Gene Symbol: Slc8a2
Description: solute carrier family 8 (sodium/calcium exchanger), member 2
Alias: Ncx2, sodium/calcium exchanger 2, Na(+)/Ca(2+)-exchange protein 2, solute carrier family 8 member 2
Species: mouse
Products:     Slc8a2

Top Publications

  1. Li J, Kajiya H, Okamoto F, Nakao A, Iwamoto T, Okabe K. Three Na+/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption. Endocrinology. 2007;148:2116-25 pubmed
    ..Mammalian NCXs form a multigene family comprising NCX1, NCX2, and NCX3 isoforms...
  2. Hilge M, Aelen J, Foarce A, Perrakis A, Vuister G. Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proc Natl Acad Sci U S A. 2009;106:14333-8 pubmed publisher
    ..In contrast to CBD1, the electrostatic switch in CBD2 is isoform- and splice variant-specific and allows for tailored exchange activities. ..
  3. Nishiyama K, Azuma Y, Morioka A, Yoshida N, Teramoto M, Tanioka K, et al. Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:1081-90 pubmed publisher
    ..In this study, we focused on the functions of the NCX isoforms, NCX1 and NCX2, in the motility of the ileum in the gastrointestinal tract...
  4. Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, et al. Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp Biochem Physiol B Biochem Mol Biol. 2003;135:9-15 pubmed
    ..Although NCX1 protein levels were decreased in heterozygous mice, there were no changes in NCX2 and NCX3 protein levels between wild type and heterozygous mice.
  5. Jeon D, Yang Y, Jeong M, Philipson K, Rhim H, Shin H. Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron. 2003;38:965-76 pubmed
    ..To define the physiological function of the exchanger in vivo, we generated mice deficient for NCX2, the major isoform in the brain...
  6. Azuma Y, Nishiyama K, Kita S, Komuro I, Nakajima H, Iwamoto T, et al. Na(+) /Ca(2+) exchanger 2-heterozygote knockout mice display decreased acetylcholine release and altered colonic motility in vivo. Neurogastroenterol Motil. 2012;24:e600-10 pubmed publisher
    ..To determine the role of NCX1 and NCX2 in gastrointestinal tissues, we examined electric field stimulation (EFS)-induced responses in the longitudinal ..
  7. Ivandic B, Utz H, Kaczmarek P, Aherrahrou Z, Axtner S, Klepsch C, et al. New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Physiol Genomics. 2001;6:137-44 pubmed
    ..Additive epistasis between Dyscalc1 and Dyscalc2 enhanced DCC. Examining recombinant inbred strains, we propose a 10-cM interval containing Dyscalc1 and discuss potential candidate genes...
  8. Poletaeva I, Perepelkina O, Boyarshinova O, Golibrodo V, Lilp I, Lipp H, et al. The ability to solve elementary logic tasks in mice with the knockout of sodium-calcium exchanger gene 2 (NCX2). Dokl Biol Sci. 2016;469:159-62 pubmed publisher
    Mice with a knockout of the sodium-calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of ..
  9. Gotoh Y, Kita S, Fujii M, Tagashira H, Horie I, Arai Y, et al. Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria. Biochem Biophys Res Commun. 2015;456:670-5 pubmed publisher
    ..Although two isoforms of NCX1 and NCX2 are coexpressed on the basolateral membrane of the distal nephron, the functional significance of these isoforms is ..

More Information


  1. Boscia F, D Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, et al. New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes. Adv Exp Med Biol. 2013;961:307-16 pubmed publisher
    ..protein expression were significantly enhanced in BV2 microglia exposed to oxygen and glucose deprivation, whereas NCX2 and NCX3 were downregulated...
  2. Pyrski M, Koo J, Polumuri S, Ruknudin A, Margolis J, Schulze D, et al. Sodium/calcium exchanger expression in the mouse and rat olfactory systems. J Comp Neurol. 2007;501:944-58 pubmed
    ..Our results suggest that Ca(2+)-extrusion by OSNs utilizes multiple different Na(+)/Ca(2+) exchangers and that different subtypes are targeted to different subcellular compartments. ..
  3. Azuma Y, Hayashi S, Nishiyama K, Kita S, Mukai K, Nakajima H, et al. Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo. Neurogastroenterol Motil. 2016;28:827-36 pubmed publisher
    ..electric field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in NCX1 and NCX2 heterozygote knockout mice (HET)...
  4. Li Z, Matsuoka S, Hryshko L, Nicoll D, Bersohn M, Burke E, et al. Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger. J Biol Chem. 1994;269:17434-9 pubmed
    ..A., Longoni, S., and Philipson, K.D. (1990) Science 250, 562-565). We now report the cloning of a second isoform (NCX2) of the Na(+)-Ca2+ exchanger which was present in a rat brain cDNA library...
  5. Nishiyama K, Tanioka K, Azuma Y, Hayashi S, Fujimoto Y, Yoshida N, et al. Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea. J Vet Med Sci. 2017;79:403-411 pubmed publisher
    ..To reveal the functional role of NCX on gastrointestinal motility, we have previously used NCX1 and NCX2 heterozygote knockout mice (HET)...
  6. Jeon D, Chu K, Jung K, Kim M, Yoon B, Lee C, et al. Na(+)/Ca(2+) exchanger 2 is neuroprotective by exporting Ca(2+) during a transient focal cerebral ischemia in the mouse. Cell Calcium. 2008;43:482-91 pubmed
    ..However, the role of NCX2 has not been defined in ischemic reperfusion injury after a transient focal cerebral ischemia...
  7. Morimoto N, Kita S, Shimazawa M, Namimatsu H, Tsuruma K, Hayakawa K, et al. Preferential involvement of Na?/Ca²? exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. Biochem Biophys Res Commun. 2012;429:186-90 pubmed publisher
    ..Within the brain, three isoforms (NCX1, NCX2, and NCX3) are widely distributed...
  8. Molinaro P, Cataldi M, Cuomo O, Viggiano D, Pignataro G, Sirabella R, et al. Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits. Adv Exp Med Biol. 2013;961:213-22 pubmed publisher
    ..Experiments performed in NCX2 and NCX3 knockout mice provided evidence that these two isoforms participate in spatial learning and memory ..
  9. Li X, Kiedrowski L, Tremblay F, Fernandez F, Perizzolo M, Winkfein R, et al. Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. J Biol Chem. 2006;281:6273-82 pubmed
    ..These data emphasize the critical and non-redundant role of NCKX2 in the local control of neuronal [Ca2+] that is essential for the development of synaptic plasticity associated with learning and memory. ..
  10. Hong H, Chakravarti A, Takahashi J. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Proc Natl Acad Sci U S A. 2004;101:1748-53 pubmed
    ..The hyh mutant provides a valuable in vivo model to study vesicle/membrane trafficking and provides insight into the potential roles of alpha-SNAP in embryogenesis and brain development. ..
  11. Yamaji R, Fujita K, Takahashi S, Yoneda H, Nagao K, Masuda W, et al. Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger. Biochim Biophys Acta. 2003;1593:269-76 pubmed
    ..encoding NCX3, which functions even under cellular ATP-depleted conditions, in addition to mRNAs encoding NCX1 and NCX2. The inhibition of Ca(2+)/calmodulin-dependent protein kinases or c-Jun/AP-1 activation caused a significant ..