Gene Symbol: Slco1a5
Description: solute carrier organic anion transporter family, member 1a5
Alias: Oatp-3, Oatp3, Slc21a7, solute carrier organic anion transporter family member 1A5, organic anion-transporting polypeptide 3, sodium-independent organic anion transporter 3, solute carrier family 21 (organic anion transporter), member 7, solute carrier family 21 member 7
Walters H, Craddock A, Fusegawa H, Willingham M, Dawson P. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000;279:G1188-200 pubmed
The rat and mouse organic anion-transporting polypeptides (oatp) subtype 3 (oatp3) were cloned to further define components of the intestinal bile acid transport system...
van de Steeg E, Wagenaar E, van der Kruijssen C, Burggraaff J, de Waart D, Elferink R, et al
. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J Clin Invest. 2010;120:2942-52 pubmed publisher
..Slco1a/1b-/- mice will provide excellent tools to study further the role of Oatp1a/1b transporters in physiology and drug disposition. ..
Sugiura T, Otake T, Shimizu T, Wakayama T, Silver D, Utsumi R, et al
. PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine. Drug Metab Pharmacokinet. 2010;25:588-98 pubmed
..Thus, PDZK1 appears to act as an adaptor for Oatp1a. This is the first demonstration of a regulatory protein directly interacting with small-intestinal OATP. ..
Hagenbuch B, Meier P. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta. 2003;1609:1-18 pubmed
..In addition, we propose a new species independent and open ended nomenclature and classification system, which is based on divergent evolution and agrees with the guidelines of the Human Genome Nomenclature Committee. ..
Sekine T, Miyazaki H, Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol. 2006;290:F251-61 pubmed
..We will also discuss the physiological roles of each organic anion transporter in the light of the transepithelial transport of organic anions in the kidneys...
Di Cosmo C, Liao X, Dumitrescu A, Philp N, Weiss R, Refetoff S. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. J Clin Invest. 2010;120:3377-88 pubmed publisher
..To our knowledge, this study is the first to demonstrate that Mct8 is involved in the secretion of TH from the thyroid gland and contributes, in part, to the low serum T4 level observed in MCT8-deficient patients. ..
Selmi Ruby S, Bouazza L, Obregon M, Conscience A, Flamant F, Samarut J, et al
. The targeted inactivation of TR? gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production. Endocrinology. 2014;155:635-46 pubmed publisher
..In conclusion, these data show that the control of thyroid hormone production involves not only TR?-dependent mechanisms acting at the level of hypothalamus and pituitary but also TR?-dependent mechanisms acting at the thyroid level. ..