Gene Symbol: Sly
Description: Sycp3 like Y-linked
Alias: Sycp3 like Y-linked, sycp3 like Y-linked
Touré A, Clemente E, Ellis P, Mahadevaiah S, Ojarikre O, Ball P, et al
. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biol. 2005;6:R102 pubmed
..The Sly family encodes a protein with homology to the chromatin-associated proteins XLR and XMR that are encoded by the X ..
Reynard L, Cocquet J, Burgoyne P. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol Reprod. 2009;81:250-7 pubmed publisher
..Of these multicopy genes, the recently described Sly has been favored as the gene underlying the spermiogenic defects associated with Y long-arm deletions...
Yamauchi Y, Riel J, Wong S, Ojarikre O, Burgoyne P, Ward M. Live offspring from mice lacking the Y chromosome long arm gene complement. Biol Reprod. 2009;81:353-61 pubmed publisher
..The present work also led to development of a new mouse model lacking NPYq gene complement that will facilitate future studies of Y-encoded gene function. ..
Cocquet J, Ellis P, Yamauchi Y, Mahadevaiah S, Affara N, Ward M, et al
. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244 pubmed publisher
..mice producing small interfering RNAs that specifically target the transcripts of the MSYq-encoded multicopy gene Sly (Sycp3-like Y-linked)...
Cocquet J, Ellis P, Mahadevaiah S, Affara N, Vaiman D, Burgoyne P. A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 2012;8:e1002900 pubmed publisher
..The Y-encoded multicopy gene Sly has been shown to have a predominant role in the epigenetic repression of post meiotic sex chromatin (PMSC) and, as ..
Riel J, Yamauchi Y, Sugawara A, Li H, Ruthig V, Stoytcheva Z, et al
. Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging. J Cell Sci. 2013;126:803-13 pubmed publisher
..The NPYq-encoded multi-copy gene Sly controls the expression of sex chromosome genes after meiosis and Sly deficiency results in a remarkable ..
Comptour A, Moretti C, Serrentino M, Auer J, Ialy Radio C, Ward M, et al
. SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. FEBS J. 2014;281:1571-84 pubmed publisher
..The MSYq gene Sly has been shown to be a key regulator of post-meiotic sex chromosome gene expression and is necessary for the ..
Moretti C, Serrentino M, Ialy Radio C, Delessard M, Soboleva T, Tores F, et al
. SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Cell Death Differ. 2017;24:1029-1044 pubmed publisher
..Deficiency in Sly, a mouse Y chromosome-encoded gene expressed only in postmeiotic male germ cells, has been shown to result in the ..