Gene Symbol: Slc8a1
Description: solute carrier family 8 (sodium/calcium exchanger), member 1
Alias: AI852629, AV344025, D930008O12Rik, Ncx1, sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Na/Ca exchanger, sodium/calcium exchanger isoform NaCa7, solute carrier family 8 member 1
Species: mouse
Products:     Slc8a1

Top Publications

  1. Yamaguchi Y, Yonemura S, Takada S. Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse. Development. 2006;133:4737-48 pubmed
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney. ..
  2. Li X, Lytton J. A circularized sodium-calcium exchanger exon 2 transcript. J Biol Chem. 1999;274:8153-60 pubmed
    Previous reports of Na/Ca exchanger gene 1 (NCX1) expression have revealed a major RNA transcript of 7 kilobase pairs (kb), minor transcripts of approximately 13 and approximately 4 kb, and a relatively abundant 1.8-kb RNA band...
  3. Koushik S, Wang J, Rogers R, Moskophidis D, Lambert N, Creazzo T, et al. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. FASEB J. 2001;15:1209-11 pubmed
  4. Conway S, Kruzynska Frejtag A, Wang J, Rogers R, Kneer P, Chen H, et al. Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue?. Ann N Y Acad Sci. 2002;976:268-81 pubmed
    ..Significantly, targeted deletion of Ncx-1 results in Ncx1-null embryos that do not have a spontaneously beating heart and die in utero...
  5. Laskowski A, Medler K. Sodium-calcium exchangers contribute to the regulation of cytosolic calcium levels in mouse taste cells. J Physiol. 2009;587:4077-89 pubmed publisher
    ..Thus, a dynamic relationship exists between calcium leak channels and calcium regulatory mechanisms in taste cells that functions to keep cytosolic calcium levels in the appropriate range for cell function. ..
  6. Hohendanner F, Ljubojević S, Macquaide N, Sacherer M, Sedej S, Biesmans L, et al. Intracellular dyssynchrony of diastolic cytosolic [Ca²?] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure. Circ Res. 2013;113:527-38 pubmed publisher
    ..Dyssynchronous intracellular [Ca²?] decay in cardiac remodeling and end-stage heart failure suggests a novel mechanism of cellular contractile dysfunction. ..
  7. Herrmann S, Lipp P, Wiesen K, Stieber J, Nguyen H, Kaiser E, et al. The cardiac sodium-calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm. Cardiovasc Res. 2013;99:780-8 pubmed publisher
    ..The sodium-calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart...
  8. Pyrski M, Koo J, Polumuri S, Ruknudin A, Margolis J, Schulze D, et al. Sodium/calcium exchanger expression in the mouse and rat olfactory systems. J Comp Neurol. 2007;501:944-58 pubmed
    ..the poststimulus Ca(2+)-clearance of mouse OSNs, we analyzed the expression of three potassium (K(+))-independent (NCX1, 2, 3) and three K(+)-dependent (NCKX1, 2, 3) Na(+)/Ca(2+) exchangers...
  9. Pott C, Yip M, Goldhaber J, Philipson K. Regulation of cardiac L-type Ca2+ current in Na+-Ca2+ exchanger knockout mice: functional coupling of the Ca2+ channel and the Na+-Ca2+ exchanger. Biophys J. 2007;92:1431-7 pubmed
    ..Modulation of subsarcolemmal Ca2+ by the Na+-Ca2+ exchanger may be an important regulator of excitation-contraction coupling. ..

More Information


  1. Larbig R, Torres N, Bridge J, Goldhaber J, Philipson K. Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. J Physiol. 2010;588:3267-76 pubmed publisher
    ..This is an important mechanism for regulation of Ca(2+) release and contractility in murine heart. ..
  2. Reuter H, Henderson S, Han T, Mottino G, Frank J, Ross R, et al. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 2003;34:19-26 pubmed
    We investigate cardiac excitation-contraction coupling in the absence of sarcolemmal Na(+) - Ca(2+) exchange using NCX1 knock out mice...
  3. Pott C, Philipson K, Goldhaber J. Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux. Circ Res. 2005;97:1288-95 pubmed
    ..Contractility is maintained by an increase in the gain of excitation-contraction coupling resulting from both a more rapid repolarization of the AP and an as yet unidentified AP-independent mechanism. ..
  4. Henderson S, Goldhaber J, So J, Han T, Motter C, Ngo A, et al. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res. 2004;95:604-11 pubmed
    ..Using Cre/loxP technology, we generated mice with a cardiac-specific knockout of the Na+-Ca2+ exchanger, NCX1. The exchanger is completely ablated in 80% to 90% of the cardiomyocytes as determined by immunoblot, ..
  5. Gao Z, Rasmussen T, Li Y, Kutschke W, Koval O, Wu Y, et al. Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate. Circ Res. 2013;112:309-17 pubmed publisher
    The sodium-calcium exchanger 1 (NCX1) is predominantly expressed in the heart and is implicated in controlling automaticity in isolated sinoatrial node (SAN) pacemaker cells, but the potential role of NCX1 in determining heart rate in ..
  6. Reuter H, Henderson S, Han T, Ross R, Goldhaber J, Philipson K. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circ Res. 2002;90:305-8 pubmed
    ..We conclude that in embryonic mouse myocytes the Na+-Ca2+ exchanger is absolutely required for the effect of cardiac glycosides on Ca2+(i). ..
  7. Wansleeben C, Feitsma H, Tertoolen L, Kroon C, Guryev V, Cuppen E, et al. A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction. Int J Dev Biol. 2010;54:1465-71 pubmed publisher
    The biological role and structure-function relationship of the Na(+)Ca(2+) exchanger NCX1 have been the subject of much investigation...
  8. Albano G, Dolder S, Siegrist M, Mercier Zuber A, Auberson M, Stoudmann C, et al. Increased bone resorption by osteoclast-specific deletion of the sodium/calcium exchanger isoform 1 (NCX1). Pflugers Arch. 2017;469:225-233 pubmed publisher
    ..Our data indicate that all three NCX isoforms (NCX1, NCX2, and NCX3) are present in murine osteoclasts...
  9. Dostanic I, Schultz J, Lorenz J, Lingrel J. The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem. 2004;279:54053-61 pubmed
    ..These results demonstrate that the alpha 1 isoform regulates cardiac contractility, and that both the alpha 1 and alpha 2 isoforms are functionally and physically coupled with the Na/Ca exchanger in heart. ..
  10. Radzyukevich T, Moseley A, Shelly D, Redden G, Behbehani M, Lingrel J, et al. The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm. Am J Physiol Cell Physiol. 2004;287:C1300-10 pubmed
    ..They further indicate that the alpha2-isoform contributes significantly less at rest than expected from its proportional content but can modulate contractility during muscle contraction. ..
  11. Li J, Kline C, Hund T, Anderson M, Mohler P. Ankyrin-B regulates Kir6.2 membrane expression and function in heart. J Biol Chem. 2010;285:28723-30 pubmed publisher
    ..Collectively, our new findings define a new role for cardiac ankyrin polypeptides in regulation of ion channel membrane expression in heart...
  12. Torrente A, Zhang R, Zaini A, Giani J, Kang J, Lamp S, et al. Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Proc Natl Acad Sci U S A. 2015;112:9769-74 pubmed publisher
    ..However, the absence of NCX-mediated depolarization in combination with impaired Ca efflux results in intermittent bursts of pacemaker activity, reminiscent of human sinus node dysfunction and "tachy-brady" syndrome. ..
  13. Koushik S, Bundy J, Conway S. Sodium-calcium exchanger is initially expressed in a heart-restricted pattern within the early mouse embryo. Mech Dev. 1999;88:119-22 pubmed
    Although the sodium-calcium exchanger (NCX1) is encoded by a single gene, it is widely expressed in both fetal and adult tissues and functions in many diverse physiological processes to maintain intracellular calcium homeostasis...
  14. Almilaji A, Yan J, Hosseinzadeh Z, Schmid E, Gawaz M, Lang F. Up-Regulation of Na+/Ca2+ Exchange in Megakaryocytes Following TGF?1 Treatment. Cell Physiol Biochem. 2016;39:693-9 pubmed publisher
    ..TGF?1 is a powerful stimulator of both, SOCE and Na+/Ca2+-exchanger activity in megakaryocytes. ..
  15. Yamashita J, Kita S, Iwamoto T, Ogata M, Takaoka M, Tazawa N, et al. Attenuation of ischemia/reperfusion-induced renal injury in mice deficient in Na+/Ca2+ exchanger. J Pharmacol Exp Ther. 2003;304:284-93 pubmed
    Using Na+/Ca2+ exchanger (NCX1)-deficient mice, the pathophysiological role of Ca2+ overload via the reverse mode of NCX1 in ischemia/reperfusion-induced renal injury was investigated...
  16. Yan J, Schmid E, Hosseinzadeh Z, Honisch S, Shumilina E, Fuchs J, et al. Impact of Janus Kinase 3 on Cellular Ca Release, Store Operated Ca(2+) Entry and Na(+)/Ca(2+) Exchanger Activity in Dendritic Cells. Cell Physiol Biochem. 2015;36:2287-98 pubmed publisher
    ..JAK3 deficiency is followed by down-regulation of cytosolic Ca(2+) release, receptor and store operated Ca(2+) entry and Na(+)/Ca(2+) exchanger activity in DCs. ..
  17. Kawanai T, Taruta A, Inoue A, Watanabe R, Ago Y, Hashimoto H, et al. Decreased expression of hippocampal Na⁺/Ca²⁺ exchanger isoform-1 by pentylenetetrazole kindling in mice. Epilepsy Res. 2015;115:109-12 pubmed publisher examined the effects of pentylenetetrazole (PTZ)-induced kindling on the mRNA expression of NCX isoforms (NCX1, NCX2 and NCX3) in mouse brain. Chronic administration of PTZ at 40mg/kg resulted in kindling seizure development...
  18. Kobayashi K, Uchida S, Mizutani S, Sasaki S, Marumo F. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol. 2001;12:1327-34 pubmed
    ..These aspects of CLC-K2 localization suggest that CLC-K2 is important in Cl(-) transport in the distal nephron segments. ..
  19. Xu L, Chen J, Li X, Ren S, Huang C, Wu G, et al. Analysis of Na(+)/Ca (2+) exchanger (NCX) function and current in murine cardiac myocytes during heart failure. Mol Biol Rep. 2012;39:3847-52 pubmed publisher
    ..the molecular mechanism underlying remodeling of I(NCX) in failing heart, we detected the protein expression of NCX1 and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) by Western blot...
  20. Bai Y, Morgan E, Giovannucci D, Pierre S, Philipson K, Askari A, et al. Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am J Physiol Heart Circ Physiol. 2013;304:H427-35 pubmed publisher
    ..A major aim of this work was to assess the role of Na(+)/Ca(2+)-exchanger, NCX1, in the above two seemingly related drug effects...
  21. Negoro T, Kin M, Takuma A, Saito K, Shimizu S, Nakano Y. Potentiated macrophage activation by acid sensing under low adiponectin levels. Mol Immunol. 2014;57:141-50 pubmed publisher
    ..Our results indicated that in AsTg mice, the Ca(2)(+) response to the acid was facilitated in M? by a low threshold of ASIC1 and NCX1 molecules and the activity of these channel was possibly regulated by adiponectin.
  22. Wu P, Kao L. Calcium regulation in mouse mesencephalic neurons-Differential roles of Na(+)/Ca(2+) exchanger, mitochondria and endoplasmic reticulum. Cell Calcium. 2016;59:299-311 pubmed publisher
  23. Linask K, Han M, Artman M, Ludwig C. Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development. Dev Dyn. 2001;221:249-64 pubmed
  24. Sarai N, Kobayashi T, Matsuoka S, Noma A. A simulation study to rescue the Na+/Ca2+ exchanger knockout mice. J Physiol Sci. 2006;56:211-7 pubmed
    ..However, Henderson et al. (2004) found that mice with the cardiospecific knockout of NCX1 lived to adulthood...
  25. Tyser R, Miranda A, Chen C, Davidson S, Srinivas S, Riley P. Calcium handling precedes cardiac differentiation to initiate the first heartbeat. elife. 2016;5: pubmed publisher
    ..Ca2+ transients, underpinned by sequential expression of the Na+-Ca2+ exchanger (NCX1) and L-type Ca2+ channel (LTCC)...
  26. Domes K, Ding J, Lemke T, Blaich A, Wegener J, Brandmayr J, et al. Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth. J Biol Chem. 2011;286:33863-71 pubmed publisher
    ..2 expression. These findings indicate that absence of the carboxyl-terminal tail differentially determines the fate of the cardiac and smooth muscle splice variant of the CaV1.2 channel in the mouse. ..
  27. Kim I, Lee C. Cloning of the mouse cardiac Na(+)-Ca2+ exchanger and functional expression in Xenopus oocytes. Ann N Y Acad Sci. 1996;779:126-8 pubmed
  28. Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015;106:163-73 pubmed publisher
    ..Immunocytochemistry demonstrated colocalization of TRPC3 with NCX1 and disruption of local interaction upon channel activation by either GSK1702934A or AngII...
  29. Reynolds J, Chiang D, Wang W, Beavers D, Dixit S, Skapura D, et al. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013;100:44-53 pubmed publisher
    ..In particular, JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the TT network. ..
  30. Ujihara Y, Mohri S, Katanosaka Y. Effects of induced Na+/Ca2+ exchanger overexpression on the spatial distribution of L-type Ca2+ channels and junctophilin-2 in pressure-overloaded hearts. Biochem Biophys Res Commun. 2016;480:564-569 pubmed publisher
    The Na+/Ca2+ exchanger 1 (NCX1) is an essential Ca2+ efflux system in cardiomyocytes. Although NCX1 is distributed throughout the sarcolemma, a subpopulation of NCX1 is localized to transverse (T)-tubules...
  31. Wang C, Dostanic S, Servant N, Chalifour L. Egr-1 negatively regulates expression of the sodium-calcium exchanger-1 in cardiomyocytes in vitro and in vivo. Cardiovasc Res. 2005;65:187-94 pubmed
    ..Microarray analyses identified increased sodium calcium exchanger-1 (NCX1) expression in catecholamine-treated -/- mice...
  32. Boscia F, D Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, et al. New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes. Adv Exp Med Biol. 2013;961:307-16 pubmed publisher
    ..We investigated the regional and temporal changes of NCX1 protein in microglial cells of the peri-infarct and core regions after permanent middle cerebral artery occlusion (..
  33. Hwa J, Beckouche N, Huang L, Kram Y, Lindskog H, Wang R. Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow. Sci Rep. 2017;7:11965 pubmed publisher
    ..We examined the development of the dorsal aorta (DA) and the cardinal vein (CV) in Ncx1 -/- mutants, which lack blood flow due to a deficiency in a sodium calcium ion exchanger expressed ..
  34. Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, et al. Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp Biochem Physiol B Biochem Mol Biol. 2003;135:9-15 pubmed
    The Na(+)/Ca(2+) exchanger (NCX1) plays a key role in maintaining Ca(2+) homeostasis in cardiomyocytes...
  35. Tsika R, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, et al. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010;285:13721-35 pubmed publisher p-phospholamban, SERCA2a, p-CX43, p-GSK-3alpha/beta, nuclear beta-catenin, GATA4, NFATc3/c4, and increased NCX1, nuclear DYKR1A, and Pur alpha/beta protein. TEAD-1 mice did not display cardiac hypertrophy...
  36. Lee L, Ghorbanian Y, Wang W, Wang Y, Kim Y, Weissman I, et al. LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage. Cell Rep. 2016;17:2286-2298 pubmed publisher
    ..Fetal liver (FL) and adult HSPCs showed 35%-40% Lyve1-Cre marking. Analysis of circulation-deficient Ncx1-/- concepti identified the YS as a major source of Lyve1-Cre labeled HSPCs...
  37. Yamaji R, Fujita K, Takahashi S, Yoneda H, Nagao K, Masuda W, et al. Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger. Biochim Biophys Acta. 2003;1593:269-76 pubmed mRNA encoding NCX3, which functions even under cellular ATP-depleted conditions, in addition to mRNAs encoding NCX1 and NCX2...
  38. Gotoh Y, Kita S, Fujii M, Tagashira H, Horie I, Arai Y, et al. Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria. Biochem Biophys Res Commun. 2015;456:670-5 pubmed publisher
    ..Although two isoforms of NCX1 and NCX2 are coexpressed on the basolateral membrane of the distal nephron, the functional significance of these ..
  39. Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamoto T, Azuma Y, et al. Na/Ca(2+) exchanger 1 transgenic mice display increased relaxation in the distal colon. Pharmacology. 2014;94:230-8 pubmed publisher
    Na(+)/Ca(2+) exchanger 1 (NCX1) is a plasma membrane transporter involved in regulating intracellular Ca(2+) concentrations. NCX1 is critical for Ca(2+) regulation in cardiac muscle, vascular smooth muscle and nerve fibers...
  40. Cho C, Kim S, Jeong M, Lee C, Shin H. The Na+ -Ca2+ exchanger is essential for embryonic heart development in mice. Mol Cells. 2000;10:712-22 pubmed
    The cardiac Na+ -Ca2+ exchanger 1 (NCX1) is thought to be the major calcium extrusion mechanism and to play an important role in the regulation of intracellular calcium in the heart...
  41. Azuma Y, Hayashi S, Nishiyama K, Kita S, Mukai K, Nakajima H, et al. Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo. Neurogastroenterol Motil. 2016;28:827-36 pubmed publisher
    ..we examined electric field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in NCX1 and NCX2 heterozygote knockout mice (HET)...
  42. Radhakrishnan V, Kojs P, Ramalingam R, Midura Kiela M, Angeli P, Kiela P, et al. Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules. J Biol Chem. 2015;290:8964-74 pubmed publisher
    b>NCX1 is a Na(+)/Ca(2+) exchanger, which is believed to provide a key route for basolateral Ca(2+) efflux in the renal epithelia, thus contributing to renal Ca(2+) reabsorption...
  43. Komuro I, Wenninger K, Philipson K, Izumo S. Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA. Proc Natl Acad Sci U S A. 1992;89:4769-73 pubmed
    ..The levels of mRNA encoding the exchanger were significantly lower in fetal hearts than in adult hearts but were unchanged in the myocardium from patients with end-stage heart failure. ..
  44. Ohtsuka M, Takano H, Suzuki M, Zou Y, Akazawa H, Tamagawa M, et al. Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model. Biochem Biophys Res Commun. 2004;314:849-53 pubmed
    ..NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. ..
  45. Wang Y, Chen L, Li M, Cha H, Iwamoto T, Zhang J. Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension. Physiol Rep. 2015;3: pubmed publisher
    ..To determine the possible roles of NCX in the vascular phenotype and function, we developed a novel mouse model (SM-NCX1 KO) in which the smooth muscle-specific NCX type-1 (NCX1) was conditionally knocked out using tamoxifen-inducible ..
  46. Kammili R, Taylor D, Xia J, Osuala K, Thompson K, Menick D, et al. Generation of novel reporter stem cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo. Stem Cells Dev. 2010;19:1437-48 pubmed publisher
    ..We conclude that the Ncx-1-43LUC mES cell line is a novel tool for monitoring early cardiac differentiation in vivo using noninvasive BLI. ..
  47. Yoshimoto M, Montecino Rodriguez E, Ferkowicz M, Porayette P, Shelley W, Conway S, et al. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A. 2011;108:1468-73 pubmed publisher
    ..We demonstrate, using Ncx1(-/-) mice that lack systemic blood circulation, that the E9 yolk sac (YS) and the intra-embryonic para-aortic ..
  48. Burr A, Millay D, Goonasekera S, Park K, Sargent M, Collins J, et al. Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Mol Cell Biol. 2014;34:1991-2002 pubmed publisher
    ..Antithetically, muscle-specific deletion of the Slc8a1 (NCX1) gene diminished hind-limb pathology in Sgcd(-/-) mice...
  49. Rhodes K, Gekas C, Wang Y, Lux C, Francis C, Chan D, et al. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2008;2:252-63 pubmed publisher
    ..Analysis of Ncx1(-/-) embryos, which lack a heartbeat, verified that HSC development is initiated in the placental vasculature ..
  50. Magyar C, White K, Rojas R, Apodaca G, Friedman P. Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells. Am J Physiol Renal Physiol. 2002;283:F29-40 pubmed
    The plasma membrane Ca2+-ATPase (PMCA) and the NCX1 Na+/Ca2+ exchanger regulate intracellular Ca2+ concentrations and mediate Ca2+ efflux in absorptive epithelial cells...
  51. Palty R, Silverman W, Hershfinkel M, Caporale T, Sensi S, Parnis J, et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci U S A. 2010;107:436-41 pubmed publisher
    ..Taken together, our results converge to the conclusion that NCLX is the long-sought mitochondrial Na(+)/Ca(2+) exchanger. ..
  52. Swift F, Franzini Armstrong C, Øyehaug L, Enger U, Andersson K, Christensen G, et al. Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc Natl Acad Sci U S A. 2012;109:3997-4001 pubmed publisher
    ..T-tubule proliferation occurs without loss of the original ordered transverse orientation and thus constitutes the basis for compensation of the declining SR function without structural disarrangement...
  53. Hudecova S, Lencesova L, Csaderova L, Sirova M, Cholujova D, Cagala M, et al. Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1?. Gen Physiol Biophys. 2011;30:196-206 pubmed publisher
    Up to now a little is known about the effect of hypoxia on the sodium calcium exchanger type 1 (NCX1) expression and function...
  54. Barsukova A, Forte M, Bourdette D. Focal increases of axoplasmic Ca2+, aggregation of sodium-calcium exchanger, N-type Ca2+ channel, and actin define the sites of spheroids in axons undergoing oxidative stress. J Neurosci. 2012;32:12028-37 pubmed publisher
    ..This study provides new insights into the mechanism of a spheroid formation at specific sites along axons undergoing oxidative stress and a basis for new neuroprotective strategies. ..
  55. Lester W, Schroder E, Burgess D, Yozwiak D, Andres D, Satin J. Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block. Cell Calcium. 2008;44:353-62 pubmed
    ..Rem also significantly slowed Ca2+ transient decay kinetics (p < 10(-3)). Rem reduced NCX1.1 protein level and function...
  56. Yan Z, Ban T, Fan Y, Chen W, Sun H, Chen H, et al. Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte. Oncotarget. 2015;6:23272-80 pubmed
  57. Roos K, Jordan M, Fishbein M, Ritter M, Friedlander M, Chang H, et al. Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. J Card Fail. 2007;13:318-29 pubmed
    The cardiac sodium-calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart...
  58. Mohler P, Davis J, Bennett V. Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. PLoS Biol. 2005;3:e423 pubmed
    ..Ankyrin-B also is not abundantly expressed in smooth muscle. We propose that the ankyrin-B-based complex is a specialized adaptation of cardiomyocytes with a role for cytosolic Ca2+ modulation. ..
  59. Koo T, Yang H, An B, Choi K, Hyun S, Jeung E. Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k). Mol Reprod Dev. 2012;79:346-55 pubmed publisher
    ..The expression of CaBP-9k, TRPV6, TRPV5, and NCX1 mRNA was high in fetal compared to maternal placenta, while CaBP-28k was abundant in the maternal placenta...
  60. Wansleeben C, van Gurp L, Feitsma H, Kroon C, Rieter E, Verberne M, et al. An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions. PLoS ONE. 2011;6:e19357 pubmed publisher
    ..We isolated amongst others novel mutant alleles for Dll1, Ptprb, Plexin-B2, Fgf10, Wnt3a, Ncx1, Scrib(Scrib, Scribbled homolog [Drosophila]) and Sec24b...
  61. Shi S, Chang B, Brunnert S. Identification and cloning of a truncated isoform of the cardiac sodium-calcium exchanger in the BALB/c mouse heart. Biochem Genet. 1998;36:119-35 pubmed
    A truncated isoform of the cardiac sodium-calcium exchanger (NCX1) was identified and cloned from BALB/c mouse heart...
  62. Zhang J, Ren C, Chen L, Navedo M, Antos L, Kinsey S, et al. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010;298:H1472-83 pubmed publisher
    Mice with smooth muscle (SM)-specific knockout of Na(+)/Ca(2+) exchanger type-1 (NCX1(SM-/-)) and the NCX inhibitor, SEA0400, were used to study the physiological role of NCX1 in mouse mesenteric arteries...
  63. Tsai C, Chiang F, Chen W, Hwang J, Tseng C, Wu C, et al. Angiotensin II induces complex fractionated electrogram in a cultured atrial myocyte monolayer mediated by calcium and sodium-calcium exchanger. Cell Calcium. 2011;49:1-11 pubmed publisher
    ..Specific genetic knockdown of NCX attenuated calcium mediated afterdepolarization and complex electrogram. ..
  64. Andrikopoulos P, Kieswich J, Harwood S, Baba A, Matsuda T, Barbeau O, et al. Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger. J Biol Chem. 2015;290:18412-28 pubmed publisher
    ..Reverse-mode NCX inhibitors and RNAi-mediated NCX1 knockdown attenuated ERK1/2 phosphorylation in response to thrombin or an agonist of PAR-1, the main endothelial ..
  65. Cho C, Lee S, Shin H, Philipson K, Lee C. Partial rescue of the Na+-Ca2+ exchanger (NCX1) knock-out mouse by transgenic expression of NCX1. Exp Mol Med. 2003;35:125-35 pubmed
    The null mutation of cardiac Na(+)-Ca(2+) exchanger (NCX1) gene in mice caused death of embryo in utero at embryonic day (ED) 9.0-9.5 and this embryonic lethality appears resulted from abnormal heart development...
  66. Pott C, Goldhaber J, Philipson K. Genetic manipulation of cardiac Na+/Ca2+ exchange expression. Biochem Biophys Res Commun. 2004;322:1336-40 pubmed
    ..Ca2+ influx in these animals is limited by a decrease of peak L-type Ca2+ current. An alternative Ca2+ efflux mechanism, presumably the plasma membrane Ca2+-ATPase, is sufficient to maintain Ca2+-homeostasis in the NCX knockout mice. ..
  67. Kita S, Iwamoto T. [Mechanisms for linking high salt intake to vascular tone: role of Na(+) pump and Na(+)/Ca²(+) exchanger coupling]. Yakugaku Zasshi. 2010;130:1399-405 pubmed
    ..accumulation raises the cytosolic Ca²(+) concentration through the involvement of Na(+)/Ca²(+) exchanger type 1 (NCX1)...
  68. Larocca T, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, et al. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-?B pathway. Am J Physiol Heart Circ Physiol. 2012;303:H353-67 pubmed publisher
    ..The cardiac Na(+)/Ca(2+) exchanger 1 (NCX1) has been implicated as a compensatory mechanism in response to reduced contractility in the heart; however, its ..
  69. Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, et al. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med. 2012;209:1167-81 pubmed publisher
    ..Altogether, we establish that adult LCs have a dual origin, bridging early embryonic and late fetal myeloid development...
  70. Fujimoto Y, Hayashi S, Azuma Y, Mukai K, Nishiyama K, Kita S, et al. Overexpression of Na+/Ca2+ exchanger 1 display enhanced relaxation in the gastric fundus. J Pharmacol Sci. 2016;132:181-186 pubmed publisher
    ..field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in smooth muscle-specific NCX1 transgenic mice (Tg). EFS caused a bi-phasic response, transient and sustained relaxation...
  71. Mani S, Egan E, Addy B, Grimm M, Kasiganesan H, Thiyagarajan T, et al. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010;48:342-51 pubmed publisher
    The Na(+)-Ca(2+) exchanger gene (Ncx1) is upregulated in hypertrophy and is often found elevated in end-stage heart failure. Studies have shown that the change in its expression contributes to contractile dysfunction...
  72. Wang J, Gao E, Rabinowitz J, Song J, Zhang X, Koch W, et al. Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol. 2011;300:H859-68 pubmed publisher
    ..phosphorylated at serine 68, relieves its inhibition on Na(+)-K(+)-ATPase but inhibits Na(+)/Ca(2+) exchanger 1 (NCX1) in cardiac myocytes...
  73. Zhang X, Ahlers B, Tucker A, Song J, Wang J, Moorman J, et al. Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation. J Biol Chem. 2006;281:7784-92 pubmed
    ..that phospholemman (PLM), a 15-kDa integral sarcolemmal phosphoprotein, inhibits the cardiac Na+/Ca2+ exchanger (NCX1)...
  74. Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, et al. Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016;6:25541 pubmed publisher
    ..Our mice provide genetic models for congenital dysfunction of the heart and should facilitate studies of both pathogenesis and therapy of cardiac disorders in humans. ..
  75. Wakimoto K, Kuro O M, Yanaka N, Omori K, Komuro I, Imai Y, et al. Isolation and characterization of Na+/Ca2+ exchanger gene and splicing isoforms in mice. DNA Seq. 2000;11:75-81 pubmed
    The Na+/Ca2+ exchanger gene NCX1 is ubiquitously expressed in mammalian tissues, and encodes several isoforms through alternative RNA splicing...
  76. Lu Y, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li X, et al. CaMKII?B mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart. PLoS ONE. 2011;6:e24724 pubmed publisher, we aim to determine the mechanism of CaMKII?B in modulating the expression of sarcolemmal Na?-Ca²? exchange (NCX1)...
  77. Barwe S, Jordan M, Skay A, Inge L, Rajasekaran S, Wolle D, et al. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit. J Mol Cell Cardiol. 2009;47:552-60 pubmed publisher
    ..This insensitivity was associated with a reduction in NCX1, one of the proteins involved in regulating cardiac contractility...
  78. Nakamura T, Jeromin A, Mikoshiba K, Wakabayashi S. Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011;109:512-23 pubmed publisher
    ..NCS-1 is an important regulator of immature heart function and hypertrophy, and it functions in part by promoting IP(3)R function, followed by CaMKII-dependent signal activation. ..
  79. Tritsch E, Mallat Y, Lefebvre F, Diguet N, Escoubet B, Blanc J, et al. An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart. Cardiovasc Res. 2013;98:372-80 pubmed publisher
    The expression of the sodium/calcium exchanger NCX1 increases during cardiac hypertrophy and heart failure, playing an important role in Ca(2+) extrusion...
  80. Kwon H, Koo J, Zufall F, Leinders Zufall T, Margolis F. Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009;4:e4260 pubmed publisher
    ..Immunohistochemistry verifies colocalization of NCX1 and OMP in the cilia and knobs of OSNs...