Slc30a8

Summary

Gene Symbol: Slc30a8
Description: solute carrier family 30 (zinc transporter), member 8
Alias: C820002P14Rik, ZnT-8, ZnT8, zinc transporter 8, solute carrier family 30 member 8
Species: mouse
Products:     Slc30a8

Top Publications

  1. Juhl K, Sarkar S, Wong R, Jensen J, Hutton J. Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes. 2008;57:2755-61 pubmed publisher
    ..the glucose responsiveness of the beta-cells and candidate diabetes autoantigens, such as insulin, IA-2 and Slc30a8 (ZnT8). The results are presented as downloadable gene lists, available at https://www.cbil.upenn...
  2. Pound L, Sarkar S, Benninger R, Wang Y, Suwanichkul A, Shadoan M, et al. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J. 2009;421:371-6 pubmed publisher
    The Slc30a8 gene encodes the islet-specific zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation...
  3. Nicolson T, Bellomo E, Wijesekara N, Loder M, Baldwin J, Gyulkhandanyan A, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 2009;58:2070-83 pubmed publisher
    ..A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated with type 2 diabetes...
  4. El Muayed M, Billings L, Raja M, Zhang X, Park P, Newman M, et al. Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J Endocrinol. 2010;206:159-69 pubmed publisher
    Genetic studies suggest that Zn transporters such as ZnT8 play a role in insulin secretion by pancreatic beta-cells; however, little is known about the dynamic roles of Zn trafficking pathways on beta-cell physiology...
  5. Pound L, Hang Y, Sarkar S, Wang Y, Milam L, Oeser J, et al. The pancreatic islet ?-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer. Biochem J. 2011;433:95-105 pubmed publisher
    The SLC30A8 gene encodes the zinc transporter ZnT-8, which provides zinc for insulin-hexamer formation...
  6. Hardy A, Wijesekara N, Genkin I, Prentice K, Bhattacharjee A, Kong D, et al. Effects of high-fat diet feeding on Znt8-null mice: differences between ?-cell and global knockout of Znt8. Am J Physiol Endocrinol Metab. 2012;302:E1084-96 pubmed publisher
    Genomewide association studies have linked a polymorphism in the zinc transporter 8 (Znt8) gene to higher risk of developing type 2 diabetes...
  7. Pound L, Sarkar S, Ustione A, Dadi P, Shadoan M, Lee C, et al. The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background. PLoS ONE. 2012;7:e40972 pubmed publisher
    The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes...
  8. Deniro M, Al Mohanna F. Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy. PLoS ONE. 2012;7:e50360 pubmed publisher
    The zinc (Zn(++)) transporter ZnT8 plays a crucial role in zinc homeostasis...
  9. Murgia C, Devirgiliis C, Mancini E, Donadel G, Zalewski P, Perozzi G. Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutr Metab Cardiovasc Dis. 2009;19:431-9 pubmed publisher
    ..b>ZnT8 is a member of the SLC30A family of zinc transporters whose overexpression in cultured pancreatic beta cells leads ..

More Information

Publications21

  1. Wijesekara N, Dai F, Hardy A, Giglou P, Bhattacharjee A, Koshkin V, et al. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia. 2010;53:1656-68 pubmed publisher
    ..Polymorphisms of ZnT8 (also known as SLC30A8) gene in man are associated with increased risk of type 2 diabetes...
  2. Lemaire K, Ravier M, Schraenen A, Creemers J, Van De Plas R, Granvik M, et al. Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci U S A. 2009;106:14872-7 pubmed publisher
    ..In this study we assessed the role of the zinc transporter ZnT8 using ZnT8-knockout (ZnT8(-/-)) mice...
  3. Solomou A, Meur G, Bellomo E, Hodson D, Tomas A, Li S, et al. The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion. J Biol Chem. 2015;290:21432-42 pubmed publisher
    b>SLC30A8 encodes a zinc transporter ZnT8 largely restricted to pancreatic islet β- and α-cells, and responsible for zinc accumulation into secretory granules...
  4. Syring K, Boortz K, Oeser J, Ustione A, Platt K, Shadoan M, et al. Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology. 2016;157:4534-4541 pubmed
    Polymorphisms in the SLC30A8 gene, which encodes the ZnT8 zinc transporter, are associated with altered susceptibility to type 2 diabetes (T2D), and SLC30A8 haploinsufficiency is protective against the development of T2D in obese humans...
  5. Gerber P, Bellomo E, Hodson D, Meur G, Solomou A, Mitchell R, et al. Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells. Diabetologia. 2014;57:1635-44 pubmed publisher
    ..Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic Zn(2+) levels...
  6. Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, et al. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 2010;59:2530-9 pubmed publisher
    ..Our results provide insight into the sequential manner by which MafA and MafB regulate islet ?-cell formation and maturation. ..
  7. Cheng Xue R, Gómez Ruiz A, Antoine N, Noël L, Chae H, Ravier M, et al. Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both ?-cells and ?-cells. Diabetes. 2013;62:1612-22 pubmed publisher
    ..Knockout of the Zn²? transporter ZnT8 (ZnT8(-/-) mice) did not prevent the glucagonostatic effect of glucose...
  8. Tamaki M, Fujitani Y, Hara A, Uchida T, Tamura Y, Takeno K, et al. The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest. 2013;123:4513-24 pubmed publisher
    Recent genome-wide association studies demonstrated that common variants of solute carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes...
  9. Tamaki M, Fujitani Y, Uchida T, Hirose T, Kawamori R, Watada H. Downregulation of ZnT8 expression in pancreatic ?-cells of diabetic mice. Islets. 2009;1:124-8 pubmed publisher
    b>Zinc transporter 8 (ZnT8) has been identified as a ?-cell-specific Zinc transporter expressed in insulin-secretory granules...
  10. Mitchell R, Hu M, Chabosseau P, Cane M, Meur G, Bellomo E, et al. Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance. Mol Endocrinol. 2016;30:77-91 pubmed publisher
    b>Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules...
  11. Berclaz C, Schmidt Christensen A, Szlag D, Extermann J, Hansen L, Bouwens A, et al. Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging. Diabetologia. 2016;59:550-9 pubmed publisher
    ..These results are contributing to a deeper understanding of human islet transplant rejection and label-free in vivo monitoring of drug efficacy. ..
  12. Wang V, Schmidt T, Chen J, Sharp P, Tantin D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol Cell Biol. 2004;24:1022-32 pubmed
    ..These findings suggest a critical role for Oct-1 during development and a stringent gene dosage effect with Oct-2 in mediating postnatal survival. ..