Gene Symbol: Slc38a3
Description: solute carrier family 38, member 3
Alias: 0610012J02Rik, D9Ucla2, Nat1, Slc38-3, Sn1, Snat3, mNAT, sodium-coupled neutral amino acid transporter 3, N system amino acids transporter NAT-1, N-system amino acid transporter 1, Na(+)-coupled neutral amino acid transporter 3, slc38a3, system N amino acid transporter 1
Species: mouse
Products:     Slc38a3

Top Publications

  1. Ruderisch N, Virgintino D, Makrides V, Verrey F. Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3. J Cereb Blood Flow Metab. 2011;31:1637-47 pubmed publisher
    ..this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature using immunofluorescent colocalization ..
  2. Xia Y, Welch C, Warden C, Lange E, Fukao T, Lusis A, et al. Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9. Mamm Genome. 1996;7:554-5 pubmed
  3. Gu S, Roderick H, Camacho P, Jiang J. Identification and characterization of an amino acid transporter expressed differentially in liver. Proc Natl Acad Sci U S A. 2000;97:3230-5 pubmed
    ..Because this protein displays functional similarities to the N-system amino acid transport, we have termed it mNAT, for murine N-system amino acid transporter...
  4. Moret C, Dave M, Schulz N, Jiang J, Verrey F, Wagner C. Regulation of renal amino acid transporters during metabolic acidosis. Am J Physiol Renal Physiol. 2007;292:F555-66 pubmed
    ..In acidosis, the mRNA of kidney system N amino acid transporter SNAT3 (SLC38A3/SN1) showed a strong induction similar to that of PEPCK, whereas all other tested mRNAs encoding glutamine or ..
  5. Busque S, Wagner C. Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney. Am J Physiol Renal Physiol. 2009;297:F440-50 pubmed publisher
    ..Expression of the glutamine transporter Slc38a3 (SNAT3) increases in kidney during metabolic acidosis (MA), suggesting a role during ammoniagenesis...
  6. Mehdizadeh S, Warden C, Wen P, Xia Y, Mehrabian M, Lusis A. The glutathione peroxidase gene, Gpx1, maps to mouse chromosome 9. Mamm Genome. 1996;7:465-6 pubmed
  7. Sidoryk Wegrzynowicz M, Lee E, Mingwei N, Aschner M. Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway. Glia. 2011;59:1732-43 pubmed publisher
    ..Exposure to ?-phorbol 12-myristate 13-acetate significantly decreased SNAT3 (system N) and ASCT2 (system ASC) protein levels...
  8. Busque S, Stange G, Wagner C. Dysregulation of the glutamine transporter Slc38a3 (SNAT3) and ammoniagenic enzymes in obese, glucose-intolerant mice. Cell Physiol Biochem. 2014;34:575-89 pubmed publisher
    ..b>SNAT3 mRNA expression was enhanced in both obese groups...
  9. Chan K, Busque S, Sailer M, Stoeger C, Bröer S, Daniel H, et al. Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney. Pflugers Arch. 2016;468:213-27 pubmed publisher
    ..We demonstrate that despite the large number of glutamine transporters, the loss of Snat3/Slc38a3 glutamine transporter has a major impact on the function of organs expressing it...

More Information


  1. Gu S, Villegas C, Jiang J. Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes. J Biol Chem. 2005;280:26055-62 pubmed
    ..In this report, we characterized the regulation of system N/A transporter 3 (SNAT3) in the liver of dietary-restricted mice and in hepatocytes treated with serum starvation and insulin...
  2. Umapathy N, Dun Y, Martin P, Duplantier J, Roon P, Prasad P, et al. Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:5151-60 pubmed publisher
    ..System N, consisting of SN1 (SNAT3) and SN2 (SNAT5), is the principal mediator of glutamine transport in retinal Müller cells...
  3. Balkrishna S, Bröer A, Welford S, Hatzoglou M, Broer S. Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression. Cell Physiol Biochem. 2014;33:1591-606 pubmed publisher
    ..Transcription of the glutamine transporter SNAT3 (Slc38a3) for instance is highly up-regulated in the kidney during metabolic acidosis to provide glutamine for ammonia ..