Gene Symbol: Slc4a5
Description: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Alias: C330006M16, C330016K18Rik, electrogenic sodium bicarbonate cotransporter 4
Species: mouse
Products:     Slc4a5

Top Publications

  1. Gröger N, Vitzthum H, Fröhlich H, Kruger M, Ehmke H, Braun T, et al. Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis. Hum Mol Genet. 2012;21:1025-36 pubmed publisher
    The human SLC4A5 gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status...
  2. Wen D, Yuan Y, Warner P, Wang B, Cornelius R, Wang France J, et al. Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. Hypertension. 2015;66:68-74 pubmed publisher
    The gene SLC4A5 encodes the Na(+)-HCO3 (-) cotransporter electrogenic 2, which is located in the distal nephron...
  3. Wen D, Yuan Y, Cornelius R, Li H, Warner P, Wang B, et al. Deficient acid handling with distal RTA in the NBCe2 knockout mouse. Am J Physiol Renal Physiol. 2015;309:F523-30 pubmed publisher
    ..In the present study, we report that a mouse model lacking the electrogenic Na(+)-HCO3 (-) cotransporter [NBCe2/Slc4a5; NBCe2 knockout (KO) mice] developed dRTA after an oral acid challenge...
  4. Millar I, Brown P. NBCe2 exhibits a 3 HCO3(-):1 Na+ stoichiometry in mouse choroid plexus epithelial cells. Biochem Biophys Res Commun. 2008;373:550-4 pubmed publisher
    The transport stoichiometry of the electrogenic sodium-bicarbonate cotransporter (SLC4A5 or NBCe2) in mouse choroid plexus was examined...
  5. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Here, we report that targeted disruption of the Slc4a5 gene encoding the electrogenic sodium bicarbonate cotransporter NBCe2 results in significant remodeling of choroid ..