Slc30a1

Summary

Gene Symbol: Slc30a1
Description: solute carrier family 30 (zinc transporter), member 1
Alias: AI839647, C130040I11Rik, Znt1, zinc transporter 1, solute carrier family 30 member 1, znT-1
Species: mouse
Products:     Slc30a1

Top Publications

  1. Andrews G, Wang H, Dey S, Palmiter R. Mouse zinc transporter 1 gene provides an essential function during early embryonic development. Genesis. 2004;40:74-81 pubmed
    ..The founding member of this family, Znt1, was discovered by virtue of its ability to efflux zinc from cells and to protect them from zinc toxicity...
  2. Palmiter R, Cole T, Findley S. ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 1996;15:1784-91 pubmed
    ..Prolonged exposure of cells expressing ZnT-2 to zinc causes an accretion of intracellular vesicles. We suggest that ZnT-2 protects these cells from zinc toxicity by facilitating zinc transport into an endosomal/lysosomal compartment. ..
  3. Palmiter R, Findley S. Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 1995;14:639-49 pubmed
    ..We propose that ZnT-1 transports zinc out of cells and that its absence accounts for the increased sensitivity of mutant cells to zinc toxicity. ..
  4. Ohana E, Sekler I, Kaisman T, Kahn N, Cove J, Silverman W, et al. Silencing of ZnT-1 expression enhances heavy metal influx and toxicity. J Mol Med (Berl). 2006;84:753-63 pubmed
    ..Taken together, our results indicate that endogenously-expressed ZnT-1, by modulating LTCC, has a dual role: regulating calcium influx, and attenuating Cd(2+) and Zn(2+) permeation and toxicity in neurons and other cell types. ..
  5. Langmade S, Ravindra R, Daniels P, Andrews G. The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem. 2000;275:34803-9 pubmed
    ..Zinc or cadmium treatment of cell lines rapidly (3 h) and dramatically (about 12-fold) induced ZnT1 mRNA levels...
  6. Ryu M, Lichten L, Liuzzi J, Cousins R. Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008;138:2076-83 pubmed publisher
    ..b>ZnT1, Zip8, and Zip10 were detected among the 12 transporter proteins tested...
  7. Davis S, McMahon R, Cousins R. Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. J Nutr. 1998;128:825-31 pubmed
    ..These results further support metallothionein as an important component for reducing the efficiency of zinc absorption at elevated zinc intakes. ..
  8. Kambe T, Yamaguchi Iwai Y, Sasaki R, Nagao M. Overview of mammalian zinc transporters. Cell Mol Life Sci. 2004;61:49-68 pubmed
    ..In this review, we review the literature of mammalian zinc transporters with emphasis on very recent findings and elicit integrative knowledge of zinc homeostasis. ..
  9. Wang Z, Stoltenberg M, Jo S, Huang L, Larsen A, Dahlstrom A, et al. Dynamic zinc pools in mouse choroid plexus. Neuroreport. 2004;15:1801-4 pubmed
    We examined the presence of Zn-transporters (ZnT1, ZnT3, ZnT4, and ZnT6) proteins and zinc ions in rat choroid epithelium with immunohistochemistry and zinc selenide autometallography (ZnSe(AMG))...

More Information

Publications19

  1. Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher
    ..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
  2. Fernandez E, Dencker L, Tallkvist J. Expression of ZnT-1 (Slc30a1) and MT-1 (Mt1) in the conceptus of cadmium treated mice. Reprod Toxicol. 2007;24:353-8 pubmed
    ..The aim of the present study was to detect ZnT-1 (Slc30a1) and MT (Mt1) protein in structures within the decidua, yolk sac and embryo of mice and to determine whether Cd ..
  3. Mellone M, Pelucchi S, Alberti L, Genazzani A, Di Luca M, Gardoni F. Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. J Neurochem. 2015;132:159-68 pubmed publisher
    ..Modulation of ZNT-1 expression in hippocampal neurons determined a shrinkage of dendritic spines and a reduction of GluN2A surface levels supporting the involvement of ZNT-1 in the dynamics of the excitatory synapse. ..
  4. Beharier O, Dror S, Levy S, Kahn J, Mor M, Etzion S, et al. ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl). 2012;90:127-38 pubmed publisher
    ..However, following reperfusion ZnT-1 levels were found to be decreased. Our findings indicate that ZnT-1 may have important role in the ischemic myocardium through its ability to interact with Raf-1 kinase. ..
  5. Wesselkamper S, Chen L, Gordon T. Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. Respir Res. 2005;6:73 pubmed
  6. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I. A role for ZnT-1 in regulating cellular cation influx. Biochem Biophys Res Commun. 2004;323:1145-50 pubmed
    ..Furthermore, ZnT-1 may play a role in cellular ion homeostasis and thereby confer protection against pathophysiological events linked to cellular Ca(2+) or Zn(2+) permeation and cell death. ..
  7. Liuzzi J, Bobo J, Lichten L, Samuelson D, Cousins R. Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis. Proc Natl Acad Sci U S A. 2004;101:14355-60 pubmed
    ..There are 16 ZnT and Zip transporters expressed in pancreas. Only two, ZnT1 and ZnT2 (both cellular Zn exporters), show a progressive down-regulation under Zn-depleted conditions...
  8. Lee J, Park J, Jang B, Knudsen T. Altered expression of genes related to zinc homeostasis in early mouse embryos exposed to di-2-ethylhexyl phthalate. Toxicol Lett. 2004;152:1-10 pubmed
    ..9 mg/kg for MT-II, and 6.6 mg/kg for ZnT-1. We conclude that DEHP exposure to pregnant dams at reasonably low levels during organogenesis stages can alter the expression of several key genes in embryonic zinc homeostasis. ..
  9. Fowler K, Saffery R, Irvine D, Trowell H, Choo K. Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis. Cytogenet Cell Genet. 1998;82:180-1 pubmed
  10. Sindreu C, Bayes A, Altafaj X, Pérez Clausell J. Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses. Mol Brain. 2014;7:16 pubmed publisher
    ..Based on the presence of a canonical PDZ I motif in the Zinc Transporter-1 protein (ZnT1), we hypothesized that ZnT1 may be targeted to synaptic compartments for local control of cytosolic zinc...