Slc6a4

Summary

Gene Symbol: Slc6a4
Description: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Alias: 5-HTT, AI323329, Htt, Sert, sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Sodium-dependent serotonin transporter (5HT transporter) (5HTT), solute carrier family 6 member 4
Species: mouse
Products:     Slc6a4

Top Publications

  1. Lira A, Zhou M, Castanon N, Ansorge M, Gordon J, Francis J, et al. Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry. 2003;54:960-71 pubmed
    As a key regulator of serotonergic activity and target of many antidepressant treatments, the serotonin transporter (SERT) represents a potential mediator of anxiety- and depression-related behaviors...
  2. Holmes A, Lit Q, Murphy D, Gold E, Crawley J. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003;2:365-80 pubmed
    Serotonin transporter (5-HTT) null mutant mice provide a model system to study the role genetic variation in the 5-HTT plays in the regulation of emotion...
  3. Heils A, Wichems C, Mossner R, Petri S, Glatz K, Bengel D, et al. Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons. J Neurochem. 1998;70:932-9 pubmed
    We have isolated and characterized the 5'-flanking regulatory region of the murine serotonin 5-HT transporter (5-HTT) gene...
  4. Mackenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci U S A. 1999;96:15251-5 pubmed
    ..of a variable number of tandem repeats within intron 2 of the gene coding for the serotonin transporter protein 5-HTT have been associated with susceptibility to affective disorders...
  5. Holmes A, Yang R, Murphy D, Crawley J. Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology. 2002;27:914-23 pubmed
    Inhibition of the serotonin transporter (5-HTT) is a principal initial target of many antidepressants. However, the contribution of the 5-HTT to their therapeutic efficacy is incompletely understood...
  6. Gobbi G, Murphy D, Lesch K, Blier P. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. J Pharmacol Exp Ther. 2001;296:987-95 pubmed
    The serotonin transporter (5-HTT) plays a key role in the regulation of serotonin (5-hydroxytryptamine, 5-HT) transmission in the pathophysiology and therapeutics of several psychiatric disorders...
  7. Baganz N, Horton R, Calderon A, Owens W, Munn J, Watts L, et al. Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc Natl Acad Sci U S A. 2008;105:18976-81 pubmed publisher
    ..A common serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT expression in vivo and elevates risk for multiple mood disorders ..
  8. Jennings K, Lesch K, Sharp T, Cragg S. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. J Neurochem. 2010;115:965-73 pubmed publisher
    Much evidence suggests that variation in expression of the 5-hydroxytryptamine (5-HT) transporter (5-HTT) is linked to risk of psychiatric illness, but the neurobiological basis of this association is uncertain...
  9. Karabeg M, Grauthoff S, Kollert S, Weidner M, Heiming R, Jansen F, et al. 5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze. PLoS ONE. 2013;8:e78238 pubmed publisher
    ..Therefore, 5-HTT knockout (-/-), heterozygous (+/-) and wildtype (+/+) mice were subjected to the Barnes maze (BM) and the Morris ..

More Information

Publications72

  1. Murphy D, Fox M, Timpano K, Moya P, Ren Patterson R, Andrews A, et al. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology. 2008;55:932-60 pubmed publisher
    ..species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in SLC6A4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with ..
  2. Narboux Nême N, Pavone L, Avallone L, Zhuang X, Gaspar P. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology. 2008;55:994-1005 pubmed publisher
    The serotonin transporter gene (SLC6A4; synonyms, SERT, 5-HTT) is expressed much more broadly during development than in adulthood...
  3. Bartolomucci A, Carola V, Pascucci T, Puglisi Allegra S, Cabib S, Lesch K, et al. Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Dis Model Mech. 2010;3:459-70 pubmed publisher
    ..studies have shown, for example, that individuals carrying the S (short) allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) have an increased risk for major depression following exposure to stress ..
  4. Murphy D, Moya P. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Curr Opin Pharmacol. 2011;11:3-10 pubmed publisher
    Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions ..
  5. Heiming R, Mönning A, Jansen F, Kloke V, Lesch K, Sachser N. To attack, or not to attack? The role of serotonin transporter genotype in the display of maternal aggression. Behav Brain Res. 2013;242:135-41 pubmed publisher
    ..The aim of the present study was to investigate the impact of 5-HT transporter (5-HTT) inactivation on maternal aggression in mice...
  6. Murphy D, Lesch K. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci. 2008;9:85-96 pubmed publisher
    Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT) function in mice have led to the identification of more than 50 different phenotypic changes, ranging from increased anxiety and stress-related behaviours ..
  7. Bengel D, Murphy D, Andrews A, Wichems C, Feltner D, Heils A, et al. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol. 1998;53:649-55 pubmed
    The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT) provides the primary mechanism for inactivation of 5-HT after its release into the synaptic cleft...
  8. Muller J, Morelli E, Ansorge M, Gingrich J. Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks. Genes Brain Behav. 2011;10:166-75 pubmed publisher
    Modulation of serotonin transporter (5-HTT) function causes changes in affective behavior, both in humans and rodents. Stressful life events likewise affect emotional behavior...
  9. Brodski C, Weisenhorn D, Signore M, Sillaber I, Oesterheld M, Broccoli V, et al. Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. J Neurosci. 2003;23:4199-207 pubmed
    ..In addition, our data suggest that the position of the MHO during embryogenesis can modulate adult locomotor activity. ..
  10. Wellman C, Izquierdo A, Garrett J, Martin K, Carroll J, Millstein R, et al. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci. 2007;27:684-91 pubmed
    A lesser-expressing form of the human 5-HT transporter (5-HTT) gene has been associated with increased fear and anxiety and vulnerability to the effects of stress...
  11. Qu Y, Villacreses N, Murphy D, Rapoport S. 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology (Berl). 2005;180:12-20 pubmed
    The serotonin reuptake transporter (SERT) helps to regulate brain serotonergic transmission and is the target of some antidepressants...
  12. Esaki T, Cook M, Shimoji K, Murphy D, Sokoloff L, Holmes A. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci U S A. 2005;102:5582-7 pubmed
    ..We have examined the effects of deletion of the 5-HT transporter (5-HTT) gene on somatosensory responses to sensory stimulation in mice...
  13. Jones K, Smith R, Edwards K, Givens B, Tilley M, Beversdorf D. Combined effect of maternal serotonin transporter genotype and prenatal stress in modulating offspring social interaction in mice. Int J Dev Neurosci. 2010;28:529-36 pubmed publisher
    ..This data indicates a possible combined effect of maternal serotonin transporter genotype and prenatal stress contributing to the production of autistic-like behaviors in offspring. ..
  14. Ichikawa M, Okamura Oho Y, Shimokawa K, Kondo S, Nakamura S, Yokota H, et al. Expression analysis for inverted effects of serotonin transporter inactivation. Biochem Biophys Res Commun. 2008;368:43-9 pubmed publisher
    Inactivation of serotonin transporter (HTT) by pharmacologically in the neonate or genetically increases risk for depression in adulthood, whereas pharmacological inhibition of HTT ameliorates symptoms in depressed patients...
  15. Ravary A, Muzerelle A, Darmon M, Murphy D, Moessner R, Lesch K, et al. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur J Neurosci. 2001;13:1349-62 pubmed
    We report here that a truncated 5-HTT protein is produced in the neurons of the raphe, in serotonin transporter (5-HTT) knockout (KO) mice...
  16. Persico A, Baldi A, Dell Acqua M, Moessner R, Murphy D, Lesch K, et al. Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport. 2003;14:341-4 pubmed
    ..programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels...
  17. Kalueff A, Jensen C, Murphy D. Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice. Brain Res. 2007;1169:87-97 pubmed
    Serotonin transporter knockout (SERT-/-) mice are extensively used as a genetic model of several neuropsychiatric disorders, and consistently display anxiety-like behaviors and inactivity in different tests...
  18. Vogel C, Mossner R, Gerlach M, Heinemann T, Murphy D, Riederer P, et al. Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci. 2003;23:708-15 pubmed
    ..Mice deficient for the 5-HT transporter (5-HTT-/- mice) are regarded as a model of lifelong treatment with a serotonin reuptake inhibitor...
  19. MacLean M, Deuchar G, Hicks M, Morecroft I, Shen S, Sheward J, et al. Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation. 2004;109:2150-5 pubmed
    ..hypertension and pulmonary vascular remodeling in mice overexpressing the gene for the 5-HT transporter (5-HTT+ mice)...
  20. Tjurmina O, Armando I, Saavedra J, Goldstein D, Murphy D. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology. 2002;143:4520-6 pubmed
    This study examined whether serotonin transporter (5-HTT) gene knockout influences adrenomedullary, sympathoneural, or hypothalamo-pituitary-adrenal responses to acute immobilization...
  21. Persico A, Mengual E, Moessner R, Hall F, Revay R, Sora I, et al. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci. 2001;21:6862-73 pubmed
    ..transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2)...
  22. Mathews T, Fedele D, Coppelli F, Avila A, Murphy D, Andrews A. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods. 2004;140:169-81 pubmed
    ..Many therapeutic and illicit drugs that modulate these functions act at the serotonin transporter (SERT), thus a mouse model with reduced transporter expression was created to further investigate the effects of ..
  23. Chen J, Li Z, Pan H, Murphy D, Tamir H, Koepsell H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci. 2001;21:6348-61 pubmed
    The enteric serotonin reuptake transporter (SERT) has been proposed to play a critical role in serotonergic neurotransmission and in the initiation of peristaltic and secretory reflexes...
  24. Riccio O, Potter G, Walzer C, Vallet P, Szabo G, Vutskits L, et al. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Mol Psychiatry. 2009;14:280-90 pubmed publisher
    The discovery that a common polymorphism (5-HTTLPR, short variant) in the human serotonin transporter gene (SLC6A4) can influence personality traits and increase the risk for depression in adulthood has led to the hypothesis that a ..
  25. Eddahibi S, Hanoun N, Lanfumey L, Lesch K, Raffestin B, Hamon M, et al. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest. 2000;105:1555-62 pubmed
    ..Previous studies demonstrated that the serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) mediates the mitogenic activity of 5-HT in pulmonary vascular SMCs and is overexpressed during hypoxia...
  26. Zhao Z, Scott M, Chiechio S, Wang J, Renner K, Gereau R, et al. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006;26:12781-8 pubmed
    ..gene expression is concomitant with downregulation of Lmx1b expression, with the exception of serotonin transporter Sert and tryptophan hydroxylase TPH2, whose expression appears to be most sensitive to Lmx1b...
  27. Armando I, Tjurmina O, Li Q, Murphy D, Saavedra J. The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression. Neuroendocrinology. 2003;78:217-25 pubmed
    High numbers of serotonin transporter (SERT) binding sites and high serotonin (5-HT) content are expressed in the adrenal medulla of wild-type (SERT+/+) mice...
  28. Hohoff C, Gorji A, Kaiser S, Willscher E, Korsching E, Ambrée O, et al. Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice. PLoS ONE. 2013;8:e58880 pubmed publisher
    ..Moreover, several of the first wave primary response genes that we found might provide promising targets for future therapeutic interventions of stress-related disorders also in humans. ..
  29. Narayanan V, Heiming R, Jansen F, Lesting J, Sachser N, Pape H, et al. Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice. PLoS ONE. 2011;6:e22600 pubmed publisher
    ..One genetic factor is for example the genetically encoded variation of the serotonin transporter (5-HTT) expression...
  30. Kalueff A, Fox M, Gallagher P, Murphy D. Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes Brain Behav. 2007;6:389-400 pubmed
    Although mice with a targeted disruption of the serotonin transporter (SERT) have been studied extensively using various tests, their complex behavioral phenotype is not yet fully understood...
  31. Daws L, Montañez S, Munn J, Owens W, Baganz N, Boyce Rustay J, et al. Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J Neurosci. 2006;26:6431-8 pubmed
    ..The 5-HT transporter (5-HTT) is the principle means of 5-HT reuptake in the brain and an obvious candidate mechanism for the effect of ethanol ..
  32. Salichon N, Gaspar P, Upton A, Picaud S, Hanoun N, Hamon M, et al. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci. 2001;21:884-96 pubmed
    ..To investigate this effect, we crossed MAOA knock-outs with mice lacking the serotonin transporter 5-HTT or the 5-HT1B receptor, two molecules present in developing sensory projections...
  33. Lewejohann L, Kloke V, Heiming R, Jansen F, Kaiser S, Schmitt A, et al. Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behav Brain Res. 2010;211:220-8 pubmed publisher
    Humans differing in the amount of serotonin transporter (5-HTT) are known to be differentially prone to neuropsychiatric disorders...
  34. Hendricks T, Fyodorov D, Wegman L, Lelutiu N, Pehek E, Yamamoto B, et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron. 2003;37:233-47 pubmed
    ..These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior. ..
  35. Schmitt A, Mossner R, Gossmann A, Fischer I, Gorboulev V, Murphy D, et al. Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J Neurosci Res. 2003;71:701-9 pubmed
    The serotonin (5HT) transporter (5HTT) regulates serotonergic neurotransmission by mediating the reuptake of 5HT from the synaptic cleft...
  36. Moy S, Nadler J, Young N, Nonneman R, Grossman A, Murphy D, et al. Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav. 2009;8:129-42 pubmed publisher
    ..Autism has been associated with altered serotonin levels and polymorphisms in SLC6A4 (SERT), the serotonin transporter gene...
  37. Bonnin A, Goeden N, Chen K, Wilson M, King J, Shih J, et al. A transient placental source of serotonin for the fetal forebrain. Nature. 2011;472:347-50 pubmed publisher
  38. Page D, Kuti O, Prestia C, Sur M. Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A. 2009;106:1989-94 pubmed publisher
    ..Two genes that have been implicated as conferring susceptibility to ASD are PTEN and Serotonin transporter (SLC6A4)...
  39. Carneiro A, Cook E, Murphy D, Blakely R. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest. 2008;118:1544-52 pubmed publisher
    ..essential contribution of the antidepressant-sensitive serotonin (5-HT) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an important role of this transporter in platelet function...
  40. Zhao S, Edwards J, Carroll J, Wiedholz L, Millstein R, Jaing C, et al. Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience. 2006;140:321-34 pubmed
    The 5-hydroxytryptamine transporter (5-HTT) regulates 5-hydroxytryptamine (5-HT) neurotransmission by removing 5-HT from the synaptic cleft...
  41. Bengel D, Heils A, Petri S, Seemann M, Glatz K, Andrews A, et al. Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. Brain Res Mol Brain Res. 1997;44:286-92 pubmed
    ..The 5-HT transporter (5-HTT) is the prime target for widely used antidepressants, psychostimulants, drugs of abuse and neurotoxins...
  42. Lebrand C, Cases O, Wehrle R, Blakely R, Edwards R, Gaspar P. Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol. 1998;401:506-24 pubmed
    Neurons in first-order sensory thalamic nuclei have been shown to express functional plasma membrane serotonin (SERT) and vesicular monoamine (VMAT2) transporters during early postnatal development...
  43. Kalueff A, Gallagher P, Murphy D. Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia. Neuroreport. 2006;17:1347-51 pubmed
    ..These results demonstrate that depression-like behavior (unlike hypoactivity) is not a baseline phenotypic feature of serotonin transporter knockout mice, suggesting anew that these mice do not represent a genetic model of depression. ..
  44. Altamura C, Dell Acqua M, Moessner R, Murphy D, Lesch K, Persico A. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex. 2007;17:1394-401 pubmed
    ..we assessed the thickness and neuronal cell density of various cerebral cortical areas in serotonin transporter (5-HTT) knockout (ko) mice, characterized by elevated extracellular 5-HT levels...
  45. Kim D, Tolliver T, Huang S, Martin B, Andrews A, Wichems C, et al. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. 2005;49:798-810 pubmed
    To evaluate the consequences of inactivation of the serotonin transporter (SERT) gene on 5-HT homeostasis and function, 5-HT synthesis and turnover rates were measured using the decarboxylase inhibition method in multiple brain regions (..
  46. Warden S, Robling A, Sanders M, Bliziotes M, Turner C. Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth. Endocrinology. 2005;146:685-93 pubmed
    Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression...
  47. Ansorge M, Zhou M, Lira A, Hen R, Gingrich J. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science. 2004;306:879-81 pubmed
    Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown...
  48. Holmes A, Murphy D, Crawley J. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry. 2003;54:953-9 pubmed
    ..Ongoing studies focus on identifying environmental, genetic, and developmental factors interacting with the htt mutation to produce these abnormalities...
  49. Li Q, Wichems C, Heils A, van De Kar L, Lesch K, Murphy D. Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther. 1999;291:999-1007 pubmed
    ..in 5-hydroxytryptamine (5-HT)(1A) receptors would be found in knockout mice lacking the serotonin transporter (5-HTT)...
  50. Line S, Barkus C, Coyle C, Jennings K, Deacon R, Lesch K, et al. Opposing alterations in anxiety and species-typical behaviours in serotonin transporter overexpressor and knockout mice. Eur Neuropsychopharmacol. 2011;21:108-16 pubmed publisher
    ..association studies have produced conflicting findings regarding the relationship between the 5-HT transporter (5-HTT) and anxiety...
  51. Upton A, Salichon N, Lebrand C, Ravary A, Blakely R, Seif I, et al. Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development. J Neurosci. 1999;19:7007-24 pubmed
    ..In both MAOA-KO and normal mice, high-affinity uptake of 5-HT and serotonin transporter (SERT) immunoreactivity are observed in retinal axons from the optic cup to retinal terminal fields in the SC and dLGN...
  52. Ziu E, Mercado C, Li Y, Singh P, Ahmed B, Freyaldenhoven S, et al. Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin. J Mol Cell Cardiol. 2012;52:1112-21 pubmed publisher
    ..5-HT-infused mice were treated with paroxetine (Prx) to block 5-HT uptake via the serotonin transporter (SERT). Prx lowered platelet [5-HT] and attenuated platelet activation and aggregation...
  53. van den Hove D, van den Hove D, Jakob S, Schraut K, Kenis G, Schmitt A, et al. Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions. PLoS ONE. 2011;6:e22715 pubmed publisher
    ..Furthermore, the variation of human serotonin transporter (5-HTT, SLC6A4) gene was suggested to exert a modulating effect on the association between early life stress and the risk for ..
  54. Fabre V, Beaufour C, Evrard A, Rioux A, Hanoun N, Lesch K, et al. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci. 2000;12:2299-310 pubmed
    By taking up serotonin (5-hydroxytryptamine, 5-HT) released in the extracellular space, the 5-HT transporter (5-HTT) regulates central 5-HT neurotransmission...
  55. Upton A, Ravary A, Salichon N, Moessner R, Lesch K, Hen R, et al. Lack of 5-HT(1B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus. Neuroscience. 2002;111:597-610 pubmed
  56. Hansen N, Uceyler N, Palm F, Zelenka M, Biko L, Lesch K, et al. Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy. Neurosci Lett. 2011;495:93-7 pubmed publisher
    ..Here, we investigated how pain behavior is modulated in mice lacking the serotonin transporter (5-HTT-/- mice) after inducing neuropathy by intraperitoneal injections of VCR...
  57. Nietzer S, Bonn M, Jansen F, Heiming R, Lewejohann L, Sachser N, et al. Serotonin transporter knockout and repeated social defeat stress: impact on neuronal morphology and plasticity in limbic brain areas. Behav Brain Res. 2011;220:42-54 pubmed publisher
    Low expression of the human serotonin transporter (5-HTT) gene presumably interacts with stressful life events enhancing susceptibility for affective disorders...
  58. Carola V, Frazzetto G, Pascucci T, Audero E, Puglisi Allegra S, Cabib S, et al. Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression. Biol Psychiatry. 2008;63:840-6 pubmed
    A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood...
  59. Zhuang X, Masson J, Gingrich J, Rayport S, Hen R. Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J Neurosci Methods. 2005;143:27-32 pubmed
    ..transcriptional control of the dopamine transporter promoter (DAT-cre mice) or the serotonin transporter promoter (SERT-cre mice)...
  60. Chang A, Chang S, Starnes D, Schroeter S, Bauman A, Blakely R. Cloning and expression of the mouse serotonin transporter. Brain Res Mol Brain Res. 1996;43:185-92 pubmed
    A mouse brain cDNA encoding the high-affinity serotonin transporter (SERT) has been identified and characterized...
  61. Carroll J, Boyce Rustay J, Millstein R, Yang R, Wiedholz L, Murphy D, et al. Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice. Behav Genet. 2007;37:214-22 pubmed
    A low-expressing polymorphic variant of the serotonin transporter (5-HTT) gene has been associated with emotional disorders in humans and non-human primates following exposure to early life trauma...
  62. Manuel M, Georgala P, Carr C, Chanas S, Kleinjan D, Martynoga B, et al. Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development. 2007;134:545-55 pubmed
    ..These findings indicate that Pax6 levels are stabilized by autoregulation, that the proliferation of cortical progenitors is sensitive to altered Pax6 levels and that cortical arealization is not. ..
  63. Holmes A, Yang R, Lesch K, Crawley J, Murphy D. Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology. 2003;28:2077-88 pubmed
    ..in the pathophysiology of these disorders by evidence that genetic variation in the promoter region of the HTT (SLC6A4) is associated with individual differences in anxiety and neural responses to fear...