Gene Symbol: Slit2
Description: slit guidance ligand 2
Alias: Drad-1, E030015M03Rik, E130320P19Rik, Slil3, b2b1200.1Clo, mKIAA4141, slit-2, slit homolog 2 protein, downregulated during adipocyte differentiation-1, neurogenic extracellular slit protein
Species: mouse
Products:     Slit2

Top Publications

  1. Shu T, Butz K, Plachez C, Gronostajski R, Richards L. Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice. J Neurosci. 2003;23:203-12 pubmed
    ..Glia within the indusium griseum and the glial wedge are greatly reduced or absent and consequently Slit2 expression is also reduced...
  2. Saha B, Hari P, Huilgol D, Tole S. Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract. J Neurosci. 2007;27:2290-7 pubmed
    ..In addition, the expression of Sema6A is aberrantly upregulated. Together, these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection. ..
  3. Yang X, Han H, Sui F, Dai Y, Chen M, Geng J. Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis. Biochem Biophys Res Commun. 2010;396:571-7 pubmed publisher
    ..Robo1 was expressed in lymphatic endothelial cells to mediate the migration and tube formation of these cells upon Slit2 stimulation, which were specifically inhibited by the function-blocking antibody R5 to Slit2/Robo1 interaction...
  4. Yuan W, Zhou L, Chen J, Wu J, Rao Y, Ornitz D. The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999;212:290-306 pubmed
    ..The unique expression pattern in limb and other organs indicates additional potential functions of the Slit gene family. ..
  5. Prince J, Cho J, Dumontier E, Andrews W, Cutforth T, Tessier Lavigne M, et al. Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J Neurosci. 2009;29:14211-22 pubmed publisher
    ..Together, these results identify Robo-2 as a receptor that controls the targeting of basal VSN axons to the posterior AOB. ..
  6. Bagri A, Marin O, Plump A, Mak J, Pleasure S, Rubenstein J, et al. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002;33:233-48 pubmed
    ..Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of ..
  7. Mommersteeg M, Andrews W, Ypsilanti A, Zelina P, Yeh M, Norden J, et al. Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium. Circ Res. 2013;112:465-75 pubmed publisher
    ..Expression of genes encoding Robo1 and Robo2 receptors and their ligands Slit2 and Slit3 was found in or around the systemic venous return and pericardium during development...
  8. Grieshammer U, Le Ma -, Plump A, Wang F, Tessier Lavigne M, Martin G. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004;6:709-17 pubmed
    ..Here we show that mouse mutants lacking either SLIT2 or its receptor ROBO2, molecules known primarily for their function in axon guidance and cell migration, develop ..
  9. Long H, Sabatier C, Ma L, Plump A, Yuan W, Ornitz D, et al. Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron. 2004;42:213-23 pubmed
    ..Previous analysis of Slit1;Slit2 double mutant spinal cords failed to reveal a defect in commissural axon guidance...

More Information


  1. Fouquet C, di Meglio T, Ma L, Kawasaki T, Long H, Hirata T, et al. Robo1 and robo2 control the development of the lateral olfactory tract. J Neurosci. 2007;27:3037-45 pubmed
    ..It is known that the septum secretes Slit1 and Slit2 which repel olfactory axons in vitro and that in Slit1-/-;Slit2-/- mutant mice, the LOT is profoundly disrupted...
  2. Plump A, Erskine L, Sabatier C, Brose K, Epstein C, Goodman C, et al. Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron. 2002;33:219-32 pubmed
    ..To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes...
  3. Shu T, Sundaresan V, McCarthy M, Richards L. Slit2 guides both precrossing and postcrossing callosal axons at the midline in vivo. J Neurosci. 2003;23:8176-84 pubmed
    ..In the developing corpus callosum, Slit2 expressed by the glial wedge guides callosal axons before they cross the midline, as they approach the ..
  4. Kadison S, Murakami F, Matise M, Kaprielian Z. The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord. Dev Biol. 2006;296:499-513 pubmed
    ..Thus, compared to FP contact, Slit-Robo interactions are more critical for driving commissural axons out of the VM and facilitating the elaboration of a subset of contralateral commissural projections. ..
  5. Thompson H, Barker D, Camand O, Erskine L. Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract. Dev Biol. 2006;296:476-84 pubmed
    ..Here, we show that slit1 and slit2, known chemorepellents for RGC axons expressed in specific regions of the diencephalon and telencephalon, help ..
  6. Inatani M, Irie F, Plump A, Tessier Lavigne M, Yamaguchi Y. Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science. 2003;302:1044-6 pubmed
    ..Furthermore, the EXT1-null brain displayed severe guidance errors in major commissural tracts, revealing a pivotal role of HS in midline axon guidance. These findings demonstrate that HS is essential for mammalian brain development. ..
  7. Piper M, Georgas K, Yamada T, Little M. Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney. Mech Dev. 2000;94:213-7 pubmed
    ..Cell 96, 795-806). Slit2 has been shown to bind Robo1, mediating both neuronal and axonal guidance in the developing central nervous system ..
  8. Bielle F, Marcos Mondejar P, Leyva Díaz E, Lokmane L, Mire E, Mailhes C, et al. Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography. Curr Biol. 2011;21:1748-55 pubmed publisher
    ..Our study thus provides a novel framework to explain how a limited set of guidance cues can generate a vast diversity of axonal responses necessary for proper wiring of the nervous system. ..
  9. Nguyen Ba Charvet K, di Meglio T, Fouquet C, Chedotal A. Robos and slits control the pathfinding and targeting of mouse olfactory sensory axons. J Neurosci. 2008;28:4244-9 pubmed publisher
    ..We have analyzed the development of olfactory projections in Slit1/Slit2 and Robo1/Robo2 single and double mutants...
  10. Lopez Bendito G, Flames N, Ma L, Fouquet C, di Meglio T, Chedotal A, et al. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci. 2007;27:3395-407 pubmed
    ..Mice deficient in Slit2 or, even more so, in both Slit1 and Slit2 have defects in multiple axonal pathways, including corticofugal, ..
  11. Thompson H, Camand O, Barker D, Erskine L. Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina. J Neurosci. 2006;26:8082-91 pubmed
    ..Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal pathfinding in different regions ..
  12. Hernández Miranda L, Cariboni A, Faux C, Ruhrberg C, Cho J, Cloutier J, et al. Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci. 2011;31:6174-87 pubmed publisher
    ..Thus, we show for the first time that Robo1 interacts with Nrp1 to modulate semaphorin signaling in the developing forebrain and direct the migration of interneurons through the subpallium and into the cortex. ..
  13. Thompson H, Andrews W, Parnavelas J, Erskine L. Robo2 is required for Slit-mediated intraretinal axon guidance. Dev Biol. 2009;335:418-26 pubmed publisher
    ..Previously, we have shown that the inhibitory guidance molecules, Slit1 and Slit2, regulate two distinct aspects of intraretinal axon guidance in a region-specific manner...
  14. Shu T, Richards L. Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci. 2001;21:2749-58 pubmed
    ..Furthermore, slit-2 repels-suppresses cortical axon growth in three-dimensional collagen gel cocultures. ..
  15. Medioni C, Bertrand N, Mesbah K, Hudry B, Dupays L, Wolstein O, et al. Expression of Slit and Robo genes in the developing mouse heart. Dev Dyn. 2010;239:3303-11 pubmed publisher
    ..Our results suggest that patterned Slit-Robo signaling may contribute to the control of oriented cell growth during chamber morphogenesis of the mammalian heart. ..
  16. Calmont A, Ivins S, van Bueren K, Papangeli I, Kyriakopoulou V, Andrews W, et al. Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development. 2009;136:3173-83 pubmed publisher
    ..We propose that the spatiotemporal control of this tightly orchestrated network of genes participates in crucial aspects of PAA development...
  17. SMITH K, Ohkubo Y, Maragnoli M, Rasin M, Schwartz M, Sestan N, et al. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006;9:787-97 pubmed
    ..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells. ..
  18. Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, et al. Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol. 2003;171:6519-26 pubmed
    ..We show that Slit2, a neuronal repellent factor, is up-regulated in the skin by allergen sensitization and down-regulates the ..
  19. Causeret F, Danne F, Ezan F, Sotelo C, Bloch Gallego E. Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev Biol. 2002;246:429-40 pubmed
    ..Our results indicate that slit silences the attractive effects of netrin-1 and could participate in the correct ventral positioning of ION, stopping the migration when cell bodies reach the floor-plate. ..
  20. Erskine L, Williams S, Brose K, Kidd T, Rachel R, Goodman C, et al. Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits. J Neurosci. 2000;20:4975-82 pubmed
    ..In vitro, slit2 is inhibitory to RGC axons, with outgrowth of both ipsilaterally and contralaterally projecting axons being ..
  21. Tole S, Mukovozov I, Huang Y, Magalhaes M, Yan M, Crow M, et al. The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. J Leukoc Biol. 2009;86:1403-15 pubmed publisher
    ..Emerging evidence shows that by inhibiting the activation of Rho-family GTPases, Slit2/Robo also inhibit migration of other cell types toward a variety of chemotactic factors in vitro and in vivo...
  22. Farmer W, Altick A, Nural H, Dugan J, Kidd T, Charron F, et al. Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals. Development. 2008;135:3643-53 pubmed publisher
    ..Genetic tests of Slit1 and Slit2, and the Slit receptors Robo1 and Robo2 were carried out in mutant mice...
  23. Nguyen Ba Charvet K, Picard Riera N, Tessier Lavigne M, Baron van Evercooren A, Sotelo C, Chedotal A. Multiple roles for slits in the control of cell migration in the rostral migratory stream. J Neurosci. 2004;24:1497-506 pubmed
    ..Slit1 and Slit2, two known chemorepellents for developing axons, can mimic this effect...
  24. Conway C, Howe K, Nettleton N, Price D, Mason J, Pratt T. Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development. J Neurosci. 2011;31:1955-70 pubmed publisher
    ..Particular Hs2st(-/-) and Hs6st1(-/-) phenotypes closely match those of Slit1(-/-) and Slit2(-/-) embryos respectively, suggesting possible functional relationships...
  25. Jaworski A, Long H, Tessier Lavigne M. Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance. J Neurosci. 2010;30:9445-53 pubmed publisher
    ..In contrast, Robo1 prevents axonal stalling after crossing. Our results reveal specialized and complementary actions of Robo1 and Robo2 in commissural axon guidance and suggest the existence of an as yet unidentified Slit receptor. ..
  26. Andrews W, Barber M, Hernadez Miranda L, Xian J, Rakic S, Sundaresan V, et al. The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons. Dev Biol. 2008;313:648-58 pubmed
    ..Interestingly, a similar increase in proliferation was observed in Slit1(-/-)/Slit2(-/-) mutant mice, suggesting that cell division is influenced by Slit-Robo signaling mechanisms...
  27. Borrell V, Cárdenas A, Ciceri G, Galcerán J, Flames N, Pla R, et al. Slit/Robo signaling modulates the proliferation of central nervous system progenitors. Neuron. 2012;76:338-52 pubmed publisher
    ..At the molecular level, the role of Slit/Robo in progenitor cells involves transcriptional activation of the Notch effector Hes1. These findings demonstrate that Robo signaling modulates progenitor cell dynamics in the developing brain. ..
  28. Marin O, Plump A, Flames N, Sánchez Camacho C, Tessier Lavigne M, Rubenstein J. Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development. 2003;130:1889-901 pubmed
    ..that the repulsive activity found in the basal telencephalon is maintained in mice deficient in both Slit1 and Slit2, suggesting that factors other than these are responsible for this activity...
  29. Niclou S, Jia L, Raper J. Slit2 is a repellent for retinal ganglion cell axons. J Neurosci. 2000;20:4962-74 pubmed
    ..purification of an RGC growth cone collapsing factor from bovine brain membranes and its identification as Slit2. Recombinant human Slit2 collapses and repels RGC growth cones from all quadrants of the chick retina...
  30. Ma L, Tessier Lavigne M. Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons. J Neurosci. 2007;27:6843-51 pubmed
    ..for developing peripheral sensory arbors in vivo, because trigeminal sensory branching above the eye is reduced in Slit2;Slit3 double or Slit1,2,3 triple mutants...
  31. Holmes G, Negus K, Burridge L, Raman S, Algar E, Yamada T, et al. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mech Dev. 1998;79:57-72 pubmed
    ..We have isolated a second human sli homolog, SLIT2, and its murine homolog Slit2...
  32. di Meglio T, Nguyen Ba Charvet K, Tessier Lavigne M, Sotelo C, Chedotal A. Molecular mechanisms controlling midline crossing by precerebellar neurons. J Neurosci. 2008;28:6285-94 pubmed publisher
    ..Last, the analysis of Robo1/2/3 triple mutants suggests that Robo3 inhibits Robo1/2 repulsion in precrossing LRN axons but not in IO axons in which it has a dominant and distinct function. ..
  33. Zakrys L, Ward R, Pediani J, Godin A, Graham G, Milligan G. Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. Biochem J. 2014;461:61-73 pubmed publisher
    ..In each case this was unaffected by the addition of Slit2, although parallel studies demonstrated the biological activity of Slit2 and its interaction with Robo1...
  34. Dunaway C, Hwang Y, Lindsley C, Cook R, Wu J, Boothby M, et al. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol. 2011;31:404-16 pubmed publisher
    ..The role of Slit2 in vascular remodeling, however, remains controversial, with reports of both pro- and antiangiogenic activity...
  35. Alpár A, Tortoriello G, Calvigioni D, Niphakis M, Milenkovic I, Bakker J, et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun. 2014;5:4421 pubmed publisher
    ..We further show the dependence of both axonal Robo1 positioning and oligodendroglial Slit2 production on cell-type-specific cannabinoid receptor activation...
  36. di Meglio T, Kratochwil C, Vilain N, Loche A, Vitobello A, Yonehara K, et al. Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons. Science. 2013;339:204-7 pubmed publisher
    ..Thus, Ezh2-dependent epigenetic regulation of intrinsic and extrinsic transcriptional programs controls topographic neuronal guidance and connectivity in the cortico-ponto-cerebellar pathway. ..
  37. Qi C, Lan H, Ye J, Li W, Wei P, Yang Y, et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. Lab Invest. 2014;94:766-76 pubmed publisher
    ..In the current study, we evaluated the role of Slit2 in skin tumor growth and invasion in mice using a two-step chemical carcinogenesis protocol...
  38. Kim M, Fontelonga T, Roesener A, Lee H, Gurung S, Mendonca P, et al. Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. Dev Biol. 2015;399:68-79 pubmed publisher
    ..Our results show that motor neurons are actively migrating cells, and are normally trapped in a static position by Slit/Robo repulsion and Netrin-1/DCC attraction. ..
  39. Svensson K, Long J, Jedrychowski M, Cohen P, Lo J, Serag S, et al. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016;23:454-66 pubmed publisher
    ..Here we identify Slit2, a 180 kDa member of the Slit extracellular protein family, as a PRDM16-regulated secreted factor from beige fat ..
  40. Hassoun H, Hanada T, Lutchman M, Sahr K, Palek J, Hanspal M, et al. Complete deficiency of glycophorin A in red blood cells from mice with targeted inactivation of the band 3 (AE1) gene. Blood. 1998;91:2146-51 pubmed
    ..Based on these findings and other published evidence, we propose that band 3 plays a chaperone-like role, which is necessary for the recruitment of GPA to the red blood cell plasma membrane. ..
  41. Herrera E, Marcus R, Li S, Williams S, Erskine L, Lai E, et al. Foxd1 is required for proper formation of the optic chiasm. Development. 2004;131:5727-39 pubmed
    ..deficient ventral diencephalon, Foxg1 invades the Foxd1 domain, Zic2 and Islet1 expression are minimized, and Slit2 prematurely expands, changes that could contribute to axon projection errors...
  42. Mirza R, Kivrak B, Erzurumlu R. Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway. J Comp Neurol. 2013;521:312-25 pubmed publisher
    ..Collectively, our studies indicate a cooperative role for netrin and slit proteins in midline attraction and crossing behavior of the ascending facial somatosensory projections during development. ..
  43. Maekawa T, Takahashi T, Fujihara M, Urushibara N, Kadowaki Kikuchi E, Nishikawa M, et al. A novel gene (drad-1) expressed in hematopoiesis-supporting stromal cell lines, ST2, PA6 and A54 preadipocytes: use of mRNA differential display. Stem Cells. 1997;15:334-9 pubmed
    ..Moreover, drad-1 was also found to be expressed in bone marrow in vivo. The function of the protein encoded by drad-1 is unknown, but the expression of the gene may be useful as a molecular marker of adipocyte differentiation. ..
  44. Le L, Cazares O, Mouw J, Chatterjee S, Macias H, Moran A, et al. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. J Cell Biol. 2016;212:707-19 pubmed publisher
    ..Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to ..
  45. London N, Zhu W, Bozza F, Smith M, Greif D, Sorensen L, et al. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci Transl Med. 2010;2:23ra19 pubmed publisher
    ..Thus, enhancing the resilience of the host vascular system to the host's innate immune response may provide a therapeutic strategy for treating multiple infectious agents. ..
  46. Tsuchiya R, Takahashi K, Liu F, Takahashi H. Aberrant axonal projections from mammillary bodies in Pax6 mutant mice: possible roles of Netrin-1 and Slit 2 in mammillary projections. J Neurosci Res. 2009;87:1620-33 pubmed publisher
    ..We found that Netrin-1 was ectopically up-regulated and that both Slit1 and Slit2 were down-regulated in the presumptive dorsal thalamus of Pax6 mutant mice...
  47. Delloye Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, et al. PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments. Nat Neurosci. 2015;18:36-45 pubmed publisher
    ..Thus, PlexinA1 mediates both Semaphorin and Slit signaling, and Slit processing generates two active fragments, each exerting distinct effects through specific receptors. ..
  48. Macias H, Moran A, Samara Y, Moreno M, Compton J, Harburg G, et al. SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number. Dev Cell. 2011;20:827-40 pubmed publisher
    ..of Robo1 and show that it induces Robo1 expression specifically in the basal layer, functioning together with SLIT2 to restrict branch formation...
  49. Greenberg J, Thompson F, Brooks S, Shannon J, Akeson A. Slit and robo expression in the developing mouse lung. Dev Dyn. 2004;230:350-60 pubmed
    ..The temporal and spatial distribution of Slit and Robo mRNAs indicate that these genes may direct the functional organization and differentiation of fetal lung mesenchyme. ..
  50. Marlow R, Binnewies M, Sorensen L, Monica S, Strickland P, Forsberg E, et al. Vascular Robo4 restricts proangiogenic VEGF signaling in breast. Proc Natl Acad Sci U S A. 2010;107:10520-5 pubmed publisher
    ..We identify a stromal, rather than epithelial, source of SLITs that inhibits blood vessel growth by signaling through endothelial ROBO4 to down-regulate VEGF/VEGFR2 signaling...
  51. Ye B, Geng Z, Ma L, Geng J. Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. J Immunol. 2010;185:6294-305 pubmed publisher
    ..We report that Clara cells in the bronchial epithelium secreted Slit2, whereas eosinophils and neutrophils expressed its cell-surface receptor, Robo1...
  52. Patel S, Huang Y, Reheman A, Pluthero F, Chaturvedi S, Mukovozov I, et al. The cell motility modulator Slit2 is a potent inhibitor of platelet function. Circulation. 2012;126:1385-95 pubmed publisher
    ..A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein, Slit2, and its transmembrane receptor, Robo-1, repel neuronal migration in the developing central nervous system...
  53. Carr L, Parkinson D, Dun X. Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system. PLoS ONE. 2017;12:e0172736 pubmed publisher
    ..While Slit1 and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 and Robo1 are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts ..
  54. Kim H, Zhang H, Li H, Wu T, Swisher S, He D, et al. Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma. Neoplasia. 2008;10:1411-20 pubmed
    ..Previous studies suggested that Slit2 might be a tumor-suppressor gene...
  55. Saito Y, Miranda Rottmann S, Ruggiu M, Park C, Fak J, Zhong R, et al. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. elife. 2016;5: pubmed publisher
  56. Fan X, Li Q, Pisarek Horowitz A, Rasouly H, Wang X, Bonegio R, et al. Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep. 2012;2:52-61 pubmed publisher
    ..In contrast to the role of nephrin that promotes actin polymerization, Slit2-Robo2 signaling inhibits nephrin-induced actin polymerization...
  57. Jaworski A, Tessier Lavigne M. Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling. Nat Neurosci. 2012;15:367-9 pubmed publisher
    ..We found that Slit2 and its Robo receptors are expressed by motor axons, and that inactivation of Slit2 or Robo1 and Robo2 in mice ..
  58. Tseng R, Chang J, Chen J, Huang W, Tang Y, Kuo I, et al. Deregulation of SLIT2-mediated Cdc42 activity is associated with esophageal cancer metastasis and poor prognosis. J Thorac Oncol. 2015;10:189-98 pubmed publisher
    b>SLIT2, a secreted protein, has been found to inactivate Cdc42 GTPase to modulate neural cell migration...
  59. Sánchez Camacho C, Ortega J, Ocaña I, Alcantara S, Bovolenta P. Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation. Dev Neurobiol. 2011;71:337-50 pubmed publisher
    ..Together, these results indicate that Bmp7 is indirectly required for corpus callosum formation by controlling the timely differentiation of its guidepost cells. ..
  60. Zhang Q, Zhou D, Lei Y, Zheng L, Chen S, Gou H, et al. Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway. Oncotarget. 2015;6:3123-35 pubmed
    b>Slit2 is often overexpressed in cancers. Slit2 is a secreted protein that binds to Roundabout (Robo) receptors to regulate cell growth and migration...
  61. Down M, Willshaw D, Pratt T, Price D. Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos. BMC Neurosci. 2013;14:9 pubmed publisher
    Previous studies have suggested that the axon guidance proteins Slit1 and Slit2 co-operate to establish the optic chiasm in its correct position at the ventral diencephalic midline...
  62. Hirata T, Nakazawa M, Yoshihara S, Miyachi H, Kitamura K, Yoshihara Y, et al. Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously. Development. 2006;133:1433-43 pubmed
    ..These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb. ..
  63. Small E, Sutherland L, Rajagopalan K, Wang S, Olson E. MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res. 2010;107:1336-44 pubmed publisher
  64. Sawamoto K, Wichterle H, Gonzalez Perez O, Cholfin J, Yamada M, Spassky N, et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006;311:629-32 pubmed
    ..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons. ..
  65. Quesnel Vallieres M, Dargaei Z, Irimia M, Gonatopoulos Pournatzis T, Ip J, Wu M, et al. Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. Mol Cell. 2016;64:1023-1034 pubmed publisher
    ..Collectively, our results provide evidence that misregulation of an nSR100-dependent splicing network controlled by changes in neuronal activity is causally linked to a substantial fraction of autism cases. ..
  66. Wang S, Ibrahim L, Kim Y, Gibson D, Leung H, Yuan W, et al. Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation. J Neurosci. 2013;33:12242-54 pubmed publisher
    ..In this study, in situ hybridization in the mouse cochlea suggests that Slit2 and its receptor, Robo1/2, exhibit apparently complementary expression patterns in the spiral ganglion and its ..
  67. Li P, Peng H, Lu W, Shuai H, Zha Q, Yeung C, et al. Role of Slit2/Robo1 in trophoblast invasion and vascular remodeling during ectopic tubal pregnancy. Placenta. 2015;36:1087-94 pubmed publisher
    For ectopic tubal pregnancy to be viable, it requires a supporting vascular network and functioning trophoblast. Slit2/Robo1 signaling plays an important role in placental angiogenesis during normal pregnancy...
  68. Hardie W, Korfhagen T, Sartor M, Prestridge A, Medvedovic M, Le Cras T, et al. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007;37:309-21 pubmed
    ..These studies support a role for epithelial cell-derived TGF-alpha in the regulation of processes that alter the airway and vascular architecture and function. ..
  69. Sun H, Dai K, Tang T, Zhang X. Regulation of osteoblast differentiation by slit2 in osteoblastic cells. Cells Tissues Organs. 2009;190:69-80 pubmed publisher
    ..The mRNAs slit2 and robo were detected in primary cell lines during their osteoblastic differentiation...
  70. Camurri L, Mambetisaeva E, Davies D, Parnavelas J, Sundaresan V, Andrews W. Evidence for the existence of two Robo3 isoforms with divergent biochemical properties. Mol Cell Neurosci. 2005;30:485-93 pubmed
    ..We propose that these properties of Robo3 may contribute to its function at the midline of the CNS. ..
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    ..In humans, genomic lesions containing Robo genes have been documented in CDH. Our findings suggest that separation of the foregut from the body wall is genetically controlled and that defects in this event may contribute to CDH. ..
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    ..Our results showed that the two genes neuropeptide Y (Npy) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes, there was gradual increase in cell ..
  73. Wilson S, Shafer B, Lee K, Dodd J. A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors. Neuron. 2008;59:413-24 pubmed publisher
    ..Our findings reveal a link between the transcriptional programs that define neuronal subtype identity and the expression of receptors that guide distinctive aspects of their trajectory. ..
  74. Kim M, Fontelonga T, Lee C, Barnum S, Mastick G. Motor axons are guided to exit points in the spinal cord by Slit and Netrin signals. Dev Biol. 2017;432:178-191 pubmed publisher
    ..Together, these results suggest that the proper position of motor exit points is determined by a "push-pull" mechanism, pulled ventrally by Netrin-1/DCC attraction and pushed dorsally by Slit/Robo repulsion. ..