21 pubmed publisher
..The expression and mutation data were consistent with the hypothesis that WDR65 was a novel gene involved in oral clefting. ..
Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, et al
. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis. Mol Biol Cell. 2013;24:2633-44 pubmed publisher
..trans-Golgi network (TGN) functions as a hub organelle in the exocytosis of clathrin-coated membrane vesicles, and SMAP2 is an Arf GTPase-activating protein that binds to both clathrin and the clathrin assembly protein (CALM)...
Sumiyoshi M, Masuda N, Tanuma N, Ogoh H, Imai E, Otsuka M, et al
. Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015;589:2754-62 pubmed publisher
..protein (SMAP) subfamily of Arf GTPase-activating proteins consists of closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes ..