Slit1

Summary

Gene Symbol: Slit1
Description: slit homolog 1 (Drosophila)
Alias: Slil1, mKIAA0813, slit homolog 1 protein, slit-1
Species: mouse

Top Publications

  1. ncbi The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
    W Yuan
    Department of Molecular Biology and Pharmacology, Department of Anatomy and Neurobiology, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 212:290-306. 1999
  2. ncbi Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb
    Jin Hyung Cho
    Montreal Neurological Institute, Centre for Neuronal Survival, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:9094-104. 2007
  3. ncbi The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons
    William Andrews
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 313:648-58. 2008
  4. pmc Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Nat Med 14:448-53. 2008
  5. doi Robos and slits control the pathfinding and targeting of mouse olfactory sensory axons
    Kim T Nguyen-Ba-Charvet
    Université Pierre et Marie Curie and Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7102, F 75005 Paris, France
    J Neurosci 28:4244-9. 2008
  6. ncbi Conserved roles for Slit and Robo proteins in midline commissural axon guidance
    Hua Long
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:213-23. 2004
  7. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
  8. pmc Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb
    Janet E A Prince
    Montreal Neurological Institute, Centre for Neuronal Survival, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:14211-22. 2009
  9. ncbi Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
    Andrew S Plump
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:219-32. 2002
  10. ncbi The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons
    Christelle Sabatier
    Howard Hughes Medical Institute, Department of Anatomy and Department of Biochemistry and Biophysics, The University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 117:157-69. 2004

Research Grants

  1. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
  3. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007

Scientific Experts

  • L Erskine
  • M H Little
  • James M Greenberg
  • K Luukko
  • William Andrews
  • Ken ichiro Kuwako
  • Valerie Vivancos
  • Victor Borrell
  • Jennifer E Round
  • Stephanie R Kadison
  • Kazunobu Sawamoto
  • Marc Tessier-Lavigne
  • Alain Chedotal
  • Thomas di Meglio
  • Kim T Nguyen-Ba-Charvet
  • Le Ma
  • Hannah Thompson
  • Oscar Marin
  • Jean François Cloutier
  • Franck Bielle
  • Guillermina López-Bendito
  • Andrew S Plump
  • Jin Hyung Cho
  • John L R Rubenstein
  • Coralie Fouquet
  • Anna Cariboni
  • Hua Long
  • John G Parnavelas
  • Grant S Mastick
  • James P Dugan
  • Sonia Garel
  • W Todd Farmer
  • Christelle Sabatier
  • Arturo Alvarez-Buylla
  • Rusella Mirza
  • Eleni Maria Amaniti
  • David Goldberg
  • John O Mason
  • Divya K Unni
  • Arlene Bravo-Ambrosio
  • Kevin M Wright
  • Constantino Sotelo
  • Paula Marcos-Mondejar
  • Luis R Hernández-Miranda
  • Maryama Keita
  • Caroline Mailhes
  • Christopher D Conway
  • Itzel Ricaño-Cornejo
  • Filippo M Rijli
  • Sebastien Ducret
  • Nicolas Renier
  • Kang Zheng
  • Naoko Kaneko
  • Alexander Jaworski
  • Andreas Holz
  • Caroline Medioni
  • Amy L Altick
  • Hikmet Feyza Nural
  • Janet E A Prince
  • Amelie Calmont
  • Nicholas Genethliou
  • John Parnavelas
  • Christopher A Jones
  • David D Ginty
  • Marc J Geisen
  • Christian Hochstim
  • Bhaskar Saha
  • Jason E Long
  • Masato Uemura
  • Jane Y Wu
  • Olivier Camand
  • David Barker
  • Holden Higginbotham
  • Tsutomu Hirata
  • Phyllis Strickland
  • Nuria Flames
  • Jean François Marion
  • Andrew Plump
  • Manuel Alvarez-Dolado
  • Fujio Murakami
  • Carol Schuurmans
  • Atsushi Tamada
  • Katja Brose
  • Corey S Goodman
  • Hynek Wichterle
  • Mark A Anselmo
  • Bernd Knöll
  • Ying Qian
  • Frédéric Causeret
  • Anil Bagri

Detail Information

Publications75

  1. ncbi The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
    W Yuan
    Department of Molecular Biology and Pharmacology, Department of Anatomy and Neurobiology, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 212:290-306. 1999
    ..Here we report the identification of three Slit homologues in the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance...
  2. ncbi Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb
    Jin Hyung Cho
    Montreal Neurological Institute, Centre for Neuronal Survival, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:9094-104. 2007
    ..These results indicate that the dorsal-to-ventral segregation of OSN axons are not solely defined by the location of OSNs within the OE but also relies on axon guidance cues...
  3. ncbi The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons
    William Andrews
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 313:648-58. 2008
    ..Interestingly, a similar increase in proliferation was observed in Slit1(-/-)/Slit2(-/-) mutant mice, suggesting that cell division is influenced by Slit-Robo signaling mechanisms...
  4. pmc Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Nat Med 14:448-53. 2008
    ....
  5. doi Robos and slits control the pathfinding and targeting of mouse olfactory sensory axons
    Kim T Nguyen-Ba-Charvet
    Université Pierre et Marie Curie and Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7102, F 75005 Paris, France
    J Neurosci 28:4244-9. 2008
    ..Recently, it has also been shown that the axon guidance molecule Slit1 and its receptor Robo2 control the dorsoventral segregation of ORN axons as they are projecting to the OB...
  6. ncbi Conserved roles for Slit and Robo proteins in midline commissural axon guidance
    Hua Long
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:213-23. 2004
    ..Previous analysis of Slit1;Slit2 double mutant spinal cords failed to reveal a defect in commissural axon guidance...
  7. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ..Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of pathways, including corticofugal, callosal, and ..
  8. pmc Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb
    Janet E A Prince
    Montreal Neurological Institute, Centre for Neuronal Survival, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:14211-22. 2009
    ..Together, these results identify Robo-2 as a receptor that controls the targeting of basal VSN axons to the posterior AOB...
  9. ncbi Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
    Andrew S Plump
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:219-32. 2002
    ..To determine the role of Slit proteins in RGC axon guidance, we disrupted Slit1 and Slit2, two of three known mouse Slit genes...
  10. ncbi The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons
    Christelle Sabatier
    Howard Hughes Medical Institute, Department of Anatomy and Department of Biochemistry and Biophysics, The University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 117:157-69. 2004
    ..These results identify a mechanism for regulating Slit repulsion that helps choreograph the precise switch from attraction to repulsion at a key intermediate axonal target...
  11. ncbi Dual branch-promoting and branch-repelling actions of Slit/Robo signaling on peripheral and central branches of developing sensory axons
    Le Ma
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:6843-51. 2007
    ..sensory arbors in vivo, because trigeminal sensory branching above the eye is reduced in Slit2;Slit3 double or Slit1,2,3 triple mutants...
  12. ncbi Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina
    Hannah Thompson
    Division of Visual Science, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    J Neurosci 26:8082-91. 2006
    ..Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal pathfinding in different ..
  13. ncbi Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits
    L Erskine
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:4975-82. 2000
    ..Using in situ hybridization, we have determined the expression patterns of robo1,2 and slit1,2,3 in the mouse retina and in the region of the developing optic chiasm, a ventral midline structure in which ..
  14. pmc Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1
    Ying Qian
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:1220-33. 2002
    ..Together, our studies demonstrate a central role for Rnx and Tlx-1 in the development of two major classes of relay sensory neurons, somatic and visceral...
  15. ncbi Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:3395-407. 2007
    ..Mice deficient in Slit2 or, even more so, in both Slit1 and Slit2 have defects in multiple axonal pathways, including corticofugal, thalamocortical, and callosal ..
  16. ncbi Robo1 and robo2 control the development of the lateral olfactory tract
    Coralie Fouquet
    Centre National de la Recherche Scientifique and Université Pierre et Marie Curie Paris 6, Unite Mixte de Recherche 7102, Paris, 75005 France
    J Neurosci 27:3037-45. 2007
    ..It is known that the septum secretes Slit1 and Slit2 which repel olfactory axons in vitro and that in Slit1-/-;Slit2-/- mutant mice, the LOT is profoundly ..
  17. ncbi Slit2 is a repellent for retinal ganglion cell axons
    S P Niclou
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 20:4962-74. 2000
    ..A comparison of the expression patterns of Slit2 and retinal axon trajectories suggests that slit2 acts as a short range repellent for retinal ganglion cell axons...
  18. ncbi Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections
    Jean François Cloutier
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:9087-96. 2004
    ..These results reveal discrete and complementary roles for secreted semaphorins and slits in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections...
  19. ncbi Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract
    Hannah Thompson
    Divisions of Visual Science and Molecular Genetics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Dev Biol 296:476-84. 2006
    ..Here, we show that slit1 and slit2, known chemorepellents for RGC axons expressed in specific regions of the diencephalon and telencephalon,..
  20. ncbi Multiple roles for slits in the control of cell migration in the rostral migratory stream
    Kim T Nguyen-Ba-Charvet
    Institut National de la Santé et de la Recherche Médicale U106, Bâtiment de Pédiatrie, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 24:1497-506. 2004
    ..b>Slit1 and Slit2, two known chemorepellents for developing axons, can mimic this effect...
  21. ncbi Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, 401 Parnassus Avenue, University of California San Francisco, CA 94143, USA
    Development 130:1889-901. 2003
    ..demonstrate that the repulsive activity found in the basal telencephalon is maintained in mice deficient in both Slit1 and Slit2, suggesting that factors other than these are responsible for this activity...
  22. ncbi Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons
    Frédéric Causeret
    INSERM U106, Hopital de la Salpetriere, 75013 Paris, France
    Dev Biol 246:429-40. 2002
    ..Our results indicate that slit silences the attractive effects of netrin-1 and could participate in the correct ventral positioning of ION, stopping the migration when cell bodies reach the floor-plate...
  23. ncbi Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis
    Phyllis Strickland
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 95064, USA
    Development 133:823-32. 2006
    ..Thus, our data establish a novel role for SLIT2 as an adhesive cue, acting in parallel with NTN1 to generate cell boundaries along ducts during bi-layered tube formation...
  24. doi Gli3 is required in Emx1+ progenitors for the development of the corpus callosum
    Eleni Maria Amaniti
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, United Kingdom
    Dev Biol 376:113-24. 2013
    ..5 due to a severe disorganization of midline guideposts. Glial wedge cells translocate prematurely and Slit1/2 are ectopically expressed in the septum...
  25. pmc Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut
    David Goldberg
    School of Dentistry, University of Western Ontario, London, Ontario, Canada
    Dev Dyn 242:9-15. 2013
    ..We tested the hypothesis that Slit/Robo chemorepulsion can contribute to the restriction of vagal sensory axons to specific targets in the gut wall...
  26. pmc Slit2 and Robo3 modulate the migration of GnRH-secreting neurons
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT UK
    Development 139:3326-31. 2012
    ..Mice lacking Slit2 or Robo3 have a reduced number of GnRH neurons in the forebrain, but a normal complement of their supporting axons, pointing to a direct role for these molecules in GnRH neuron migration...
  27. doi Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography
    Franck Bielle
    INSERM, U1024, Avenir Team, 75005 Paris, France
    Curr Biol 21:1748-55. 2011
    ..show that this topography is set in a small hub, the corridor, which contains matching rostrocaudal gradients of Slit1 and Netrin 1...
  28. pmc Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway
    Rusella Mirza
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 521:312-25. 2013
    ..We also found that slit1, -2 or -3 single or double knockout mice have impaired development of the trigeminal-lemniscal pathway...
  29. pmc Dystroglycan organizes axon guidance cue localization and axonal pathfinding
    Kevin M Wright
    The Solomon H Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 76:931-44. 2012
    ..These findings establish a novel role for glycosylated dystroglycan as a key determinant of axon guidance cue distribution and function in the mammalian nervous system...
  30. pmc Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling
    Arlene Bravo-Ambrosio
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 139:1435-46. 2012
    ..Our studies support the view that Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling...
  31. doi Slit/Robo signaling modulates the proliferation of central nervous system progenitors
    Victor Borrell
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    Neuron 76:338-52. 2012
    ..Conversely, production of IPCs is enhanced in Robo1/2 and Slit1/2 mutants, suggesting that Slit/Robo signaling modulates the transition between primary and intermediate ..
  32. doi Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons
    Thomas di Meglio
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Science 339:204-7. 2013
    ..Thus, Ezh2-dependent epigenetic regulation of intrinsic and extrinsic transcriptional programs controls topographic neuronal guidance and connectivity in the cortico-ponto-cerebellar pathway...
  33. doi Multiple Slits regulate the development of midline glial populations and the corpus callosum
    Divya K Unni
    The Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia
    Dev Biol 365:36-49. 2012
    ..defects (but not complete agenesis) in 100% of Slit2(-/-) mice and 30% of Slit3(-/-) mice, whereas 100% of Slit1(-/-); Slit2(-/-) mice displayed complete agenesis of the corpus callosum...
  34. pmc MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord
    Kang Zheng
    College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
    J Neurosci 30:8245-50. 2010
    ..By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue...
  35. pmc Genetic dissection of the function of hindbrain axonal commissures
    Nicolas Renier
    INSERM, U968, Paris, F 75012, France
    PLoS Biol 8:e1000325. 2010
    ..To our knowledge, this study is one of the first to link defects in commissural axon guidance with specific cellular and behavioral phenotypes...
  36. doi Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression
    Ken ichiro Kuwako
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neuron 67:407-21. 2010
    ..Together, these findings indicate that Msi1-mediated posttranscriptional regulation of Robo3 controls midline crossing of precerebellar neurons...
  37. doi New neurons clear the path of astrocytic processes for their rapid migration in the adult brain
    Naoko Kaneko
    Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Neuron 67:213-23. 2010
    ..New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes...
  38. pmc Robo2 is required for Slit-mediated intraretinal axon guidance
    Hannah Thompson
    Institute of Ophthalmology, University College London, England, UK
    Dev Biol 335:418-26. 2009
    ..Previously, we have shown that the inhibitory guidance molecules, Slit1 and Slit2, regulate two distinct aspects of intraretinal axon guidance in a region-specific manner...
  39. doi Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance
    Alexander Jaworski
    Division of Research, Genentech Inc, South San Francisco, California 94080, USA
    J Neurosci 30:9445-53. 2010
    ..Robo1 and Robo2 are receptors for the midline repellents Slit1-Slit3, and upregulation of Robos in post-crossing axons allows expulsion from the floor plate and prevents ..
  40. doi The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology
    Jennifer E Round
    Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, United States
    Mol Cell Neurosci 47:265-73. 2011
    ..These findings indicate a specific role for Nck2 in linking Robo activation to the cytoskeleton rearrangements that shape cortical neuron morphology...
  41. pmc Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain
    Luis R Hernández-Miranda
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:6174-87. 2011
    ..Thus, we show for the first time that Robo1 interacts with Nrp1 to modulate semaphorin signaling in the developing forebrain and direct the migration of interneurons through the subpallium and into the cortex...
  42. doi Slit2 activity in the migration of guidepost neurons shapes thalamic projections during development and evolution
    Franck Bielle
    INSERM, U1024, 75005 Paris, France
    Neuron 69:1085-98. 2011
    ..Our study reveals that subtle differences in the migration of conserved intermediate target neurons trigger large-scale changes in thalamic connectivity, and opens perspectives on Slit functions and the evolution of brain wiring...
  43. doi Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain
    Itzel Ricaño-Cornejo
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico
    J Neurosci Res 89:1531-41. 2011
    ..Moreover, absence of both Slit1 and Slit2 or Robo1 and Robo2 in mutant mouse embryos revealed aberrant TPOC trajectories, resulting in abnormal ..
  44. doi Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 31:1955-70. 2011
    ..Particular Hs2st(-/-) and Hs6st1(-/-) phenotypes closely match those of Slit1(-/-) and Slit2(-/-) embryos respectively, suggesting possible functional relationships...
  45. ncbi On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion
    Bernd Knöll
    MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Hospital Campus, London SE1 1UL, UK
    Development 130:5073-82. 2003
    ..In vitro assays show that Slit1-Slit3 chemorepel VNO axons, suggesting that basal axons are guided to the posterior AOB due to chemorepulsive ..
  46. pmc Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals
    James P Dugan
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Mol Cell Neurosci 46:347-56. 2011
    ..The mdDA axons made significant pathfinding errors in Slit1/2 and Robo1/2 knockout mice, including spreading out in the diencephalon to form a wider tract...
  47. pmc The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance
    Andreas Holz
    Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106 Braunschweig, Germany
    Development 137:4249-60. 2010
    ..As both factors affect floor plate development, control of commissural axon trajectories might be the underlying mechanism...
  48. pmc Expression of Slit and Robo genes in the developing mouse heart
    Caroline Medioni
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Faculte des Sciences, Parc Valrose Nice, France
    Dev Dyn 239:3303-11. 2010
    ..Our results suggest that patterned Slit-Robo signaling may contribute to the control of oriented cell growth during chamber morphogenesis of the mammalian heart...
  49. pmc Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm
    Amelie Calmont
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Development 136:3173-83. 2009
    ..We propose that the spatiotemporal control of this tightly orchestrated network of genes participates in crucial aspects of PAA development...
  50. doi Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord
    Nicholas Genethliou
    The Cyprus Institute of Neurology and Genetics, Airport Avenue, No 6, Agios Dometios 2370, Nicosia, Cyprus
    Biochem Biophys Res Commun 382:69-73. 2009
    ..9. We further show that NKX2.2 is necessary to induce the expression of Slit1 and Sulfatase 1 (Sulf1) in the vSC in a PAX6-independent manner...
  51. pmc Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases
    Valerie Vivancos
    MRC Centre for Developmental Neurobiology, King s College, Guy s Campus, London, SE1 1UL, UK
    Neural Dev 4:7. 2009
    ..In this study, we investigated a possible role of Wnts and the planar cell polarity (PCP) pathway in this process...
  52. pmc Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways
    Carol Schuurmans
    IGBMC, Illkirch, CU de Strasbourg, France
    EMBO J 23:2892-902. 2004
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons...
  53. ncbi Slit and robo expression in the developing mouse lung
    James M Greenberg
    Divisions of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 230:350-60. 2004
    ..The temporal and spatial distribution of Slit and Robo mRNAs indicate that these genes may direct the functional organization and differentiation of fetal lung mesenchyme...
  54. ncbi Slit and robo: expression patterns in lung development
    Mark A Anselmo
    Pediatric Pulmonary Unit, Massachusetts General Hospital for Children, Harvard Medical School, Jackson 14, GRJ 1416, 55 Fruit St, Boston, MA 02114, USA
    Gene Expr Patterns 3:13-9. 2003
    ..We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development...
  55. ncbi Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth
    Keijo Luukko
    Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, N 5009, Bergen, Norway
    Mech Dev 120:270-6. 2003
    ..We investigated the developmental fate of the signaling center using the recently characterized Slit1 enamel knot marker as a lineage tracer during morphogenesis of the first molar and crown calcification in the ..
  56. pmc Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex
    Hynek Wichterle
    The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:727-32. 2003
    ..In addition, we propose that chemotactic guidance cues superimposed over the permissive corridor facilitate efficient dorsal migration of MGE cells...
  57. ncbi Conserved modularity and potential for alternate splicing in mouse and human Slit genes
    Melissa Little
    Institute for Molecular Bioscience and Centre for Functional and Applied Genomics, University of Queensland, St Lucia, Australia
    Int J Dev Biol 46:385-91. 2002
    The vertebrate Slit gene family currently consists of three members; Slit1, Slit2 and Slit3...
  58. ncbi Slit1 and slit2 proteins control the development of the lateral olfactory tract
    Kim T Nguyen-Ba-Charvet
    Institut National de la Santé et de la Recherche Médicale U106, Bâtiment de Pédiatrie, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 22:5473-80. 2002
    ..the role of Slit proteins in mediating olfactory axon guidance in vivo using mice with targeted deletions in the Slit1 and Slit2 genes...
  59. ncbi The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum
    P Chapouton
    Max Planck Institute for Neurobiology, Am Klopferspitz 18a, D 82152 Planegg Martinsried, Germany
    Development 128:5149-59. 2001
    ..Taken together, these results show that distinct cues located in the cortico-striatal boundary restrict cells in the dorsal and ventral telencephalon...
  60. ncbi Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation
    S Løes
    Department of Anatomy and Cell Biology, University of Bergen, Arstadveien 19, Bergen, Norway
    Mech Dev 107:155-7. 2001
    ..In search of novel molecules involved in tooth morphogenesis, we analyzed mRNA expression of Slit1, -2 and -3, earlier characterized as secreted signals needed for axonal pathfinding and their two receptors Robo1 ..
  61. ncbi Expression patterns of Slit and Robo family members during vertebrate limb development
    N Vargesson
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Mech Dev 106:175-80. 2001
    We report the cloning and expression during limb development of the chicken Slit1, Slit2, and Slit3 ligands, and Robo1 and Robo2 receptor genes...
  62. ncbi Sim1 and Sim2 are required for the correct targeting of mammillary body axons
    Jean François Marion
    Research Center, Hopital Sainte Justine, 3175 Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
    Development 132:5527-37. 2005
    ..Instead, MB axons are splayed and grow towards the midline. Slit1 and Slit2, which code for secreted molecules that induce the repulsion of ROBO1-producing axons, are expressed in ..
  63. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
    ..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons...
  64. ncbi GSK3beta and PKCzeta function in centrosome localization and process stabilization during Slit-mediated neuronal repolarization
    Holden Higginbotham
    Biomedical Sciences Graduate Program, University of California, San Diego, CA 92093 0691, USA
    Mol Cell Neurosci 32:118-32. 2006
    ..Our findings suggest that activation of cell polarity signaling and positioning of the centrosome ahead of the nucleus are important steps in repolarization in response to guidance cues...
  65. doi Molecular mechanisms controlling midline crossing by precerebellar neurons
    Thomas di Meglio
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7102, Universite Pierre et Marie Curie, UMR 7102, F 75005 Paris, France
    J Neurosci 28:6285-94. 2008
    ..Robo1 and Robo2, also regulates precerebellar neuron behavior at the floor plate, we studied the phenotype of Slit1/2 and Robo1/2/3 compound mutants...
  66. pmc Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling
    Marc J Geisen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR 7104, CU de Strasbourg, Illkirch, France
    PLoS Biol 6:e142. 2008
    ..Moreover, the migration defects observed in Hoxa2 and Hoxb2 mutant mice were phenocopied in compound Robo1;Robo2, Slit1;Slit2, and Robo2;Slit2 knockout animals, indicating that these guidance molecules act downstream of Hox genes to ..
  67. ncbi OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections
    Masato Uemura
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Nat Neurosci 10:1151-9. 2007
    ..The inability of the striatum to extend axons is also observed in vitro. These results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections...
  68. ncbi Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously
    Tsutomu Hirata
    Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Development 133:1433-43. 2006
    ..These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb...
  69. ncbi Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ..the expression of ErbB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4), Robo2 (roundabout homolog 2), Slit1 (slit homolog 1), and PK2 (prokineticin 2), which have all been shown to play essential roles in this migration.
  70. pmc Dual role for LIM-homeodomain gene Lhx2 in the formation of the lateral olfactory tract
    Bhaskar Saha
    Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai 400 005, India
    J Neurosci 27:2290-7. 2007
    ..In addition, the expression of Sema6A is aberrantly upregulated. Together, these findings reveal a dual role for Lhx2, in the OB as well as in the lateral telencephalon, for establishing the LOT projection...
  71. ncbi The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord
    Stephanie R Kadison
    Department of Pathology and Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center Rm 624, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Dev Biol 296:499-513. 2006
    ..Surprisingly, even though gli2 mutants lack a FP, slit1-3 mRNA and their receptors (Robo1/2) are expressed in a wild-type-like manner...
  72. pmc The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain
    S Bertuzzi
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 13:3092-105. 1999
    ..Vax1 therefore regulates the guidance properties of a set of anterior midline cells that orchestrate axon trajectories in the developing mammalian forebrain...
  73. ncbi Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections
    Oscar Marin
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, USA
    Development 129:761-73. 2002
    ..Furthermore, analysis of the expression of candidate molecules in the basal telencephalon and hypothalamus of Nkx2-1 mutants suggests that Slit2 contributes to this activity...
  74. pmc Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code
    Christian Hochstim
    Division of Biology 216 76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 133:510-22. 2008
    ..astrocytes (WMA) in the spinal cord, which can be distinguished by the combinatorial expression of Reelin and Slit1. These astrocyte subtypes derive from progenitor domains expressing the homeodomain transcription factors Pax6 and ..
  75. pmc Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals
    W Todd Farmer
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Development 135:3643-53. 2008
    ..Genetic tests of Slit1 and Slit2, and the Slit receptors Robo1 and Robo2 were carried out in mutant mice...

Research Grants5

  1. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..
  2. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ....
  3. Murine Atlas of Genitourinary Development
    Melissa Little; Fiscal Year: 2007
    ..abstract_text> ..