Slc30a3

Summary

Gene Symbol: Slc30a3
Description: solute carrier family 30 (zinc transporter), member 3
Alias: Znt3, zinc transporter 3, solute carrier family 30 member 3, znT-3
Species: mouse
Products:     Slc30a3

Top Publications

  1. Palmiter R, Cole T, Quaife C, Findley S. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996;93:14934-9 pubmed
    The murine ZnT3 gene was cloned by virtue of its homology to the ZnT2 gene, which encodes a membrane protein that facilitates sequestration of zinc in endosomal vesicles...
  2. Lee J, Cole T, Palmiter R, Suh S, Koh J. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc Natl Acad Sci U S A. 2002;99:7705-10 pubmed
    ..transgenic mice (hAPP(+)) expressing cerebral amyloid plaque pathology were crossed with mice lacking zinc transporter 3 (ZnT3(-/-)), which is required for zinc transport into synaptic vesicles...
  3. Salazar G, Craige B, Love R, Kalman D, Faundez V. Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci. 2005;118:1911-21 pubmed
    ..in AP-3 deficiencies, in which synaptic vesicle zinc is depleted because the synaptic-vesicle-specific zinc transporter 3 does not reach synaptic vesicles...
  4. Lee J, Kim J, Palmiter R, Koh J. Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Exp Neurol. 2003;184:337-47 pubmed
    ..Furthermore, compared with zinc transporter 3 (Znt3)-null mice, Znt3/Mt3 double-null mice exhibited further reductions in neuronal death in CA1 following ..
  5. Newell Litwa K, Salazar G, Smith Y, Faundez V. Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles. Mol Biol Cell. 2009;20:1441-53 pubmed publisher
    ..Our results demonstrate that lysosomal and lysosome-related organelle biogenesis mechanisms regulate steady-state synaptic vesicle protein composition from shared early endosomes. ..
  6. Doering P, Danscher G, Larsen A, Bruhn M, Søndergaard C, Stoltenberg M. Changes in the vesicular zinc pattern following traumatic brain injury. Neuroscience. 2007;150:93-103 pubmed
    ..Balb/c mice, ZnT3 knockout (ZnT3-Ko) mice, a mouse genetically knocked out for the protein ZnT3 responsible for sequestering zinc ..
  7. Valente T, Auladell C. Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact. Mol Cell Neurosci. 2002;21:189-204 pubmed
    We examine the expression pattern of ZnT3 in the cerebral and cerebellar areas of mouse brain throughout development. During embryogenesis and early postnatal stages, ZnT3 transcripts were detected in several areas...
  8. Cole T, Robbins C, Wenzel H, Schwartzkroin P, Palmiter R. Seizures and neuronal damage in mice lacking vesicular zinc. Epilepsy Res. 2000;39:153-69 pubmed
    ..and seizure-related neuronal damage in mice with targeted disruption of the gene encoding the zinc transporter, ZnT3 (ZnT3-/- mice)...
  9. Salazar G, Love R, Werner E, Doucette M, Cheng S, Levey A, et al. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. Mol Biol Cell. 2004;15:575-87 pubmed
    ..We explored this hypothesis by analyzing the targeting of ZnT3 and synaptophysin both to PC12 synaptic-like microvesicles (SLMV) as well as SV isolated from wild-type and AP-3-..

More Information

Publications61

  1. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
    ..A survey of the expression and localization of zinc transporter (ZnT) family members identified ZnT2, ZnT3, and ZnT4 as likely mediators of vesicular zinc accumulation in M1 cells...
  2. Lee J, Cole T, Palmiter R, Koh J. Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. J Neurosci. 2000;20:RC79 pubmed
    ..To test this hypothesis, kainate seizure-induced neuronal death was examined in zinc transporter 3 gene (ZnT3)-null mice, a strain that completely lacks histochemically reactive zinc in synaptic vesicles...
  3. Cole T, Wenzel H, Kafer K, Schwartzkroin P, Palmiter R. Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A. 1999;96:1716-21 pubmed
    The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing neurons, suggesting its possible role in vesicular zinc transport...
  4. Kalappa B, Anderson C, Goldberg J, Lippard S, Tzounopoulos T. AMPA receptor inhibition by synaptically released zinc. Proc Natl Acad Sci U S A. 2015;112:15749-54 pubmed publisher
    ..Our results establish zinc as an activity-dependent, endogenous modulator of AMPARs that tunes fast excitatory neurotransmission and plasticity in glutamatergic synapses. ..
  5. Wang Z, Stoltenberg M, Jo S, Huang L, Larsen A, Dahlstrom A, et al. Dynamic zinc pools in mouse choroid plexus. Neuroreport. 2004;15:1801-4 pubmed
    We examined the presence of Zn-transporters (ZnT1, ZnT3, ZnT4, and ZnT6) proteins and zinc ions in rat choroid epithelium with immunohistochemistry and zinc selenide autometallography (ZnSe(AMG))...
  6. Kambe T, Yamaguchi Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cell Mol Life Sci. 2004;61:49-68 pubmed
    ..In this review, we review the literature of mammalian zinc transporters with emphasis on very recent findings and elicit integrative knowledge of zinc homeostasis. ..
  7. Chen H, Bagri A, Zupicich J, Zou Y, Stoeckli E, Pleasure S, et al. Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron. 2000;25:43-56 pubmed
    ..Our results show that neuropilin-2 is an essential component of the Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS. ..
  8. Qian J, Noebels J. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. J Neurosci. 2006;26:6089-95 pubmed
    ..The ability to examine release dynamics with zinc fluorescence detection will facilitate exploration of the molecular pharmacology and plasticity of exocytosis at many CNS synapses. ..
  9. Ohana E, Sekler I, Kaisman T, Kahn N, Cove J, Silverman W, et al. Silencing of ZnT-1 expression enhances heavy metal influx and toxicity. J Mol Med (Berl). 2006;84:753-63 pubmed
    ..Taken together, our results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types. ..
  10. Lee J, Kim J, Byun H, Palmiter R, Koh J. Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain. Brain Res. 2011;1418:12-22 pubmed publisher
    ..b>ZnT3, which is prominently expressed in the brain, facilitates the concentration of free zinc in pre-synaptic vesicles...
  11. Khan M, Goldsmith C, Huang Z, Georgiou J, Luyben T, Roder J, et al. Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices. Proc Natl Acad Sci U S A. 2014;111:6786-91 pubmed publisher
    ..This synapse-level two-photon Zn(2+) imaging method enables monitoring of presynaptic Zn(2+) dynamics for improving the understanding of physiological roles of mobile Zn(2+) in regular and aberrant neurologic function. ..
  12. Chi Z, Wang X, Cai J, Stoltenberg M, Danscher G, Wang Z. Zinc transporter 3 immunohistochemical tracing of sprouting mossy fibres. Neurochem Int. 2008;52:1305-9 pubmed publisher
    b>Zinc transporter 3 (ZNT3) has been shown to transport zinc ions from the cytosol into presynaptic vesicles in the mammalian brain...
  13. Friedlich A, Lee J, van Groen T, Cherny R, Volitakis I, Cole T, et al. Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci. 2004;24:3453-9 pubmed
    ..Parenchymal beta-amyloid deposition is dependent on the activity of zinc transporter 3 (ZnT3), a neocortical synaptic vesicle membrane protein that causes enrichment of exchangeable Zn2+ in the ..
  14. Kalappa B, Tzounopoulos T. Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc. Eneuro. 2017;4: pubmed publisher
    ..Together, these findings demonstrate that synaptically released zinc is a modulator of excitatory short-term plasticity, which shapes information transfer among excitatory synapses. ..
  15. Sindreu C, Palmiter R, Storm D. Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory. Proc Natl Acad Sci U S A. 2011;108:3366-70 pubmed publisher
    ..Here we show that mice lacking the synapse-specific vesicular zinc transporter ZnT3 (ZnT3KO mice) have reduced activation of the Erk1/2 MAPK in hippocampal mossy fiber terminals, disinhibition of ..
  16. Linkous D, Flinn J, Koh J, Lanzirotti A, Bertsch P, Jones B, et al. Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles. J Histochem Cytochem. 2008;56:3-6 pubmed
    ..histochemically reactive zinc is lacking or if, indeed, total elemental zinc is missing from neurons lacking the Slc30a3 gene, which encodes the ZNT3 protein...
  17. Schubert S, Lamoureux N, Kilian K, Klein Hitpass L, Hashemolhosseini S. Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem. 2008;283:5460-5 pubmed publisher
    ..5. Our data demonstrate for the first time that genes encoding key regulators of placental tissue formation and architecture are regulated by GCMa. ..
  18. Wang Z, Danscher G, Dahlstrom A, Li J. Zinc transporter 3 and zinc ions in the rodent superior cervical ganglion neurons. Neuroscience. 2003;120:605-16 pubmed
    ..e. contain vesicles that have zinc transporter 3 (ZnT3) proteins in their membranes and contain zinc ions...
  19. Yoo M, Kim T, Yoon Y, Koh J. Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation. Sci Rep. 2016;6:28548 pubmed publisher
    To investigate the role of synaptic zinc in the ASD pathogenesis, we examined zinc transporter 3 (ZnT3) null mice. At 4-5 weeks of age, male but not female ZnT3 null mice exhibited autistic-like behaviors...
  20. Doering P, Stoltenberg M, Penkowa M, Rungby J, Larsen A, Danscher G. Chemical blocking of zinc ions in CNS increases neuronal damage following traumatic brain injury (TBI) in mice. PLoS ONE. 2010;5:e10131 pubmed publisher
    ..Twenty-four hours after TBI ZnT3-KO mice (mice without vesicular zinc) were compared to littermate Wild Type (WT) mice (mice with vesicular zinc) ..
  21. Liguz Lecznar M, Nowicka D, Czupryn A, Skangiel Kramska J. Dissociation of synaptic zinc level and zinc transporter 3 expression during postnatal development and after sensory deprivation in the barrel cortex of mice. Brain Res Bull. 2005;66:106-13 pubmed
    ..The present study focused on the relationship between synaptic zinc and zinc transporter 3 (ZnT3) protein expression in the barrel cortex of mice during postnatal development and after sensory ..
  22. Anderson C, Radford R, Zastrow M, Zhang D, Apfel U, Lippard S, et al. Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc. Proc Natl Acad Sci U S A. 2015;112:E2705-14 pubmed publisher
    ..These results demonstrate a physiological role for endogenous synaptic as well as tonic zinc in inhibiting extrasynaptic NMDARs and thereby fine tuning neuronal excitability and signaling. ..
  23. Helgager J, Huang Y, McNamara J. Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. J Comp Neurol. 2014;522:3885-99 pubmed publisher
    ..Unexpectedly, pY816 immunoreactivity was increased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack vesicular zinc...
  24. Kambe T. An overview of a wide range of functions of ZnT and Zip zinc transporters in the secretory pathway. Biosci Biotechnol Biochem. 2011;75:1036-43 pubmed
    ..Recent questions concerning zinc released into the cytoplasm from the secretory pathway, which then functions as an intracellular signaling molecule, are also briefly reviewed, emphasizing zinc transporter functions. ..
  25. Lee E, Lee H, Huang T, Chung C, Shin W, Kim K, et al. Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation. Nat Commun. 2015;6:7168 pubmed publisher
    ..These results suggest that trans-synaptic Zn mobilization induced by clioquinol rescues social deficits in mouse models of ASD through postsynaptic Src and NMDAR activation. ..
  26. Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher
    ..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
  27. Martel G, Hevi C, Friebely O, Baybutt T, Shumyatsky G. Zinc transporter 3 is involved in learned fear and extinction, but not in innate fear. Learn Mem. 2010;17:582-90 pubmed publisher
    ..b>Zinc transporter 3 (ZnT3) knock-out (KO) mice are well suited to test the role of zinc in learned fear, because ZnT3 is ..
  28. Thackray S, McAllister B, Dyck R. Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice. Behav Brain Res. 2017;321:36-49 pubmed publisher
    ..In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function...
  29. Perez Rosello T, Anderson C, Ling C, Lippard S, Tzounopoulos T. Tonic zinc inhibits spontaneous firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission. Neurobiol Dis. 2015;81:14-9 pubmed publisher
    ..observed zinc-mediated inhibition in spontaneous firing is present in mice lacking the vesicular zinc transporter (ZnT3), indicating that non-vesicular zinc inhibits spontaneous firing...
  30. Smidt K, Jessen N, Petersen A, Larsen A, Magnusson N, Jeppesen J, et al. SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS ONE. 2009;4:e5684 pubmed publisher
    ..Knock-down of the ZnT-3 gene lowers insulin secretion in vitro and affects in vivo glucose metabolism after streptozotocin treatment. ..
  31. Nakashima A, Butt R, Dyck R. Alterations in protein and gene expression within the barrel cortices of ZnT3 knockout mice: experience-independent and dependent changes. Neurochem Int. 2011;59:860-70 pubmed publisher
    ..Recent studies have reported that mice deficient in zinc transporter-3 protein (ZnT3) and thus, vesicular zinc, have significant behavioural and biochemical deficits...
  32. Adlard P, Parncutt J, Lal V, James S, Hare D, Doble P, et al. Metal chaperones prevent zinc-mediated cognitive decline. Neurobiol Dis. 2015;81:196-202 pubmed publisher
    Zinc transporter-3 (ZnT3) protein is responsible for loading zinc into presynaptic vesicles and consequently controls the availability of zinc at the glutamatergic synapse...
  33. da Rocha T, Korb C, Schuch J, Bamberg D, De Andrade F, Fiegenbaum M. SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults. Nutr Res. 2014;34:742-8 pubmed publisher
    ..The objective of this study was to determine the effects of solute carrier family 30 member 3 (SLC30A3) and 15-kd selenoprotein (SEP15) polymorphisms on zinc and selenium concentrations, ..
  34. Li Y, Andereggen L, Yuki K, Omura K, Yin Y, Gilbert H, et al. Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Proc Natl Acad Sci U S A. 2017;114:E209-E218 pubmed publisher
    ..accumulation in amacrine cell processes involves the Zn2+ transporter protein ZnT-3, and deletion of slc30a3, the gene encoding ZnT-3, promotes RGC survival and axon regeneration...
  35. Bai S, Sheline C, Zhou Y, Sheline C. A reduced zinc diet or zinc transporter 3 knockout attenuate light induced zinc accumulation and retinal degeneration. Exp Eye Res. 2013;108:59-67 pubmed publisher
    ..We light exposed (70 kLux of white light for 50 h) Zn(2+) transporter 3 knockout (ZnT3-KO, no synaptic Zn(2+)), or RPE65 knockout mice (RPE65-KO, lack rhodopsin cycling), or C57/BI6/J controls and ..
  36. Perez Rosello T, Anderson C, Schopfer F, Zhao Y, Gilad D, Salvatore S, et al. Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. J Neurosci. 2013;33:9259-72 pubmed publisher
    ..We reveal a previously unknown action of synaptic Zn(2+): synaptic Zn(2+) inhibits glutamate release by promoting 2-AG synthesis. ..
  37. Cole T, Martyanova A, Palmiter R. Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse. Brain Res. 2001;891:253-65 pubmed
    ..Here we use zinc transporter-3 (ZnT3) knockout mice, which are depleted of synaptic vesicle zinc, to assess the consequences of removing this potential ..
  38. Nydegger I, Rumschik S, Zhao J, Kay A. Evidence for an extracellular zinc-veneer in rodent brains from experiments with Zn-ionophores and ZnT3 knockouts. ACS Chem Neurosci. 2012;3:761-6 pubmed publisher
    ..In addition, we show that ZnT3 null mice, which lack the transporter responsible for stocking synaptic vesicles, nevertheless do have a zinc ..
  39. Wightman P, Hayward B, Bonthron D. The genes encoding glucokinase regulatory protein and ketohexokinase co-localize to mouse chromosome 5. Mamm Genome. 1997;8:700-1 pubmed
  40. Ponnoth D, Nayeem M, Kunduri S, Tilley S, Zeldin D, Ledent C, et al. Role of ?-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice. Am J Physiol Regul Integr Comp Physiol. 2012;302:R400-8 pubmed publisher
    ..These data suggest that, in the absence of A(2A)AR, Cyp4a induces vasoconstriction through MAPK via upregulation of A(1)AR and PKC-?. ..
  41. Martel G, Hevi C, Kane Goldsmith N, Shumyatsky G. Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex. Behav Brain Res. 2011;223:233-8 pubmed publisher
    Since zinc transporter ZnT3 is localized to the hippocampus and perirhinal cortex, we used ZnT3 knockout mice (KO) to analyze the role of ZnT3 in memory and behavior dependent on these brain regions...
  42. Lopantsev V, Wenzel H, Cole T, Palmiter R, Schwartzkroin P. Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice. Neuroscience. 2003;116:237-48 pubmed
    ..We took advantage of zinc transporter 3 knockout mice, which lack vesicular zinc, to study the possible physiological role of this heavy metal in ..
  43. Lavoie N, Jeyaraju D, Peralta M, Seress L, Pellegrini L, Toth K. Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals. J Neurosci. 2011;31:18251-65 pubmed publisher
    ..We propose that functionally diverse vesicle pools with unique membrane protein composition support different modes of transmission and are generated via distinct recycling pathways. ..
  44. Chabrol E, Navarro V, Provenzano G, Cohen I, Dinocourt C, Rivaud Pechoux S, et al. Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice. Brain. 2010;133:2749-62 pubmed publisher
    ..We conclude that LGI1(+/-) and LGI1(-/-) mice may provide useful models for lateral temporal lobe epilepsy, and more generally idiopathic focal epilepsy. ..
  45. Zheng W, Wang T, Yu D, Feng W, Nie Y, Stoltenberg M, et al. Elevation of zinc transporter ZnT3 protein in the cerebellar cortex of the AbetaPP/PS1 transgenic mouse. J Alzheimers Dis. 2010;20:323-31 pubmed publisher
    ..Here we present data showing an elevated expression of zinc transporter 3 (ZnT3) protein, revealed by immunoblotting assay, in the cerebellum of the amyloid-beta protein precursor (..
  46. Adlard P, Parncutt J, Finkelstein D, Bush A. Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?. J Neurosci. 2010;30:1631-6 pubmed publisher
    Zinc transporter-3 (ZnT3) protein controls synaptic vesicular Zn(2+) levels, which is predicted to regulate normal cognitive function...
  47. Choi B, Kim I, Kim J, Kho A, Lee S, Lee B, et al. Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model. Neurobiol Dis. 2016;94:205-12 pubmed publisher
    The present study aimed to evaluate the role of zinc transporter 3 (ZnT3) on multiple sclerosis (MS) pathogenesis...
  48. Salazar G, Falcon Perez J, Harrison R, Faundez V. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. PLoS ONE. 2009;4:e5896 pubmed publisher
    ..Here, we described a novel oligomerization mechanism affecting solute carrier family 30 member 3/zinc transporter 3 (SLC30A3/ZnT3)...
  49. Suh S, Jo S, Vajda Z, Danscher G. Adrenalectomy-induced ZnT3 downregulation in mouse hippocampus is followed by vesicular zinc depletion. Neurosci Lett. 2005;377:164-9 pubmed
    ..b>ZnT3 resides in the synaptic vesicle membranes of ZEN neurons and is believed to move zinc ions into the vesicles...
  50. Vergnano A, Rebola N, Savtchenko L, Pinheiro P, Casado M, Kieffer B, et al. Zinc dynamics and action at excitatory synapses. Neuron. 2014;82:1101-14 pubmed publisher
    ..By specifically moderating GluN2A-NMDAR signaling, zinc acts as a widespread activity-dependent regulator of neuronal circuits. ..
  51. Larimore J, Tornieri K, Ryder P, Gokhale A, Zlatic S, Craige B, et al. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell. 2011;22:4854-67 pubmed publisher
    ..Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals...
  52. Carter R, Aiba I, Dietz R, Sheline C, Shuttleworth C. Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation. J Cereb Blood Flow Metab. 2011;31:1073-84 pubmed publisher
    ..produced large FluoZin-3 increases that propagated with the event, and signals were abolished in tissues from ZnT3 knockout animals lacking synaptic Zn(2+)...