Gene Symbol: Slc35c1
Description: solute carrier family 35, member C1
Alias: E430007K15Rik, fuct1, GDP-fucose transporter 1, multispan transmembrane protein fuct1
Species: mouse
Products:     Slc35c1

Top Publications

  1. Hellbusch C, Sperandio M, Frommhold D, Yakubenia S, Wild M, Popovici D, et al. Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J Biol Chem. 2007;282:10762-72 pubmed
    ..quot; Due to defective Golgi GDP-fucose transporter (SLC35C1) activity, patients show a hypofucosylation of glycoproteins and present clinically with mental and growth ..
  2. Rabionet M, van der Spoel A, Chuang C, von Tümpling Radosta B, Litjens M, Bouwmeester D, et al. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem. 2008;283:13357-69 pubmed publisher
    ..Thus, our data imply that both glycans and the particular acyl chains of germinal sphingolipids are relevant for proper completion of meiosis. ..
  3. Lu L, Hou X, Shi S, Korner C, Stanley P. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. J Biol Chem. 2010;285:36245-54 pubmed publisher
    ..Inactivation of the Golgi GDP-fucose transporter Slc35c1 in mouse or human does not cause marked defects in Notch signaling during development, and shows milder ..
  4. Yakubenia S, Frommhold D, Schölch D, Hellbusch C, Korner C, Petri B, et al. Leukocyte trafficking in a mouse model for leukocyte adhesion deficiency II/congenital disorder of glycosylation IIc. Blood. 2008;112:1472-81 pubmed publisher
    ..disorder of glycosylation IIc (CDG-IIc), is a human disease in which a defective GDP-fucose transporter (SLC35C1) causes developmental defects and an immunodeficiency that is based on the lack of fucosylated selectin ligands...