Gene Symbol: Slx
Description: Sycp3 like X-linked
Alias: EG664958, Xmr, Sycp3 like X-linked
Reynard L, Turner J, Cocquet J, Mahadevaiah S, Touré A, Hoog C, et al
. Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR. Biol Reprod. 2007;77:329-35 pubmed
The mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr/Slx) has previously been described as encoding a testis-specific nuclear protein expressed during male meiotic prophase, and during which it becomes concentrated in ..
Cocquet J, Ellis P, Yamauchi Y, Riel J, Karacs T, Rattigan A, et al
. Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation. Mol Biol Cell. 2010;21:3497-505 pubmed publisher
..The X chromosome carries two multicopy genes related to Sly: Slx and Slxl1...
Calenda A, Allenet B, Escalier D, Bach J, Garchon H. The meiosis-specific Xmr gene product is homologous to the lymphocyte Xlr protein and is a component of the XY body. EMBO J. 1994;13:100-9 pubmed
..The protein product of this newly identified gene, called Xmr (Xlr-related, meiosis regulated), is located in the nuclei of spermatocytes, early in the prophase of the first ..
Di Carlo A, Travia G, De Felici M. The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int J Dev Biol. 2000;44:241-4 pubmed
..This strongly supports the hypothesis that primordial germ cells are programmed to enter meiosis unrespective of the sex and that foetal testis produces a factor that inhibits such programme. ..
Costa Y, Speed R, Gautier P, Semple C, Maratou K, Turner J, et al
. Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006;15:2324-34 pubmed
..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC...
Cocquet J, Ellis P, Mahadevaiah S, Affara N, Vaiman D, Burgoyne P. A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. PLoS Genet. 2012;8:e1002900 pubmed publisher
..of post meiotic sex chromatin (PMSC) and, as such, represses X and Y genes, among which are its X-linked homologs Slx and Slxl1...
Comptour A, Moretti C, Serrentino M, Auer J, Ialy Radio C, Ward M, et al
. SSTY proteins co-localize with the post-meiotic sex chromatin and interact with regulators of its expression. FEBS J. 2014;281:1571-84 pubmed publisher
..Moreover, SSTY proteins interact with SLY protein and its X-linked homolog SLX/SLXL1, and may be required for localization of SLX/SLY proteins in the spermatid nucleus and sex chromatin...