Slc40a1

Summary

Gene Symbol: Slc40a1
Description: solute carrier family 40 (iron-regulated transporter), member 1
Alias: Dusg, Fpn1, IREG1, MTP, MTP1, Ol5, Pcm, Slc11a3, Slc39a1, solute carrier family 40 member 1, SLC11A3 iron transporter, duodenal-specific, ferroportin 1, iron-regulated transporter 1, metal transporter protein 1, metal transporting protein 1, polycythaemia, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, solute carrier family 39 (iron-regulated transporter), member 1
Species: mouse
Products:     Slc40a1

Top Publications

  1. Meynard D, Kautz L, Darnaud V, Canonne Hergaux F, Coppin H, Roth M. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet. 2009;41:478-81 pubmed publisher
  2. De Domenico I, Zhang T, Koening C, Branch R, London N, Lo E, et al. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J Clin Invest. 2010;120:2395-405 pubmed publisher
    ..The results of our study suggest a new function for hepcidin in modulating acute inflammatory responses. ..
  3. Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, et al. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood. 2011;118:1912-22 pubmed publisher
    ..the recycling of iron from senescent erythrocytes by macrophages, a process in which the iron exporter ferroportin (Fpn1) is considered to be essential...
  4. Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, et al. Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages. Arch Biochem Biophys. 2011;508:101-9 pubmed publisher
    ..b>Ferroportin 1 (Fpn1) is the sole iron exporter in mammals, and it also regulates iron reutilization...
  5. Chen H, Su T, Attieh Z, Fox T, McKie A, Anderson G, et al. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Blood. 2003;102:1893-9 pubmed
    ..Ireg1 (SLC11A3, also known as Ferroportin1 or Mtp1) is the putative intestinal basolateral iron transporter...
  6. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt S, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-81 pubmed
    ..We propose that Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload. ..
  7. Andriopoulos B, Corradini E, Xia Y, Faasse S, Chen S, Grgurevic L, et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009;41:482-7 pubmed publisher
    ..These data support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expression and iron metabolism in vivo. ..
  8. McKie A, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309 pubmed
    ..We describe here the isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells...
  9. Zohn I, De Domenico I, Pollock A, Ward D, Goodman J, Liang X, et al. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007;109:4174-80 pubmed
    Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1)...

More Information

Publications83

  1. Wu L, Leenders A, Cooperman S, Meyron Holtz E, Smith S, Land W, et al. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res. 2004;1001:108-17 pubmed
    ..several iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter ferroportin (SLC11A3, Ireg, MTP1) have been cloned and characterized...
  2. Zhang D, Hughes R, Ollivierre Wilson H, Ghosh M, Rouault T. A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab. 2009;9:461-73 pubmed publisher
    Ferroportin (FPN1), the sole characterized mammalian iron exporter, has an iron-responsive element (IRE) in its 5' untranslated region, which ensures that its translation is repressed by iron regulatory proteins (IRPs) in iron-deficient ..
  3. Nemeth E, Tuttle M, Powelson J, Vaughn M, Donovan A, Ward D, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-3 pubmed
    ..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface. ..
  4. Troadec M, Ward D, Lo E, Kaplan J, De Domenico I. Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux. Blood. 2010;116:4657-64 pubmed publisher
    ..Ferroportin1 (FPN1) expression can be transcriptionally regulated by iron as well as other transition metals...
  5. Donovan A, Lima C, Pinkus J, Pinkus G, Zon L, Robine S, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 2005;1:191-200 pubmed
    Ferroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin and causes it to be internalized and degraded...
  6. Knutson M, Vafa M, Haile D, Wessling Resnick M. Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood. 2003;102:4191-7 pubmed
    The expression of ferroportin1 (FPN1) in reticuloendothelial macrophages supports the hypothesis that this iron-export protein participates in iron recycling from senescent erythrocytes...
  7. Jeong S, David S. Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem. 2003;278:27144-8 pubmed
    ..We also show that GPI-Cp colocalizes on the astrocyte cell surface with the divalent metal transporter IREG1 and is physically associated with IREG1...
  8. Yang F, Liu X, Quinones M, Melby P, Ghio A, Haile D. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786-91 pubmed
    ..This change in iron metabolism contributes to the development of the anemia of inflammation. MTP1, the duodenal enterocyte basolateral iron exporter, is also expressed in the cells of the reticuloendothelial ..
  9. Abboud S, Haile D. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-12 pubmed
    ..This gene, termed metal transporter protein (mtp1), is expressed in tissues involved in body iron homeostasis including the developing and mature reticuloendothelial ..
  10. Delaby C, Pilard N, Gonçalves A, Beaumont C, Canonne Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood. 2005;106:3979-84 pubmed
    ..These data are consistent with a direct iron export by ferroportin through the plasma membrane of macrophages and strongly support an efficient posttranscriptional down-regulation of ferroportin by hepcidin in these cells. ..
  11. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron Holtz E, et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001;27:209-14 pubmed
    ..Thus, misregulation of iron metabolism leads to neurodegenerative disease in Ireb2(-/-) mice and may contribute to the pathogenesis of comparable human neurodegenerative diseases. ..
  12. Duce J, Tsatsanis A, Cater M, James S, Robb E, Wikhe K, et al. Iron-export ferroxidase activity of ?-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 2010;142:857-67 pubmed publisher
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD. ..
  13. Paradkar P, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward D. Iron depletion limits intracellular bacterial growth in macrophages. Blood. 2008;112:866-74 pubmed publisher
  14. Liu X, Nguyen N, Marquess K, Yang F, Haile D. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis. 2005;35:47-56 pubmed
    ..acute inflammation has demonstrated inflammation-induced downregulation of intestinal and MPS iron exporter, ferroportin 1, mRNA and protein...
  15. Delaby C, Oustric V, Schmitt C, Muzeau F, Robreau A, Letteron P, et al. Epistasis in iron metabolism: complex interactions between Cp, Mon1a, and Slc40a1 loci and tissue iron in mice. Mamm Genome. 2013;24:427-38 pubmed
    ..epistatic interactions, the effects of Mon1a on macrophage iron export are conditioned by the genotype at the Slc40a1 locus. Only mice that are C57BL/10ScSnA homozygous at both loci display a lower spleen iron burden...
  16. McKie A, Wehr K, Simpson R, Peters T, Hentze M, Farzaneh F. Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. Biochem Soc Trans. 1998;26:S264 pubmed
  17. Canonne Hergaux F, Donovan A, Delaby C, Wang H, Gros P. Comparative studies of duodenal and macrophage ferroportin proteins. Am J Physiol Gastrointest Liver Physiol. 2006;290:G156-63 pubmed
    ..These cells appear to use the same transporter, ferroportin (Slc40a1), to export iron...
  18. Luo Q, Zhou Y, Chen M, Liu L, Ma J, Zhang M, et al. Fasting up-regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway. J Cell Physiol. 2018;233:30-37 pubmed publisher
    ..Here, we investigated the effects of fasting or ghrelin on the expression of hepcidin, ferroportin 1 (Fpn1), transferrin receptor 1 (TfR1), ferritin light chain (Ft-L) proteins, and ghrelin, and also hormone ..
  19. Seo Y, Wessling Resnick M. Ferroportin deficiency impairs manganese metabolism in flatiron mice. FASEB J. 2015;29:2726-33 pubmed publisher
    ..These combined results demonstrate that Fpn plays a central role in Mn transport and that flatiron mice provide an excellent genetic model to explore the role of this exporter in Mn homeostasis. - ..
  20. Mao J, McKean D, Warrier S, Corbin J, Niswander L, Zohn I. The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Development. 2010;137:3079-88 pubmed publisher
    ..Following implantation of the mouse embryo, ferroportin 1 (Fpn1) is essential for the transport of iron from the mother to the fetus and is expressed in the visceral ..
  21. Li W, Liu Y, Dong W, Tuo Q, Liu D, Wu F, et al. [Impacts of Mycobacterium tuberculosis with different virulence on expressions of ferroportin and ferritin in infected macrophages]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:710-3 pubmed
    ..tuberculosis can lead to increased Fn expression and decreased FPN expression in macrophages, and the levels of Fn and FPN in the infected macrophages are both related to the strength of the virulence of M.tuberculosis. ..
  22. Yang A, Zhao J, Lu M, Gu Y, Zhu Y, Chen D, et al. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..898). Women with GDM transport iron more actively than those without GDM at term pregnancy. Maternal iron metabolism in GDM may play a role in fetal/placental iron demand and in the overall outcome of pregnancy. ..
  23. Lakhal Littleton S, Wolna M, Carr C, Miller J, Christian H, Ball V, et al. Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proc Natl Acad Sci U S A. 2015;112:3164-9 pubmed publisher
    ..Both findings have significant implications for the assessment and treatment of cardiac complications of iron dysregulation. ..
  24. Mok H, Jelinek J, Pai S, Cattanach B, Prchal J, Youssoufian H, et al. Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice. Development. 2004;131:1859-68 pubmed
    Coding region mutations in the principal basolateral iron transporter of the duodenal enterocyte, ferroportin 1 (FPN1), lead to autosomal dominant reticuloendothelial iron overload in humans...
  25. Huang M, Austin C, Sari M, Rahmanto Y, Ponka P, Vyoral D, et al. Hepcidin bound to ?2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels. J Biol Chem. 2013;288:25450-65 pubmed publisher
    Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1). We demonstrated that hepcidin is complexed to the blood transport protein, ?2-macroglobulin (?2M) (Peslova, G., Petrak, J., Kuzelova, K., Hrdy, I., Halada, P...
  26. De Domenico I, Ward D, Langelier C, Vaughn M, Nemeth E, Sundquist W, et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007;18:2569-78 pubmed
    ..Depletion of proteins involved in multivesicular body trafficking (Endosome Sorting Complex Required for Transport proteins), by small-interfering RNA, reduces the trafficking of Fpn-green fluorescent to the lysosome. ..
  27. Matak P, Matak A, Moustafa S, Aryal D, Benner E, Wetsel W, et al. Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A. 2016;113:3428-35 pubmed publisher
    ..We demonstrate that loss of transferrin receptor 1, but not loss of ferroportin, can cause neurodegeneration in a subset of dopaminergic neurons in mice. ..
  28. Marro S, Barisani D, Chiabrando D, Fagoonee S, Muckenthaler M, Stolte J, et al. Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression. Gastroenterology. 2007;133:1261-1271 pubmed
  29. Iacovelli J, Mlodnicka A, Veldman P, Ying G, Dunaief J, Schumacher A. Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res. 2009;1289:85-95 pubmed publisher
    ..The radiation-induced polycythaemia (Pcm) mutation, a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), disrupts transcriptional and post-transcriptional regulation of this pivotal iron transporter...
  30. Aguirre P, Mena N, Tapia V, Arredondo M, Nunez M. Iron homeostasis in neuronal cells: a role for IREG1. BMC Neurosci. 2005;6:3 pubmed
    ..response consisting of increased synthesis of the iron-storage protein ferritin and the iron export transporter IREG1, and decreased synthesis of the iron import transporter DMT1...
  31. De Domenico I, Lo E, Ward D, Kaplan J. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proc Natl Acad Sci U S A. 2009;106:3800-5 pubmed publisher
    ..These results provide a molecular explanation for the dominant inheritance of hepcidin resistant iron overload disease. ..
  32. Stokes B, Sabatino J, Zohn I. High levels of iron supplementation prevents neural tube defects in the Fpn1ffe mouse model. Birth Defects Res. 2017;109:81-91 pubmed publisher
    ..Our previous studies with the flatiron (ffe) mouse model of Ferroportin1 (Fpn1) deficiency suggest that iron is required for neural tube closure and forebrain development raising the possibility ..
  33. Lymboussaki A, Pignatti E, Montosi G, Garuti C, Haile D, Pietrangelo A. The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. J Hepatol. 2003;39:710-5 pubmed
    MTP1/Ferroportin1/IREG1, the product of the SLC40A1 gene, is a main iron export protein in mammals. However, the way this gene is regulated by iron is still unclear...
  34. Drakesmith H, Nemeth E, Ganz T. Ironing out Ferroportin. Cell Metab. 2015;22:777-87 pubmed publisher
    ..Fundamental questions about the structure and biology of ferroportin remain to be answered. ..
  35. Chung J, Haile D, Wessling Resnick M. Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux. Proc Natl Acad Sci U S A. 2004;101:2700-5 pubmed
    ..To examine whether cellular copper status affects expression of the iron exporter ferroportin-1 (FPN1), J774 macrophage cells were exposed to 10-100 microM CuSO(4) for up to 20 h...
  36. Raha A, VAISHNAV R, FRIEDLAND R, Bomford A, Raha Chowdhury R. The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun. 2013;1:55 pubmed publisher
    ..Imbalance in the levels and distribution of ferritin light-chain further indicate a failure to utilize and release iron by damaged and degenerating neurons. ..
  37. Mok H, Mlodnicka A, Hentze M, Muckenthaler M, Schumacher A. The molecular circuitry regulating the switch between iron deficiency and overload in mice. J Biol Chem. 2006;281:7946-51 pubmed
    ..of the radiation-induced polycythaemia (Pcm) mutation revealed a 58-bp microdeletion in the promoter region of ferroportin 1 (Fpn1), the sole cellular iron exporter identified to date...
  38. Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, et al. Mice with hepcidin-resistant ferroportin accumulate iron in the retina. FASEB J. 2016;30:813-23 pubmed publisher
    ..The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Müller cells, but may limit iron transport into the retina from vascular endothelial cells. ..
  39. Schulz K, Kroner A, David S. Iron efflux from astrocytes plays a role in remyelination. J Neurosci. 2012;32:4841-7 pubmed publisher
    ..These data suggest that iron efflux from astrocytes plays a role in remyelination by either direct effects on OPCs or indirectly by affecting glial activation. ..
  40. Willemetz A, Lenoir A, Deschemin J, Lopez Otin C, Ramsay A, Vaulont S, et al. Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis. Blood. 2014;124:441-4 pubmed publisher
  41. Seo Y, Elkhader J, Wessling Resnick M. Distribution of manganese and other biometals in flatiron mice. Biometals. 2016;29:147-55 pubmed publisher
    ..Taken together, these results indicate that Fpn deficiency decreases Mn trafficking out of the brain, alters body Fe, Mn, Zn and Cu levels, and promotes metal accumulation in olfactory bulbs. ..
  42. Van Zandt K, Sow F, Florence W, Zwilling B, Satoskar A, Schlesinger L, et al. The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome. J Leukoc Biol. 2008;84:689-700 pubmed publisher
    Intracellular pathogens, including Mycobacterium tuberculosis, obtain iron from the host for their survival. Ferroportin 1 (FPN1; SLC40A1) is the sole iron exporter from mammalian cells and is expressed in the duodenum and macrophages...
  43. Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama K. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab. 2011;14:339-51 pubmed publisher
    ..The liver-specific mutant mice died with acute liver failure when fed a high-iron diet. Thus, our results uncover a major role for FBXL5 in ensuring an appropriate supply of iron to cells. ..
  44. De Domenico I, Ward D, Nemeth E, Vaughn M, Musci G, Ganz T, et al. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005;102:8955-60 pubmed
    Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1, and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation...
  45. Fuqua B, Lu Y, Darshan D, Frazer D, Wilkins S, Wolkow N, et al. The multicopper ferroxidase hephaestin enhances intestinal iron absorption in mice. PLoS ONE. 2014;9:e98792 pubmed publisher
    ..These mouse models will serve as valuable tools to study the role of hephaestin and associated proteins in iron transport in the small intestine and other tissues. ..
  46. Kautz L, Gabayan V, Wang X, Wu J, Onwuzurike J, Jung G, et al. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep. 2013;5:1436-42 pubmed publisher
    ..Our results strongly argue against any significant role of macrophage iron in atherosclerosis progression in mice. ..
  47. Haile D. Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. Cytogenet Cell Genet. 2000;88:328-9 pubmed
  48. White C, Yuan X, Schmidt P, Bresciani E, Samuel T, Campagna D, et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 2013;17:261-70 pubmed publisher
    ..Our results reveal HRG1 as the long-sought heme transporter for heme-iron recycling in macrophages and suggest that genetic variations in HRG1 could be modifiers of human iron metabolism. ..
  49. Rivera S, Nemeth E, Gabayan V, Lopez M, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood. 2005;106:2196-9 pubmed
    ..The rapid and sustained action of a single dose of hepcidin makes it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis. ..
  50. Gardenghi S, Marongiu M, Ramos P, Guy E, Breda L, Chadburn A, et al. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood. 2007;109:5027-35 pubmed
    ..However, in 1-year-old th3/+ animals, Hamp1 levels rise and it is rather the increase of ferroportin (Fpn1) that sustains iron accumulation, thus revealing a fundamental role of this iron transporter in the iron overload ..
  51. Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608-616 pubmed publisher
    ..They also suggest that small molecules that partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases. ..
  52. De Domenico I, Ward D, Musci G, Kaplan J. Evidence for the multimeric structure of ferroportin. Blood. 2007;109:2205-9 pubmed
    Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease...
  53. Starzyński R, Canonne Hergaux F, Lenartowicz M, Krzeptowski W, Willemetz A, Styś A, et al. Ferroportin expression in haem oxygenase 1-deficient mice. Biochem J. 2013;449:69-78 pubmed publisher
    ..Furthermore, we show that iron/haem-mediated toxicity are responsible for renal injury documented in the kidneys of Hmox1-/- mice. ..
  54. Han C, Koo J, Kim S, Gardenghi S, Rivella S, Strnad P, et al. Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt. Nat Commun. 2016;7:13817 pubmed publisher
    ..HSC-specific ferroportin deletion also ameliorates liver fibrosis. In summary, hepcidin suppresses liver fibrosis by impeding TGF?1-induced Smad3 phosphorylation in HSCs, which depends on Akt activated by a deficiency of ferroportin. ..
  55. Vernay B, Koch M, Vaccarino F, Briscoe J, Simeone A, Kageyama R, et al. Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci. 2005;25:4856-67 pubmed
    ..Altogether, these results demonstrate that Otx2 is required from E10.5 onward to regulate neuronal subtype identity and neurogenesis in the midbrain. ..
  56. Iacovelli J, Zhao C, Wolkow N, Veldman P, Gollomp K, Ojha P, et al. Generation of Cre transgenic mice with postnatal RPE-specific ocular expression. Invest Ophthalmol Vis Sci. 2011;52:1378-83 pubmed publisher
    ..These mice should facilitate study of the multifunctional RPE and the generation of mouse models of human retinal disease. ..
  57. Takeuchi K, Bjarnason I, Laftah A, Latunde Dada G, Simpson R, McKie A. Expression of iron absorption genes in mouse large intestine. Scand J Gastroenterol. 2005;40:169-77 pubmed
    ..ferric reductase) was expressed at very low levels in the large intestine, compared to the duodenum, while Ireg1 and DMT1 were expressed at significant levels in the large intestine and were increased in iron-deficient caecum, ..
  58. Guida C, Altamura S, Klein F, Galy B, Boutros M, Ulmer A, et al. A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood. 2015;125:2265-75 pubmed publisher
  59. Chung J, Prohaska J, Wessling Resnick M. Ferroportin-1 is not upregulated in copper-deficient mice. J Nutr. 2004;134:517-21 pubmed
    Body iron status regulates ferroportin-1 (FPN1) expression such that intestinal mRNA levels are enhanced by anemia, whereas liver transcripts are increased by iron overload. In vitro evidence suggests that copper also upregulates FPN1...
  60. Yoshida T, Kumashiro Y, Iwata T, Ishihara J, Umemoto T, Shiratsuchi Y, et al. Requirement of integrin ?3 for iron transportation during enamel formation. J Dent Res. 2012;91:1154-9 pubmed publisher
    ..The results suggested that CD61 regulates the expressions of Slc11a2 and Slc40a1, both of which are involved in iron transportation in epithelial tissues...
  61. Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, et al. Hypoxia-inducible factor-2? mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140:2044-55 pubmed publisher
    ..Therapies that target FPN might be developed for patients with iron-related disorders. ..
  62. Yoon D, Pastore Y, Divoky V, Liu E, Mlodnicka A, Rainey K, et al. Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006;281:25703-11 pubmed
    ..defects in iron homeostasis, Hif1alpha-/- yolk sac and/or embryos demonstrated aberrant mRNA levels of hepcidin, Fpn1, Irp1, and frascati...
  63. Knutson M, Oukka M, Koss L, Aydemir F, Wessling Resnick M. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci U S A. 2005;102:1324-8 pubmed
    b>Ferroportin 1 (FPN1) is transmembrane protein involved in iron homeostasis. In the duodenum, FPN1 localizes to the basolateral surface of enterocytes where it appears to export iron out of the cell and into the portal circulation...
  64. Corna G, Caserta I, Monno A, Apostoli P, Manfredi A, Camaschella C, et al. The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin. J Immunol. 2016;197:1914-25 pubmed publisher
    ..These results highlight the existence of a local pathway of iron recycling that plays a nonredundant role in the myogenic differentiation of muscle precursors, limiting the adipose degeneration of the tissue. ..
  65. Latunde Dada G, Vulpe C, Anderson G, Simpson R, McKie A. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004;1690:169-76 pubmed
    ..Dcytb, and DMT1 mRNA and protein increased markedly in the duodenum of mice given PHZ. The efflux protein Ireg1 also increased in the duodenum of the treated mice...
  66. Aydemir F, Jenkitkasemwong S, Gulec S, Knutson M. Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages. J Nutr. 2009;139:434-8 pubmed publisher
    ..Collectively, these data are consistent with the hypothesis that iron increases macrophage ferroportin mRNA levels by inducing transcription of the ferroportin gene. ..
  67. Tajima S, Ikeda Y, Enomoto H, Imao M, Horinouchi Y, Izawa Ishizawa Y, et al. Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice. Eur J Nutr. 2015;54:709-19 pubmed publisher
    ..Angiotensin II (ANG II) altered the expression of duodenal iron transporters and reduced hepcidin levels, contributing to the alteration of body iron distribution. ..
  68. Ben Othman R, Flannery A, Miguel D, Ward D, Kaplan J, Andrews N. Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. PLoS Pathog. 2014;10:e1003901 pubmed publisher
    ..Thus, inhibition of ferroportin expression is a specific strategy used by L. amazonensis to inhibit iron export and promote their own intracellular growth. ..
  69. Veuthey T, D Anna M, Roque M. Role of the kidney in iron homeostasis: renal expression of Prohepcidin, Ferroportin, and DMT1 in anemic mice. Am J Physiol Renal Physiol. 2008;295:F1213-21 pubmed publisher
    ..kidney function in iron metabolism under hemolytic anemia studying renal expression of Prohepcidin, Ferroportin (MTP1), and divalent metal transporter 1 (DMT1)...
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    ..These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores. ..
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    ..In this study, we found that NO up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells...
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    ..Previous reports concerning gene expression levels of the duodenal iron transporters DMT1 and IREG1 in HH patients and animal models are controversial, however, and in many cases only mRNA expression levels were ..
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    ..These results reveal a novel mechanism underlying neogenin regulation of HJV-BMP signaling...