Gene Symbol: Slc4a7
Description: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Alias: E430014N10Rik, NBC3, NBCn1, NBCn1-G, Tg(Thy1-SNCA)12Mjff, sodium bicarbonate cotransporter 3, Na-bicarbonate cotransporter, sodium bicarbonate cotransporter NBCn1-A, sodium bicarbonate cotransporter NBCn1-B, sodium bicarbonate cotransporter NBCn1-D, sodium bicarbonate cotransporter NBCn1-H, sodium bicarbonate cotransporter NBCn1-c
Species: mouse
Products:     Slc4a7

Top Publications

  1. Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, et al. Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet. 2003;34:313-9 pubmed
    ..and auditory systems have a specific requirement for H+ disposal mediated by the sodium bicarbonate cotransporter NBC3 (refs. 7,8)...
  2. Boedtkjer E, Bentzon J, Dam V, Aalkjaer C. Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling. Cardiovasc Res. 2016;111:227-39 pubmed publisher
    ..Formula: see text]-cotransport via NBCn1 (Slc4a7) mediates net acid extrusion and controls steady-state intracellular pH (pHi) in VSMCs of mouse carotid arteries ..
  3. Lopez I, Acuna D, Galbraith G, Bok D, Ishiyama A, Liu W, et al. Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7). Brain Res Dev Brain Res. 2005;160:63-77 pubmed
    ..disruption of the gene encoding the stilbene-insensitive electroneutral sodium bicarbonate cotransporter (NBC3; slc4a7) exhibit cochlear and retinal degeneration...
  4. Boedtkjer E, Praetorius J, Aalkjaer C. NBCn1 (slc4a7) mediates the Na+-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. Circ Res. 2006;98:515-23 pubmed
    ..4 pH units magnitude) in all 3 vascular beds when CO2/bicarbonate was omitted. RT-PCR analyses showed that NBCn1 (slc4a7) is the only Na+-dependent bicarbonate transporter of the slc4 family detectable at the mRNA level in all 3 ..
  5. Boedtkjer E, Praetorius J, Füchtbauer E, Aalkjaer C. Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol. 2008;294:C591-603 pubmed
    The expression pattern of the electroneutral Na(+)-HCO(3)(-)cotransporter NBCn1 (slc4a7) was investigated by beta-galactosidase staining of mice with a LacZ insertion into the NBCn1 gene...
  6. Lee S, Axelsen T, Andersen A, Vahl P, Pedersen S, Boedtkjer E. Disrupting Na⁺, HCO₃⁻-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development. Oncogene. 2016;35:2112-22 pubmed publisher
    ..association studies have indicated a possible link between the Na⁺, HCO₃⁻-cotransporter NBCn1 (SLC4A7) and breast cancer. We tested the functional consequences of NBCn1 knockout (KO) for breast cancer development...
  7. Chen M, Praetorius J, Zheng W, Xiao F, Riederer B, Singh A, et al. The electroneutral Na?:HCO?? cotransporter NBCn1 is a major pHi regulator in murine duodenum. J Physiol. 2012;590:3317-33 pubmed publisher
    ..expression (within the upper GI tract) has been reported for the electroneutral Na+:HCO3 ? cotransporter NBCn1 (Slc4a7)...
  8. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  9. Reiners J, Nagel Wolfrum K, Jürgens K, Märker T, Wolfrum U. Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease. Exp Eye Res. 2006;83:97-119 pubmed
    ..that the USH2 proteins USH2A and VLGR1b as well as the candidate for USH2B, the sodium bicarbonate co-transporter NBC3, are also integrated into this USH protein network...

More Information


  1. Reiners J, Van Wijk E, Märker T, Zimmermann U, Jürgens K, te Brinke H, et al. Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2. Hum Mol Genet. 2005;14:3933-43 pubmed
    ..between the scaffold protein harmonin (USH1C) and the USH2A protein, VLGR1 (USH2C) and the candidate for USH2B, NBC3. We pinpoint these interactions to interactions between the PDZ1 domain of harmonin and the PDZ-binding motifs at ..
  2. Chen L, Choi I, Haddad G, Boron W. Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 2007;293:R2412-20 pubmed
    ..the effect of chronic continuous hypoxia on the expression of two electroneutral Na-coupled HCO3(-) transporters, SLC4a7 (NBCn1) and SLC4a10 (NCBE), in mouse brain, the first such study on any acid-base transporter...
  3. Park M, Ko S, Choi J, Muallem G, Thomas P, Pushkin A, et al. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem. 2002;277:50503-9 pubmed
    ..transporters mediate HCO(3)(-) salvage, the Na(+)/H(+) exchanger (NHE3) and the Na(+)-HCO(3)(-) cotransport (NBC3). In a previous work, we show that CFTR interacts with NHE3 to regulate its activity (Ahn, W., Kim, K. W., Lee, J...
  4. Boedtkjer E, Praetorius J, Matchkov V, Stankevicius E, Mogensen S, Füchtbauer A, et al. Disruption of Na+,HCO?? cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²? sensitivity, and hypertension development in mice. Circulation. 2011;124:1819-29 pubmed publisher
    ..We investigated whether Na(+), HCO?- transporter NBCn1, by regulating intracellular pH(pH?), influences artery function and blood pressure regulation...
  5. Singh A, Xia W, Riederer B, Jurić M, Li J, Zheng W, et al. Essential role of the electroneutral Na+-HCO3- cotransporter NBCn1 in murine duodenal acid-base balance and colonic mucus layer build-up in vivo. J Physiol. 2013;591:2189-204 pubmed publisher
    ..This study investigated the significance of the electroneutral Na(+)-HCO3(-) cotransporter NBCn1 for duodenal defence against acid and colonic mucus release...
  6. Kim Y, Verlander J, Matthews S, Kurtz I, Shin W, Weiner I, et al. Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice. Am J Physiol Renal Physiol. 2005;289:F1262-72 pubmed
    ..Moreover, kidneys from Slc26a4 null mice had reduced H(+)-ATPase, NBC3 and RhBG total protein expression, particularly within type B and non-A, non-B intercalated cells, although RhCG ..
  7. Praetorius J, Nejsum L, Nielsen S. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Am J Physiol Cell Physiol. 2004;286:C601-10 pubmed
    ..Furthermore, the stilbene-insensitive Na+-HCO3- cotransporter, NBCn1, was also localized to the basolateral plasma membrane domain of the choroid plexus epithelium...
  8. Bonde L, Boedtkjer E. Extracellular acidosis and very low [Na+ ] inhibit NBCn1- and NHE1-mediated net acid extrusion from mouse vascular smooth muscle cells. Acta Physiol (Oxf). 2017;221:129-141 pubmed publisher
    The electroneutral Na+ , HCO3- cotransporter NBCn1 and Na+ /H+ exchanger NHE1 regulate acid-base balance in vascular smooth muscle cells (VSMCs) and modify artery function and structure...
  9. Coley A, Ruffin V, Moss F, Hopfer U, Boron W. Immunocytochemical identification of electroneutral Na?-coupled HCO?? transporters in freshly dissociated mouse medullary raphé neurons. Neuroscience. 2013;246:451-67 pubmed publisher
    ..We also co-labeled with polyclonal antibodies against the three nNCBTs: NBCn1, NDCBE, and NBCn2...