Gene Symbol: Slc2a3
Description: solute carrier family 2 (facilitated glucose transporter), member 3
Alias: AA408729, AL023014, AL024341, AU040424, C78366, Glut-3, Glut3, solute carrier family 2, facilitated glucose transporter member 3, glucose transporter type 3, brain
Species: mouse
Products:     Slc2a3

Top Publications

  1. Cheng L, Chen C, Luo P, Tan M, Qiu M, Johnson R, et al. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003;23:9961-7 pubmed
    ..2, drives 5-HT differentiation in the dorsal spinal cord. Our studies therefore define a molecular pathway necessary and sufficient to specify the serotonergic neurotransmitter phenotype. ..
  2. Aghayan M, Rao L, Smith R, Jarett L, Charron M, Thorens B, et al. Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development. Development. 1992;115:305-12 pubmed
    ..This observation suggests a different functional significance for these isoforms during mouse preimplantation development. ..
  3. Choeiri C, Staines W, Messier C. Immunohistochemical localization and quantification of glucose transporters in the mouse brain. Neuroscience. 2002;111:19-34 pubmed
    ..In the brain, Glut2, Glut5 and Glut8 are found at relatively low levels whereas Glut1, Glut3 and Glut4 were reported in abundance in several brain regions...
  4. Nagamatsu S, Kornhauser J, Burant C, Seino S, Mayo K, Bell G. Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization. J Biol Chem. 1992;267:467-72 pubmed
    Complementary DNAs encoding the mouse GLUT3/brain facilitative glucose transporter have been isolated and sequenced...
  5. Hogan A, Heyner S, Charron M, Copeland N, Gilbert D, Jenkins N, et al. Glucose transporter gene expression in early mouse embryos. Development. 1991;113:363-72 pubmed
    ..Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11. ..
  6. Schmidt S, Richter M, Montag D, Sartorius T, Gawlik V, Hennige A, et al. Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice. Am J Physiol Endocrinol Metab. 2008;295:E1084-94 pubmed publisher
    Homozygous deletion of the gene of the neuronal glucose transporter GLUT3 (Slc2a3) in mice results in embryonic lethality, whereas heterozygotes (Slc2a3+/-) are viable...
  7. Rajakumar A, Thamotharan S, Raychaudhuri N, Menon R, Devaskar S. Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons. J Biol Chem. 2004;279:26768-79 pubmed
    ..By employing the primer extension assay, the transcription start site of the murine Glut 3 gene in the brain was localized to -305 bp 5' to the ATG translation start codon...
  8. Ganguly A, McKnight R, Raychaudhuri S, Shin B, Ma Z, Moley K, et al. Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction. Am J Physiol Endocrinol Metab. 2007;292:E1241-55 pubmed
    Glucose transporter isoform-3 (GLUT3) is the trophoblastic facilitative glucose transporter...
  9. Khan J, Rajakumar R, McKnight R, Devaskar U, Devaskar S. Developmental regulation of genes mediating murine brain glucose uptake. Am J Physiol. 1999;276:R892-900 pubmed

More Information


  1. Zhao Y, Fung C, Shin D, Shin B, Thamotharan S, Sankar R, et al. Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders. Mol Psychiatry. 2010;15:286-99 pubmed publisher
    ..This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the ..
  2. Ganguly A, Devaskar S. Glucose transporter isoform-3-null heterozygous mutation causes sexually dimorphic adiposity with insulin resistance. Am J Physiol Endocrinol Metab. 2008;294:E1144-51 pubmed publisher
    We examined male and female glucose transporter isoform-3 (GLUT3; placenta)-null heterozygous(+/-) mutation-carrying mice and compared them with age- and sex-matched wild-type(+/+) littermates...
  3. Pantaleon M, Harvey M, Pascoe W, James D, Kaye P. Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst. Proc Natl Acad Sci U S A. 1997;94:3795-800 pubmed
    ..We identified and localized the primary transporter in TE cells. It is glucose transporter GLUT3, previously described in the mouse as neuron-specific...
  4. Schmidt S, Hommel A, Gawlik V, Augustin R, Junicke N, Florian S, et al. Essential role of glucose transporter GLUT3 for post-implantation embryonic development. J Endocrinol. 2009;200:23-33 pubmed publisher
    Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo...
  5. Thamotharan S, Stout D, Shin B, Devaskar S. Temporal and spatial distribution of murine placental and brain GLUT3-luciferase transgene as a readout of in vivo transcription. Am J Physiol Endocrinol Metab. 2013;304:E254-66 pubmed publisher
    To investigate in vivo transcription of the facilitative glucose transporter isoform-GLUT3 gene, we created GLUT3-firefly luciferase transgenic mouse lines that demonstrate tissue-specific [adult: brain > testis ? skeletal muscle > ..
  6. Tunster S, Van de Pette M, John R. Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Dis Model Mech. 2011;4:814-21 pubmed publisher
  7. Nagamatsu S, Nakamichi Y, Sawa H. Glucose transporter expression and functional role of hexokinase in insulin biosynthesis in mouse beta TC3 cells. Am J Physiol. 1995;269:C480-6 pubmed
  8. Borson N, Salo W, Drewes L. Canine brain glucose transporter 3: gene sequence, phylogenetic comparisons and analysis of functional sites. Gene. 1996;168:251-6 pubmed
    There has been a sparsity of various mammalian neuronal glucose transporter 3-encoding sequences(Glut3) available for the purposes of alignment studies...
  9. Mulder J, Aguado T, Keimpema E, Barabas K, Ballester Rosado C, Nguyen L, et al. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A. 2008;105:8760-5 pubmed publisher
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis. ..
  10. Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008;14:62-75 pubmed publisher
    ..These results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development and control of the E2F1-p53 apoptotic axis. ..
  11. Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland N, Gilbert D, et al. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999;163:5039-48 pubmed
    ..The Mincle gene locus was mapped at 0.6 centiMorgans proximal to CD4 on mouse chromosome 6. ..
  12. Fidler T, Middleton E, Rowley J, Boudreau L, Campbell R, Souvenir R, et al. Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol. 2017;37:1628-1639 pubmed publisher
    ..Here we evaluate the contribution of GLUT3 (glucose transporter 3) to platelet function to better understand glucose metabolism in platelets...
  13. Hahn T, Barth S, Graf R, Engelmann M, Beslagic D, Reul J, et al. Placental glucose transporter expression is regulated by glucocorticoids. J Clin Endocrinol Metab. 1999;84:1445-52 pubmed
    ..In the present study, the glucose carrier proteins GLUT1 and GLUT3 were localized in the trophoblast and endothelium of the human, rat, and mouse placenta...
  14. Chauvin T, Xie F, Liu T, Nicora C, Yang F, Camp D, et al. A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87:141 pubmed publisher
    ..This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function. ..
  15. Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao X, et al. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. J Mol Biol. 1992;226:747-61 pubmed
    ..These results suggest multiple cellular targets for the action of these proteins during development. ..
  16. Maeng H, Lim H, Jeong Y, Woo A, Kang J, Lee W, et al. Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects. Immunobiology. 2009;214:311-20 pubmed publisher
    ..Application of vitamin C to T cells in vitro did not recapitulate previously reported in vivo responses to vitamin C, suggesting that in vivo, vitamin C modulates T cells indirectly through other components of the microenvironment. ..
  17. Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, et al. Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009;106:12127-32 pubmed publisher
  18. Frankfater C, Maus E, Gaal K, Segade F, Copeland N, Gilbert D, et al. Organization of the mouse microfibril-associated glycoprotein-2 (MAGP-2) gene. Mamm Genome. 2000;11:191-5 pubmed
    ..We have characterized both mRNA species and determined that they do not code for different variants of the protein. ..
  19. Constancia M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, et al. Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems. Proc Natl Acad Sci U S A. 2005;102:19219-24 pubmed
    ..this up-regulation of transport occurs, at least in part, through increased expression of the transporter genes Slc2a3 and Slc38a4, the imprinted member of the System A amino acid transporter gene family...
  20. Pathak B, Shaughnessy J, Meneton P, Greeb J, Shull G, Jenkins N, et al. Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene. Genomics. 1996;33:124-7 pubmed
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping. ..
  21. Hsu D, Guo Y, Alberts G, Copeland N, Gilbert D, Jenkins N, et al. Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation. J Biol Chem. 1996;271:13786-95 pubmed
    ..These results indicate that increased expression of a TEF-1-related protein may be important for both mitogen-stimulated fibroblast proliferation and skeletal muscle cell differentiation. ..
  22. Mlynarski E, Sheridan M, Xie M, Guo T, Racedo S, McDonald McGinn D, et al. Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome. Am J Hum Genet. 2015;96:753-64 pubmed publisher
    ..Our analysis revealed that a duplication of SLC2A3 was the most frequent CNV identified in the first cohort...
  23. Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S. Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014;275:134-44 pubmed publisher
    ..transporter 1 (GLUT1), which is a major transporter for glucose, but increased placental mRNA levels of Slc2a3/GLUT3...
  24. Chen Y, Shin B, Thamotharan S, Devaskar S. Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression. Endocrinology. 2013;154:1598-611 pubmed publisher
    The murine neuronal facilitative glucose transporter isoform 3 (Glut3) is developmentally regulated, peaking in expression at postnatal day (PN)14...
  25. Ohtsuka H, Mafune Y, Tsunashima K, Takahashi H, Kominami R. Difference in allelic expression of genes probably associated with tumor progression in murine fibrosarcomas and cell lines. Jpn J Cancer Res. 1994;85:1015-22 pubmed
    ..In some of the tumors and cell lines, p53, E-cadherin and Glut3 genes showed remarkable differences in allelic expression, one allele being poorly expressed...
  26. Angulo C, Castro M, Rivas C, Segretain D, Maldonado R, Yañez A, et al. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J Cell Physiol. 2008;217:708-16 pubmed publisher
    ..OMG) transport by 42GPA9 Sertoli cells correspond to facilitative hexose transporters GLUT1, GLUT2 and GLUT3 expressed in these cells...
  27. William D, Saitta B, Gibson J, Traas J, Markov V, Gonzalez D, et al. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol. 2007;305:172-86 pubmed
    ..Our results demonstrate that human and mouse in vitro models can recapitulate oscillatory expression observed in embryo and that a number of genes in multiple developmental pathways display dynamic expression in vitro. ..
  28. Umekawa T, Sugiyama T, Kihira T, Murabayashi N, Zhang L, Nagao K, et al. Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism. Endocrinology. 2008;149:3980-8 pubmed publisher
    ..In particular, increased hTRX-1 activity and the resulting modified placental redox state may play an important role in fetal growth by increasing the availability of glucose. ..
  29. Yamaguchi M, Sakata M, Ogura K, Miyake A. Gestational changes of glucose transporter gene expression in the mouse placenta and decidua. J Endocrinol Invest. 1996;19:567-9 pubmed
    ..In this study, the gestational changes of GLUT1 and GLUT3 mRNA level in the mouse placenta and decidua were analyzed by Northern blot analysis...
  30. Huang S, Tsai S, Lin J, Wu C, Yen G. Cytoprotective effects of hesperetin and hesperidin against amyloid ?-induced impairment of glucose transport through downregulation of neuronal autophagy. Mol Nutr Food Res. 2012;56:601-9 pubmed publisher
  31. Miranda P, Allaire A, Sosnik J, Visconti P. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod. 2009;80:897-904 pubmed publisher
    ..Taking into consideration the requirement of the acrosome reaction for sperm to become fusogenic, these results suggest that membrane raft dynamics may have a role in sperm-egg membrane interaction. ..
  32. Wyrwoll C, Seckl J, Holmes M. Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice. Endocrinology. 2009;150:1287-93 pubmed publisher
    ..Our data suggest that restriction of fetal growth in 11beta-HSD2(-/-) mice is mediated, at least in part, via altered placental transport of nutrients and reduction in placental vascularization. ..
  33. Fukuzumi M, Shinomiya H, Shimizu Y, Ohishi K, Utsumi S. Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1. Infect Immun. 1996;64:108-12 pubmed
    ..These results suggest that macrophage responses to LPS are supported by a rapid and sustained glucose influx via GLUT1 and that this is a participating factor in the development of systemic hypoglycemia when endotoxemia is prolonged. ..
  34. Saijoh Y, Fujii H, Meno C, Sato M, Hirota Y, Nagamatsu S, et al. Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1996;1:239-52 pubmed
    ..A large proportion of pluripotent cell-specific genes appear to be downstream targets of Oct-3. ..
  35. Ganguly A, Collis L, Devaskar S. Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice. Endocrinology. 2012;153:3995-4007 pubmed publisher
    ..CR) decreased placenta and fetal weights in wild-type (wt) and glucose transporter (Glut) 3 heterozygous null (glut3(+/-)) mice...
  36. Smith D, Gridley T. Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos. Development. 1992;116:555-61 pubmed
    ..Expression of Glut-1 was fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc expression was down-regulated and was observed in the eye and the spinal cord.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  37. Thamotharan S, Raychaudhuri N, Tomi M, Shin B, Devaskar S. Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1? in transactivating murine neuroblastic glucose transporter. Am J Physiol Endocrinol Metab. 2013;304:E583-98 pubmed publisher
    We have shown in vitro a hypoxia-induced time-dependent increase in facilitative glucose transporter isoform 3 (GLUT3) expression in N2A murine neuroblasts...
  38. Keith B, Adelman D, Simon M. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc Natl Acad Sci U S A. 2001;98:6692-7 pubmed
    ..5. These results demonstrate that Arnt and Arnt2 have both unique and overlapping essential functions in embryonic development. ..
  39. Kayano T, Fukumoto H, Eddy R, Fan Y, Byers M, Shows T, et al. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem. 1988;263:15245-8 pubmed
  40. Vannucci S, Rutherford T, Wilkie M, Simpson I, Lauder J. Prenatal expression of the GLUT4 glucose transporter in the mouse. Dev Neurosci. 2000;22:274-82 pubmed
    ..These findings suggest that GLUT4-mediated glucose transport may play important roles during development of the brain and nonneuronal tissues in the mouse embryo. ..
  41. Gutiérrez Torres D, González Horta C, Del Razo L, Infante Ramírez R, Ramos Martínez E, Levario Carrillo M, et al. Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice. Biomed Res Int. 2015;2015:175025 pubmed publisher
    ..The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology...
  42. Guillam M, Dupraz P, Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes. 2000;49:1485-91 pubmed
    ..We show that in the absence of GLUT2, no compensatory expression of either GLUT1 or GLUT3 is observed and that glucokinase is expressed at normal levels...
  43. Gould G, Holman G. The glucose transporter family: structure, function and tissue-specific expression. Biochem J. 1993;295 ( Pt 2):329-41 pubmed
  44. Ryder J, Kawano Y, Chibalin A, Rincon J, Tsao T, Stenbit A, et al. In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle. Biochem J. 1999;342 ( Pt 2):321-8 pubmed
    ..Neither GLUT3 nor GLUT5 appeared to account for insulin-stimulated glucose-transport activity in wild-type or GLUT4-null muscle...
  45. Zha X, Hu Z, Ji S, Jin F, Jiang K, Li C, et al. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. Cancer Lett. 2015;359:97-106 pubmed publisher
    ..fibroblasts (MEFs) and human cancer cell lines consistently indicate that the expression of glucose transporter 3 (Glut3) is dramatically up-regulated by mTOR...
  46. Kind K, Collett R, Harvey A, Thompson J. Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst. Mol Reprod Dev. 2005;70:37-44 pubmed
    ..001). These results suggest that the preimplantation mouse embryo has the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes. ..
  47. Maher F, Vannucci S, Takeda J, Simpson I. Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain. Biochem Biophys Res Commun. 1992;182:703-11 pubmed
    Polyclonal anti-peptide antisera were raised to the C-terminal sequence of mouse- and human-GLUT3 glucose transporter isoforms...
  48. Yi T, Gilbert D, Jenkins N, Copeland N, Ihle J. Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6. Genomics. 1992;14:793-5 pubmed
    ..Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes. ..
  49. Moley K, Chi M, Mueckler M. Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos. Am J Physiol. 1998;275:E38-47 pubmed
    ..These findings suggest that, in response to a maternal diabetic state, preimplantation mouse embryos experience a decrease in glucose utilization directly related to a decrease in glucose transport at both the mRNA and protein levels. ..
  50. Ida Yonemochi H, Nakatomi M, Harada H, Takata H, Baba O, Ohshima H. Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars. Dev Biol. 2012;363:52-61 pubmed publisher
  51. Shen X, Han Y, Yang B, Cui X, Kim N. Hyperglycemia reduces mitochondrial content and glucose transporter expression in mouse embryos developing in vitro. J Reprod Dev. 2009;55:534-41 pubmed
    ..Both transcripts and protein synthesis of the glucose transporters Glut1 and Glut3 were reduced in blastocysts cultured in the presence of either 25 or 55 mM glucose...
  52. Sakakura Y, Shibui T, Irie K, Yajima T. Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice. Eur J Oral Sci. 2008;116:341-52 pubmed publisher
    ..for hypoxia-inducible factor-1alpha (HIF-1alpha), glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), and glucose transporter 5 (GLUT5), and using enzyme histochemistry for glucose-6-phosphate isomerase (GPI), ..
  53. Dupressoir A, Vernochet C, Harper F, Guégan J, Dessen P, Pierron G, et al. A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011;108:E1164-73 pubmed publisher
    ..Although some are absolutely required for completion of pregnancy, others are still amenable to "epigenetic" compensations, thus illustrating the complexity of the molecular machinery that developed during placental evolution. ..
  54. Vannucci S, Gibbs E, Simpson I. Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. Am J Physiol. 1997;272:E267-74 pubmed
    ..The results of this study indicate that the db/db mouse has markedly decelerated brain growth accompanied by global reductions in glucose metabolism that are not due to reductions in glucose transport capacity. ..
  55. Hao J, Li W, Dan J, Ye X, Wang F, Zeng X, et al. Reprogramming- and pluripotency-associated membrane proteins in mouse stem cells revealed by label-free quantitative proteomics. J Proteomics. 2013;86:70-84 pubmed publisher
    ..This membrane proteomic resource of pluripotent stem cells would be expected to inspire further investigations leading to discovery of new regulatory factors or membrane markers for reprogramming and pluripotency. ..
  56. Stuart C, Ross I, Howell M, McCurry M, Wood T, Ceci J, et al. Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake. Brain Res. 2011;1384:15-22 pubmed publisher
    ..Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells...
  57. Maher F, Vannucci S, Simpson I. Glucose transporter proteins in brain. FASEB J. 1994;8:1003-11 pubmed
    ..concentration at the blood-brain barrier as well as in parenchymal cells (45-kDa form), most likely in astrocytes, GLUT3 expressed in neurons, and GLUT5 in microglia...
  58. Ren B, Deng L, Wang J, Zhu Y, Wei L, Zhou Q. Hypoxia regulation of facilitated glucose transporter-1 and glucose transporter-3 in mouse chondrocytes mediated by HIF-1alpha. Joint Bone Spine. 2008;75:176-81 pubmed
  59. Oyake M, Onodera O, Shiroishi T, Takano H, Takahashi Y, Kominami R, et al. Molecular cloning of murine homologue dentatorubral-pallidoluysian atrophy (DRPLA) cDNA: strong conservation of a polymorphic CAG repeat in the murine gene. Genomics. 1997;40:205-7 pubmed
  60. Gould G, Brant A, Kahn B, Shepherd P, McCoid S, Gibbs E. Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice. Diabetologia. 1992;35:304-9 pubmed
    ..blot analysis of human tissues has demonstrated the expression of the brain-type glucose transporter isoform (GLUT 3) in liver, muscle and fat, raising the possibility that this transporter isoform may play a role in the regulation ..
  61. Kawauchi K, Araki K, Tobiume K, Tanaka N. p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol. 2008;10:611-8 pubmed publisher
    ..Activation of NF-kappaB, by loss of p53, caused an increase in the rate of aerobic glycolysis and upregulation of Glut3. Oncogenic Ras-induced cell transformation and acceleration of aerobic glycolysis in p53-deficient cells were ..
  62. McClory H, Williams D, Sapp E, Gatune L, Wang P, DiFiglia M, et al. Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice. Acta Neuropathol Commun. 2014;2:179 pubmed publisher
    ..Glucose transporter 3 (Glut3) handles most glucose uptake in neurons. Here we investigated rab11 involvement in Glut3 trafficking...
  63. Sarkar D, Singh S. Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. Andrology. 2017;5:749-762 pubmed publisher
    ..Glucose uptake by Sertoli cells is mediated through glucose transporter 3 (GLUT3) under the influence of THs to meet energy requirement of developing germ cells...
  64. Nagamatsu S, Sawa H, Inoue N, Nakamichi Y, Takeshima H, Hoshino T. Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos. Biochem J. 1994;300 ( Pt 1):125-31 pubmed
    This study was designed to determine whether glucose regulates the gene expression of glucose transporter GLUT3 in neurons...