Gene Symbol: Sly
Description: Sycp3 like Y-linked
Alias: Sycp3 like Y-linked, sycp3 like Y-linked
Species: mouse
Products:     Sly

Top Publications

  1. Touré A, Clemente E, Ellis P, Mahadevaiah S, Ojarikre O, Ball P, et al. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biol. 2005;6:R102 pubmed
    ..The Sly family encodes a protein with homology to the chromatin-associated proteins XLR and XMR that are encoded by the X ..
  2. Reynard L, Cocquet J, Burgoyne P. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol Reprod. 2009;81:250-7 pubmed publisher
    ..Of these multicopy genes, the recently described Sly has been favored as the gene underlying the spermiogenic defects associated with Y long-arm deletions...
  3. Yamauchi Y, Riel J, Wong S, Ojarikre O, Burgoyne P, Ward M. Live offspring from mice lacking the Y chromosome long arm gene complement. Biol Reprod. 2009;81:353-61 pubmed publisher
    ..The present work also led to development of a new mouse model lacking NPYq gene complement that will facilitate future studies of Y-encoded gene function. ..
  4. Cocquet J, Ellis P, Yamauchi Y, Mahadevaiah S, Affara N, Ward M, et al. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244 pubmed publisher
    ..mice producing small interfering RNAs that specifically target the transcripts of the MSYq-encoded multicopy gene Sly (Sycp3-like Y-linked)...
  5. Cocquet J, Ellis P, Mahadevaiah S, Affara N, Vaiman D, Burgoyne P. A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 2012;8:e1002900 pubmed publisher
    ..The Y-encoded multicopy gene Sly has been shown to have a predominant role in the epigenetic repression of post meiotic sex chromatin (PMSC) and, as ..
  6. Riel J, Yamauchi Y, Sugawara A, Li H, Ruthig V, Stoytcheva Z, et al. Deficiency of the multi-copy mouse Y gene Sly causes sperm DNA damage and abnormal chromatin packaging. J Cell Sci. 2013;126:803-13 pubmed publisher
    ..The NPYq-encoded multi-copy gene Sly controls the expression of sex chromosome genes after meiosis and Sly deficiency results in a remarkable ..
  7. Comptour A, Moretti C, Serrentino M, Auer J, Ialy Radio C, Ward M, et al. SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. FEBS J. 2014;281:1571-84 pubmed publisher
    ..The MSYq gene Sly has been shown to be a key regulator of post-meiotic sex chromosome gene expression and is necessary for the ..
  8. Moretti C, Serrentino M, Ialy Radio C, Delessard M, Soboleva T, Tores F, et al. SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Cell Death Differ. 2017;24:1029-1044 pubmed publisher
    ..Deficiency in Sly, a mouse Y chromosome-encoded gene expressed only in postmeiotic male germ cells, has been shown to result in the ..